Gene

KWMTBOMO06070  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014518

Annotation

PREDICTED:_protein-tyrosine_sulfotransferase?_partial_[Papilio_machaon]

Location

Bomo_Chr10(-):17560443-17561914      View in EpiBrowser

Full name

Protein-tyrosine sulfotransferase      

Alternative Name

Transport and Golgi organization protein 13
Tyrosylprotein sulfotransferase

Location in the cell

Mitochondrial   Reliability : 1.841

CDS

ATGTGGCGCGGCGCGCGGGCTCGGGTCGCGGCGGCGCTGGGGCTCGCCGCGCTGCTGCTGTGGGCCTGGGGCGCCGCCCCGCCACGCTCGAGCGACCGACAGGCGCCAGTCGCCGGACGCGACTTGCCGCTCATCTTCATCGGCGGCGTACCGCGCTCCGGCACCACGCTGATGCGGGCCATGCTGGACGCACATCCGGACGTGCGCTGCGGCCAGGAGACGCGCGTGGTGCCTCGCATCCTGCAGATGCGCGAGCACTGGGCCCGCTCTCAGAAAGAAAGCGTGCGTCTCGAGCAGGCCGGAGTCTCCCGCGCCGTGCTCAATAACGCCATCGCGGCCTTCTGTCTCGAGGTGATCGTGCGGCACGGCGACCCGGCACCGCGGCTCTGCAACAAAGATCCGCTCGTGCTCAAGATGGGTACGTACGTGCTGGAGCTCTTCCCGAACGCGAAGTTCCTGTTCATGGTTCGAGATGGGCGCGCCACCGTGCACTCCATCATCACAAGGAAGGTGACCATTACTGGATTCGACCTGACGAGCTACCGGCAATGTCTCACAAAGTGGAACCATGCCGTGGAACTGATGTACCAACAGTGCAAGACGATGGGATCAGACAAATGTCTTATGGTGCGCTATGAGTCGCTCGTGTTGTGGCCGCGGGAGACGATGCGACAGGTGCTTGACTTCCTGGAACTGCCCTGGGACGAGGCGGTGCTGCACCACGAGCAGTACATCAATCAGCCGAACGGAGTTGCGCTATCCAATGTGGAGCGGTCGTCGGACCAGGTGGTGCGCGCAGTGAACCGCGACGCGCTGGACAAGTGGGTGGGCGCCTTGCCGGCCGACGTGCGGGCCGACATGCCTCAGCTGGCGCCGATGCTGTCGGTGCTGGGCTACAACCCGTGGGACAATCCGCCGCCCTACCACGCGCATTCGCCGCCGCCCGCTCTCGATACCTAA

Protein

MWRGARARVAAALGLAALLLWAWGAAPPRSSDRQAPVAGRDLPLIFIGGVPRSGTTLMRAMLDAHPDVRCGQETRVVPRILQMREHWARSQKESVRLEQAGVSRAVLNNAIAAFCLEVIVRHGDPAPRLCNKDPLVLKMGTYVLELFPNAKFLFMVRDGRATVHSIITRKVTITGFDLTSYRQCLTKWNHAVELMYQQCKTMGSDKCLMVRYESLVLWPRETMRQVLDFLELPWDEAVLHHEQYINQPNGVALSNVERSSDQVVRAVNRDALDKWVGALPADVRADMPQLAPMLSVLGYNPWDNPPPYHAHSPPPALDT

Description

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides (By similarity). Has a role in protein secretion.

Catalytic Activity

3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]

Similarity

Belongs to the protein sulfotransferase family.

Keywords

Alternative splicing   Complete proteome   Disulfide bond   Glycoprotein   Golgi apparatus   Membrane   Reference proteome   Signal-anchor   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Protein-tyrosine sulfotransferase
splice variant  In isoform B.

Uniprot

H9JY98   A0A2H1V6U6   A0A2W1BS58   A0A3S2TCT0   A0A194Q3W4   A0A2Z5UM17   + More
A0A212FEJ6   A0A1E1WQB9   A0A0N1PFN7   A0A0L7L2Y5   T1PLM3   B4JJJ2   A0A0Q9X255   A0A1L8DW40   A0A0Q9WEA6   A0A0K8TT10   B4N2K8   S4PMJ5   Q9VYB7-2   A8JUV2   A0A1W4WE25   A0A1L8DW55   A0A0C9R5V7   A0A182Y4V7   A0A1I8MZU1   A0A182R7V3   A0A182VSP5   A0A182SXR3   A0A182M3E4   B4IG37   B4L4J9   B4M2K7   A0A182V5H3   A0A1I8NYI1   B4R4D7   M9PEH9   Q9VYB7   A0A0L0BKT2   A0A1W4W246   A0A182KK65   B3MVV9   Q7PNJ6   B4GXN1   M9PHI3   A0A084WFR8   W8BUV0   B4Q2D3   A0A182K396   A0A0M5JDU8   Q29HH7   A0A0K8WJN8   A0A182N1M5   A0A182PL19   B3NWM2   A0A182NMY5   W5JHY7   A0A2M3Z556   A0A182R032   W8B2Y3   A0A1Q3FA66   A0A182FIJ4   A0A2M4A4C1   A0A2M4BQK3   B0X4U0   A0A026WEU4   A0A232FGX3   K7IQC3   A0A182ITS5   A0A1Q3FDA8   A0A034VCM2   A0A034VE86   A0A023ESZ8   A0A0K8UPI6   A0A088AVM2   A0A195CCX8   A0A151WSP8   A0A023ER50   F4WJF5   A0A195BWD0   A0A023ER20   A0A0L7RIN8   A0A0J7L1I5   A0A023ER02   A0A2A3EK85   A0A154PE83   E2C2L6   A0A2J7R7P1   A0A2J7R7P7   A0A0N0BHR0   D6X260   A0A1Y1M665   A0A1B6J699   A0A1B6LIM7   A0A1B6LRB0   E0VHZ2   A0A067RLC6   A0A1B0Y0C2   A0A2S2NM82   A0A1B6DHI7   A0A1B6DNH9  

EC Number

2.8.2.20

Pubmed

19121390    28756777    26354079    22118469    26227816    17994087    + More
26369729    23622113    10731132    12537572    12537569    16452979    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25244985    25315136    18057021    26108605    20966253    12364791    14747013    17210077    24438588    24495485    17550304    15632085    20920257    23761445    24508170    30249741    28648823    20075255    25348373    24945155    21719571    20798317    18362917    19820115    28004739    20566863    24845553   

EMBL

BABH01042775    ODYU01000961    SOQ36506.1    KZ150039    PZC74583.1    RSAL01000349    + More
RVE42281.1    KQ459472    KPJ00233.1    AP017499    BBB06787.1    AGBW02008947    OWR52117.1    GDQN01001876    JAT89178.1    KQ460784    KPJ12205.1    JTDY01003272    KOB69832.1    KA648838    AFP63467.1    CH916370    EDV99744.1    CH963925    KRF98914.1    GFDF01003438    JAV10646.1    CH940651    KRF82470.1    GDAI01000332    JAI17271.1    EDW78597.2    GAIX01003520    JAA89040.1    AY124548    AE014298    AY119073    BT021950    ABW09407.1    GFDF01003407    JAV10677.1    GBYB01003335    JAG73102.1    AXCM01011898    CH480835    EDW48771.1    CH933810    EDW07477.2    EDW65911.1    KRF82471.1    CM000366    EDX17839.1    AGB95362.1    JRES01001705    KNC20700.1    CH902625    EDV35104.2    AAAB01008963    EAA12079.6    CH479196    EDW27508.1    AGB95360.1    ATLV01023392    KE525342    KFB49062.1    GAMC01013646    JAB92909.1    CM000162    EDX01594.2    CP012528    ALC49544.1    CH379064    EAL31781.3    GDHF01000941    JAI51373.1    CH954180    EDV47184.2    ADMH02001203    ETN63741.1    GGFM01002895    MBW23646.1    AXCN02001440    GAMC01013644    GAMC01013643    JAB92912.1    GFDL01010647    JAV24398.1    GGFK01002322    MBW35643.1    GGFJ01006112    MBW55253.1    DS232354    EDS40555.1    KK107260    QOIP01000001    EZA54181.1    RLU27219.1    NNAY01000253    OXU29689.1    GFDL01009563    JAV25482.1    GAKP01019085    GAKP01019083    JAC39867.1    GAKP01019086    GAKP01019084    JAC39868.1    GAPW01002134    JAC11464.1    GDHF01023717    JAI28597.1    KQ978023    KYM97938.1    KQ982769    KYQ50874.1    GAPW01001968    JAC11630.1    GL888182    EGI65733.1    KQ976401    KYM92590.1    GAPW01002003    JAC11595.1    KQ414582    KOC70832.1    LBMM01001421    KMQ96354.1    GAPW01002028    JAC11570.1    KZ288220    PBC32185.1    KQ434874    KZC09734.1    GL452167    EFN77815.1    NEVH01006727    PNF36855.1    PNF36853.1    KQ435745    KOX76592.1    KQ971371    EFA09909.1    GEZM01039769    JAV81214.1    GECU01012999    JAS94707.1    GEBQ01016435    JAT23542.1    GEBQ01013800    JAT26177.1    DS235172    EEB12998.1    KK852556    KDR21420.1    KT000409    ANI86007.1    GGMR01005671    MBY18290.1    GEDC01029721    GEDC01012218    GEDC01011482    GEDC01003081    JAS07577.1    JAS25080.1    JAS25816.1    JAS34217.1    GEDC01014830    GEDC01010076    JAS22468.1    JAS27222.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000007151    UP000053240    UP000037510    + More
UP000001070    UP000007798    UP000008792    UP000000803    UP000192221    UP000076408    UP000095301    UP000075900    UP000075920    UP000075901    UP000075883    UP000001292    UP000009192    UP000075903    UP000095300    UP000000304    UP000037069    UP000075882    UP000007801    UP000007062    UP000008744    UP000030765    UP000002282    UP000075881    UP000092553    UP000001819    UP000075884    UP000075885    UP000008711    UP000000673    UP000075886    UP000069272    UP000002320    UP000053097    UP000279307    UP000215335    UP000002358    UP000075880    UP000005203    UP000078542    UP000075809    UP000007755    UP000078540    UP000053825    UP000036403    UP000242457    UP000076502    UP000008237    UP000235965    UP000053105    UP000007266    UP000009046    UP000027135   

PRIDE

H9JY98    Q9VYB7    M9PEH9   

Interpro

IPR027417   P-loop_NTPase        + More
IPR026634   TPST       

SUPFAM

SSF52540   SSF52540       

ProteinModelPortal

H9JY98   A0A2H1V6U6   A0A2W1BS58   A0A3S2TCT0   A0A194Q3W4   A0A2Z5UM17   + More
A0A212FEJ6   A0A1E1WQB9   A0A0N1PFN7   A0A0L7L2Y5   T1PLM3   B4JJJ2   A0A0Q9X255   A0A1L8DW40   A0A0Q9WEA6   A0A0K8TT10   B4N2K8   S4PMJ5   Q9VYB7-2   A8JUV2   A0A1W4WE25   A0A1L8DW55   A0A0C9R5V7   A0A182Y4V7   A0A1I8MZU1   A0A182R7V3   A0A182VSP5   A0A182SXR3   A0A182M3E4   B4IG37   B4L4J9   B4M2K7   A0A182V5H3   A0A1I8NYI1   B4R4D7   M9PEH9   Q9VYB7   A0A0L0BKT2   A0A1W4W246   A0A182KK65   B3MVV9   Q7PNJ6   B4GXN1   M9PHI3   A0A084WFR8   W8BUV0   B4Q2D3   A0A182K396   A0A0M5JDU8   Q29HH7   A0A0K8WJN8   A0A182N1M5   A0A182PL19   B3NWM2   A0A182NMY5   W5JHY7   A0A2M3Z556   A0A182R032   W8B2Y3   A0A1Q3FA66   A0A182FIJ4   A0A2M4A4C1   A0A2M4BQK3   B0X4U0   A0A026WEU4   A0A232FGX3   K7IQC3   A0A182ITS5   A0A1Q3FDA8   A0A034VCM2   A0A034VE86   A0A023ESZ8   A0A0K8UPI6   A0A088AVM2   A0A195CCX8   A0A151WSP8   A0A023ER50   F4WJF5   A0A195BWD0   A0A023ER20   A0A0L7RIN8   A0A0J7L1I5   A0A023ER02   A0A2A3EK85   A0A154PE83   E2C2L6   A0A2J7R7P1   A0A2J7R7P7   A0A0N0BHR0   D6X260   A0A1Y1M665   A0A1B6J699   A0A1B6LIM7   A0A1B6LRB0   E0VHZ2   A0A067RLC6   A0A1B0Y0C2   A0A2S2NM82   A0A1B6DHI7   A0A1B6DNH9  

PDB

5WRJ     E-value=3.93733e-104,     Score=965

KEGG

101739802    K01021 protein-tyrosine sulfotransferase [EC:2.8.2.20] | (RefSeq) protein-tyrosine sulfotransferase

GO

GO:0006478   GO:0008476   GO:0016021   GO:0005794   GO:0000139   GO:0009306  

PANTHER

PTHR12788  

Subcellular location

Golgi apparatus membrane  

SignalP

Position:   1 - 24,         Likelihood:  0.894201

 

 

Length:

319

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

18.63141

Exp number, first 60 AAs:

18.58278

Total prob of N-in:

0.95659

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  26

outside

27  -  319

 

 

Pi

2.263482

Theta

5.984251

Tajima's D

-1.799661

CLR

0.072022

CSRT

0.0254987250637468

Interpretation

Uncertain