SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO05952  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA002905
Annotation
acyl-CoA_binding_protein-like_[Bombyx_mori]
Location
Bomo_Chr10(-):15313785-15322300      View in EpiBrowser
Full name
Glycylpeptide N-tetradecanoyltransferase       + More
Putative acyl-CoA-binding protein      
Acyl-CoA-binding protein      
Alternative Name
Diazepam-binding inhibitor
Endozepine
Location in the cell
Cytoplasmic   Reliability : 1.155 Mitochondrial   Reliability : 1.611 Nuclear   Reliability : 1.343
 

Sequence

CDS
ATGTCTCTCGACGAGCAATTCAAACAGGTCGCCGATAAGGTTAGGAACTGGAAGACCAAGCCCAGTGACGATGAGAACCTTGCGCTGTACTCCCTGTACAAGCAGGCTACCATAGGTGATGTTAACATTGCCCAGCCCAGCGGTCTTGTGGAGAGCGCCAAGTGGAAGGCATGGAACGGTCGCAAAGGCATCTCCCAAGACGATGCCAAGAAGCAATACATCGAAAATGCGGAGAAACTCCACTCCAAATACGCATAA
Protein
MSLDEQFKQVADKVRNWKTKPSDDENLALYSLYKQATIGDVNIAQPSGLVESAKWKAWNGRKGISQDDAKKQYIENAEKLHSKYA

Summary

Description
Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.
Catalytic Activity
N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
Subunit
Monomer.
Similarity
Belongs to the NMT family.
Belongs to the ACBP family.
Keywords
Lipid-binding   Transport   Acetylation   Antibiotic   Antimicrobial   Complete proteome   Direct protein sequencing   Endoplasmic reticulum   Golgi apparatus   Phosphoprotein   Reference proteome  
Feature
chain  Putative acyl-CoA-binding protein
peptide  DBI(32-86)
Uniprot
Q9NBL4   B6A8H5   A0A2A4JD00   A0A212EIV0   A0A194QSK1   A0A194Q462   + More
A0A3S2LW36   A0A0L7LQH8   A0A3B5PQA5   A0A096LVF1   A0A3B3XRJ7   A0A0U1TZF3   A0A3B5MXB6   A0A3B5MR50   A0A3B3TM68   A0A315VKU0   A0A3B3HQS9   H2LZN4   A0A3B3TMA4   A0A3B5MRY1   A0A3P9I9I6   A0A3P9PP87   A0A3P9IA54   L7M062   A0A3B3TKH4   A0A3S3PAZ7   N6TVX9   A0A3P9KQF8   A0A293M2U1   C9W1N3   A0A224YWY9   A0A131Z3T5   A0A3P9KQE8   D6WZ83   A0A3P9PPH4   A0A0L0CCA2   A0A1Z5LGF7   A0A3Q2QPD4   A0A023GEB1   A0A1E1X1P4   G3MN85   A0A3B3V5H0   A0A096LVE3   A0A0P4ZM17   P0C8L7   T1J8I7   A0A2L2XZX7   A0A131XCF6   A0A2I4BTS4   A0A0M3IGG1   A0A3Q2ZNI2   A0A0C9SBL6   A0A1E1XUA6   A0A023FGA8   A0A0P5ESK5   A0A0P5UWT3   D6WZ84   F0J9W9   A0A3P9PP31   E9FZI4   A0A0P4YRG3   J3JW29   A0A087TTJ1   C1LJT2   K7J2N9   A0A023FVY4   A0A0M3JYL8   A0A3B3D5K4   E9GPQ6   A0A151NAC9   I6NMR1   C1LJT1   V8NHT2   A0A3Q2G8T7   A0A3B3BH34   P12026   A0A3Q2C7V2   A0A3Q2QPC3   Q2M0T7   A0A1S3K540   Q6LE27   A0A1U7SME5   A0A1S3K426   E9RJY0   A0A3P7MD27   A0A1D1ZFS7   A0A3B1IXM0   A0A0E9WMX6   A8HG13   A0A1A9ZFV3   H2AX83   A0A1A9V2V4   A0A182G862   A0A232EHZ7   A0A1B0FKR3   A0A087ZSM9   A0A2A3EFW8   A0A3B4E267   A0A084VX07   B4GR37  
EC Number
2.3.1.97
Pubmed
11267899    19121390    22118469    26354079    26227816    23542700    + More
29703783    17554307    25576852    23537049    20650005    24029695    28797301    26830274    18362917    19820115    26108605    28528879    28503490    22216098    26561354    28049606    26131772    29209593    21362191    21292972    22516182    20075255    29451363    22293439    24297900    3289918    8375398    15632085    17994087    26383154    8948484    21382452    25329095    25613341    18519026    22123960    26483478    28648823    24438588   
EMBL
BABH01019010    AF246696    AAF78043.1    DQ875235    ABK29477.1    NWSH01002062    + More
PCG69273.1    AGBW02014561    AGBW02009690    OWR41423.1    OWR50108.1    KQ461175    KPJ07960.1    KQ459472    KPJ00134.1    RSAL01000002    RVE54989.1    JTDY01000324    KOB77702.1    AYCK01006471    AYCK01006472    AYCK01006473    AYCK01006474    AYCK01006475    AYCK01006476    AYCK01006477    EU252315    ACD11893.1    NHOQ01001560    PWA23778.1    GACK01007594    JAA57440.1    NCKU01008582    NCKU01008573    NCKU01000338    NCKU01000337    RWS01809.1    RWS01818.1    RWS15928.1    RWS15936.1    APGK01059191    KB741292    KI207321    ENN70457.1    ERL95657.1    GFWV01010335    MAA35064.1    EZ406185    ACX53980.1    GFPF01007196    MAA18342.1    GEDV01002590    JAP85967.1    KQ971372    EFA10395.1    JRES01000611    KNC29865.1    GFJQ02000732    JAW06238.1    GBBM01003201    GBBM01003200    JAC32217.1    GFAC01006003    JAT93185.1    JO843336    AEO34953.1    GDIP01215053    LRGB01001581    JAJ08349.1    KZS11387.1    CK326514    JH431954    IAAA01006435    LAA01438.1    GEFH01005330    JAP63251.1    GBZX01002897    JAG89843.1    GFAA01000631    JAU02804.1    GBBK01004464    GBBK01004463    JAC20019.1    GDIQ01265097    JAJ86627.1    GDIP01107616    JAL96098.1    EFA10396.1    BK007670    DAA34640.1    GL733192    GL732528    EFX63161.1    EFX87261.1    GDIP01234245    JAI89156.1    APGK01059192    BT127447    AEE62409.1    ENN70458.1    KK116675    KFM68430.1    FN319232    CAX74960.1    GBBL01002408    GBBL01002407    JAC24913.1    UYRR01031289    VDK48604.1    GL732557    EFX78428.1    AKHW03003672    KYO33764.1    JN254628    AEZ53129.1    FN319231    CAX74959.1    AZIM01003864    ETE61511.1    AB019792    DQ885192    CH379069    EAL30839.1    L77976    AAT00460.1    AB618203    BAJ83550.1    UYRU01076779    VDN27344.1    GDJX01002104    JAT65832.1    GBXM01017652    JAH90925.1    EU042104    ABW04128.1    HE650826    CCF58983.1    JXUM01151551    KQ571245    KXJ68217.1    NNAY01004411    OXU17938.1    CCAG010019559    KZ288266    PBC30182.1    ATLV01017829    KE525195    KFB42501.1    CH479188    EDW40222.1   
Proteomes
UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000283053    + More
UP000037510    UP000002852    UP000028760    UP000261480    UP000261380    UP000261500    UP000001038    UP000265200    UP000242638    UP000285301    UP000019118    UP000030742    UP000265180    UP000007266    UP000037069    UP000265000    UP000076858    UP000192220    UP000036681    UP000264800    UP000000305    UP000054359    UP000002358    UP000036680    UP000261560    UP000050525    UP000265020    UP000008227    UP000001819    UP000085678    UP000189705    UP000018467    UP000092445    UP000005220    UP000078200    UP000069940    UP000249989    UP000215335    UP000092444    UP000005203    UP000242457    UP000261440    UP000030765    UP000008744   
PRIDE
Q9NBL4    P12026   
Pfam
PF00887   ACBP        + More
PF02799   NMT_C
PF01233   NMT
Interpro
IPR014352   FERM/acyl-CoA-bd_prot_sf        + More
IPR035984   Acyl-CoA-binding_sf       
IPR000582   Acyl-CoA-binding_protein       
IPR022408   Acyl-CoA-binding_prot_CS       
IPR022677   MyristoylCoA_TrFase_C       
IPR000903   MyristoylCoA_TrFase       
IPR022676   MyristoylCoA_TrFase_N       
IPR022678   MyristoylCoA_TrFase_CS       
IPR016181   Acyl_CoA_acyltransferase       
SUPFAM
SSF47027   SSF47027        + More
SSF55729   SSF55729       
Gene 3D
1.20.80.10    
CDD
cd00435  ACBP
ProteinModelPortal
Q9NBL4   B6A8H5   A0A2A4JD00   A0A212EIV0   A0A194QSK1   A0A194Q462   + More
A0A3S2LW36   A0A0L7LQH8   A0A3B5PQA5   A0A096LVF1   A0A3B3XRJ7   A0A0U1TZF3   A0A3B5MXB6   A0A3B5MR50   A0A3B3TM68   A0A315VKU0   A0A3B3HQS9   H2LZN4   A0A3B3TMA4   A0A3B5MRY1   A0A3P9I9I6   A0A3P9PP87   A0A3P9IA54   L7M062   A0A3B3TKH4   A0A3S3PAZ7   N6TVX9   A0A3P9KQF8   A0A293M2U1   C9W1N3   A0A224YWY9   A0A131Z3T5   A0A3P9KQE8   D6WZ83   A0A3P9PPH4   A0A0L0CCA2   A0A1Z5LGF7   A0A3Q2QPD4   A0A023GEB1   A0A1E1X1P4   G3MN85   A0A3B3V5H0   A0A096LVE3   A0A0P4ZM17   P0C8L7   T1J8I7   A0A2L2XZX7   A0A131XCF6   A0A2I4BTS4   A0A0M3IGG1   A0A3Q2ZNI2   A0A0C9SBL6   A0A1E1XUA6   A0A023FGA8   A0A0P5ESK5   A0A0P5UWT3   D6WZ84   F0J9W9   A0A3P9PP31   E9FZI4   A0A0P4YRG3   J3JW29   A0A087TTJ1   C1LJT2   K7J2N9   A0A023FVY4   A0A0M3JYL8   A0A3B3D5K4   E9GPQ6   A0A151NAC9   I6NMR1   C1LJT1   V8NHT2   A0A3Q2G8T7   A0A3B3BH34   P12026   A0A3Q2C7V2   A0A3Q2QPC3   Q2M0T7   A0A1S3K540   Q6LE27   A0A1U7SME5   A0A1S3K426   E9RJY0   A0A3P7MD27   A0A1D1ZFS7   A0A3B1IXM0   A0A0E9WMX6   A8HG13   A0A1A9ZFV3   H2AX83   A0A1A9V2V4   A0A182G862   A0A232EHZ7   A0A1B0FKR3   A0A087ZSM9   A0A2A3EFW8   A0A3B4E267   A0A084VX07   B4GR37  
PDB
2CB8     E-value=3.39006e-13,     Score=175

Ontologies

KEGG
692575    K08762 diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein) | (RefSeq) ACB
GO
GO:0000062   GO:0004379   GO:0006499   GO:0008289   GO:0005794   GO:0042742   GO:0005783   GO:0046872   GO:0004784   GO:0005525   GO:0030131   GO:0005488   GO:0005622   GO:0007264   GO:0008026   GO:0016597  
PANTHER
PTHR11377  

Topology

Subcellular location
Endoplasmic reticulum   Golgi localization is dependent on ligand binding.   With evidence from 2 publications.
Golgi apparatus   Golgi localization is dependent on ligand binding.   With evidence from 2 publications.
Length:
85
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00103
Exp number, first 60 AAs:
0.00103
Total prob of N-in:
0.25288
outside
1  -  85
 
 

Population Genetic Test Statistics

Pi
268.208361
Theta
192.763266
Tajima's D
1.183237
CLR
0
CSRT
0.706864656767162
Interpretation
Uncertain
Peptides ×
Source Sequence Identity Evalue
28556443 TKPSDDENLALYSLYK 100.00 4e-21
28556443 QYIENAEK 100.00 4e-21
28556443 QATIGDVNIAQPSGLVESAKWK 100.00 4e-10
28556443 QATIGDVNIAQPSGLVESAKWK 100.00 4e-10
28556443 QATIGDVNIAQPSGLVESAK 100.00 4e-10
28556443 QATIGDVNIAQPSGLVESAK 100.00 4e-10
28556443 ATIGDVNIAQPSGLVESAK 100.00 5e-09
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 QATIGDVNIAQPSGLVESAK 100.00 2e-08
28556443 PSDDENLALYSLYK 100.00 2e-08
28556443 PSDDENLALYSLYK 100.00 2e-08
28556443 NWKTKPSDDENLALYSLYK 100.00 4e-08
28556443 TKPSDDENLALYS 100.00 4e-08
28556443 MSLDEQFK 100.00 4e-08
28556443 YIAGTPIVDQR 100.00 1e-07
28556443 QATIGDVNIAQPSGLVESAKWK 100.00 6e-07
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSLYK 100.00 2e-05
28556443 TKPSDDENLALYSL 100.00 2e-05
28556443 TIGDVNIAQPSGLVESAK 100.00 2e-05
28556443 NWKTKPSDDENLALYSLYK 100.00 5e-04
28556443 KQATIGDVNIAQPSGLVESAK 100.00 5e-04
28556443 QYIENAEK 100.00 6e-04
28556443 IAQPSGLVESAK 100.00 6e-04
28556443 QYIENAEKLHSK 100.00 0.003
28556443 NWKTKPSDDENLALYSLYK 100.00 0.006
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