Gene

KWMTBOMO06086  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009132

Annotation

PREDICTED:_tubulin_beta_chain-like_[Amyelois_transitella]

Location

Bomo_Chr11(-):166544-177164      View in EpiBrowser

Full name

Tubulin beta chain       + More
Tubulin beta-1 chain      

Alternative Name

Beta-1-tubulin

Location in the cell

Cytoplasmic   Reliability : 3.502

CDS

ATGCGTGAAATAGTTCATTTGCAGACCGGACAATGTGGCAATCAAATAGGATCGAAGTTCTGGGAAATAATCTCGGACGAGCACGGGATCGACACGACTGGACACTACCACGGAGAGAGCGACTTGCAGCTCGAGAGAATCGGTGTTTACTACAACGAAGCTGATGACGGCAAGCGCTTCGTGCCCCGCGCCGTTCTGGTGGACCTGGAGCCTGGGACCATGGACGCCATCAAGTCCTCGACGTACGGAGCGCTGTTCCGGCCGGACAACTACGTGTTTGGACAGAGCGGGGCAGGGAATAACTGGGCTAAAGGTCACTACACAGAAGGCGCTGAGCTGGTGGAATCCGTGCTGGACGTCGTCAGGAAGGAGGCCGAGGGCTGCGATTGCTTACAGGGCTTCCAGTTGACCCATTCCTTGGGAGGGGGGACGGGGTCCGGCCTTGGAACCCTCCTCCTCAGCAAACTCCGCGAGGAATACCCCGATAGGATTGTCAATACTTTCAGCGTTGTACCCTCGCCGAAGGTGTCAGATACCGTTGTGGAGCCGTACAACGCGACCCTCTCCGTGCACCAGCTGGTGGAGAACACGGACGAGACGTTCTGCATCGACAACGAGGCGCTTTACGACATCTGCTTCAGGACGTTGAGACTTGCCTCGCCCACCTACGGCGACCTCAATCACTTAGTTTCGTTGACCATGTCCGGGGTGACCACTTGTCTTCGTTTCCCGGGACAGCTGAACGCGGATCTACGGAAGCTGGCTGTTAACATGGTCCCGTTCCCGAGGCTACACTTCTTCATGCCTGGTTTCGCTCCACTGACGGCTCGTAACAGTCAAGTGTACCGCGCCCTGACCGTCCCAGAGCTGTCGCAGCAGCTGTTCAGTCCCGTGAACATGATGGCAGCCTGCGACCCTCGGCACGGGAGGTACCTCACAGTGGCCGCCATATTCCGCGGCAGGATGTCGATGAAGGAGGTTGACGAGCAGATGCTAGCCGTTCAGGACAAGAATTCTAGTTACTTCGTGGAGTGGATCCCTAACAACGTGAAGGTGGCGGTGTGCGACGTGCCGCCGCGCGGCGTCAAGATGGCCGCCACCTTCGTCGGCAACACGACCGCCATCCAAGAGATATTCAAACGGATCTCGGAGCAGTTCACGCTGATGTTCAGGAGGAAGGCGTTCCTGCACTGGTACACCGGGGAGGGGATGGACGAGATGGAGTTCACGGAGGCCGAGAGCAACATGAACGATCTCGTCTCCGAGTACCAGCAGTACGAGGAGGTTGGCGTCGACGACGGAGACTTCGAGGACCAGGAGGAAATACCAGAGGAGGACTATTTAGAAGAAGCCTAA

Protein

MREIVHLQTGQCGNQIGSKFWEIISDEHGIDTTGHYHGESDLQLERIGVYYNEADDGKRFVPRAVLVDLEPGTMDAIKSSTYGALFRPDNYVFGQSGAGNNWAKGHYTEGAELVESVLDVVRKEAEGCDCLQGFQLTHSLGGGTGSGLGTLLLSKLREEYPDRIVNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLRLASPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARNSQVYRALTVPELSQQLFSPVNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLAVQDKNSSYFVEWIPNNVKVAVCDVPPRGVKMAATFVGNTTAIQEIFKRISEQFTLMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYEEVGVDDGDFEDQEEIPEEDYLEEA

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

Subunit

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with mgr and Vhl.

Similarity

Belongs to the tubulin family.

Keywords

Complete proteome   Cytoplasm   Cytoskeleton   GTP-binding   Microtubule   Nucleotide-binding   Phosphoprotein   Reference proteome  

Feature

chain  Tubulin beta-1 chain

Uniprot

A0A0N1PGL8   A0A2A4K7R7   A0A212EVB6   A0A067QYS6   A0A1V9X5G4   A0A224XCJ7   + More
A0A0P4W3J2   A0A0V0G3G1   A0A170XZV4   A0A069DTP4   A0A226F2P2   A0A1E1XCR6   R4WCS2   A0A023GK59   G3MKF8   A0A224YT70   A0A023FK66   A0A131XPI7   A0A0K8RBZ1   A0A336MJ16   A0A1S3K224   D3PFV4   A0A0K2V4C9   A0A2J7R1W4   A0A336MPH1   A0A0V0G2I5   A0A069DZ10   R4G8S6   C1BJ29   A0A1I7YN91   K1PN21   R4G4U5   A0A3P8Z2M3   I4DMM6   A0A3S2M7U1   A0A2Z5T6R2   A0A1E1W3A9   A9YLN3   I4DIS9   A0A2M4CSY1   Q8T8B2   W5M3A6   G1KQV3   A0A1W4X306   A0A0A9Z399   A0A060X6Y9   A0A3Q3G5W8   A0A1W4VI24   A0A1L8E5H8   B4LNW8   A0A023ESD5   F6M9L9   W8BUE6   D3TR30   B4KME5   A0A1A9YJQ2   G1E6C4   A0A0G4AL61   A0A0K8V9H2   A0A1A9UYD7   T1DI49   A0A1B0ARL6   B5DUR1   A0A1Q3EUF9   B4GIN0   U5EUT8   A0A0A9Z013   A0A0A9X553   B4PB80   A0A161MFA0   A0A2J7QIE5   A0A2J7QRF5   A0A0M4EEV8   A0A1I8NLG0   B3MGF8   B4MRR0   B4HPG7   B4J625   B3NJN5   A0A0A1WMS2   A0A0P5UMT9   A0A1L8EHS1   A0A1A9ZRE2   A0A0K8TT89   A0A1A9WAB8   B4QE31   A0A0L0C7Y7   A0A0P6G935   A0A336M9C0   T1PF10   Q17GX9   Q27U48   Q24560   A0A1S3STF6   A0A2K5UIR6   A0A1Y1KNW8   A0A2R7WYX9   J3JY08   A0A131XWH3   T1DF12  

Pubmed

26354079    22118469    24845553    28327890    27129103    26334808    + More
28503490    23691247    22216098    28797301    28049606    26392177    22992520    25069045    22651552    12459208    19121390    25401762    24755649    17994087    24945155    24495485    20353571    26252388    24330624    15632085    17550304    25830018    26369729    22936249    26108605    25315136    17510324    16907828    3119300    10731132    12537572    18327897    22451918    28004739    22516182   

EMBL

KQ458725    KPJ05384.1    NWSH01000089    PCG79700.1    AGBW02012215    OWR45432.1    + More
KK852818    KDR15677.1    MNPL01023288    OQR68825.1    GFTR01006309    JAW10117.1    GDKW01000582    JAI56013.1    GECL01003605    JAP02519.1    GEMB01003850    JAR99404.1    GBGD01001446    JAC87443.1    LNIX01000001    OXA63748.1    GFAC01002138    JAT97050.1    AK416954    BAN20169.1    GBBM01001101    JAC34317.1    JO842359    AEO33976.1    GFPF01006317    MAA17463.1    GBBK01002480    JAC22002.1    GEFH01000319    JAP68262.1    GADI01005146    JAA68662.1    UFQS01001300    UFQT01001300    SSX10184.1    SSX29905.1    BT120510    ADD24150.1    HACA01027819    CDW45180.1    NEVH01008202    PNF34826.1    UFQS01001981    UFQT01001981    SSX12850.1    SSX32292.1    GECL01003768    JAP02356.1    GBGD01001455    JAC87434.1    ACPB03005525    GAHY01000457    JAA77053.1    BT074608    ACO09032.1    JH817378    EKC25407.1    ACPB03021733    GAHY01000456    JAA77054.1    AK402544    BAM19166.1    RSAL01000012    RVE53452.1    LC328975    BBA78422.1    GDQN01009594    JAT81460.1    EU234504    ABY47891.1    AK401197    BAM17819.1    GGFL01004284    MBW68462.1    BABH01035358    AB072308    BAB86853.1    AHAT01021582    GBHO01005781    JAG37823.1    FR904845    CDQ72615.1    GFDF01000126    JAV13958.1    CH940648    EDW61137.1    GAPW01001430    JAC12168.1    JF767013    AEF32528.1    GAMC01001610    JAC04946.1    EZ423882    ADD20158.1    CH933808    EDW09833.1    JN029962    AEJ84083.1    KR133399    AKM70869.1    GDHF01016881    JAI35433.1    GALA01001146    JAA93706.1    JXJN01002474    CH674335    EDY71630.1    GFDL01016207    JAV18838.1    CH479183    EDW36350.1    GANO01001316    JAB58555.1    GBHO01005780    JAG37824.1    GBHO01028818    JAG14786.1    CM000158    EDW91493.1    GEMB01003849    JAR99405.1    NEVH01013629    PNF28355.1    NEVH01011896    PNF31182.1    CP012524    ALC42690.1    CH902619    EDV35701.1    CH963850    EDW74799.1    CH480816    EDW48605.1    CH916367    EDW01883.1    CH954179    EDV55213.2    GBXI01014311    JAC99980.1    GDIP01112154    JAL91560.1    GFDG01000517    JAV18282.1    GDAI01000029    JAI17574.1    CM000362    CM002911    EDX07818.1    KMY95122.1    JRES01001535    JRES01000890    KNC22195.1    KNC27524.1    GDIQ01047153    GDIQ01002074    JAN47584.1    UFQT01000630    UFQT01000929    SSX25891.1    SSX28043.1    KA647387    AFP62016.1    CH477254    EAT45945.1    DQ377071    M20419    AE013599    BT003242    AQIA01022892    GEZM01080243    JAV62278.1    KK855763    PTY23825.1    BT128131    AEE63092.1    GEFM01004769    JAP71027.1    GAMD01003291    JAA98299.1   

Proteomes

UP000053268    UP000218220    UP000007151    UP000027135    UP000192247    UP000198287    + More
UP000085678    UP000235965    UP000015103    UP000095287    UP000005408    UP000265140    UP000283053    UP000005204    UP000018468    UP000001646    UP000192223    UP000193380    UP000261660    UP000192221    UP000008792    UP000009192    UP000092443    UP000078200    UP000092460    UP000001819    UP000008744    UP000002282    UP000092553    UP000095300    UP000007801    UP000007798    UP000001292    UP000001070    UP000008711    UP000092445    UP000091820    UP000000304    UP000037069    UP000095301    UP000008820    UP000092444    UP000000803    UP000087266    UP000233100   

PRIDE

D3PFV4    K1PN21    Q8T8B2    Q27U48    Q24560   

Pfam

PF00091   Tubulin        + More
PF03953   Tubulin_C
PF10294   Methyltransf_16

Interpro

IPR018316   Tubulin/FtsZ_2-layer-sand-dom        + More
IPR000217   Tubulin       
IPR023123   Tubulin_C       
IPR036525   Tubulin/FtsZ_GTPase_sf       
IPR017975   Tubulin_CS       
IPR037103   Tubulin/FtsZ_C_sf       
IPR002453   Beta_tubulin       
IPR013838   Beta-tubulin_BS       
IPR008280   Tub_FtsZ_C       
IPR003008   Tubulin_FtsZ_GTPase       
IPR019410   Methyltransf_16       
IPR029063   SAM-dependent_MTases       

SUPFAM

SSF52490   SSF52490        + More
SSF55307   SSF55307       
SSF53335   SSF53335       

Gene 3D

1.10.287.600     3.30.1330.20     3.40.50.1440    

ProteinModelPortal

A0A0N1PGL8   A0A2A4K7R7   A0A212EVB6   A0A067QYS6   A0A1V9X5G4   A0A224XCJ7   + More
A0A0P4W3J2   A0A0V0G3G1   A0A170XZV4   A0A069DTP4   A0A226F2P2   A0A1E1XCR6   R4WCS2   A0A023GK59   G3MKF8   A0A224YT70   A0A023FK66   A0A131XPI7   A0A0K8RBZ1   A0A336MJ16   A0A1S3K224   D3PFV4   A0A0K2V4C9   A0A2J7R1W4   A0A336MPH1   A0A0V0G2I5   A0A069DZ10   R4G8S6   C1BJ29   A0A1I7YN91   K1PN21   R4G4U5   A0A3P8Z2M3   I4DMM6   A0A3S2M7U1   A0A2Z5T6R2   A0A1E1W3A9   A9YLN3   I4DIS9   A0A2M4CSY1   Q8T8B2   W5M3A6   G1KQV3   A0A1W4X306   A0A0A9Z399   A0A060X6Y9   A0A3Q3G5W8   A0A1W4VI24   A0A1L8E5H8   B4LNW8   A0A023ESD5   F6M9L9   W8BUE6   D3TR30   B4KME5   A0A1A9YJQ2   G1E6C4   A0A0G4AL61   A0A0K8V9H2   A0A1A9UYD7   T1DI49   A0A1B0ARL6   B5DUR1   A0A1Q3EUF9   B4GIN0   U5EUT8   A0A0A9Z013   A0A0A9X553   B4PB80   A0A161MFA0   A0A2J7QIE5   A0A2J7QRF5   A0A0M4EEV8   A0A1I8NLG0   B3MGF8   B4MRR0   B4HPG7   B4J625   B3NJN5   A0A0A1WMS2   A0A0P5UMT9   A0A1L8EHS1   A0A1A9ZRE2   A0A0K8TT89   A0A1A9WAB8   B4QE31   A0A0L0C7Y7   A0A0P6G935   A0A336M9C0   T1PF10   Q17GX9   Q27U48   Q24560   A0A1S3STF6   A0A2K5UIR6   A0A1Y1KNW8   A0A2R7WYX9   J3JY08   A0A131XWH3   T1DF12  

PDB

5N5N     E-value=0,     Score=1987

KEGG

101739769    K07375 tubulin beta | (RefSeq) tubulin beta chain-like

PATHWAY

04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0003924   GO:0005200   GO:0005874   GO:0007017   GO:0005525   GO:0000226   GO:0000278   GO:0003725   GO:0016020   GO:0003677   GO:0000723   GO:0005634   GO:0006260  

PANTHER

PTHR11588  

Subcellular location

  

Length:

451

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01126

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00449

outside

1  -  451

 

 

Pi

179.511587

Theta

141.877449

Tajima's D

0.964132

CLR

12.658862

CSRT

0.647017649117544

Interpretation

Uncertain