Gene

KWMTBOMO06027

Pre Gene Modal

BGIBMGA002870

Annotation

fanconi_anemia_group_J_protein_[Danaus_plexippus]

Location

Bomo_Chr10(-):16743497-16746961      View in EpiBrowser

Full name

Regulator of telomere elongation helicase 1 homolog      

Location in the cell

Nuclear   Reliability : 2.745

CDS

ATGCCTGATATAATGATATCCGGTATTCCCGTAAGTTTTCCCTTCGACCCTTACGATGTGCAGAAAGAATACATGTGCCGTGTAATTGAGAGCCTTCAGAATAACACTAACGCAATATTGGAGTCTCCTACCGGAACTGGAAAGACCCTTAGTCTATTGTGTTCATCATTAGCATGGCTACTAGTGAAAAAGGCTCAACTGCAAATGAACGCGCAGGTCGGTAATTTTTCAGATCACAGCGGTTTTACTGGCAAGTTAATAGATAACTTAAAATCTGGCACTGGAAAATCCAAGGATGCGTCTTGGGGTATGCCTAAAATCATATATTCTTCCAGAACACATTCACAATTAACACAGGCTATGCAGGAATTGAAGAGGTCAAGTTACAAGCATGTCAAAGCTGCGGTCTTGGGCTCCCGAGATCAGATGTGCATTCATCCTGAAGTTTCGAAAGAACCAAACAACAACAATAAAGTAAATATGTGCCAACTAAAAGTGAAATCTAGAACTTGCTTCTTTTATAACAATGTTGAATCTAAAAAGGATGACAGAGCAGTGAAAGGTGATGATATTTTAGATATAGAAGATTTAGTAGGTGTAGGAAAGAAATTAAAATGCTGTCCATATTATTTATCGAAGGAGCTAAAACAAGATGCTGATATAATATTTATGCCATATAATTATTTATTGGATCCAAAATCAAGAAAGGCAAATGGAGTGGAACTCATGAATAACATTGTTATTTTGGATGAGGCTCATAATGTTGAAAAAATGTGTGAAGAATCTGCATCTCTTCAGATTAGGACCACAGATATAGCTCTGTGTATTGATGAAATAACACATGTCATGAAGAGCTTTAGTGAGAATAGTGAGGAGCAGATAGATGCAACAGTTGATAGTAACCAACCTAAAGATTTTACTTGTGATGATTTATGTATACTGAAAGAAATGATGCTGGCCTTTGAAAAGGCTGTAGATGATATAGAAGTTGGGAGAGAGGGTAGTACATATCCAGGTGGTTTTATATTTGATTTGCTGTCCAAGGCTGAAATCAGAGATCATAACCAAATGGCCGTGATAACTATGATTGAGAATCTCATTCAATATCTAGCAACAGCAAGTTCATCACCCTTTCAACGCAAAGGTGTTGGGTTGCAGAAAATTGTAGATCTTCTAAATGTTGTGTTTAGTGGCACTAGTCATTCACACAAAGAAAGGGTTAAGCTATGTTACAAAGTACATGTACAAGTTGAGGATAAAAAAAGCAATAAGAAAACAGAAGGTTGGGGTGCACTGAAGCCGAACAGTTCTAAATCTACAGAGAGGATACTAAGTTACTGGTGCTTCAGCCCTGGTTTTGGCATGAAGCAATTACTTGAACAGAATGTTAGAAGCATAATATTGACAAGTGGTACTTTAGCACCTTTAAAACCCCTCATATCTGAACTGGGTATTCCAATAGGTGTACAGTTAGAAAATCCACATATTGTTAAATCAAATCAAATATGTGTAAAAATTATTGGACAAGGGCCAGATGGGGTCCAACTAAATTCTAATTATCAGAACAGAGACAATCCTAAGTATATATCCTCTTTGGGAAGAACAATATTAAGTTTTAGCAGAGTTGTACCAGATGGACTTTTAGTATTCTTCCCTTCATACCCAATCATGAATAAATGCCAAGAAATGTGGCAGTCTGAAGGAATTTGGACTAATATTAACAGCATCAAACCAATATTTGTGGAACCGCAAAGGAAAGATACATTCAATGCTATCATTAAAGATTACTACAGCAAAATAAGTGATCCAAGTACACGGGGTGCATGTTTTATGGCAGTTTGTAGAGGTAAAGTGTCAGAAGGGTTGGATTTTGCTGATATGAATGGAAGAGCTGTGATAATAACTGGGTTACCATTTCCTCCTCTTAAGGATCCAAGAATTGTATTGAAGAAGAAATATTTAGACGAATTGAGAATGAAAGAAAAGGACTTTTTGTCAGGAGACGAATGGTACTCTTTAGAAGCAACTAGAGCCGTCAATCAGGCTATTGGCAGAGTTATAAGGCATCAGAATGATTATGGTGCTATTCTTCTGTGTGATAGCCGATTCAACAGTCCAAAATTAAAAGGTCAGTTGTCAGCTTGGCTACGTAATTACATAAATGTGTCCAATAAATTTGGTGAGACTGTCAGTGAAATATGCCGCTTCTATAAGAATGCTGAAATGGCATTGCCTGCTCCAAAACTAAAGCCGTTGATGTCAAATGAATCAAACAGACAACAATCTGTCAATGTTGGTGGAGTATCATTTCCAATTACAGTTGCTAGGACTGTTAAATCTACTAAAAAGAATAGTTTAGTGGCAATAAACAAAAGAACTGCTGAAGACAATTTATTAGCAAATGTATCTAAAAAGAAAAAATACAAAATTAAACCCTTTGGTTTTGATGAAAATTTGAAAAGTGAACCTAGTAACATAGTAGAGAAAACTGCACCTACATCACTAGTAGATTTTGTTAAAGAAATAAAGGTTTTATTACAACCAGAACAATATAAATTATTTCAAGGTTCAATATCAGCTTATAAAAGAGAAGGGGATTTTTCAGCATTTGTGACCACCCTAGGAATTTTGTTACCAAGAACTTAA

Protein

MPDIMISGIPVSFPFDPYDVQKEYMCRVIESLQNNTNAILESPTGTGKTLSLLCSSLAWLLVKKAQLQMNAQVGNFSDHSGFTGKLIDNLKSGTGKSKDASWGMPKIIYSSRTHSQLTQAMQELKRSSYKHVKAAVLGSRDQMCIHPEVSKEPNNNNKVNMCQLKVKSRTCFFYNNVESKKDDRAVKGDDILDIEDLVGVGKKLKCCPYYLSKELKQDADIIFMPYNYLLDPKSRKANGVELMNNIVILDEAHNVEKMCEESASLQIRTTDIALCIDEITHVMKSFSENSEEQIDATVDSNQPKDFTCDDLCILKEMMLAFEKAVDDIEVGREGSTYPGGFIFDLLSKAEIRDHNQMAVITMIENLIQYLATASSSPFQRKGVGLQKIVDLLNVVFSGTSHSHKERVKLCYKVHVQVEDKKSNKKTEGWGALKPNSSKSTERILSYWCFSPGFGMKQLLEQNVRSIILTSGTLAPLKPLISELGIPIGVQLENPHIVKSNQICVKIIGQGPDGVQLNSNYQNRDNPKYISSLGRTILSFSRVVPDGLLVFFPSYPIMNKCQEMWQSEGIWTNINSIKPIFVEPQRKDTFNAIIKDYYSKISDPSTRGACFMAVCRGKVSEGLDFADMNGRAVIITGLPFPPLKDPRIVLKKKYLDELRMKEKDFLSGDEWYSLEATRAVNQAIGRVIRHQNDYGAILLCDSRFNSPKLKGQLSAWLRNYINVSNKFGETVSEICRFYKNAEMALPAPKLKPLMSNESNRQQSVNVGGVSFPITVARTVKSTKKNSLVAINKRTAEDNLLANVSKKKKYKIKPFGFDENLKSEPSNIVEKTAPTSLVDFVKEIKVLLQPEQYKLFQGSISAYKREGDFSAFVTTLGILLPRT

Description

ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Similarity

Belongs to the helicase family. RAD3/XPD subfamily.

Keywords

4Fe-4S   ATP-binding   Complete proteome   DNA damage   DNA repair   DNA-binding   Helicase   Hydrolase   Iron   Iron-sulfur   Metal-binding   Nucleotide-binding   Nucleus   Reference proteome   Phosphoprotein  

Feature

chain  Regulator of telomere elongation helicase 1 homolog

Uniprot

H9J035   A0A2H1WP52   A0A212FNT3   A0A0N1IBH3   A0A0L7L3L6   A0A194Q5A6   + More
A0A0C9RZ03   A0A151X296   A0A195FIS8   A0A195E471   A0A195BT71   E2AJX8   A0A0N0BBZ8   A0A026WGY7   A0A195D325   F4W6K7   A0A158P2B2   E2C016   A0A2A3EJ04   A0A232F640   A0A154P5P8   A0A3R7MH68   E9JAI1   Q16X92   B0W9F4   A0A2K7P6B7   A0A1Q3EW05   A0A336L6I5   A0A0K8VFB4   A0A0K8VZL5   A0A310SHL9   A0A0P4WD16   A0A034W2S9   A0A0A1WV39   W8BLX8   A0A182RMV3   A0A336L6N2   A0A0L0BRH8   A0A182ME41   A0A1I8MHF9   A0A182W5F6   B3MSG8   B4JNS2   A0A1I8PPA1   A0A0M5J160   A0A0P5ZJ03   A0A0P5DSB6   A0A0P5RTG5   A0A0P6ADZ3   A0A0P5DD32   A0A0P5V4B7   A0A2J7QUE4   B4L1Z2   A0A182XXV8   A0A182KC05   B4PZB4   A0A3L8E0B1   A0A3B0J6K2   B4M891   E9GJP0   A0A0N8EPH5   U4UI39   A0A1W4VFH5   Q7QEI1   A0A0J7KNW7   A0A182TKD5   A0A1B0A073   B3NSW1   A0A182IA08   A0A1W4VT40   A0A084VQ93   A0A1W4VSF6   Q29FS3   A0A182X7D1   B4GU19   A0A182VKP5   A0A182PWK2   A0A1A9WGJ1   A0A1Y1LUN1   A0A1B0CHR4   A0A1A9XDU5   A0A1B0B8H1   A0A182JAL0   A0A182N072   A0A0P4ZVY6   A0A0P4ZI32   A0A0P4ZR51   A0A0P5STK6   A0A0P5TA30   A0A0P4ZRG7   A0A0P5TA38   B4NDG5   A0A1A9VRD2   M9PGH6   Q9W484   A0A182QAZ7   A0A182MAW6   A0A182WI58   A0A0P5SEI0   A0A1B0D175  

EC Number

3.6.4.12

Pubmed

19121390    22118469    26354079    26227816    20798317    24508170    + More
21719571    21347285    28648823    21282665    17510324    25348373    25830018    24495485    26108605    25315136    17994087    25244985    30249741    21292972    23537049    12364791    24438588    15632085    28004739    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17989248    18327897   

EMBL

BABH01018874    ODYU01010033    SOQ54851.1    AGBW02004392    OWR55404.1    KQ461186    + More
KPJ07377.1    JTDY01003232    KOB69911.1    KQ459472    KPJ00190.1    GBYB01014614    GBYB01014615    GBYB01014616    JAG84381.1    JAG84382.1    JAG84383.1    KQ982580    KYQ54508.1    KQ981523    KYN40303.1    KQ979657    KYN19953.1    KQ976408    KYM91136.1    GL440100    EFN66294.1    KQ435966    KOX67941.1    KK107250    EZA54344.1    KQ976885    KYN07303.1    GL887707    EGI70342.1    ADTU01007051    GL451712    EFN78712.1    KZ288227    PBC31745.1    NNAY01000911    OXU25960.1    KQ434809    KZC06664.1    QCYY01000940    ROT81658.1    GL770368    EFZ10173.1    CH477545    DS231864    GFDL01015555    JAV19490.1    UFQS01002091    UFQT01002091    SSX13190.1    SSX32629.1    GDHF01014761    JAI37553.1    GDHF01007961    JAI44353.1    KQ763209    OAD55149.1    GDRN01080265    JAI62259.1    GAKP01009071    JAC49881.1    GBXI01011791    JAD02501.1    GAMC01004460    JAC02096.1    UFQS01001166    UFQT01001166    SSX09317.1    SSX29219.1    JRES01001467    KNC22680.1    AXCM01014096    CH902622    CH916371    CP012528    ALC49144.1    GDIP01225111    GDIP01044398    LRGB01001363    JAM59317.1    KZS12158.1    GDIP01169111    JAJ54291.1    GDIQ01114576    JAL37150.1    GDIP01032041    JAM71674.1    GDIP01158072    JAJ65330.1    GDIP01104977    JAL98737.1    NEVH01011186    PNF32201.1    CH933810    CM000162    QOIP01000002    RLU25923.1    OUUW01000003    SPP77637.1    CH940653    GL732548    EFX80285.1    GDIQ01006668    JAN88069.1    KB632308    ERL92013.1    AAAB01008847    LBMM01004880    KMQ92022.1    CH954180    APCN01001081    ATLV01015151    KE525003    KFB40137.1    CH379065    CH479190    GEZM01046290    JAV77354.1    AJWK01012600    JXJN01009934    GDIP01211670    JAJ11732.1    GDIP01212516    JAJ10886.1    GDIP01209068    JAJ14334.1    GDIP01138674    JAL65040.1    GDIP01133099    JAL70615.1    GDIP01209069    JAJ14333.1    GDIP01130476    JAL73238.1    CH964239    AE014298    AGB95108.1    BT021290    EU217688    EU217689    EU217690    EU217691    EU217692    EU217693    EU217694    EU217695    EU217696    EU217697    EU217698    EU217699    AXCN02001428    AXCM01000817    GDIP01140776    JAL62938.1    AJVK01002427    AJVK01002428    AJVK01002429   

Proteomes

UP000005204    UP000007151    UP000053240    UP000037510    UP000053268    UP000075809    + More
UP000078541    UP000078492    UP000078540    UP000000311    UP000053105    UP000053097    UP000078542    UP000007755    UP000005205    UP000008237    UP000242457    UP000215335    UP000076502    UP000283509    UP000008820    UP000002320    UP000075900    UP000037069    UP000075883    UP000095301    UP000075920    UP000007801    UP000001070    UP000095300    UP000092553    UP000076858    UP000235965    UP000009192    UP000076408    UP000075881    UP000002282    UP000279307    UP000268350    UP000008792    UP000000305    UP000030742    UP000192221    UP000007062    UP000036403    UP000075902    UP000092445    UP000008711    UP000075840    UP000030765    UP000001819    UP000076407    UP000008744    UP000075903    UP000075885    UP000091820    UP000092461    UP000092443    UP000092460    UP000075880    UP000075884    UP000007798    UP000078200    UP000000803    UP000075886    UP000092462   

PRIDE

H9J035    Q16X92    B0W9F4    B3MSG8    B4JNS2    B4L1Z2    + More
B4PZB4    B4M891    Q7QEI1    B3NSW1    Q29FS3    B4GU19    B4NDG5    M9PGH6    Q9W484   

Pfam

PF06733   DEAD_2        + More
PF13307   Helicase_C_2
PF16545   CCM2_C

Interpro

IPR010614   DEAD_2        + More
IPR030845   RTEL1       
IPR014001   Helicase_ATP-bd       
IPR013020   Rad3/Chl1-like       
IPR006555   ATP-dep_Helicase_C       
IPR014013   Helic_SF1/SF2_ATP-bd_DinG/Rad3       
IPR027417   P-loop_NTPase       
IPR006554   Helicase-like_DEXD_c2       
IPR032375   CCM2_C       
IPR002464   DNA/RNA_helicase_DEAH_CS       

SUPFAM

SSF52540   SSF52540       

ProteinModelPortal

H9J035   A0A2H1WP52   A0A212FNT3   A0A0N1IBH3   A0A0L7L3L6   A0A194Q5A6   + More
A0A0C9RZ03   A0A151X296   A0A195FIS8   A0A195E471   A0A195BT71   E2AJX8   A0A0N0BBZ8   A0A026WGY7   A0A195D325   F4W6K7   A0A158P2B2   E2C016   A0A2A3EJ04   A0A232F640   A0A154P5P8   A0A3R7MH68   E9JAI1   Q16X92   B0W9F4   A0A2K7P6B7   A0A1Q3EW05   A0A336L6I5   A0A0K8VFB4   A0A0K8VZL5   A0A310SHL9   A0A0P4WD16   A0A034W2S9   A0A0A1WV39   W8BLX8   A0A182RMV3   A0A336L6N2   A0A0L0BRH8   A0A182ME41   A0A1I8MHF9   A0A182W5F6   B3MSG8   B4JNS2   A0A1I8PPA1   A0A0M5J160   A0A0P5ZJ03   A0A0P5DSB6   A0A0P5RTG5   A0A0P6ADZ3   A0A0P5DD32   A0A0P5V4B7   A0A2J7QUE4   B4L1Z2   A0A182XXV8   A0A182KC05   B4PZB4   A0A3L8E0B1   A0A3B0J6K2   B4M891   E9GJP0   A0A0N8EPH5   U4UI39   A0A1W4VFH5   Q7QEI1   A0A0J7KNW7   A0A182TKD5   A0A1B0A073   B3NSW1   A0A182IA08   A0A1W4VT40   A0A084VQ93   A0A1W4VSF6   Q29FS3   A0A182X7D1   B4GU19   A0A182VKP5   A0A182PWK2   A0A1A9WGJ1   A0A1Y1LUN1   A0A1B0CHR4   A0A1A9XDU5   A0A1B0B8H1   A0A182JAL0   A0A182N072   A0A0P4ZVY6   A0A0P4ZI32   A0A0P4ZR51   A0A0P5STK6   A0A0P5TA30   A0A0P4ZRG7   A0A0P5TA38   B4NDG5   A0A1A9VRD2   M9PGH6   Q9W484   A0A182QAZ7   A0A182MAW6   A0A182WI58   A0A0P5SEI0   A0A1B0D175  

PDB

5SVA     E-value=4.93349e-58,     Score=572

KEGG

101736870    K11136 regulator of telomere elongation helicase 1 [EC:3.6.4.12] | (RefSeq) regulator of telomere el

GO

GO:0005634   GO:0004003   GO:0006260   GO:0006281   GO:0005524   GO:0051539   GO:0046872   GO:0003677   GO:0006310   GO:0000723   GO:0010569   GO:1904430   GO:0070182   GO:0090657   GO:0045910   GO:0032508   GO:0006139   GO:0003676   GO:0008026   GO:0016818  

Subcellular location

Nucleus  

Length:

881

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00588999999999998

Exp number, first 60 AAs:

0.00262

Total prob of N-in:

0.00014

outside

1  -  881

 

 

Pi

12.88839

Theta

15.51874

Tajima's D

0.395327

CLR

0.067125

CSRT

0.494075296235188

Interpretation

Uncertain