Pre Gene Modal
BGIBMGA001700
Annotation
ubiquitin-related_modifier_1_homolog_[Bombyx_mori]
Full name
Ubiquitin-related modifier 1 homolog
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Ubiquitin-related modifier 1
Ubiquitin-related modifier 1
Location in the cell
Cytoplasmic Reliability : 1.689
Sequence
CDS
ATGGCAGAAACTCTAACTGTAGAAGTGATGTTTGGGGGCGGAGCGGAATTGCTCTTTAATAAAGTAAAGAGGAAAGAAATTGCACTGCCGCCGTTGAAGACATTTTTACCGGATTCTCAAAATCAGAATTGGACGTTAAAAGAGCTGTTGATTTGGTTAAAAGACAACCTGCTGGTGGAAAGAGAAGAGTTGTTCTTGAAGGATGATTCTGTCCGACCTGGTATACTCGTGTTGATCAATGAAGAAGACTGGGAGCTCCACGGACAGTTAAATTATGAACTCAAAGAAAATGATAAAATCATGTTCATATCGACGTTGCATGGCGGTTAA
Protein
MAETLTVEVMFGGGAELLFNKVKRKEIALPPLKTFLPDSQNQNWTLKELLIWLKDNLLVEREELFLKDDSVRPGILVLINEEDWELHGQLNYELKENDKIMFISTLHGG
Summary
Description
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Subunit
Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
Similarity
Belongs to the URM1 family.
Keywords
Complete proteome
Cytoplasm
Isopeptide bond
Reference proteome
tRNA processing
Ubl conjugation pathway
3D-structure
Alternative splicing
Feature
chain Ubiquitin-related modifier 1 homolog
splice variant In isoform 3.
splice variant In isoform 3.
Uniprot
Q1HQ10
A0A2W1BG39
A0A2H1V943
S4PI46
A0A0N1IHF7
A0A0N1PHF2
+ More
A0A2A4K4H3 A0A1E1WUI1 A0A1E1W1W1 A0A2B4SCG0 F6QJ94 G9KWQ5 T1JNE3 A0A1S3HHT5 I3N9W6 F1RR84 A0A3Q3LFD6 A0A2Y9J818 A0A250Y8V4 E2QUA4 A0A3Q7TVE0 A0A3Q2WIG4 Q9D2P4 A0A2Y9EIN8 A0A384B4T6 A0A3Q3K0Q3 A0A3B4G0N1 A0A3P8QVS3 A0A3P9CKW5 A0A341CUN5 B6ID11 W5PKI4 A9YUB5 Q148F0 H0WIL7 A0A286XDJ6 L5K8Z7 A0A2Y9HCF6 A0A2U3YZS1 L5LKU8 A0A2R8MU10 A0A2K6U7C5 S7Q1L3 A0A3B3QC32 A0A091DID9 K9IGJ4 A0A3Q7QEY9 A0A2U3VD99 A0A3Q4GR69 I3J7T7 A0A340YID5 S9X4G9 A0A2Y9NSU0 A0A2Y9DJD0 A0A2K6FYJ1 A0A2K6MG60 A0A2K5XZC3 A0A2I3M0N5 A0A2K6QLN3 A0A2K5LZW6 A0A2K5HGV1 G7PRF7 I0FVD5 A0A2K5EZG7 A0A2I2YGW8 A0A2R9AJ31 A0A2I3RXE9 A0A024R8C7 Q9BTM9 G1MAC0 M3W4T2 A0A1B6GC70 A0A2I3GQ10 A0A1U7R1H4 G5ASE8 A0A2K5RLG5 G3PZD9 A0A3Q1C6E7 A0A3P8SCK5 H2PTI8 A0A3M6U6F2 A0A147A0D2 G3SPZ4 A0A3B4XCB7 A0A3B4T3M5 A0A1E1WWI6 V3ZY87 A0A3B4Z2I5 A0A1S2ZZ35 A0A1B6H6I1 A0A384CQ46 A0A3Q4BZP9 A0A0D2WT70 A0A1A6HS45 A0A3P9KU05 A0A1B6MLT9 A0A023F8A1 A0A0B8RVK3 A0A1B6E8T3 A0A3Q1K7C0
A0A2A4K4H3 A0A1E1WUI1 A0A1E1W1W1 A0A2B4SCG0 F6QJ94 G9KWQ5 T1JNE3 A0A1S3HHT5 I3N9W6 F1RR84 A0A3Q3LFD6 A0A2Y9J818 A0A250Y8V4 E2QUA4 A0A3Q7TVE0 A0A3Q2WIG4 Q9D2P4 A0A2Y9EIN8 A0A384B4T6 A0A3Q3K0Q3 A0A3B4G0N1 A0A3P8QVS3 A0A3P9CKW5 A0A341CUN5 B6ID11 W5PKI4 A9YUB5 Q148F0 H0WIL7 A0A286XDJ6 L5K8Z7 A0A2Y9HCF6 A0A2U3YZS1 L5LKU8 A0A2R8MU10 A0A2K6U7C5 S7Q1L3 A0A3B3QC32 A0A091DID9 K9IGJ4 A0A3Q7QEY9 A0A2U3VD99 A0A3Q4GR69 I3J7T7 A0A340YID5 S9X4G9 A0A2Y9NSU0 A0A2Y9DJD0 A0A2K6FYJ1 A0A2K6MG60 A0A2K5XZC3 A0A2I3M0N5 A0A2K6QLN3 A0A2K5LZW6 A0A2K5HGV1 G7PRF7 I0FVD5 A0A2K5EZG7 A0A2I2YGW8 A0A2R9AJ31 A0A2I3RXE9 A0A024R8C7 Q9BTM9 G1MAC0 M3W4T2 A0A1B6GC70 A0A2I3GQ10 A0A1U7R1H4 G5ASE8 A0A2K5RLG5 G3PZD9 A0A3Q1C6E7 A0A3P8SCK5 H2PTI8 A0A3M6U6F2 A0A147A0D2 G3SPZ4 A0A3B4XCB7 A0A3B4T3M5 A0A1E1WWI6 V3ZY87 A0A3B4Z2I5 A0A1S2ZZ35 A0A1B6H6I1 A0A384CQ46 A0A3Q4BZP9 A0A0D2WT70 A0A1A6HS45 A0A3P9KU05 A0A1B6MLT9 A0A023F8A1 A0A0B8RVK3 A0A1B6E8T3 A0A3Q1K7C0
Pubmed
28756777
23622113
26354079
17495919
23236062
28087693
+ More
16341006 16141072 19468303 15489334 21183079 16046629 25186727 15057822 20809919 21993624 23258410 29240929 23149746 25362486 22002653 25319552 22722832 16136131 11181995 14702039 15164053 19017811 21209336 20010809 17975172 21993625 30382153 28503490 23254933 17554307 25474469 25476704
16341006 16141072 19468303 15489334 21183079 16046629 25186727 15057822 20809919 21993624 23258410 29240929 23149746 25362486 22002653 25319552 22722832 16136131 11181995 14702039 15164053 19017811 21209336 20010809 17975172 21993625 30382153 28503490 23254933 17554307 25474469 25476704
EMBL
DQ443242
KZ150166
PZC72644.1
ODYU01001060
SOQ36774.1
GAIX01000289
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JAA92271.1 KQ460546 KPJ14057.1 KQ458725 KPJ05355.1 NWSH01000192 PCG78562.1 GDQN01000603 JAT90451.1 GDQN01010076 JAT80978.1 LSMT01000131 PFX26222.1 AEYP01042601 JP020736 AES09334.1 JH431980 AGTP01020095 AGTP01020096 AEMK02000005 GFFW01004747 JAV40041.1 AAEX03006856 AK019352 AK049227 AK049849 AL928926 CH466542 BC026994 AC114363 BC169094 AAI69094.1 AMGL01074817 EU295697 BC118391 AAQR03035948 AAQR03035949 AAQR03035950 AAQR03035951 AAQR03035952 AAKN02030178 KB030979 ELK07241.1 KB110951 ELK26571.1 KE164341 EPQ17168.1 KN122233 KFO31899.1 GABZ01008643 JAA44882.1 AERX01011681 KB016853 EPY83293.1 AHZZ02008125 AQIA01023406 CM001290 EHH57073.1 JU336544 JU471574 JV048340 AFE80297.1 AFH28378.1 AFI38411.1 CABD030066931 AJFE02077557 AJFE02077558 AJFE02077559 AJFE02077560 AC192633 NBAG03000232 PNI69057.1 CH471090 EAW87784.1 AK001880 AK300877 AL359091 BC003581 ACTA01081200 AANG04002451 GECZ01009757 JAS60012.1 ADFV01020839 ADFV01020840 ADFV01020841 ADFV01020842 JH166728 GEBF01004764 EHA99958.1 JAN98868.1 ABGA01253120 ABGA01387475 ABGA01387476 ABGA01387477 ABGA01387478 ABGA01387479 ABGA01387480 ABGA01387481 ABGA01387482 ABGA01387483 NDHI03003456 PNJ45561.1 RCHS01002157 RMX49191.1 GCES01014711 JAR71612.1 GFAC01007844 JAT91344.1 KB203219 ESO85936.1 GECU01037435 GECU01036648 JAS70271.1 JAS71058.1 KE346369 KJE95555.1 LZPO01017295 OBS81039.1 GEBQ01003138 JAT36839.1 GBBI01001161 JAC17551.1 GBSH01003020 JAG66007.1 GEDC01002959 JAS34339.1
JAA92271.1 KQ460546 KPJ14057.1 KQ458725 KPJ05355.1 NWSH01000192 PCG78562.1 GDQN01000603 JAT90451.1 GDQN01010076 JAT80978.1 LSMT01000131 PFX26222.1 AEYP01042601 JP020736 AES09334.1 JH431980 AGTP01020095 AGTP01020096 AEMK02000005 GFFW01004747 JAV40041.1 AAEX03006856 AK019352 AK049227 AK049849 AL928926 CH466542 BC026994 AC114363 BC169094 AAI69094.1 AMGL01074817 EU295697 BC118391 AAQR03035948 AAQR03035949 AAQR03035950 AAQR03035951 AAQR03035952 AAKN02030178 KB030979 ELK07241.1 KB110951 ELK26571.1 KE164341 EPQ17168.1 KN122233 KFO31899.1 GABZ01008643 JAA44882.1 AERX01011681 KB016853 EPY83293.1 AHZZ02008125 AQIA01023406 CM001290 EHH57073.1 JU336544 JU471574 JV048340 AFE80297.1 AFH28378.1 AFI38411.1 CABD030066931 AJFE02077557 AJFE02077558 AJFE02077559 AJFE02077560 AC192633 NBAG03000232 PNI69057.1 CH471090 EAW87784.1 AK001880 AK300877 AL359091 BC003581 ACTA01081200 AANG04002451 GECZ01009757 JAS60012.1 ADFV01020839 ADFV01020840 ADFV01020841 ADFV01020842 JH166728 GEBF01004764 EHA99958.1 JAN98868.1 ABGA01253120 ABGA01387475 ABGA01387476 ABGA01387477 ABGA01387478 ABGA01387479 ABGA01387480 ABGA01387481 ABGA01387482 ABGA01387483 NDHI03003456 PNJ45561.1 RCHS01002157 RMX49191.1 GCES01014711 JAR71612.1 GFAC01007844 JAT91344.1 KB203219 ESO85936.1 GECU01037435 GECU01036648 JAS70271.1 JAS71058.1 KE346369 KJE95555.1 LZPO01017295 OBS81039.1 GEBQ01003138 JAT36839.1 GBBI01001161 JAC17551.1 GBSH01003020 JAG66007.1 GEDC01002959 JAS34339.1
Proteomes
UP000005204
UP000053240
UP000053268
UP000218220
UP000225706
UP000002280
+ More
UP000000715 UP000085678 UP000005215 UP000008227 UP000261640 UP000248482 UP000002254 UP000286640 UP000264840 UP000000589 UP000248484 UP000261681 UP000261600 UP000261460 UP000265100 UP000265160 UP000252040 UP000002494 UP000002356 UP000291000 UP000009136 UP000005225 UP000005447 UP000010552 UP000248481 UP000245341 UP000008225 UP000233220 UP000261540 UP000028990 UP000286641 UP000245340 UP000261580 UP000005207 UP000265300 UP000248483 UP000248480 UP000233160 UP000233180 UP000233140 UP000028761 UP000233200 UP000233060 UP000233080 UP000009130 UP000233100 UP000233020 UP000001519 UP000240080 UP000002277 UP000005640 UP000008912 UP000011712 UP000001073 UP000189706 UP000006813 UP000233040 UP000007635 UP000257160 UP000265080 UP000001595 UP000275408 UP000007646 UP000261360 UP000261420 UP000030746 UP000261400 UP000079721 UP000261680 UP000261620 UP000008743 UP000092124 UP000265180 UP000265040
UP000000715 UP000085678 UP000005215 UP000008227 UP000261640 UP000248482 UP000002254 UP000286640 UP000264840 UP000000589 UP000248484 UP000261681 UP000261600 UP000261460 UP000265100 UP000265160 UP000252040 UP000002494 UP000002356 UP000291000 UP000009136 UP000005225 UP000005447 UP000010552 UP000248481 UP000245341 UP000008225 UP000233220 UP000261540 UP000028990 UP000286641 UP000245340 UP000261580 UP000005207 UP000265300 UP000248483 UP000248480 UP000233160 UP000233180 UP000233140 UP000028761 UP000233200 UP000233060 UP000233080 UP000009130 UP000233100 UP000233020 UP000001519 UP000240080 UP000002277 UP000005640 UP000008912 UP000011712 UP000001073 UP000189706 UP000006813 UP000233040 UP000007635 UP000257160 UP000265080 UP000001595 UP000275408 UP000007646 UP000261360 UP000261420 UP000030746 UP000261400 UP000079721 UP000261680 UP000261620 UP000008743 UP000092124 UP000265180 UP000265040
PRIDE
Pfam
PF09138 Urm1
SUPFAM
SSF54285
SSF54285
Gene 3D
CDD
ProteinModelPortal
Q1HQ10
A0A2W1BG39
A0A2H1V943
S4PI46
A0A0N1IHF7
A0A0N1PHF2
+ More
A0A2A4K4H3 A0A1E1WUI1 A0A1E1W1W1 A0A2B4SCG0 F6QJ94 G9KWQ5 T1JNE3 A0A1S3HHT5 I3N9W6 F1RR84 A0A3Q3LFD6 A0A2Y9J818 A0A250Y8V4 E2QUA4 A0A3Q7TVE0 A0A3Q2WIG4 Q9D2P4 A0A2Y9EIN8 A0A384B4T6 A0A3Q3K0Q3 A0A3B4G0N1 A0A3P8QVS3 A0A3P9CKW5 A0A341CUN5 B6ID11 W5PKI4 A9YUB5 Q148F0 H0WIL7 A0A286XDJ6 L5K8Z7 A0A2Y9HCF6 A0A2U3YZS1 L5LKU8 A0A2R8MU10 A0A2K6U7C5 S7Q1L3 A0A3B3QC32 A0A091DID9 K9IGJ4 A0A3Q7QEY9 A0A2U3VD99 A0A3Q4GR69 I3J7T7 A0A340YID5 S9X4G9 A0A2Y9NSU0 A0A2Y9DJD0 A0A2K6FYJ1 A0A2K6MG60 A0A2K5XZC3 A0A2I3M0N5 A0A2K6QLN3 A0A2K5LZW6 A0A2K5HGV1 G7PRF7 I0FVD5 A0A2K5EZG7 A0A2I2YGW8 A0A2R9AJ31 A0A2I3RXE9 A0A024R8C7 Q9BTM9 G1MAC0 M3W4T2 A0A1B6GC70 A0A2I3GQ10 A0A1U7R1H4 G5ASE8 A0A2K5RLG5 G3PZD9 A0A3Q1C6E7 A0A3P8SCK5 H2PTI8 A0A3M6U6F2 A0A147A0D2 G3SPZ4 A0A3B4XCB7 A0A3B4T3M5 A0A1E1WWI6 V3ZY87 A0A3B4Z2I5 A0A1S2ZZ35 A0A1B6H6I1 A0A384CQ46 A0A3Q4BZP9 A0A0D2WT70 A0A1A6HS45 A0A3P9KU05 A0A1B6MLT9 A0A023F8A1 A0A0B8RVK3 A0A1B6E8T3 A0A3Q1K7C0
A0A2A4K4H3 A0A1E1WUI1 A0A1E1W1W1 A0A2B4SCG0 F6QJ94 G9KWQ5 T1JNE3 A0A1S3HHT5 I3N9W6 F1RR84 A0A3Q3LFD6 A0A2Y9J818 A0A250Y8V4 E2QUA4 A0A3Q7TVE0 A0A3Q2WIG4 Q9D2P4 A0A2Y9EIN8 A0A384B4T6 A0A3Q3K0Q3 A0A3B4G0N1 A0A3P8QVS3 A0A3P9CKW5 A0A341CUN5 B6ID11 W5PKI4 A9YUB5 Q148F0 H0WIL7 A0A286XDJ6 L5K8Z7 A0A2Y9HCF6 A0A2U3YZS1 L5LKU8 A0A2R8MU10 A0A2K6U7C5 S7Q1L3 A0A3B3QC32 A0A091DID9 K9IGJ4 A0A3Q7QEY9 A0A2U3VD99 A0A3Q4GR69 I3J7T7 A0A340YID5 S9X4G9 A0A2Y9NSU0 A0A2Y9DJD0 A0A2K6FYJ1 A0A2K6MG60 A0A2K5XZC3 A0A2I3M0N5 A0A2K6QLN3 A0A2K5LZW6 A0A2K5HGV1 G7PRF7 I0FVD5 A0A2K5EZG7 A0A2I2YGW8 A0A2R9AJ31 A0A2I3RXE9 A0A024R8C7 Q9BTM9 G1MAC0 M3W4T2 A0A1B6GC70 A0A2I3GQ10 A0A1U7R1H4 G5ASE8 A0A2K5RLG5 G3PZD9 A0A3Q1C6E7 A0A3P8SCK5 H2PTI8 A0A3M6U6F2 A0A147A0D2 G3SPZ4 A0A3B4XCB7 A0A3B4T3M5 A0A1E1WWI6 V3ZY87 A0A3B4Z2I5 A0A1S2ZZ35 A0A1B6H6I1 A0A384CQ46 A0A3Q4BZP9 A0A0D2WT70 A0A1A6HS45 A0A3P9KU05 A0A1B6MLT9 A0A023F8A1 A0A0B8RVK3 A0A1B6E8T3 A0A3Q1K7C0
PDB
1WGK
E-value=6.32398e-30,
Score=319
Ontologies
GO
PANTHER
Topology
Subcellular location
Cytoplasm
Length:
109
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.01952
Exp number, first 60 AAs:
0.01952
Total prob of N-in:
0.18663
outside
1 - 109
Population Genetic Test Statistics
Pi
354.301633
Theta
190.538589
Tajima's D
2.585528
CLR
0
CSRT
0.950552472376381
Interpretation
Uncertain
