Gene

KWMTBOMO05999  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002820

Annotation

PREDICTED:_transmembrane_GTPase_Marf_isoform_X3_[Amyelois_transitella]

Location

Bomo_Chr10(+):15951308-15964177      View in EpiBrowser

Full name

Transmembrane GTPase Marf      

Alternative Name

Mitochondrial assembly regulatory factor
Mitofusin

Location in the cell

Cytoplasmic   Reliability : 1.393 Mitochondrial   Reliability : 1.103 Nuclear   Reliability : 1.593

CDS

ATGGCGGCGTATGTTAACCGAACGATATCGATGATGGCTGGTGACGGGCCACACAATGTGTCGATGTTGAACAACGGCTCGGTACGTGTGAACATGCAAAATGTTGACTCCCCGCTCCAGATATTCGTCAGAGCGAAGAAGAAGATAAACGATATATTTGTGGAGATTGACGATTATGTCAAAGATGCTGTCACTTTTATGCATGCTGTATCGGGTGAGAATGGCATTGCCACACCACAGGATATGGGCAATGTGGAGTCATATGTGTCAAAGGTGGAAGCCATCAGAGAGGTTCTCAAGCGAGATCATATGAAAGTTGCTTTCTTTGGAAGGACAAGCAATGGCAAAAGCACAGTTATAAATGCGATGCTCCATGACAAAATCCTACCGAGCGGGATAGGACACACGACTAACTGCTTCTTGCAAGTTGAAGGTTCTGATACAAACGAAGCCTACATGAGAACGGAAGGCTGCGAGGAGAAACTTAATGTACAGTCCGTAAGCCAATTAGGTCACGCCCTGTGCGCGACTCGTCTGCAAGAGTGCTCGCTGGTGCACGTGCACTGGCCCCGCGAGCTGTGCGCGCTGCTGCGGGACGACGTGGTGCTGGTGGACAGCCCCGGCGTGGACGTGACGCCGAACCTCGACACGTGGATCGACAAGTACTGCCTCGACGCGGACGTGTTCGTGCTCGTGGCCAACGCAGAGTCCACGCTCATGGTCACTGAGAAGAACTTCTTTCACAAAGTATCGACGAAGATATCCCAACCGAATATATTTATACTGAACAATCGCTGGGACGCGTCCGCCTCCGAGCCGGAGTATATGGAGCAGGTACGCACACAACACGCGAACCGCTGCGTCGACTTCTTATCGCGTGAGCTGCGTGTGTGCTCCCCTAAAGAGGCTGAGGAGAGGATCTTCTTCATATCCGCCAAGGAAGCCCTGCTCACCAGGATGCGTGATCGAGAGAAACCTGTCTCTTCTCCGATCCTGGCGGAGGGTCACCAGGTGCGCTACTTCGAGTTCGTGGACTTCGAGCGCAAGTTTGAGGAGTGCATCAGCCAGTCGGCCGTGCGCACCAAGTTCGCGCAGCACTCGCGCCGCGGCAAGAACATCGCTGGGGACGTCATGGCGGCTCTCGACCGGGTGTACAACATAGCAACAGAGCAAAAGGCAGCCAAGGTCGAGAAGCAGAGGATACTGCACGAGCAGCTGTCGTCCATAGAGGAACAGTTGACCACCATCACGAGGCAGATGAAGGACAAGATCAACAGGATGGTTGAGAGCGTGGAGCACAAGGTATCTCTAACCCTGAGTCAAGAGATCCGTCGTCTGTCGGCCCTCGTCGATGAATACGAATCGGAATTCCGTCCGGAGCGACCCGCCCTCGAGCAGTACAAGCGAGCCCTGCACCGGCACGTCGAGGCGGGGCTAGGGTCTAGACTCAAGAAGAGACTATCTTCAGATATAGGAAACGAAATGGACGTAGTTCAAAAGGAGATGGCCGAACGCATGTACAACATCCTCCCCACCAACAAGCGGGCCGCCGCAGCGAACTACATCATACCTCACCAGCAGCCCTTCGAGGTGCTGTACCGGCTGAACTGCGACAACCTCTGCGCCGACTTCAACGAAGACTTGTCGTTCCGCTTCTCGTACGGGATCACGGCTCTCATCCAACGGTTCCAGGGAAAGAATACTAATCGGATCGCTTTGAATAACCCCCCACAGTACACTCAGATCCCGGCCAGCATCACCCCGGTGTCGGCGTTGCCCCCCGCCCCCCGCGCCGCGCTGCCCGTGCTCAGCGCGGAGGAGTGGGGGCTGCTCTCCAAGTTCGCGCTGGGGGCCCTCACGTCGCAGGGGACCATGGGGGGCCTGTTGCTCTCCGGATTGCTGCTGAAGACGGTGGGGTGGCGCGTGCTGGCGGTGACGGGGCTGGCGTACGGCGCGCTGTACGCGTACGAGCGCCTCACGTGGACGGCCAAGGCGCAGGAGCGCGTCTTCAAGCGCCAGTACGTCGCGCACGCCGGCAAGAAGCTGCGCCTCATCGTCGACCTCACCTCCGCCAACTGCAGCCACCAAGTGCAGCAGGAGCTGTCCACGATGTTCGCCCGGCTGTGTCGGCTCATCGACGAGGCCACCACGGAGATGGACGCCGAGCTGTCCGGGGTGCGGGACGCCATCAAGATGCTGGACGACGCCTCCACGTCTGCGAAGAAGCTGCGGAACAAGGCGAACTATCTGTCGCACGAGCTCGAGCTGTTCGAAGAGGCCTTCCTCAAGCACAATAATTAA

Protein

MAAYVNRTISMMAGDGPHNVSMLNNGSVRVNMQNVDSPLQIFVRAKKKINDIFVEIDDYVKDAVTFMHAVSGENGIATPQDMGNVESYVSKVEAIREVLKRDHMKVAFFGRTSNGKSTVINAMLHDKILPSGIGHTTNCFLQVEGSDTNEAYMRTEGCEEKLNVQSVSQLGHALCATRLQECSLVHVHWPRELCALLRDDVVLVDSPGVDVTPNLDTWIDKYCLDADVFVLVANAESTLMVTEKNFFHKVSTKISQPNIFILNNRWDASASEPEYMEQVRTQHANRCVDFLSRELRVCSPKEAEERIFFISAKEALLTRMRDREKPVSSPILAEGHQVRYFEFVDFERKFEECISQSAVRTKFAQHSRRGKNIAGDVMAALDRVYNIATEQKAAKVEKQRILHEQLSSIEEQLTTITRQMKDKINRMVESVEHKVSLTLSQEIRRLSALVDEYESEFRPERPALEQYKRALHRHVEAGLGSRLKKRLSSDIGNEMDVVQKEMAERMYNILPTNKRAAAANYIIPHQQPFEVLYRLNCDNLCADFNEDLSFRFSYGITALIQRFQGKNTNRIALNNPPQYTQIPASITPVSALPPAPRAALPVLSAEEWGLLSKFALGALTSQGTMGGLLLSGLLLKTVGWRVLAVTGLAYGALYAYERLTWTAKAQERVFKRQYVAHAGKKLRLIVDLTSANCSHQVQQELSTMFARLCRLIDEATTEMDAELSGVRDAIKMLDDASTSAKKLRNKANYLSHELELFEEAFLKHNN

Description

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission (By similarity).

Catalytic Activity

GTP + H2O = GDP + H(+) + phosphate

Similarity

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.

Keywords

Alternative splicing   Coiled coil   Complete proteome   GTP-binding   Hydrolase   Membrane   Mitochondrion   Mitochondrion outer membrane   Nucleotide-binding   Phosphoprotein   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Transmembrane GTPase Marf
splice variant  In isoform 2.

Uniprot

H9IZY5   A0A194Q3Q4   A0A212EHK1   A0A2A4JN98   A0A0N0U5N6   A0A0L7QU79   + More
A0A088A1V1   A0A232EUT0   D6X0Y4   K7J2Q7   A0A1B6EQB9   A0A1Y1M5B5   A0A151XDH4   A0A0C9QF62   E2AJ70   A0A195C0R9   A0A154PSK0   A0A2A3ELQ1   E2C5A5   A0A2J7RLY1   A0A067RG51   A0A2J7Q823   A0A151JZ80   A0A2J7Q826   U4U0M6   E0W1N1   U4U7P1   A0A069DW95   A0A224XKA2   A0A1B6FXW6   A0A1B6E5A2   A0A0V0G5D8   A0A1B6DM15   A0A026WUY2   T1HN33   A0A3L8D8E0   A0A0P5KIR2   A0A0N8CFU0   A0A182XV89   E9GGH3   A0A336LLH5   U5EVN5   A0A0K8TM46   A0A182JPZ7   A0A1B6KHF7   A0A084VAJ8   A0A182VRI9   A0A182MLY6   W8BLS3   A0A0K8VW17   A0A182Q5C8   W5JL04   A0A2M4A406   A0A182HGT0   A0A336K1Q3   A0A182NFK2   A0A182VEB8   A0A182U957   A0A182P9S6   Q7PY95   A0A182F6U5   A0A182X2R1   A0A1B6L1W0   T1JMD1   A0A2M4BEN0   A0A2M3Z1T2   A0A0P6CWD6   A0A0M3QZD3   A0A2M4BEW3   A0A1B6DDV5   A0A034VE49   A0A182RNZ3   A0A0P6EBP7   A0A182JIE9   A0A1A9WT32   T1P9C3   Q7YU24   B4L2G6   A0A1A9XYI5   A0A1B0ASS6   A0A1A9VWY0   A0A1A9Z3W2   B4PYS3   B3NXS3   A0A1A9YUD3   F4X1N2   Q7YU24-2   A0A0R1E9R8   A0A182H8J7   A0A1S4F7U9   A0A0Q5T5B2   B4M7X8   A0A023EVU9   A0A0Q9WZD8   Q29IJ1   B3MXY1   Q17CQ1   A0A1Q3FFY5   B4JNY8  

EC Number

3.6.5.-

Pubmed

19121390    26354079    22118469    28648823    18362917    19820115    + More
20075255    28004739    20798317    24845553    23537049    20566863    26334808    24508170    30249741    25244985    21292972    26369729    24438588    24495485    20920257    23761445    12364791    14747013    17210077    25348373    25315136    12598526    10731132    12537572    12537569    12128227    18327897    17994087    17550304    18057021    21719571    26483478    24945155    15632085    17510324   

EMBL

BABH01018950    KQ459472    KPJ00168.1    AGBW02014864    OWR40973.1    NWSH01001058    + More
PCG72880.1    KQ435776    KOX74882.1    KQ414735    KOC62175.1    NNAY01002089    OXU22112.1    KQ971372    EFA09534.1    GECZ01029624    GECZ01006188    GECZ01002613    JAS40145.1    JAS63581.1    JAS67156.1    GEZM01041604    GEZM01041603    JAV80258.1    KQ982294    KYQ58403.1    GBYB01013141    GBYB01013142    GBYB01013143    JAG82908.1    JAG82909.1    JAG82910.1    GL439967    EFN66510.1    KQ978379    KYM94484.1    KQ435050    KZC14238.1    KZ288215    PBC32685.1    GL452770    EFN76838.1    NEVH01002587    PNF41840.1    KK852705    KDR18029.1    NEVH01016978    PNF24730.1    KQ981432    KYN41680.1    PNF24729.1    KB631843    ERL86642.1    DS235872    EEB19537.1    ERL86641.1    GBGD01000561    JAC88328.1    GFTR01007987    JAW08439.1    GECZ01014731    JAS55038.1    GEDC01004221    GEDC01002891    JAS33077.1    JAS34407.1    GECL01002826    JAP03298.1    GEDC01010579    JAS26719.1    KK107111    EZA58914.1    ACPB03015200    QOIP01000011    RLU16551.1    GDIQ01209141    JAK42584.1    GDIP01135927    LRGB01000725    JAL67787.1    KZS16364.1    GL732543    EFX81498.1    UFQS01000045    UFQT01000045    SSW98420.1    SSX18806.1    GANO01000940    JAB58931.1    GDAI01002402    JAI15201.1    GEBQ01029641    GEBQ01029091    JAT10336.1    JAT10886.1    ATLV01004127    KE524190    KFB34992.1    AXCM01002852    GAMC01004530    GAMC01004529    JAC02026.1    GDHF01009240    JAI43074.1    AXCN02000208    ADMH02001255    ETN63434.1    GGFK01002139    MBW35460.1    APCN01005945    SSW98421.1    SSX18807.1    AAAB01008987    EAA01124.5    EGK97464.1    GEBQ01022356    GEBQ01016652    JAT17621.1    JAT23325.1    JH431842    GGFJ01002351    MBW51492.1    GGFM01001741    MBW22492.1    GDIQ01087584    JAN07153.1    CP012528    ALC49223.1    GGFJ01002350    MBW51491.1    GEDC01013523    JAS23775.1    GAKP01018566    GAKP01018565    JAC40387.1    GDIQ01070838    JAN23899.1    KA645326    KA645327    AFP59956.1    AF355475    AE014298    AY095019    BT010027    CH933810    EDW06842.1    JXJN01002979    CM000162    EDX01009.1    KRK05878.1    CH954180    EDV47374.1    KQS30466.1    CCAG010019883    GL888538    EGI59639.1    KRK05877.1    JXUM01118571    JXUM01118572    KQ566201    KXJ70328.1    KQS30467.1    CH940653    EDW62895.1    GAPW01000255    JAC13343.1    KRF93834.1    CH379063    EAL32662.2    CH902630    EDV38596.1    CH477305    EAT44145.1    GFDL01008577    JAV26468.1    CH916371    EDV92431.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000218220    UP000053105    UP000053825    + More
UP000005203    UP000215335    UP000007266    UP000002358    UP000075809    UP000000311    UP000078542    UP000076502    UP000242457    UP000008237    UP000235965    UP000027135    UP000078541    UP000030742    UP000009046    UP000053097    UP000015103    UP000279307    UP000076858    UP000076408    UP000000305    UP000075881    UP000030765    UP000075920    UP000075883    UP000075886    UP000000673    UP000075840    UP000075884    UP000075903    UP000075902    UP000075885    UP000007062    UP000069272    UP000076407    UP000092553    UP000075900    UP000075880    UP000091820    UP000095301    UP000000803    UP000009192    UP000092443    UP000092460    UP000078200    UP000092445    UP000002282    UP000008711    UP000092444    UP000007755    UP000069940    UP000249989    UP000008792    UP000001819    UP000007801    UP000008820    UP000001070   

PRIDE

H9IZY5    Q7YU24   

Pfam

PF04799   Fzo_mitofusin        + More
PF00350   Dynamin_N
PF10231   DUF2315

Interpro

IPR027417   P-loop_NTPase        + More
IPR030381   G_DYNAMIN_dom       
IPR027094   Mitofusin_fam       
IPR006884   Fzo/mitofusin_HR2       
IPR027088   Mitofusin-1       
IPR022812   Dynamin_SF       
IPR018796   APOPT       
IPR027089   Mitofusin-2       
IPR036259   MFS_trans_sf       

SUPFAM

SSF52540   SSF52540        + More
SSF103473   SSF103473       

ProteinModelPortal

H9IZY5   A0A194Q3Q4   A0A212EHK1   A0A2A4JN98   A0A0N0U5N6   A0A0L7QU79   + More
A0A088A1V1   A0A232EUT0   D6X0Y4   K7J2Q7   A0A1B6EQB9   A0A1Y1M5B5   A0A151XDH4   A0A0C9QF62   E2AJ70   A0A195C0R9   A0A154PSK0   A0A2A3ELQ1   E2C5A5   A0A2J7RLY1   A0A067RG51   A0A2J7Q823   A0A151JZ80   A0A2J7Q826   U4U0M6   E0W1N1   U4U7P1   A0A069DW95   A0A224XKA2   A0A1B6FXW6   A0A1B6E5A2   A0A0V0G5D8   A0A1B6DM15   A0A026WUY2   T1HN33   A0A3L8D8E0   A0A0P5KIR2   A0A0N8CFU0   A0A182XV89   E9GGH3   A0A336LLH5   U5EVN5   A0A0K8TM46   A0A182JPZ7   A0A1B6KHF7   A0A084VAJ8   A0A182VRI9   A0A182MLY6   W8BLS3   A0A0K8VW17   A0A182Q5C8   W5JL04   A0A2M4A406   A0A182HGT0   A0A336K1Q3   A0A182NFK2   A0A182VEB8   A0A182U957   A0A182P9S6   Q7PY95   A0A182F6U5   A0A182X2R1   A0A1B6L1W0   T1JMD1   A0A2M4BEN0   A0A2M3Z1T2   A0A0P6CWD6   A0A0M3QZD3   A0A2M4BEW3   A0A1B6DDV5   A0A034VE49   A0A182RNZ3   A0A0P6EBP7   A0A182JIE9   A0A1A9WT32   T1P9C3   Q7YU24   B4L2G6   A0A1A9XYI5   A0A1B0ASS6   A0A1A9VWY0   A0A1A9Z3W2   B4PYS3   B3NXS3   A0A1A9YUD3   F4X1N2   Q7YU24-2   A0A0R1E9R8   A0A182H8J7   A0A1S4F7U9   A0A0Q5T5B2   B4M7X8   A0A023EVU9   A0A0Q9WZD8   Q29IJ1   B3MXY1   Q17CQ1   A0A1Q3FFY5   B4JNY8  

PDB

5GOM     E-value=1.93319e-110,     Score=1023

KEGG

101737843    K06030 mitofusin 2 [EC:3.6.5.-] | (RefSeq) transmembrane GTPase Marf

PATHWAY

04137    Mitophagy - animal - Bombyx mori (domestic silkworm)
04214    Apoptosis - fly - Bombyx mori (domestic silkworm)

GO

GO:0005525   GO:0005741   GO:0016021   GO:0003924   GO:0008053   GO:0031306   GO:0051646   GO:0097193   GO:0048662   GO:0090140   GO:0019896   GO:0007029   GO:0008344   GO:0070584   GO:0006697   GO:0007005   GO:0034976   GO:0034389   GO:0010636   GO:0005740   GO:1904115   GO:0005509   GO:0005622   GO:0007264   GO:0008026   GO:0016597  

PANTHER

PTHR10465:SF2   PTHR10465   PTHR10465:SF1  

Subcellular location

Mitochondrion outer membrane  

Length:

766

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

10.81101

Exp number, first 60 AAs:

0.00041

Total prob of N-in:

0.00066

outside

1  -  766

 

 

Pi

16.913195

Theta

20.545314

Tajima's D

-0.512399

CLR

1.120078

CSRT

0.24208789560522

Interpretation

Uncertain