Gene

KWMTBOMO06073

Pre Gene Modal

BGIBMGA001713

Annotation

PREDICTED:_protein_toll-like_[Amyelois_transitella]

Location

Bomo_Chr11(-):27527-33415      View in EpiBrowser

Full name

Protein toll      

Location in the cell

Extracellular   Reliability : 1.188 PlasmaMembrane   Reliability : 1.654

CDS

ATGCTGATATTGTTGTTGCTGGCATTGGCATCGGTGTCGGCATGTCCGGAGCAGTGCTGGTGTACCGACGGCGAGGAGCTGAACTACCAGTGCAGCCGTCCCTCGACCAACTTGATTGTGGGCGCGCGGCCCAGGGACTATGTCAATATAGACTGCATGGGCGGCGAGCTGGTCTGCGCGGAGTTCCCCGAGATAGACACGCCCGCGACCACGCAGCTGCCGAGCCTCTCCCTGCGCGAGTGCTCGCTGCCGCCTCTCTCGTGTCTGCTGCAAAAGGTTCACGCCGAGGACGTGAAGACTGTCGTGTTCAAGAACGCCATCAACCCCCTGAACGCGGACGCCTTCAAGGGCCTGGGGATCACTGCGCTCATGATGTTTAATGCAGGGGCTCAGACAACAGTCCCCGTGGACGTGCTGAGGAGTCTCCCGAAGCTGACGCACTTCCGGCTGAATGCCGGACGCAACATCACGCTCCACGCCAACATGTTCGCCAACACGCCGCCCCTCAAGTACTTGGAGCTGTCCGACGCCAAAATCACGGTGCTGCCGGACGACGCCTTCCTGGGGCTGAACGTGCTGGAGCAGCTCAACGTGTGGGAGAACGAGATCGCCAACATCACGGCAGGAGCCTTCCGCGGTCTGCACAACGTGACGGTGCTCTCCCTGAACAAAAACCGCATCCAGGCGCTGCCGGCCGGCCTGTTCGCCAGCACGCCGCGCCTTCTCAACCTCACCATGATGAGGAACTCGTTCCGGTATCTCGACTCGGAGACCTTCCGAGGACTCGATCACATACAGGAGATCAAAATCTCTAACAACGTTCCGCTTACTCTCAAAGAGGCGGTGTTCTCGAACCTCCCGGCACTGAGGACGTTACAACTGGACCTCAGCTCGATCCGCGAGCTCCCGGAGGAGTTCATCAGCAACTCCCCGCTGCGGACCCTGTCGCTCGCGCGCAACCAGCTCCGAGTCCTGCCGCGGAGCGTGCTGCGGGGGCAGACGCAGCTGACGTCGCTGACCCTGAGCTACAACGCCGTGGCGGAGCTGGCCCCCGAGCTGTTCGCCGACCTGAGGGCGCTCGAGACCTTCGTCATGGACGGCAACGAGCTGCAGGTGTTGCCGGACTCGCTGTTCTCGGGGCTGAGGAACTTGACTACGGTCTCGTTGAGGAACAACAAGATCAGCGTCATCTCCATGAACACGTTCCAAGGGGCCACGTCCATCCGCACGCTGGATCTCTCTTACAATCGGCTGGCGTTTGCGCCGGACAGCCTCTACTCTCCGCTCAATCAACTGCACAAGCTGCAGACCCTGACCCTCGCCTGGAACAACATCACCTCCATCTACGACGACTGGCGATACGTGTTCGTGGAACTGGTGAAGCTGGACCTGTCCGGGAACGCCATCGGCGACCTCACGGACAGCGACCTGCACTTCTTTAGCGAGGGGGTGACGGTGGACCTGCAGCACAACAACGTCTCCACGGTCCTCATGTCCGGCGTGCTCCGCGCTGCCAACGCCACCGTGCTGCTGCAGCACAACCCTCTCGCGTGCGACTGCTCCCTGTACTCCCTGCTGGACTGGCTGGCTGGCGGCCCCCGCAGCCTCAGACTCGAGGTCGGCGACACCAGGTGCGCCGGGCCCGCGGAGCTCGGCGGGTACAGAGTGACGGACGTGCCCCCCGCGAGCCTGTACTGCGCCGTCCCGTGCGGGGGCTGCTCGTGCCGCCTGGTGCCGGGGCTGGACGCCGTGCAGGGGACCTGCGCGCGTGACGTCACCACGGTCGACCCTCAGACATACGGCGTCACCACCTTCTCCCTCCGCCTGCAGCACGCCGCCCCCCCCGCGCTGGCCGCCCTCCCGCCGTACGTGCGGAGCCTCGACCTGTCGGCCCTCAACCTGACGGAGCCCCCCTGCAACGTGTCCGAGTCTCTCATGCGACTGGATCTGTCCGACAACGCGCTGGCGGTGGCGCCGAGCTGCTTGTTGCGGCGCAACGTGACGGTCCGCCTGGCCGGGAACCCGCTGGCGTGCGACTGCCGCCACGCCGAGGAGGTGGCCCTGCTCGCGGCACACAGGCACCTGGTGGAGGACTACGAGAACGTGACCTGCGCCGGCCAGGAGAGGCTGGAGCAGGTGGACGCGGCGCGGCTGTGCGACGTGGTGGTGGCGGCGCTGGTGGGCGGCTGCCTGGCGGCGGCGGGCGCGCTGCTGGTGGCGGGCGTGGTGCTGTTCCACCGGTACCGGCTGGAGGTGCTGGCGTGGCTGCACGCCCGGCGGCCGCGCCCGCGCCGCGCCGCGCCCGCCGCGTGCCGCTACGACGTGCTGGTGTCGAGCGCGGAGGGGGAGGCGGCGTGGGGCGCGCGCGGGGTGCGGGCGGCGGAGCGCGGGGGGCTGCGCGCGTGCTGGCCGGAGCGCGACTGGGCGGCGGGGGAGCTGCTGCCGGCGCGCATCGCCGCGTCGCTGCACGACTGCCGCGCGGCGCTGCTGTTCGTCTCGCGGAGCTACATGGCGTCCCCGTGGTGCCGGCTCACGTTCCTGCTGGCGCAGGCTCGCGCGGCGCACGTGTCCTCGTTCCGCGTGGTGGTGGTGCTGCTGGAGGAGCCCGGCCCCGAGGAGCGGGAGCTGCGCGCCTACCTGGCGGCGCGGCCCCCGCTCAAGCCCGCGGACCCGCTGCTCTGGGAGAAGGTGCTGTACAAGCTGCGCCCGCGACGCGCCTCGCAGAAGAAGCTGTACCGGTCGCTCGTGAAGAACGGTCTCCAACTGCAGCTGGACGTGGAGGGGAAGCTCACCAACCCCGCCTTCGTCAAGGACCACGACTGA

Protein

MLILLLLALASVSACPEQCWCTDGEELNYQCSRPSTNLIVGARPRDYVNIDCMGGELVCAEFPEIDTPATTQLPSLSLRECSLPPLSCLLQKVHAEDVKTVVFKNAINPLNADAFKGLGITALMMFNAGAQTTVPVDVLRSLPKLTHFRLNAGRNITLHANMFANTPPLKYLELSDAKITVLPDDAFLGLNVLEQLNVWENEIANITAGAFRGLHNVTVLSLNKNRIQALPAGLFASTPRLLNLTMMRNSFRYLDSETFRGLDHIQEIKISNNVPLTLKEAVFSNLPALRTLQLDLSSIRELPEEFISNSPLRTLSLARNQLRVLPRSVLRGQTQLTSLTLSYNAVAELAPELFADLRALETFVMDGNELQVLPDSLFSGLRNLTTVSLRNNKISVISMNTFQGATSIRTLDLSYNRLAFAPDSLYSPLNQLHKLQTLTLAWNNITSIYDDWRYVFVELVKLDLSGNAIGDLTDSDLHFFSEGVTVDLQHNNVSTVLMSGVLRAANATVLLQHNPLACDCSLYSLLDWLAGGPRSLRLEVGDTRCAGPAELGGYRVTDVPPASLYCAVPCGGCSCRLVPGLDAVQGTCARDVTTVDPQTYGVTTFSLRLQHAAPPALAALPPYVRSLDLSALNLTEPPCNVSESLMRLDLSDNALAVAPSCLLRRNVTVRLAGNPLACDCRHAEEVALLAAHRHLVEDYENVTCAGQERLEQVDAARLCDVVVAALVGGCLAAAGALLVAGVVLFHRYRLEVLAWLHARRPRPRRAAPAACRYDVLVSSAEGEAAWGARGVRAAERGGLRACWPERDWAAGELLPARIAASLHDCRAALLFVSRSYMASPWCRLTFLLAQARAAHVSSFRVVVVLLEEPGPEERELRAYLAARPPLKPADPLLWEKVLYKLRPRRASQKKLYRSLVKNGLQLQLDVEGKLTNPAFVKDHD

Description

Receptor for the cleaved activated form of spz, spaetzle C-106 (PubMed:12872120). Binding to spaetzle C-106 activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin (PubMed:12872120, PubMed:8808632, PubMed:10973475). Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo (PubMed:3931919). Promotes heterophilic cellular adhesion (PubMed:2124970). Involved in synaptic targeting of motoneurons RP5 and V to muscle 12 (M12); functions as a repulsive cue inhibiting motoneuron synapse formation on muscle 13 (M13) to guide RP5 and V to the neighboring M12, where its expression is repressed by tey (PubMed:20504957). May also function in embryonic neuronal survival and the synaptic targeting of SNa motoneurons (PubMed:19018662).

Subunit

In the absence of ligand, forms a low-affinity disulfide-linked homodimer (PubMed:24733933). In the presence of ligand, crystal structures show one Tl molecule bound to a spaetzle C-106 homodimer (PubMed:24282309, PubMed:24733933). However, the active complex probably consists of two Tl molecules bound to a spaetzle C-106 homodimer (PubMed:24282309, PubMed:24733933). This is supported by in vitro experiments which also show binding of the spaetzle C-106 dimer to 2 Tl receptors (PubMed:12872120). Ligand binding induces conformational changes in the extracellular domain of Tl (PubMed:24282309). This may enable a secondary homodimerization interface at the C-terminus of the Tl extracellular domain (PubMed:24282309).

Similarity

Belongs to the Toll-like receptor family.

Keywords

3D-structure   Cell adhesion   Cell membrane   Complete proteome   Cytoplasm   Developmental protein   Disulfide bond   Glycoprotein   Immunity   Innate immunity   Leucine-rich repeat   Membrane   Polymorphism   Receptor   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Protein toll

Uniprot

A0A3S2N5Q0   A0A2H1VMZ9   A0A212EH66   A0A3S2L8N6   A0A346RAF5   A0A346RAF6   + More
E0VZA1   A0A1Q3F3Z4   A0A1Q3F421   A0A1Q3F3Z7   A0A1Q3F3T6   A0A1Q3F420   A0A1Q3F3V2   A0A1Q3F3T9   A0A1Q3F412   A0A1Q3F3X6   A0A1B6C0H1   Q8MQU8   Q171J8   A0A067R3H7   A0A182PVM9   A0A026W7S0   A0A154NYN7   K7ITQ2   A0A1I8PSW5   B3M3C1   A0A220W1H4   A0A2C9GWS9   B0WN59   B4NIA8   Q6V673   Q6V670   B4QWS2   Q6V667   Q6V672   Q6V669   Q6V666   A0A1S4JMI6   A0A2C9H6H6   T2GGK5   P08953   A0A0B4KHY4   A0A1L8E2X4   A0A310S7W9   B3P637   A0A182M8X8   E2BBY4   A0A2A3EQD4   A0A1J1HJF0   A0A182Y4Y2   A0A182KC65   A0A232ENK3   A0A1I8MJA6   A0A088AG15   A0A2J7QHL1   D6WCW7   A0A0D3QDD7   A0A0L0CQI3   A0A182UFK6   A0A1J1J3Y3   A0A3B0K7X3   A0A0D3QDL8   M9ZZE2   A0A182IDR8   A0A0D3QDL3   Q24622   A0A0D3QCR2   A0A0D3QCQ2   A0A0D3QDC7   Q8WRE5   B4JY71   B4K8Y1   Q6V671   A0A182XNF0   A0A182GPG4   A0A0D3QCQ7   A0A0D3QD03   A0A1A9VTQ4   Q29B96   A0A2P8ZIM5   A0A182GPV4   B4LWB8   Q17F73   A0A0C9RW22   A0A232FI58   B4PSC7   A0A158P3M6   A0A0A9XC66   A0A195BXZ5   A0A146L775   Q8MQU7   A0A151JAL5   A0A2R7WSN3   A0A1B0GER6   U5EVX5   A0A0C9PYP0  

Pubmed

22118469    29910977    20566863    12542637    17510324    24845553    + More
24508170    30249741    20075255    17994087    28648996    12930753    2449285    10731132    12537572    12537569    3931919    2124970    1879347    8808632    10973475    12617819    12872120    15373972    19018662    22464169    20504957    23596340    24282309    23245851    24733933    12537568    12537573    12537574    16110336    17569856    17569867    20798317    25244985    28648823    25315136    18362917    19820115    25552603    26108605    23497397    8112609    12213252    12364791    14747013    17210077    26483478    15632085    29403074    18057021    17550304    21347285    25401762    26823975   

EMBL

RSAL01000357    RVE42220.1    ODYU01003280    SOQ41832.1    AGBW02014946    OWR40833.1    + More
RSAL01000543    RVE41412.1    MH243021    AXS59155.1    MH243022    AXS59156.1    DS235851    EEB18707.1    GFDL01012806    JAV22239.1    GFDL01012744    JAV22301.1    GFDL01012753    JAV22292.1    GFDL01012819    JAV22226.1    GFDL01012745    JAV22300.1    GFDL01012814    JAV22231.1    GFDL01012813    JAV22232.1    GFDL01012754    JAV22291.1    GFDL01012785    JAV22260.1    GEDC01030285    GEDC01009347    GEDC01003617    JAS07013.1    JAS27951.1    JAS33681.1    AY124196    AAM97775.1    CH477452    EAT40676.1    KK852931    KDR13629.1    KK107356    QOIP01000010    EZA52048.1    RLU17569.1    KQ434773    KZC03990.1    CH902617    EDV43582.1    KX373883    ASK86670.2    DS232007    EDS31490.1    CH964272    EDW83690.1    AY349917    AAQ64868.1    AY349920    AAQ64871.1    CM000364    EDX14589.1    AY349922    AY349923    AAQ64873.1    AAQ64874.1    AY349918    AAQ64869.1    AY349921    AAQ64872.1    AY349924    AAQ64875.1    BT150335    AGW25617.1    M19969    AE014297    BT031153    AY349649    AY349650    AY349651    AY349652    AY349653    AY349654    AY349655    AY121616    AGB96375.1    GFDF01000994    JAV13090.1    KQ775195    OAD52269.1    CH954182    EDV53507.1    AXCM01000253    GL447175    EFN86808.1    KZ288197    PBC33714.1    CVRI01000006    CRK88159.1    NNAY01003140    OXU19918.1    NEVH01013973    PNF28085.1    KQ971311    EEZ99323.1    KP274549    AJC98695.1    JRES01000062    KNC34506.1    CVRI01000070    CRL07112.1    OUUW01000005    SPP81101.1    KP274553    AJC98699.1    KC355234    AGK40934.1    APCN01004779    APCN01004780    KP274545    KP274548    KP274550    AJC98691.1    AJC98694.1    AJC98696.1    L25390    AAA28942.1    KP274552    AJC98698.1    KP274542    AJC98688.1    KP274533    KP274534    KP274535    KP274536    KP274537    KP274538    KP274539    KP274540    KP274541    KP274544    KP274551    AJC98679.1    AJC98680.1    AJC98681.1    AJC98682.1    AJC98683.1    AJC98684.1    AJC98685.1    AJC98686.1    AJC98687.1    AJC98690.1    AJC98697.1    AF444780    AAAB01008811    AAL37901.1    EAA45376.1    CH916377    EDV90633.1    CH933806    EDW16578.1    AY349919    AAQ64870.1    JXUM01078342    JXUM01078343    KP274547    AJC98693.1    KP274543    KP274546    AJC98689.1    AJC98692.1    CM000070    EAL27102.2    PYGN01000045    PSN56345.1    JXUM01001876    KQ560129    KXJ84298.1    CH940650    EDW67652.2    KRF83383.1    CH477273    EAT45212.2    GBYB01011961    JAG81728.1    NNAY01000160    OXU30431.1    CM000160    EDW98589.2    ADTU01008265    GBHO01026374    GBHO01026373    GBHO01026372    GBHO01026370    JAG17230.1    JAG17231.1    JAG17232.1    JAG17234.1    KQ976394    KYM93165.1    GDHC01015553    GDHC01008551    JAQ03076.1    JAQ10078.1    AY124197    AAM97776.1    KQ979262    KYN22067.1    KK855435    PTY22556.1    CCAG010012576    CCAG010012577    CCAG010012578    CCAG010012579    GANO01001683    JAB58188.1    GBYB01006639    GBYB01006641    GBYB01006643    JAG76406.1    JAG76408.1    JAG76410.1   

Proteomes

UP000283053    UP000007151    UP000009046    UP000008820    UP000027135    UP000075885    + More
UP000053097    UP000279307    UP000076502    UP000002358    UP000095300    UP000007801    UP000075900    UP000002320    UP000007798    UP000000304    UP000075920    UP000000803    UP000008711    UP000075883    UP000008237    UP000242457    UP000183832    UP000076408    UP000075881    UP000215335    UP000095301    UP000005203    UP000235965    UP000007266    UP000037069    UP000075902    UP000268350    UP000075903    UP000075840    UP000007062    UP000001070    UP000009192    UP000076407    UP000069940    UP000078200    UP000001819    UP000245037    UP000249989    UP000008792    UP000002282    UP000005205    UP000078540    UP000078492    UP000092444   

PRIDE

T2GGK5    P08953   

Pfam

PF13855   LRR_8        + More
PF01582   TIR
PF01463   LRRCT
PF13306   LRR_5
PF13676   TIR_2
PF01462   LRRNT
PF00560   LRR_1
PF12799   LRR_4
PF12366   Casc1

Interpro

IPR001611   Leu-rich_rpt        + More
IPR000157   TIR_dom       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR032675   LRR_dom_sf       
IPR000483   Cys-rich_flank_reg_C       
IPR035897   Toll_tir_struct_dom_sf       
IPR026906   LRR_5       
IPR000372   LRRNT       
IPR025875   Leu-rich_rpt_4       
IPR022110   Casc1_domain       

SUPFAM

SSF52200   SSF52200       

Gene 3D

3.40.50.10140     3.80.10.10    

ProteinModelPortal

A0A3S2N5Q0   A0A2H1VMZ9   A0A212EH66   A0A3S2L8N6   A0A346RAF5   A0A346RAF6   + More
E0VZA1   A0A1Q3F3Z4   A0A1Q3F421   A0A1Q3F3Z7   A0A1Q3F3T6   A0A1Q3F420   A0A1Q3F3V2   A0A1Q3F3T9   A0A1Q3F412   A0A1Q3F3X6   A0A1B6C0H1   Q8MQU8   Q171J8   A0A067R3H7   A0A182PVM9   A0A026W7S0   A0A154NYN7   K7ITQ2   A0A1I8PSW5   B3M3C1   A0A220W1H4   A0A2C9GWS9   B0WN59   B4NIA8   Q6V673   Q6V670   B4QWS2   Q6V667   Q6V672   Q6V669   Q6V666   A0A1S4JMI6   A0A2C9H6H6   T2GGK5   P08953   A0A0B4KHY4   A0A1L8E2X4   A0A310S7W9   B3P637   A0A182M8X8   E2BBY4   A0A2A3EQD4   A0A1J1HJF0   A0A182Y4Y2   A0A182KC65   A0A232ENK3   A0A1I8MJA6   A0A088AG15   A0A2J7QHL1   D6WCW7   A0A0D3QDD7   A0A0L0CQI3   A0A182UFK6   A0A1J1J3Y3   A0A3B0K7X3   A0A0D3QDL8   M9ZZE2   A0A182IDR8   A0A0D3QDL3   Q24622   A0A0D3QCR2   A0A0D3QCQ2   A0A0D3QDC7   Q8WRE5   B4JY71   B4K8Y1   Q6V671   A0A182XNF0   A0A182GPG4   A0A0D3QCQ7   A0A0D3QD03   A0A1A9VTQ4   Q29B96   A0A2P8ZIM5   A0A182GPV4   B4LWB8   Q17F73   A0A0C9RW22   A0A232FI58   B4PSC7   A0A158P3M6   A0A0A9XC66   A0A195BXZ5   A0A146L775   Q8MQU7   A0A151JAL5   A0A2R7WSN3   A0A1B0GER6   U5EVX5   A0A0C9PYP0  

KEGG

101735584    no KO assigned | (RefSeq) leucine-rich repeat-containing G-protein coupled receptor 5-like

GO

GO:0016021   GO:0045087   GO:0007165   GO:0004721   GO:0032991   GO:0004896   GO:0004888   GO:0035208   GO:0009897   GO:1902875   GO:0005769   GO:0007526   GO:0040015   GO:0007155   GO:0032154   GO:0007507   GO:0008063   GO:0009950   GO:0046627   GO:0045944   GO:0016201   GO:0002229   GO:0005887   GO:0019955   GO:0061760   GO:0030308   GO:0042802   GO:0009611   GO:0007416   GO:0070976   GO:0009986   GO:0002225   GO:0002804   GO:0050830   GO:0005886   GO:0002224   GO:0006954   GO:0005515   GO:0007166   GO:0016020   GO:0003677   GO:0000723   GO:0005634   GO:0006260  

Subcellular location

Cell membrane   In the fat body, detected in puntate structures along the cell periphery. Becomes evenly distributed in the cytoplasm 1 hour after bacterial infection.   With evidence from 11 publications.
Cytoplasm   In the fat body, detected in puntate structures along the cell periphery. Becomes evenly distributed in the cytoplasm 1 hour after bacterial infection.   With evidence from 11 publications.

SignalP

Position:   1 - 14,         Likelihood:  0.999259

 

 

Length:

940

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

21.38441

Exp number, first 60 AAs:

0.00059

Total prob of N-in:

0.00049

outside

1  -  722

TMhelix

723  -  745

inside

746  -  940

 

 

Pi

38.031649

Theta

144.971991

Tajima's D

-1.772944

CLR

375.917455

CSRT

0.0303484825758712

Interpretation

Uncertain