Gene

KWMTBOMO06106  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001695

Annotation

PREDICTED:_lysosomal_alpha-mannosidase-like?_partial_[Bombyx_mori]

Location

Bomo_Chr11(-):507050-536584      View in EpiBrowser

Full name

Alpha-mannosidase      

Location in the cell

Cytoplasmic   Reliability : 2.544

CDS

ATGCTGGTACTCGCGCTGCTGTGCCTCCTGAGCATATCATCAAGCGTTCCCCTGCATGACCAGATAACTCCGAGGCCCGGGGAGACGTGTGGCTATGAGAGCTGTCCGAAGACCGAGCCGGGTGTGCTGAACGTCCACATCGTACCCCACACCCACGACGACGTCGGCTGGCTGAAGACCGTCGACCAGTACTATTACGGAAGCAGGAACAACATACAGAAGGCTGGCGTTCAATACATTCTGGATTCGGTTGTCAAGGAGCTGTGGGAAGACCCGAAGCGACGGTTTATCTACGTGGAGACGGCTTTCTTCTGGAAGTGGTGGGTCAGGCAGTCCCGTCGGGTCAAGAGTAAGGTCCACACCCTCGTCAGGCAGGGGCGGCTTCAATTCGTCGGTGGGGCGTGGTCCATGAACGATGAGGCCGCAGTGCACTATCAAAGTACCATCGATCAATTCACTTGGGGTCTCAGCAAATTGAACGAGACCTTCGGTTACTGCGGCTTGCCCCGGGTTGGCTGGCAGATCGACCCGTTCGGGCACTCGAGGGAGCTGGCTTCGCTGCTGTCCGCCATGGGATATGACGGCTTGTTCCTGGGCAGGATCGATTATCAAGACAAGAGGACCAGACTCCGAGACAAGACCATGGAGATGGTATGGAGGGGCGACGACGACTTGGGCAAGAAGTCAGACATCTTCACGGGCGCTTTGTACAACACATACTCTCCGCCGGCCGGGTTCTGCTTCGACGTCCTGTGTGACGACGAGCCCATAGTGGACGACGCTGGCTCGCCGCTGTACAATGTCGACAACAAGATGACCCTATTTCTGAACTACGTTAAAAAGCAATCGCAACATTATCGAACGGACAATGTCATCATCACGATGGGAGGAGATTTCACTTACCAAGACGCCGCGATGTGGTACACGAATCTGGACAAGCTGATTGAATATTCAAATCTGAAGGCGGCCAAAGACGATCTGAAGATTAAGCTGTTTTATTCGACGCCTAATTGTTATCTGAAAGCCATAAAAGACGCGAATCCGGTGTTGCCAACGAAACAAGACGACTTCTTCCCGTACGCGAGCGACCCGACCGCTTACTGGACCGGGTACTTCACCTCGAGACCGACCACCAAGTACTTCGAGAGAGAGGGGAACGCTTACCTGCAGATGGTGAAACAGCTGCAGGTGTTGTCGAATTTGGAAAGGCACAACGAGTTCATTCTGAACGAACTGAAGAGCGCAATGGGCATAATGCAACACCACGACGCCATCACCGGCACCGAGAAGCAGCACGTCGCTCATGACTACGAAAGGATCCTGAGCACCGCCATCGACGACGCTCTACTCGTCGCCAGACAGGCCTTCAACAAAGCCGCCCAGGGCGACTCCGGGAAGGCTCCGCTGTTCAGCTACGACAGGTGTCACTTCAACGAATCCAGATGCCACACGTCGGAGACCAGCGAAACGTTCATGCGATTAAGAGGATCAGAGTCAGGGTCAGTTGTTGGCCGGATCAGCACCAAGAGGCTCGATGCGGCCTATAAGCCGGCTGTCTTGCAGGTGACCGTTTACAACCCGTTGGCTTGGGGCGTCAGGGAGGCGGTGAAGCTGCCGGTCACGTATGGACACTACGAGGTCTACGCTCCGAATGGCGATAAAATCGTGACGCAACTGGTCGAGATACCGGACGAGGTTAAGCGCATACCGAACCGACGGTCTGAGGCCACTCACGAGTTGGTGTTCATTGCGCACTTACATCCGTTGGGCGTGAAATCGTTCTACGTTAAAAGAGTTTCGACAACGAAAAGGGCAATCGCTAACGGCAGCTATTTGGAATGGATCAGTGGCGAGGGGGTCCGGTCCGATGGCTATTTAGATAGGCTCAATCAGATAGCCGACGTCAAAGACCTCACGAATCTCGGCCTAGATGCTATTGTTGATGAAGGCAAGGAACCTTTGTGGGAAGATGCAAATGGAACTGGTGCGGCTTTCAAAGGGACTATGAAGAAAAGAGAGACGGACGACTTTAAGATATCGTTCGCGTATTACCCGGGCTGCTTGGGGAACAATGAGGTACCCGCTAACCGCAGTTCAGGCGCGTACATCTTCAGGCCGAACTCGACAAAAGCAATCGGTCTGAACGTGGAATCTGTGAGTGAAATTAGCGGCGACCTACTCAGCGAGGTTCGAACTAAGATACGCGGAAACGTTTTGAGCATCAAGCGTGTTTACAAGGAATTCGATTTTATTGAGCACGAGTGGCTCGTGGGCCCGATAAGCGTCGACGACGGCATCGGCAAGGAGTACGTGGTCAAGTACCAGACGGATATAATAAATAATGGAGAGTTTTACACGGATTCAAACGGCCGACAGATGCTGAAGAGGAAACTGAACGCGCGTCCTCAGTGGAACTTGACGTTGACCGAGCCGGTGCCCGGGAATTATTATCCGGTCACGAACGAGATCTACATCGAGAACGGCGAGAGGTTCACGGTCTTGACGGACCGATCGCAAGGCGGAACCTCGCTCGTCGAAGGCGAAGTGGAACTGATGCTGCACAGGAGATTGCTGCACGACGACGCGTTCGGCGTCGGTGAGGCCCTGAACGAAACGGTTCTCGGCTCGGGGCTGGTGGTTCGCGGGAAACACCGGATCCTGCGCTCGAAGGATCCGGTTGAGATCGCGAAAAGCGTTTTCCAAATGCACCTGCCGCCCGTGGTCTTCGTTTCCGACGCCTCAGGCCTCAGCTACGAGCAATGGATGAGGTTGGAGAATTGCAAGAAGTTTGTCAAGACCCCGATGCCTGACGGGCTCCATCTGCTCACCCTGGAGCCTTGGGGCGACCAGATCCTGTTGAGAATCGAAAACTACAAGACCGGTGCCGAAGATTCGACCATCGAAATTGACCTGCAGGGCATATTCAACGGTATCCATATCAAAAGCGTAAAAGAGACAACGCTAGCCGCAAACCAGTGGCTGGACGACTATGATAAGTGGACTTGGAATACGGAAGGAGACTTTTACGAAAGCTTCAACAAGAAATACGGGAGCTTCGAGGCCGTGAACAAAGCTGTCGACGGACCTGACGTCAGAGAGGACGAAGGCCTCAAAATCAAACTTAAAGCGAAGGAGATAAGGTCGTTTATAGCGGATATCGAATATACCGACTAA

Protein

MLVLALLCLLSISSSVPLHDQITPRPGETCGYESCPKTEPGVLNVHIVPHTHDDVGWLKTVDQYYYGSRNNIQKAGVQYILDSVVKELWEDPKRRFIYVETAFFWKWWVRQSRRVKSKVHTLVRQGRLQFVGGAWSMNDEAAVHYQSTIDQFTWGLSKLNETFGYCGLPRVGWQIDPFGHSRELASLLSAMGYDGLFLGRIDYQDKRTRLRDKTMEMVWRGDDDLGKKSDIFTGALYNTYSPPAGFCFDVLCDDEPIVDDAGSPLYNVDNKMTLFLNYVKKQSQHYRTDNVIITMGGDFTYQDAAMWYTNLDKLIEYSNLKAAKDDLKIKLFYSTPNCYLKAIKDANPVLPTKQDDFFPYASDPTAYWTGYFTSRPTTKYFEREGNAYLQMVKQLQVLSNLERHNEFILNELKSAMGIMQHHDAITGTEKQHVAHDYERILSTAIDDALLVARQAFNKAAQGDSGKAPLFSYDRCHFNESRCHTSETSETFMRLRGSESGSVVGRISTKRLDAAYKPAVLQVTVYNPLAWGVREAVKLPVTYGHYEVYAPNGDKIVTQLVEIPDEVKRIPNRRSEATHELVFIAHLHPLGVKSFYVKRVSTTKRAIANGSYLEWISGEGVRSDGYLDRLNQIADVKDLTNLGLDAIVDEGKEPLWEDANGTGAAFKGTMKKRETDDFKISFAYYPGCLGNNEVPANRSSGAYIFRPNSTKAIGLNVESVSEISGDLLSEVRTKIRGNVLSIKRVYKEFDFIEHEWLVGPISVDDGIGKEYVVKYQTDIINNGEFYTDSNGRQMLKRKLNARPQWNLTLTEPVPGNYYPVTNEIYIENGERFTVLTDRSQGGTSLVEGEVELMLHRRLLHDDAFGVGEALNETVLGSGLVVRGKHRILRSKDPVEIAKSVFQMHLPPVVFVSDASGLSYEQWMRLENCKKFVKTPMPDGLHLLTLEPWGDQILLRIENYKTGAEDSTIEIDLQGIFNGIHIKSVKETTLAANQWLDDYDKWTWNTEGDFYESFNKKYGSFEAVNKAVDGPDVREDEGLKIKLKAKEIRSFIADIEYTD

Cofactor

Zn(2+)

Similarity

Belongs to the glycosyl hydrolase 38 family.

Feature

chain  Alpha-mannosidase

Uniprot

A0A2J7RN33   A0A2J7RN15   A0A336LVA7   A0A336LYZ7   A0A1Q3FMY3   U5EV98   + More
A0A023EX89   A0A1S4FBS2   A0A067R124   A0A1J1I5Z3   A0A336M0Y1   A0A084VFG7   B4JQ04   A0A0C9Q6G3   A0A182IPC8   A0A1Q3FMS6   A0A1J1I212   B3MJI9   A0A2P8Z1T1   A0A1I8M2X1   A0A1S4HD42   Q178V9   A0A182QEX5   A0A0P8XGR3   Q5TS83   A0A084VFG4   A0A182KMH3   A0A182VJW0   Q178W0   A0A1A9ZH71   W5JQI4   A0A1S4GYN8   D6WI18   A0A1W4WS90   A0A3G5BIG9   A0A182IBN6   A0A1A9W6T1   A0A195F0Z8   A0A0K8UEK7   A0A026VXZ2   A0A023EWA7   A0A0K8U3N4   A0A0Q9WJC0   A0A0K8VTI9   A0A182WFK9   A0A1A9XCE3   A0A0Q9XIT5   A0A1I8M2X3   A0A1W4WSD2   A0A182UGZ7   A0A0M4ER29   B4G755   A0A1S4GYP5   A0A1I8QCY1   A0A1B0B0M4   A0A1Q3FJU6   B4Q9B2   A0A1Y1KHF4   A0A0A1WZV2   A0A1W4UG04   Q9VKV1   A0A0J9R086   A0A0K8VT60   E9IED8   A0A182KMH4   A0A0Q5WN53   B4LVB7   A0A1W4UUP0   A0A151IBC4   B3N5F1   Q8IPB7   A0A0R1DR73   A0A182X605   A0A0A1XEF2   A0A2M4DMV2   A0A1I8QD07   A0A195DWW0   A0A034V6I7   W8APD9   J9JL57   A0A0K8WDF9   A0A158NP11   E2B6B9   A0A2H8TPV8   A0A1L8DQQ1   A0A1L8DR39   A0A1W7RA88   A0A2S2R8V4   A0A0P6FNV7   A0A0N8EK80   A0A164XCC5   A0A0P5NKK4   A0A0P5A6R2   A0A0P5Z7T6   A0A0P5ACP0  

EC Number

3.2.1.-

Pubmed

24945155    24845553    24438588    17994087    29403074    25315136    + More
12364791    17510324    20966253    20920257    23761445    18362917    19820115    30400621    24508170    30249741    22936249    28004739    25830018    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    21282665    17550304    25348373    24495485    21347285    20798317   

EMBL

NEVH01002545    PNF42229.1    PNF42230.1    UFQS01000218    UFQT01000218    SSX01504.1    + More
SSX21884.1    SSX01503.1    SSX21883.1    GFDL01006179    JAV28866.1    GANO01001972    JAB57899.1    GAPW01000077    JAC13521.1    KK853110    KDR11229.1    CVRI01000038    CRK93801.1    UFQT01000391    SSX23894.1    ATLV01012390    KE524787    KFB36711.1    CH916372    EDV98984.1    GBYB01009698    JAG79465.1    GFDL01006180    JAV28865.1    CRK93802.1    CH902620    EDV32357.1    PYGN01000238    PSN50451.1    AAAB01008944    CH477358    EAT42740.1    AXCN02000716    KPU73915.1    EAL40242.3    ATLV01012389    KFB36708.1    EAT42739.1    ADMH02000752    ETN65165.1    KQ971332    EEZ99703.1    MK075175    AYV99578.1    APCN01000712    APCN01000713    APCN01000714    APCN01000715    KQ981891    KYN33784.1    GDHF01027225    GDHF01012263    JAI25089.1    JAI40051.1    KK107648    QOIP01000008    EZA48346.1    RLU19783.1    GAPW01000098    JAC13500.1    GDHF01030990    JAI21324.1    CH940649    KRF81022.1    GDHF01010454    JAI41860.1    CH933807    KRG03704.1    CP012523    ALC39282.1    CH479180    EDW28309.1    JXJN01006781    GFDL01007289    JAV27756.1    CM000361    CM002910    EDX04554.1    KMY89555.1    GEZM01085309    JAV60008.1    GBXI01009935    JAD04357.1    AF145601    AE014134    AAD38576.1    AAF52958.2    KMY89556.1    GDHF01010271    GDHF01002021    JAI42043.1    JAI50293.1    GL762576    EFZ21090.1    CH954177    KQS70602.1    EDW63296.2    KQ978112    KYM96921.1    EDV59030.2    AAN10754.1    CM000157    KRJ97497.1    GBXI01004996    JAD09296.1    GGFL01014681    MBW78859.1    KQ980167    KYN17373.1    GAKP01021245    JAC37707.1    GAMC01015917    GAMC01015916    GAMC01015915    GAMC01015914    JAB90640.1    ABLF02026049    GDHF01003182    JAI49132.1    ADTU01022012    ADTU01022013    ADTU01022014    GL445930    EFN88812.1    GFXV01004418    MBW16223.1    GFDF01005288    JAV08796.1    GFDF01005289    JAV08795.1    GFAH01000335    JAV48054.1    GGMS01017236    MBY86439.1    GDIQ01056497    JAN38240.1    GDIQ01018628    JAN76109.1    LRGB01001005    KZS14076.1    GDIQ01144965    JAL06761.1    GDIP01203317    JAJ20085.1    GDIP01060333    JAM43382.1    GDIP01201762    JAJ21640.1   

Proteomes

UP000235965    UP000027135    UP000183832    UP000030765    UP000001070    UP000075880    + More
UP000007801    UP000245037    UP000095301    UP000008820    UP000075886    UP000007062    UP000075882    UP000075903    UP000092445    UP000000673    UP000007266    UP000192223    UP000075840    UP000091820    UP000078541    UP000053097    UP000279307    UP000008792    UP000075920    UP000092443    UP000009192    UP000075902    UP000092553    UP000008744    UP000095300    UP000092460    UP000000304    UP000192221    UP000000803    UP000008711    UP000078542    UP000002282    UP000076407    UP000078492    UP000007819    UP000005205    UP000008237    UP000076858   

PRIDE

Q8IPB7   

Pfam

PF09261   Alpha-mann_mid        + More
PF07748   Glyco_hydro_38C
PF17677   Glyco_hydro38C2
PF01074   Glyco_hydro_38N

Interpro

IPR015341   Glyco_hydro_38_cen        + More
IPR011013   Gal_mutarotase_sf_dom       
IPR011330   Glyco_hydro/deAcase_b/a-brl       
IPR000602   Glyco_hydro_38_N       
IPR041147   GH38_C       
IPR037094   Glyco_hydro_38_cen_sf       
IPR027291   Glyco_hydro_38_N_sf       
IPR028995   Glyco_hydro_57/38_cen_sf       
IPR013780   Glyco_hydro_b       
IPR011682   Glyco_hydro_38_C       

SUPFAM

SSF88713   SSF88713        + More
SSF88688   SSF88688       
SSF74650   SSF74650       

Gene 3D

1.20.1270.50     2.60.40.1180     3.20.110.10    

ProteinModelPortal

A0A2J7RN33   A0A2J7RN15   A0A336LVA7   A0A336LYZ7   A0A1Q3FMY3   U5EV98   + More
A0A023EX89   A0A1S4FBS2   A0A067R124   A0A1J1I5Z3   A0A336M0Y1   A0A084VFG7   B4JQ04   A0A0C9Q6G3   A0A182IPC8   A0A1Q3FMS6   A0A1J1I212   B3MJI9   A0A2P8Z1T1   A0A1I8M2X1   A0A1S4HD42   Q178V9   A0A182QEX5   A0A0P8XGR3   Q5TS83   A0A084VFG4   A0A182KMH3   A0A182VJW0   Q178W0   A0A1A9ZH71   W5JQI4   A0A1S4GYN8   D6WI18   A0A1W4WS90   A0A3G5BIG9   A0A182IBN6   A0A1A9W6T1   A0A195F0Z8   A0A0K8UEK7   A0A026VXZ2   A0A023EWA7   A0A0K8U3N4   A0A0Q9WJC0   A0A0K8VTI9   A0A182WFK9   A0A1A9XCE3   A0A0Q9XIT5   A0A1I8M2X3   A0A1W4WSD2   A0A182UGZ7   A0A0M4ER29   B4G755   A0A1S4GYP5   A0A1I8QCY1   A0A1B0B0M4   A0A1Q3FJU6   B4Q9B2   A0A1Y1KHF4   A0A0A1WZV2   A0A1W4UG04   Q9VKV1   A0A0J9R086   A0A0K8VT60   E9IED8   A0A182KMH4   A0A0Q5WN53   B4LVB7   A0A1W4UUP0   A0A151IBC4   B3N5F1   Q8IPB7   A0A0R1DR73   A0A182X605   A0A0A1XEF2   A0A2M4DMV2   A0A1I8QD07   A0A195DWW0   A0A034V6I7   W8APD9   J9JL57   A0A0K8WDF9   A0A158NP11   E2B6B9   A0A2H8TPV8   A0A1L8DQQ1   A0A1L8DR39   A0A1W7RA88   A0A2S2R8V4   A0A0P6FNV7   A0A0N8EK80   A0A164XCC5   A0A0P5NKK4   A0A0P5A6R2   A0A0P5Z7T6   A0A0P5ACP0  

PDB

6B9P     E-value=3.76021e-155,     Score=1410

KEGG

101736912    K12311 lysosomal alpha-mannosidase [EC:3.2.1.24] | (RefSeq) lysosomal alpha-mannosidase-like

PATHWAY

00511    Other glycan degradation - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0004559   GO:0006013   GO:0030246   GO:0046872   GO:0004571   GO:0016021   GO:0005774   GO:0006517   GO:0016798   GO:0008152   GO:0005576   GO:0004553   GO:0008270   GO:0003824   GO:0005975   GO:0015923   GO:0005634   GO:0006260  

SignalP

Position:   1 - 15,         Likelihood:  0.997810

 

 

Length:

1057

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0253399999999999

Exp number, first 60 AAs:

0.01927

Total prob of N-in:

0.00104

outside

1  -  1057

 

 

Pi

210.623017

Theta

172.223727

Tajima's D

1.412322

CLR

0.448859

CSRT

0.773311334433278

Interpretation

Uncertain