Gene

KWMTBOMO06028  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002831

Annotation

PREDICTED:_probable_elongator_complex_protein_2_[Papilio_xuthus]

Location

Bomo_Chr10(+):16749032-16763685      View in EpiBrowser

Full name

Probable elongator complex protein 2      

Alternative Name

Stat3-interacting protein homolog

Location in the cell

Cytoplasmic   Reliability : 1.852

CDS

ATGGAACATACGGTACAAAATACAGAGGGAACCGAAGTCCCTCCGCAGACCCAGAGGTTCCAAACGATCCGTGAGAATGGGATTATCGACAATCCGAACGGCCCTCCTCTGTATGGAGTCAAATGGAAGAAGCTGGTATTTGGGAGCCCCGGCCCAGAGATGGGAGCAGTACTCCACGCGAGGCCGGACTTGTGCTTTATAAAGCAAAAGTCTTTGTCCAGGCGTGAAGTACCGCTTCGCTCTGTTGAGGACTCCCAGCATTTTGGACGCCAACTTGGCTTTGCCTTCCAAATGACTCCGAAACTGGACATCGCTCGAAATGTCGACCCCAAGTATCCCAATACTCTCGGAAGGTTGCAGGGATACTCCTTGGAATTGCGGCGCCATGACAAAGGGGTGTCTGTAGAACAAGTGTATACATCTGTCGCCTGTAACCGCAAACCTGAAGTGGTAGACTGGAATTACGACGGGATAATTTGTTACGGTGCCTGTAATGCTGTTGTTGTTTGTGATCCGAATGAAAAAACTAAAGATAGAGTAACAGTACTGAGTCACCATACAGGACACGTAAACTCTGTAAAATGGATACACAATCATAATGGCCAAACAACAGAGTTGCTCTCTTGCTCAGTTGATAAGACTGCTGTCATCTGGACATTACAAAACGGTTGCTGGAACGTCACCAGTATTCTCAAGGGACATACAGAAGGAGTTACTAATATATATGGAAATTACCATAGAGACCGACTTACTATTTACACTGCGTCCACTGATTCTACCATTAGAGTTTGGGAAAGGATAGAAGGTACGGTAACCCTCAAGCAAAGTATATCTCTACATTCTGGTTTATGTCTCACCCTTCACGCGCAAATACTACCATGCGCAAATAAACCGCTATTACTTTGTGCACTGGATGACCACAAAATACATATATTCGTTGGTGAGGACTATCACAGAGCGCATACTCTGGTTGGACACGAAGACTGGGTTAGGGGACTTGACGTGTTGGAAGTTGATAACGACACAATTATCGTAGCGTCGGCTTCTCAAGATACATACATTCGTCTGTGGAAGATACAAAAGGTCAAAGCACAACCGGAGTCCAAACTGATTAAGGTTGAGGAAAAAGTGTTCCATGCATATGACAATCTTTGGTCTGTGAAACTTGAGGCAGTGCTTGCCGGTCATGAAGCCTGGGTCTATGGGGTACAATGGCATCCTTATAGTTTTGATGGTCCTACTAAAAAGCCGGTATACCGTCTCCTGTCATCATCACTGGACAAAACCCTGATTATTTGGGAGCCAGACTCCAGTAGTACAGACGAAGGTGTCTGGGTAGAGAAGGTCAGGGTGGGCGAAGTGGGAGGCGGAGGCTTGGGTTTCTACGGGAGCCGTTTTGGACCAGAAGGTATGTCCTTCTTGGGACATGGTTACAATGGCTCTTTTCACATTTGGACTTTTGATAAGGAAAGTGAGCAGTGGTCCCCGAGCGTGGTGTGCGGCGGACACTTCATGTCGGTGGAGGACGTCGCCTGGGAGCCGCGCCAGGGCCGCTACCTGCTCAGCGTCTCCGCAGACCAGACCACGAGACTCCACGCCCCGGTCCGGAGGAGCGATGGTTCCGTGGCCTGGCACGAGCTGGCCCGGCCGCAGATCCACGGCTACGACATGTCGGCCGTAGCCCCCCTCACCGCCACCACCTTCGCGTCCGCCGCCGAGGAGAAGGTCATCAGGGTCTTCACAGCACCGCACAACTTCATCAGCAATTTCAAGAACCTCGTGGGAGAAGTCCTCGTCGCAAATAACGAGAAAGGTCCGGAGGGCGCTTCGGTCCCCTCGCTGGGCTTGTCCAACAAGGCCGTGTTCATAGAGGAGCAGGGCGGCTCAGGCGCCGGTGACGACGGCGACGGCTACTTTGCGCCCGTCGATATGAAAGAGCCGCCCACTGAGGAGACGTTGGTCCAGAACACGCTGTGGCCGGAGCTGCAGAAGCTGTACGGGCACGGCGGGGAGGTGTTCGCGCTGCACGCCGCGCCCGACGGGACCCTGCTCGCCTCCGCCGCCCGGGCCACCGACGCCACGCACGCCGCGCTCGTGCTGTGGGAAACCGCGAAATGGCAGCAAATACAAAAGATAGAGTCCCACACGCTGACAATAACGCAGCTCGCGTTCTCGCCGGACAGTCAGAAGTTATTGTCCGTGTCTCGGGACCGGCGCTGGACGCTGTACCGCCGGCTGCCGGGGTCTAGCAGGTTCGAGGTGGCCGCCACCAGCGACAAGAGCAACGGCGTGCACTCCAGGATCGTGTGGTGCTGTGCGTGGGCTCCCGACGCGCGCATGTTCGCCACCGGCTCCAGGGATGGCAAGGTCTGTTTGTGGGCGAAATCAGATACGTGCACCGACACGTCGCTAAAGGAGTACGCGCTGCACGGGAGCCCTCTGGAGGCCGGCGCCTCCGTGACGGCGCTGGCGTGCACGGGGCGCGGGGAGCGCTGCGTGCTGGCCGTGGGGCTGGAGACGGGCGCCGTCGACATATACAGGGCAGACGACTGGCGCCTCCTGCACCGCATGGACCACAGCTCGGCGCATCACCTGACCGTGAAGAGGTTAACATTTAATCCAAAATATGAGGGTAGCGATGAAACGTTGTTGGCGAGTGCGGGCGCCGATCACGTCGTGAGGATACATCGCCTCAAAATAACTTATTAA

Protein

MEHTVQNTEGTEVPPQTQRFQTIRENGIIDNPNGPPLYGVKWKKLVFGSPGPEMGAVLHARPDLCFIKQKSLSRREVPLRSVEDSQHFGRQLGFAFQMTPKLDIARNVDPKYPNTLGRLQGYSLELRRHDKGVSVEQVYTSVACNRKPEVVDWNYDGIICYGACNAVVVCDPNEKTKDRVTVLSHHTGHVNSVKWIHNHNGQTTELLSCSVDKTAVIWTLQNGCWNVTSILKGHTEGVTNIYGNYHRDRLTIYTASTDSTIRVWERIEGTVTLKQSISLHSGLCLTLHAQILPCANKPLLLCALDDHKIHIFVGEDYHRAHTLVGHEDWVRGLDVLEVDNDTIIVASASQDTYIRLWKIQKVKAQPESKLIKVEEKVFHAYDNLWSVKLEAVLAGHEAWVYGVQWHPYSFDGPTKKPVYRLLSSSLDKTLIIWEPDSSSTDEGVWVEKVRVGEVGGGGLGFYGSRFGPEGMSFLGHGYNGSFHIWTFDKESEQWSPSVVCGGHFMSVEDVAWEPRQGRYLLSVSADQTTRLHAPVRRSDGSVAWHELARPQIHGYDMSAVAPLTATTFASAAEEKVIRVFTAPHNFISNFKNLVGEVLVANNEKGPEGASVPSLGLSNKAVFIEEQGGSGAGDDGDGYFAPVDMKEPPTEETLVQNTLWPELQKLYGHGGEVFALHAAPDGTLLASAARATDATHAALVLWETAKWQQIQKIESHTLTITQLAFSPDSQKLLSVSRDRRWTLYRRLPGSSRFEVAATSDKSNGVHSRIVWCCAWAPDARMFATGSRDGKVCLWAKSDTCTDTSLKEYALHGSPLEAGASVTALACTGRGERCVLAVGLETGAVDIYRADDWRLLHRMDHSSAHHLTVKRLTFNPKYEGSDETLLASAGADHVVRIHRLKITY

Description

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation (By similarity). Involved in the regulation of the STAT pathway.

Cofactor

Zn(2+)

Subunit

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit.

Similarity

Belongs to the WD repeat ELP2 family.
Belongs to the peptidase M3 family.

Keywords

Complete proteome   Cytoplasm   Nucleus   Reference proteome   Repeat   Transcription   Transcription regulation   WD repeat  

Feature

chain  Probable elongator complex protein 2

Uniprot

A0A194Q9U2   A0A2H1WPH4   S4PFA2   A0A212FNU5   A0A0N1PGV3   A0A067QSM5   + More
Q7K4B3   A0A0J9R9T9   B4QAL7   B3NN66   B4HMS8   A0A1W4VDT8   B4GG80   Q28XJ0   A0A2J7PSL6   B4P851   A0A3B0JSP6   B3MIJ2   A0A1Y1LNG0   A0A1I8NDI4   B4J7S5   B4LKN2   A0A1I8P377   A0A1B6DSR2   B4MNY5   A0A2J7PSM3   A0A0M4E7R5   A0A182I6K8   A0A0L0BTW9   Q7QII6   A0A182UHV4   A0A182WWC9   B4KN16   A0A1A9UKW0   A0A182Y827   A0A1A9WBK9   Q17BP0   B0X467   A0A1A9ZY04   A0A1B0FAI1   A0A182PIP1   A0A2R5LAE9   A0A182JS67   A0A182N9F9   W5J5A9   A0A131YKI7   L7M717   A0A336LX18   A0A182QQW7   J9JK52   A0A182MII9   A0A182RJF4   A0A182GVL9   A0A182FGR6   A0A1B0C0Q1   A0A336MNI7   A0A1A9YI10   D6WZ43   A0A293LZX7   A0A182WBD2   A0A3B4BRI1   A0A232EXK8   R7TWN9   A0A154NZT9   C3ZDE2   A0A2S2N9V7   A0A2H8TKS5   A0A2S2NP18   A0A0V0G6E8   A0A0B7ACE9   A0A182UPU1   A0A0J7KPZ0   A0A1D5NVT8   A0A2D0PZT2   A0A2D0PYV0   H2TTI1   A0A1E1XSK5   A0A1V4J8D5   E2A929   A0A224XBQ5   A0A3Q3K5X2   A0A2D0PX48   A0A3Q3LQ26   A0A3Q3LQ60   A0A088ASE9   A0A1E1XGG7   A0A3Q4GSW1   A0A2G8JW57   L7US92   A0A1L8FS31   A0A023F078   G3MKN6   A0A3B4BI07   A0A2A3E2L5   A0A3Q1IUF5   A0A3P8QM12   A0A286Y893   A0A3N0XZH5   A0A2J7PSM6   B5DDH6  

Pubmed

26354079    23622113    22118469    24845553    10731132    12537572    + More
12537569    22936249    17994087    15632085    17550304    28004739    25315136    26108605    12364791    14747013    17210077    25244985    17510324    20920257    23761445    26830274    25576852    26483478    18362917    19820115    28648823    23254933    18563158    15592404    21551351    29209593    20798317    28503490    25186727    29023486    24748431    27762356    25474469    22216098    25463417    23594743   

EMBL

KQ459472    KPJ00191.1    ODYU01010033    SOQ54852.1    GAIX01004112    JAA88448.1    + More
AGBW02004392    OWR55405.1    KQ461186    KPJ07376.1    KK853329    KDR08420.1    AE013599    AY052019    CM002911    KMY92838.1    CM000362    EDX06522.1    CH954179    EDV56586.1    CH480816    EDW47290.1    CH479183    EDW35500.1    CM000071    EAL26326.1    NEVH01021926    PNF19328.1    CM000158    EDW90098.1    OUUW01000001    SPP74138.1    CH902619    EDV38068.1    GEZM01055123    JAV73126.1    CH916367    EDW01131.1    CH940648    EDW61755.1    GEDC01008629    JAS28669.1    CH963848    EDW73824.1    PNF19332.1    CP012524    ALC40621.1    APCN01003655    JRES01001351    KNC23456.1    AAAB01008807    EAA03956.4    CH933808    EDW08843.1    CH477319    EAT43673.1    DS232330    EDS40144.1    CCAG010018439    GGLE01002324    MBY06450.1    ADMH02002185    ETN57929.1    GEDV01008744    JAP79813.1    GACK01005189    JAA59845.1    UFQT01000246    SSX22350.1    AXCN02000560    ABLF02017489    ABLF02017490    AXCM01002307    JXUM01091356    JXUM01091357    KQ563907    KXJ73085.1    JXJN01023720    UFQS01001398    UFQT01001398    SSX10691.1    SSX30373.1    KQ971372    EFA10370.2    GFWV01007565    MAA32295.1    NNAY01001755    OXU23027.1    AMQN01010605    KB308219    ELT98174.1    KQ434786    KZC05189.1    GG666612    EEN49497.1    GGMR01001385    MBY14004.1    GFXV01002083    MBW13888.1    GGMR01006321    MBY18940.1    GECL01002476    JAP03648.1    HACG01031834    CEK78699.1    LBMM01004441    KMQ92418.1    AADN05000026    GFAA01001157    JAU02278.1    LSYS01008581    OPJ68426.1    GL437711    EFN70014.1    GFTR01008042    JAW08384.1    GFAC01000831    JAT98357.1    MRZV01001176    PIK40001.1    KC207886    AGC50884.1    CM004477    OCT74375.1    GBBI01003812    JAC14900.1    JO842437    AEO34054.1    KZ288425    PBC25940.1    BX927389    RJVU01057109    ROK35835.1    PNF19329.1    BC164575    AAI64575.1   

Proteomes

UP000053268    UP000007151    UP000053240    UP000027135    UP000000803    UP000000304    + More
UP000008711    UP000001292    UP000192221    UP000008744    UP000001819    UP000235965    UP000002282    UP000268350    UP000007801    UP000095301    UP000001070    UP000008792    UP000095300    UP000007798    UP000092553    UP000075840    UP000037069    UP000007062    UP000075902    UP000076407    UP000009192    UP000078200    UP000076408    UP000091820    UP000008820    UP000002320    UP000092445    UP000092444    UP000075885    UP000075881    UP000075884    UP000000673    UP000075886    UP000007819    UP000075883    UP000075900    UP000069940    UP000249989    UP000069272    UP000092460    UP000092443    UP000007266    UP000075920    UP000261440    UP000215335    UP000014760    UP000076502    UP000001554    UP000075903    UP000036403    UP000000539    UP000221080    UP000005226    UP000190648    UP000000311    UP000261600    UP000261640    UP000005203    UP000261580    UP000230750    UP000186698    UP000261520    UP000242457    UP000265040    UP000265100    UP000000437   

PRIDE

Q7K4B3    L7M717    G3MKN6   

Pfam

PF00400   WD40        + More
PF01432   Peptidase_M3

Interpro

IPR036322   WD40_repeat_dom_sf        + More
IPR037289   Elp2       
IPR017986   WD40_repeat_dom       
IPR001680   WD40_repeat       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR020472   G-protein_beta_WD-40_rep       
IPR011047   Quinoprotein_ADH-like_supfam       
IPR019775   WD40_repeat_CS       
IPR024077   Neurolysin/TOP_dom2       
IPR033851   M3A_MIP       
IPR001567   Pept_M3A_M3B       
IPR011041   Quinoprot_gluc/sorb_DH       
IPR011048   Haem_d1_sf       

SUPFAM

SSF50978   SSF50978        + More
SSF50998   SSF50998       
SSF50952   SSF50952       
SSF51004   SSF51004       

Gene 3D

2.130.10.10     1.10.1370.10    

CDD

cd06457  M3A_MIP

ProteinModelPortal

A0A194Q9U2   A0A2H1WPH4   S4PFA2   A0A212FNU5   A0A0N1PGV3   A0A067QSM5   + More
Q7K4B3   A0A0J9R9T9   B4QAL7   B3NN66   B4HMS8   A0A1W4VDT8   B4GG80   Q28XJ0   A0A2J7PSL6   B4P851   A0A3B0JSP6   B3MIJ2   A0A1Y1LNG0   A0A1I8NDI4   B4J7S5   B4LKN2   A0A1I8P377   A0A1B6DSR2   B4MNY5   A0A2J7PSM3   A0A0M4E7R5   A0A182I6K8   A0A0L0BTW9   Q7QII6   A0A182UHV4   A0A182WWC9   B4KN16   A0A1A9UKW0   A0A182Y827   A0A1A9WBK9   Q17BP0   B0X467   A0A1A9ZY04   A0A1B0FAI1   A0A182PIP1   A0A2R5LAE9   A0A182JS67   A0A182N9F9   W5J5A9   A0A131YKI7   L7M717   A0A336LX18   A0A182QQW7   J9JK52   A0A182MII9   A0A182RJF4   A0A182GVL9   A0A182FGR6   A0A1B0C0Q1   A0A336MNI7   A0A1A9YI10   D6WZ43   A0A293LZX7   A0A182WBD2   A0A3B4BRI1   A0A232EXK8   R7TWN9   A0A154NZT9   C3ZDE2   A0A2S2N9V7   A0A2H8TKS5   A0A2S2NP18   A0A0V0G6E8   A0A0B7ACE9   A0A182UPU1   A0A0J7KPZ0   A0A1D5NVT8   A0A2D0PZT2   A0A2D0PYV0   H2TTI1   A0A1E1XSK5   A0A1V4J8D5   E2A929   A0A224XBQ5   A0A3Q3K5X2   A0A2D0PX48   A0A3Q3LQ26   A0A3Q3LQ60   A0A088ASE9   A0A1E1XGG7   A0A3Q4GSW1   A0A2G8JW57   L7US92   A0A1L8FS31   A0A023F078   G3MKN6   A0A3B4BI07   A0A2A3E2L5   A0A3Q1IUF5   A0A3P8QM12   A0A286Y893   A0A3N0XZH5   A0A2J7PSM6   B5DDH6  

PDB

5M2N     E-value=1.42275e-66,     Score=646

KEGG

101736743    K11374 elongator complex protein 2 | (RefSeq) probable elongator complex protein 2

GO

GO:0033588   GO:0002098   GO:0005634   GO:0043248   GO:0005737   GO:0061133   GO:0000502   GO:0006368   GO:0006627   GO:0005759   GO:0046872   GO:0004222   GO:0008023   GO:0016021   GO:0000993   GO:0005829   GO:0003824   GO:0005515   GO:0005524   GO:0006139   GO:0008026   GO:0016818   GO:0004003   GO:0003677   GO:0000723   GO:0006260  

PANTHER

PTHR44111  

Subcellular location

Cytoplasm  
Nucleus  

Length:

902

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00205

Exp number, first 60 AAs:

0.00016

Total prob of N-in:

0.00013

outside

1  -  902

 

 

Pi

20.544788

Theta

17.204113

Tajima's D

0.249421

CLR

0.387959

CSRT

0.450277486125694

Interpretation

Uncertain