Gene

KWMTBOMO06102

Pre Gene Modal

BGIBMGA001698

Annotation

PREDICTED:_copper_chaperone_for_superoxide_dismutase_[Papilio_machaon]

Location

Bomo_Chr11(-):430944-437804      View in EpiBrowser

Full name

Superoxide dismutase [Cu-Zn]       + More
Copper chaperone for superoxide dismutase      

Alternative Name

Superoxide dismutase copper chaperone

Location in the cell

Cytoplasmic   Reliability : 1.894 Extracellular   Reliability : 1.579

CDS

ATGCTGACTACTAAGCTAGAGGTCCTGGTGAACTTCGATTCATCTGTTGATGACCAGTTCCTCGAGAAGACTATTAAGACATTGAAAACTCACGACGGAATCAAGGAGGTGGGTTTCAAGGACGGTGCTTTTGTCGTGGAGACGGTGCTCCCAAGCGCGAACGTTCTGGACGTGGTCGGCTCCGTGACGGGGAGACCAGCCGTGATCCAAGGTTTTGGGGAAACACAATCGGCCGTCGCCATGGTCTCGGACCAATCGTGCTGCAATAAGATCCTGGGCGTGGTCAGGCTGCAGCAGACGGCCGAGGGCCCGCTGGTGGCTGACGGCAGCATCGACGGACTAAGCCCCGGGAGGCACGGGCTCCACGTATATGAGTCCGGGGATTTAAGTCAGGGCTGCAATTCCATAGGGGGGCATTATAATCCGTCGGGGGGACCGCACGGGGGGCCCGGCGATCCCCCGGATCGGAGGCACGCCGGCGATCTCGGAAACATTACAGCCGACGCAAACGGCAGAGCTGCATTCAGGATTGTCGATGATGTCCTAAAAGTGTGGGACGTGATCGGTAGGTCTATGGGCGTGACCGAGCGGGGGGACGACTGCGGCCGCGGAGACGGCACCTCCAGGGTCGACGGGAACTCGGGACCGATATTAGCGTGTGGCATCATAGCCAGGTCGGCGGGAATCTTTCAGAATCCGAAGCGGATATGCGCCTGCGACGGGGTAGTGGTGTGGGATGAACGAGATAAACCGCTGGCGGGCAGCGGGAGGAGAGGTCAGGGGGACCGCGCCCCCAGCGAGGGGGGCTGCTGTGGCAAGGCAGGCAAAACCACGAAAGGAAGTAATAACAAAGGGGACCGATGTGGGGCAGGGGACGGTGGGGGTGGCAACGGTAAAACATGCTGTAAAGTGTAG

Protein

MLTTKLEVLVNFDSSVDDQFLEKTIKTLKTHDGIKEVGFKDGAFVVETVLPSANVLDVVGSVTGRPAVIQGFGETQSAVAMVSDQSCCNKILGVVRLQQTAEGPLVADGSIDGLSPGRHGLHVYESGDLSQGCNSIGGHYNPSGGPHGGPGDPPDRRHAGDLGNITADANGRAAFRIVDDVLKVWDVIGRSMGVTERGDDCGRGDGTSRVDGNSGPILACGIIARSAGIFQNPKRICACDGVVVWDERDKPLAGSGRRGQGDRAPSEGGCCGKAGKTTKGSNNKGDRCGAGDGGGGNGKTCCKV

Description

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Delivers copper to copper zinc superoxide dismutase (SOD1).

Catalytic Activity

2 H(+) + 2 superoxide = H2O2 + O2

Cofactor

Cu cation
Zn(2+)
Cu(2+)

Subunit

Homodimer, and heterodimer with SOD1. Interacts with COMMD1 (By similarity). Interacts with XIAP/BIRC4 (By similarity).

Similarity

Belongs to the Cu-Zn superoxide dismutase family.
In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

Keywords

Chaperone   Complete proteome   Copper   Cytoplasm   Disulfide bond   Isopeptide bond   Metal-binding   Phosphoprotein   Reference proteome   Ubl conjugation   Zinc  

Feature

chain  Copper chaperone for superoxide dismutase

Uniprot

H9IWR6   A0A2A4IVF1   A0A2H1V0V1   A0A0N1I5U1   A0A0N1IG53   S4P4K3   + More
A0A212ENZ9   A0A1B6G5Y1   A0A088A6F0   A0A2A3E370   A0A0L7R8J2   A0A158P3W4   A0A0M8ZPP8   A0A224XLJ0   A0A069DQU5   K7IYR3   C3Z3X0   A0A023F796   A0A067R164   E2BK27   A0A2J7R1W1   A0A151J8W2   R4G7S6   A0A0J7N4P1   A0A195CNY2   F4WKV5   E2AUD2   A0A2H8TIP7   A0A151WVL5   A0A195BKR7   A0A1U7Q4Z1   J9JTJ9   G3I4K4   A0A1A9YE99   A0A1A9W9Q9   A0A151JVJ1   A0A3L8DQH2   A0A154PQE2   A0A0A9WBK0   A0A026W1C0   A0A1B0AZL2   A0A1A6HW90   Q543K2   Q9WU84   A0A060YNP3   A0A0P4VXF6   A0A1U7T321   A0A0G2JSZ9   I3ME75   A0A3L7HWE1   Q9JK72   A0A0R4IHZ8   A0A0F8AKW0   F1QCS3   A0A2K8FTM4   A0A1A9VID8   A0A2K6F7Q4   D3TN65   W8C4D0   F6YJP8   L8Y595   A0A061IBV5   A0A2Y9JU61   A0A3Q2FVL3   A0A3B4DU04   A0A2K6T6L0   A0A1A7YS36   A0A1A7WRV0   A0A250YE74   B4LJV9   A0A2U9B0H9   A0A091DBB1   A0A0Q9W625   B5X3L5   A0A3Q3K2N1   A0A1A8GPI5   A0A2Y9JZY3   A0A1A8FIV1   A0A2K5RIY8   A0A1A8BXI3   A0A1A8UMW4   A0A1L8GK44   A0A1A7ZTS6   A0A1A8KT13   A0A1A8I878   A0A3G1PVI3   A0A2U3YVZ7   A0A2J8QBB0   B3MHH4   H0WLC7   A0A1A8QGN1   A0A1A8L3W1   J3KNF4   A0A1A8SF48   H2Q473   G3R2G0   A0A286ZIZ7   A0A2J8U030  

EC Number

1.15.1.1

Pubmed

19121390    26354079    23622113    22118469    21347285    26334808    + More
20075255    18563158    25474469    24845553    20798317    21719571    21804562    30249741    25401762    26823975    24508170    10349636    11042159    11076861    11217851    12466851    12040188    16141073    21183079    10694572    10773661    15489334    16141072    24755649    27129103    15057822    15632090    29704459    10964676    23594743    25835551    20353571    24495485    17495919    23385571    23929341    28087693    17994087    20433749    27762356    28965584    16554811    21269460    24275569    16136131    22398555   

EMBL

BABH01020973    BABH01020974    NWSH01007082    PCG63103.1    ODYU01000153    SOQ34441.1    + More
KQ458725    KPJ05369.1    KQ460546    KPJ14045.1    GAIX01005929    JAA86631.1    AGBW02013590    OWR43196.1    GECZ01011968    JAS57801.1    KZ288405    PBC26155.1    KQ414632    KOC67190.1    ADTU01008606    KQ435922    KOX68555.1    GFTR01004472    JAW11954.1    GBGD01002466    JAC86423.1    GG666577    EEN52884.1    GBBI01001597    JAC17115.1    KK852818    KDR15674.1    GL448740    EFN83935.1    NEVH01008202    PNF34824.1    KQ979480    KYN21259.1    GAHY01002207    JAA75303.1    LBMM01010188    KMQ87620.1    KQ977513    KYN02187.1    GL888206    EGI65197.1    GL442815    EFN62989.1    GFXV01002202    MBW14007.1    KQ982708    KYQ51807.1    KQ976453    KYM85320.1    ABLF02025275    JH001255    EGW06367.1    KQ981701    KYN37474.1    QOIP01000005    RLU22631.1    KQ434998    KZC13330.1    GBHO01038485    GBRD01011502    GDHC01008675    JAG05119.1    JAG54322.1    JAQ09954.1    KK107570    EZA48859.1    JXJN01006362    JXJN01006363    LZPO01008032    OBS82506.1    AK050072    CH466612    BAC34057.1    EDL33071.1    AF121906    AF173379    AK010264    BC026938    FR914611    CDQ93182.1    GDKW01002328    JAI54267.1    AC126581    CH473953    EDM12426.1    AGTP01072334    RAZU01000139    RLQ70153.1    AF255305    BC158586    FO904860    KQ041578    KKF24683.1    BX511071    KY618831    AQW43017.1    EZ422867    ADD19143.1    GAMC01002377    JAC04179.1    KB370292    ELV09526.1    KE673007    ERE78744.1    HADX01011145    SBP33377.1    HADW01006981    SBP08381.1    GFFW01002857    JAV41931.1    CH940648    EDW61613.1    CP026244    AWO97434.1    KN122776    KFO28362.1    KRF80102.1    BT045634    ACI33896.1    HAEC01004844    SBQ72921.1    HAEB01012833    SBQ59360.1    HADZ01007274    SBP71215.1    HAEJ01008205    SBS48662.1    CM004472    OCT84183.1    HADY01006875    SBP45360.1    HAEE01015487    SBR35537.1    HAED01007070    SBQ93251.1    KY660271    AVQ09312.1    NBAG03000050    PNI93550.1    CH902619    EDV37974.1    AAQR03144760    AAQR03144761    HAEG01012692    SBR93005.1    HAEF01002108    SBR39490.1    AP001157    HAEI01013815    SBS16284.1    AACZ04016225    GABC01004358    JAA06980.1    CABD030079815    AEMK02000006    NDHI03003478    PNJ38629.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000005203    + More
UP000242457    UP000053825    UP000005205    UP000053105    UP000002358    UP000001554    UP000027135    UP000008237    UP000235965    UP000078492    UP000036403    UP000078542    UP000007755    UP000000311    UP000075809    UP000078540    UP000189706    UP000007819    UP000001075    UP000092443    UP000091820    UP000078541    UP000279307    UP000076502    UP000053097    UP000092460    UP000092124    UP000000589    UP000193380    UP000189704    UP000002494    UP000005215    UP000273346    UP000000437    UP000078200    UP000233160    UP000002280    UP000011518    UP000030759    UP000248482    UP000265020    UP000261440    UP000233220    UP000008792    UP000246464    UP000028990    UP000087266    UP000261600    UP000233040    UP000186698    UP000245341    UP000007801    UP000005225    UP000005640    UP000002277    UP000001519    UP000008227   

PRIDE

H9IWR6    G3I4K4    Q9WU84    Q9JK72    J3KNF4   

Pfam

PF00080   Sod_Cu        + More
PF00403   HMA
PF12813   XPG_I_2

Interpro

IPR036423   SOD-like_Cu/Zn_dom_sf        + More
IPR024134   SOD_Cu/Zn_/chaperone       
IPR001424   SOD_Cu_Zn_dom       
IPR006121   HMA_dom       
IPR018152   SOD_Cu/Zn_BS       
IPR036163   HMA_dom_sf       
IPR026832   Asteroid       
IPR029060   PIN-like_dom_sf       
IPR039436   Asteroid_dom       

SUPFAM

SSF49329   SSF49329        + More
SSF55008   SSF55008       
SSF88723   SSF88723       

Gene 3D

2.60.40.200    

CDD

cd00305  Cu-Zn_Superoxide_Dismutase
cd00371  HMA

ProteinModelPortal

H9IWR6   A0A2A4IVF1   A0A2H1V0V1   A0A0N1I5U1   A0A0N1IG53   S4P4K3   + More
A0A212ENZ9   A0A1B6G5Y1   A0A088A6F0   A0A2A3E370   A0A0L7R8J2   A0A158P3W4   A0A0M8ZPP8   A0A224XLJ0   A0A069DQU5   K7IYR3   C3Z3X0   A0A023F796   A0A067R164   E2BK27   A0A2J7R1W1   A0A151J8W2   R4G7S6   A0A0J7N4P1   A0A195CNY2   F4WKV5   E2AUD2   A0A2H8TIP7   A0A151WVL5   A0A195BKR7   A0A1U7Q4Z1   J9JTJ9   G3I4K4   A0A1A9YE99   A0A1A9W9Q9   A0A151JVJ1   A0A3L8DQH2   A0A154PQE2   A0A0A9WBK0   A0A026W1C0   A0A1B0AZL2   A0A1A6HW90   Q543K2   Q9WU84   A0A060YNP3   A0A0P4VXF6   A0A1U7T321   A0A0G2JSZ9   I3ME75   A0A3L7HWE1   Q9JK72   A0A0R4IHZ8   A0A0F8AKW0   F1QCS3   A0A2K8FTM4   A0A1A9VID8   A0A2K6F7Q4   D3TN65   W8C4D0   F6YJP8   L8Y595   A0A061IBV5   A0A2Y9JU61   A0A3Q2FVL3   A0A3B4DU04   A0A2K6T6L0   A0A1A7YS36   A0A1A7WRV0   A0A250YE74   B4LJV9   A0A2U9B0H9   A0A091DBB1   A0A0Q9W625   B5X3L5   A0A3Q3K2N1   A0A1A8GPI5   A0A2Y9JZY3   A0A1A8FIV1   A0A2K5RIY8   A0A1A8BXI3   A0A1A8UMW4   A0A1L8GK44   A0A1A7ZTS6   A0A1A8KT13   A0A1A8I878   A0A3G1PVI3   A0A2U3YVZ7   A0A2J8QBB0   B3MHH4   H0WLC7   A0A1A8QGN1   A0A1A8L3W1   J3KNF4   A0A1A8SF48   H2Q473   G3R2G0   A0A286ZIZ7   A0A2J8U030  

PDB

6FP6     E-value=2.05862e-43,     Score=441

KEGG

101741095    K04569 copper chaperone for superoxide dismutase | (RefSeq) copper chaperone for superoxide dismutas

GO

GO:0006801   GO:0046872   GO:0004784   GO:0030001   GO:0019430   GO:0005634   GO:0005737   GO:0016532   GO:0005507   GO:0016021   GO:0051353   GO:0019899   GO:0005758   GO:0055114   GO:0003824   GO:0005975   GO:0004559   GO:0016020   GO:0003677   GO:0000723   GO:0006260  

PANTHER

PTHR10003   PTHR15665  

Subcellular location

Cytoplasm  

Length:

304

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00539

Exp number, first 60 AAs:

0.00216

Total prob of N-in:

0.01291

outside

1  -  304

 

 

Pi

168.045589

Theta

144.740148

Tajima's D

1.034685

CLR

0

CSRT

0.670016499175041

Interpretation

Uncertain