Gene

KWMTBOMO05994

Pre Gene Modal

BGIBMGA002885

Annotation

PREDICTED:_matrix_metalloproteinase-25-like_[Papilio_machaon]

Location

Bomo_Chr10(-):15916509-15925967      View in EpiBrowser

Full name

Matrix metalloproteinase-25      

Alternative Name

Leukolysin
Membrane-type matrix metalloproteinase 6
Membrane-type-6 matrix metalloproteinase

Location in the cell

Cytoplasmic   Reliability : 1.967

CDS

ATGTTATACCAGAATGCATTGATCACTCAGTTAGCTGCCGCTGAGACTATATCCAAGAATCAATACAAAATATATGACTGTATTCAGTACTCCGACACAATGCTTTCCAGTTACATACTTCAAATTTTGTGCATCAGTTTGGTGCAGTGTAGAACCATTTATTTGGAGCTAAACTCCCCTACGCTTGACGAGGTCAATTTTTTGCTACAATATGGATACTTATCGAAAGATTTGGCCGGAGTTGGCTACACTTACACGTCACAATCTATTTCCGAAGCGGTCAAGAAAATGCAGGCCTTCGCAGGGCTACCACAAACAGGAGTACTGGATGAACCAACTAAGCAGTTATTCAAAAGAAAAAGATGCGGTTTGAAAGATATAGATGAAGACTCGCACGCAAGAAATCGCAGATACATTATACAAGAAGGATGGAATAAACGCGAGGTCACTTACAGACTCCTGAATGGTTCAAGTACAATGAGCAAGGATCGCATAGAAAGGCTTCTAGAGAATGGTTTGGAGGTTTGGGCGCCCCACGGGAACCTCCACTTCACGAAACTAGATGAAGGCAAAGCGGACATACAAGTTTATTTCGCTTCCGGCAACCATGGAGACGGGTTCCCCTTCGATGGCCCTGGTCGAGTAGTGGCTCACGCGTTTCCACCGCCACTCGGCGATATACATTTTGATGATGACGAGACCTGGGGAGTTGAGTCTGATATATCTGAAGACGGAGAAGAAGACATCACGGACTTCTTCGCGGTGGCCGTCCACGAGATCGGACACTCTCTGGGCATGTCACATTCTAACGTCAAATCTTCTGTTATGTATCCATATTATCAGCTGCCCGTTGACAAGCTACACGTGGACGACATATTGGGCATGCAAGAGTTGTACTTAAACGTAAAAGGTTCTGAAGAATCAGAGGGCACCGAACGCACGGTAGGGTCGTCGCAGGCGCCCAGGTTCACGAAGACGGACAGCGAGGAGTTCGATGACGCGCCCGACCTATGCATGACCAACTACGACACCTTGCAAGTCATACACGGCAAAATATACGTGTTCGAAGAAGAGTGGGTCACAGTTCTTCGTGATAGAAACGTCAGAGAGCCCGGGTACCCGAAGAGATTCCATGAGCTTTTCATTGGTCTCCCGTCCAGCATCAAAGTTATACGGACCATCTATGAGAAACACGATCGGAACGTTGTCGTCTTTTCAGAAAACAAATACTGGGAGTTCAGTCCGTCATTCCGTCTGATGAGGCGTGGCTCTCTCACGGATTACTCCATCCCGGACAACGTTACAGAGTTGACCACAGTGTTCATATCCAATTACAACAACAGGACATATCTGATCGAGGAGGAAAGGTATTGGCGGTACGATGAACTAACCGGTACGATGGATGAAGATTACCCAAAGGATATGTCGACATGGCGGGACGTACCGTACCCTGTCGATGCTGCTATTGTTTGGAAAGAAGACACATTCTTCTTCCAAGGTCCTCGTTTTTGGCGCTTTGATAACAACCTCGTCCGAGCACACGAGTACTACCCGCTCCCGACCGCACAGATATGGTTCGACTGCGAATCCAACTTCGAAATGACCTACTACACCATCAACGACGGACCATAA

Protein

MLYQNALITQLAAAETISKNQYKIYDCIQYSDTMLSSYILQILCISLVQCRTIYLELNSPTLDEVNFLLQYGYLSKDLAGVGYTYTSQSISEAVKKMQAFAGLPQTGVLDEPTKQLFKRKRCGLKDIDEDSHARNRRYIIQEGWNKREVTYRLLNGSSTMSKDRIERLLENGLEVWAPHGNLHFTKLDEGKADIQVYFASGNHGDGFPFDGPGRVVAHAFPPPLGDIHFDDDETWGVESDISEDGEEDITDFFAVAVHEIGHSLGMSHSNVKSSVMYPYYQLPVDKLHVDDILGMQELYLNVKGSEESEGTERTVGSSQAPRFTKTDSEEFDDAPDLCMTNYDTLQVIHGKIYVFEEEWVTVLRDRNVREPGYPKRFHELFIGLPSSIKVIRTIYEKHDRNVVVFSENKYWEFSPSFRLMRRGSLTDYSIPDNVTELTTVFISNYNNRTYLIEEERYWRYDELTGTMDEDYPKDMSTWRDVPYPVDAAIVWKEDTFFFQGPRFWRFDNNLVRAHEYYPLPTAQIWFDCESNFEMTYYTINDGP

Description

May activate progelatinase A.

Cofactor

Zn(2+)
Ca(2+)

Miscellaneous

The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.

Similarity

Belongs to the peptidase M10A family.

Keywords

Calcium   Cell membrane   Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Extracellular matrix   Glycoprotein   GPI-anchor   Hydrolase   Lipoprotein   Membrane   Metal-binding   Metalloprotease   Protease   Reference proteome   Repeat   Secreted   Signal   Zinc   Zymogen   Transmembrane   Transmembrane helix  

Feature

chain  Matrix metalloproteinase-25
propeptide  Removed in mature form

Uniprot

H9J050   A0A2A4JN69   A0A2H1VTH2   A0A3S2MAS1   A0A194QR79   A0A194Q490   + More
A0A212EHL2   A0A1W4XAM5   A0A0P6IUC8   Q17GF9   T1J720   V4B204   E9H7T7   A0A0V1G433   A0A0V1JCY4   A0A0V0UA13   A0A0V1EZ73   A0A0V1AX01   A0A0V1NVP9   A0A0V1DCQ9   A0A0V0YC80   A0A0V1LUQ3   A0A0V0X6E0   A0A0V1N7S9   A0A0V1AGY6   A0A0V1HWH9   A0A1B6E667   A0A1S3IIW9   A0A2U3YHN6   A0A1B6JEY3   A0A2Y9HQC8   A0A341CK80   A0A340WWZ7   A0A341CMU7   A0A3Q7VEP0   A0A1S3IHV8   M3YUT5   A0A1S3ANG9   A0A2K6LW56   A0A2Y9KLT4   I3LFQ7   A0A2H8TY38   I3ISV9   A0A2Y9PY05   A0A3B4EIB8   A0A2Y9EET4   A0A2U3ZJG9   Q9NPA2   G1REM2   H0XKJ6   A0A1L8EZ04   A0A3Q7PH61   H2QAF3   Q3U435   A0A1S3IH52   F6ZUV1   M5FK30   A0A0B6Z285   A0A1W0XBN1   K1R1S7   A0A210PXF2   A0A1L8HQI6   A0A384A469   A0A085MEC9   A0A2K5N5V4   A0A0D9RCT1   A0A2K5IAT9   Q86GD7   A0A1L8ERA4   A0A3B1K2T9   A0A2K5ZWB8   A0A096NLA4   A0A3P8UVH5   A0A3P8UTX2   A0A2K5UE31   F6YUR1   A0A1L8I0U7   A0A3L7HAA5   F1N1F5   A4IIY9   A0A131XDU2   A0A2K6FVN0   A0A3P8UY86   F6QXB2   M3X751   A0A087YP28   H9GGG5   A0A2K5PYH1   A0A3B3U183   A0A1U7QY82   A0A3P8UY75   T1KNP2   A0A2G9R803   A0A3B3WWI7   A0A2K5E2B0   A0A1S3LFN6   G1U2J8   A0A2I3SF35   A0A2U9CEQ6   A0A2K6U6Z4  

EC Number

3.4.24.-

Pubmed

19121390    26354079    22118469    26999592    17510324    23254933    + More
21292972    23594743    10706098    10628838    11034316    27762356    16136131    16141072    15489334    19892987    19393038    22992520    28812685    24929829    25329095    24487278    17431167    29704459    28049606    20431018    17975172    21881562    21993624   

EMBL

BABH01018950    BABH01018951    BABH01018952    NWSH01001058    PCG72883.1    ODYU01004342    + More
SOQ44113.1    RSAL01000002    RVE54959.1    KQ461175    KPJ07992.1    KQ459472    KPJ00164.1    AGBW02014864    OWR40976.1    GDUN01000558    JAN95361.1    CH477259    EAT45766.1    JH431902    KB200505    ESP01496.1    GL732601    EFX72236.1    JYDT01000004    KRY92957.1    JYDS01000013    JYDV01000001    KRZ32835.1    KRZ46247.1    JYDJ01000035    KRX47973.1    JYDR01000003    KRY78876.1    JYDH01000192    KRY28755.1    JYDM01000092    KRZ87979.1    JYDI01000013    KRY59303.1    JYDU01000025    KRX98046.1    JYDW01000003    KRZ63153.1    JYDK01000012    KRX83564.1    JYDO01000004    KRZ80010.1    JYDQ01000001    KRY23933.1    JYDP01000022    KRZ14720.1    GEDC01025185    GEDC01003893    JAS12113.1    JAS33405.1    GECU01009845    JAS97861.1    AEYP01027796    AEYP01027797    AEYP01027798    AEMK02000018    GFXV01006637    MBW18442.1    BX510645    LO018620    AJ239053    AF145442    AF185270    AB042328    AJ272137    CH471112    ADFV01048390    ADFV01048391    AAQR03078194    AAQR03078195    AAQR03078196    CM004482    OCT64582.1    AC196449    NBAG03000299    PNI44531.1    AK154458    BC112379    GJ062847    DAA15654.1    HACG01015176    CEK62041.1    MTYJ01000005    OQV24830.1    JH818024    EKC39793.1    NEDP02005420    OWF41146.1    CM004467    OCT98341.1    KL363199    KFD55575.1    AQIB01117902    AB106142    BAC66058.1    CM004483    OCT61861.1    AHZZ02018218    AQIA01041731    JSUE03025506    CM004466    OCU01955.1    RAZU01000243    RLQ62888.1    BC136206    AAI36207.1    GEFH01004800    JAP63781.1    AAMC01006081    AAMC01006082    AAMC01006083    AANG04001668    AYCK01001016    AYCK01001017    AYCK01001018    AYCK01001019    AYCK01001020    AAWZ02029520    AAWZ02029521    AAWZ02029522    AAWZ02029523    CAEY01000277    KV955468    PIO23990.1    CP026258    AWP15074.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000053268    UP000007151    + More
UP000192223    UP000008820    UP000030746    UP000000305    UP000054995    UP000054805    UP000054826    UP000055048    UP000054632    UP000054776    UP000054924    UP000054653    UP000054815    UP000054721    UP000054673    UP000054843    UP000054783    UP000055024    UP000085678    UP000245341    UP000248481    UP000252040    UP000265300    UP000286642    UP000000715    UP000079721    UP000233180    UP000248482    UP000008227    UP000000437    UP000248483    UP000261440    UP000248484    UP000245340    UP000005640    UP000001073    UP000005225    UP000186698    UP000286641    UP000002277    UP000000589    UP000002281    UP000005408    UP000242188    UP000261681    UP000233060    UP000029965    UP000233080    UP000018467    UP000233140    UP000028761    UP000265120    UP000233100    UP000006718    UP000273346    UP000009136    UP000233160    UP000008143    UP000011712    UP000028760    UP000001646    UP000233040    UP000261500    UP000189706    UP000015104    UP000261480    UP000233020    UP000087266    UP000001811    UP000246464    UP000233220   

PRIDE

H9J050    I3LFQ7    Q9NPA2    Q3U435    F1N1F5   

Pfam

PF00045   Hemopexin        + More
PF00413   Peptidase_M10
PF01471   PG_binding_1

Interpro

IPR006026   Peptidase_Metallo        + More
IPR018487   Hemopexin-like_repeat       
IPR024079   MetalloPept_cat_dom_sf       
IPR021190   Pept_M10A       
IPR033739   M10A_MMP       
IPR036375   Hemopexin-like_dom_sf       
IPR001818   Pept_M10_metallopeptidase       
IPR028733   MMP25       
IPR002477   Peptidoglycan-bd-like       
IPR036365   PGBD-like_sf       
IPR000585   Hemopexin-like_dom       
IPR021158   Pept_M10A_Zn_BS       
IPR028726   MMP17       
IPR018486   Hemopexin_CS       

SUPFAM

SSF50923   SSF50923        + More
SSF47090   SSF47090       

Gene 3D

2.110.10.10     3.40.390.10    

CDD

cd04278  ZnMc_MMP
cd00094  HX

ProteinModelPortal

H9J050   A0A2A4JN69   A0A2H1VTH2   A0A3S2MAS1   A0A194QR79   A0A194Q490   + More
A0A212EHL2   A0A1W4XAM5   A0A0P6IUC8   Q17GF9   T1J720   V4B204   E9H7T7   A0A0V1G433   A0A0V1JCY4   A0A0V0UA13   A0A0V1EZ73   A0A0V1AX01   A0A0V1NVP9   A0A0V1DCQ9   A0A0V0YC80   A0A0V1LUQ3   A0A0V0X6E0   A0A0V1N7S9   A0A0V1AGY6   A0A0V1HWH9   A0A1B6E667   A0A1S3IIW9   A0A2U3YHN6   A0A1B6JEY3   A0A2Y9HQC8   A0A341CK80   A0A340WWZ7   A0A341CMU7   A0A3Q7VEP0   A0A1S3IHV8   M3YUT5   A0A1S3ANG9   A0A2K6LW56   A0A2Y9KLT4   I3LFQ7   A0A2H8TY38   I3ISV9   A0A2Y9PY05   A0A3B4EIB8   A0A2Y9EET4   A0A2U3ZJG9   Q9NPA2   G1REM2   H0XKJ6   A0A1L8EZ04   A0A3Q7PH61   H2QAF3   Q3U435   A0A1S3IH52   F6ZUV1   M5FK30   A0A0B6Z285   A0A1W0XBN1   K1R1S7   A0A210PXF2   A0A1L8HQI6   A0A384A469   A0A085MEC9   A0A2K5N5V4   A0A0D9RCT1   A0A2K5IAT9   Q86GD7   A0A1L8ERA4   A0A3B1K2T9   A0A2K5ZWB8   A0A096NLA4   A0A3P8UVH5   A0A3P8UTX2   A0A2K5UE31   F6YUR1   A0A1L8I0U7   A0A3L7HAA5   F1N1F5   A4IIY9   A0A131XDU2   A0A2K6FVN0   A0A3P8UY86   F6QXB2   M3X751   A0A087YP28   H9GGG5   A0A2K5PYH1   A0A3B3U183   A0A1U7QY82   A0A3P8UY75   T1KNP2   A0A2G9R803   A0A3B3WWI7   A0A2K5E2B0   A0A1S3LFN6   G1U2J8   A0A2I3SF35   A0A2U9CEQ6   A0A2K6U6Z4  

PDB

1SU3     E-value=1.28728e-48,     Score=489

KEGG

101737757    K08003 matrix metalloproteinase-25 (membrane-inserted) [EC:3.4.24.-] | (RefSeq) matrix metalloprotei

GO

GO:0008270   GO:0004222   GO:0031012   GO:0046872   GO:0008237   GO:0016021   GO:0005615   GO:0030198   GO:0030574   GO:0006954   GO:0005886   GO:0060022   GO:0035579   GO:0016020   GO:0031225   GO:0043312   GO:0006508   GO:0009986   GO:0016504   GO:0005509   GO:0005622   GO:0007264   GO:0008026   GO:0016597  

PANTHER

PTHR10201:SF142   PTHR10201:SF21  

Subcellular location

Cell membrane  
Secreted  
Extracellular space  
Extracellular matrix  

Length:

543

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.353150000000001

Exp number, first 60 AAs:

0.35092

Total prob of N-in:

0.01781

outside

1  -  543

 

 

Pi

16.009646

Theta

20.148202

Tajima's D

-1.048133

CLR

10.012875

CSRT

0.128343582820859

Interpretation

Uncertain