Gene

KWMTBOMO05950  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002906

Annotation

acyl-CoA_binding_protein_[Bombyx_mori]

Location

Bomo_Chr10(-):15298366-15307950      View in EpiBrowser

Full name

Acyl-CoA-binding protein homolog       + More
Acyl-CoA-binding protein      

Alternative Name

Diazepam-binding inhibitor homolog
Diazepam-binding inhibitor
Endozepine
EP

Location in the cell

Cytoplasmic   Reliability : 1.808

CDS

ATGTCTCTCCAAGAAAAATTTGACCAAGCCGCAGCCAACGTGAAGAACCTGAAAGCTCTTCCAACTGATGCCCAACTCCTTAACTTGTATGCCCATTTCAAACAGGCCACAGTTGGAGATGCCGATCCAGCCAATAGACCTGGTCTTCTAGACTTGAAGGGTAAAGCTAAATTTGACGCTTGGCACAAACTGGCCGGCACTTCGAAGGAGGATGCCCAGAAAGCCTACATCGAGATCGTCGAAGGTCTCATAGCTTCCATCGGCCTCAAAGAATAA

Protein

MSLQEKFDQAAANVKNLKALPTDAQLLNLYAHFKQATVGDADPANRPGLLDLKGKAKFDAWHKLAGTSKEDAQKAYIEIVEGLIASIGLKE

Description

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor (By similarity).
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Subunit

Monomer.

Similarity

Belongs to the ACBP family.

Keywords

Lipid-binding   Transport   Acetylation   Complete proteome   Direct protein sequencing   Endoplasmic reticulum   Golgi apparatus   Phosphoprotein   Reference proteome   3D-structure   Antibiotic   Antimicrobial  

Feature

chain  Acyl-CoA-binding protein homolog
peptide  Triakontatetraneuropeptide

Uniprot

H9J071   Q9NBL5   P31824   A0A194QRJ8   I4DIN1   I4DM59   + More
A0A194Q3L7   A0A3G1T1N8   A0A212F8S3   S4NRC4   Q6F456   Q6RVD2   A0A0L7LRA7   D2SNW2   A0A076FX45   A0A3S2PLN9   A0A0P0ELD1   A0A1V0M8B8   A0A2H1WH92   A0A3B0E215   Q3ULV8   A0A3L7HKD0   P11030   A0A250Y8P0   Q548W7   Q71U42   P31786   K7J2N9   A0A1L8EFR7   G3H5D5   W6NI80   G3HTK8   M3XPD9   A0A1S3FJG3   L8Y1P3   A0A3Q7WVT1   Q6PBE8   W5PSF3   P82934   U3FZT8   A0A1I8N243   Q8WN94   A0A099YUV9   U5ES18   Q9TQX6   G1LPH3   S7NCD3   A0A0N4X0X3   P07107   A0A2Y9HPH7   F6ZEV8   A0A232EHZ7   A0A3Q7N305   A0A2U3W938   A0A1U7QBI0   A0A088F9H6   A0A182XLT1   A0NCC5   J9NTT2   Q4VWZ5   A0A2I2U6R0   A0A2Y9LG21   A0A3Q7TUQ4   L5LHM2   A0A182IA89   A0A151M0V0   P12026   L8HQB5   A0A093IUI0   A0A016VGG7   A0A1S2ZUP3   B4KGV9   A0A2U3X363   B4GR37   C3V6N0   A0A3P9LVL2   A0A139ATS2   F6R7V5   A0A1S3K426   A0A1I8QE19   A0A337SLC2   R4WD32   H0UTW1   G5D6Q4   A0A0L0C0K1   A0A1J1IYJ7   A0A2U3YV59   A0A0M4DZW2   A0A2K5QQS7   U3EU42   A0A2K6UYW5   K7F621   S7Q296   A0A1W4V7D9   A0A2G9V2W1   W8BSQ3   A0A226MTB7   A0A226P018   S7QGY0   A0A1V4K5Z5  

Pubmed

19121390    11267899    8375571    26354079    22651552    22118469    + More
23622113    26227816    20074338    24817326    26445454    28349297    10349636    11042159    11076861    11217851    12466851    16141073    29704459    3463960    2821429    1469708    8964506    15489334    7690962    2803267    2769267    28087693    12040188    18034455    21183079    23806337    23576753    2615592    12106288    16141072    20075255    21804562    23385571    20809919    11342056    17012783    23915248    25315136    8609609    20010809    2881742    3525533    3663196    1622397    17953517    1931985    1518047    8358232    8503960    11491287    19892987    28648823    12364791    14747013    17210077    16341006    16055366    19468303    17975172    22293439    3289918    8375398    22751099    25730766    17994087    17554307    25977457    17495919    23691247    21993624    23353015    26108605    25243066    17381049    24495485    24621616   

EMBL

BABH01019011    BABH01019012    AF246695    AAF78042.1    L11449    S65642    + More
KQ461175    KPJ07959.1    AK401149    BAM17771.1    AK402377    BAM18999.1    KQ459472    KPJ00133.1    MG992462    AXY94900.1    AGBW02009690    OWR50109.1    GAIX01012916    JAA79644.1    AB180434    BAD26678.1    AY489291    AAR37334.1    JTDY01000324    KOB77696.1    EZ407246    NWSH01002062    ACX53803.1    PCG69270.1    KF960744    AII21946.1    RSAL01000002    RVE54990.1    KT261733    ALJ30273.1    KU755524    ARD71234.1    ODYU01008642    SOQ52397.1    RBVL01000295    RKO09596.1    AK145278    BAE26340.1    RAZU01000200    RLQ66358.1    M14201    M20268    Z11991    S51442    S51427    S51426    X96560    BC084717    Z21846    GFFW01004803    JAV39985.1    AF220221    EF437365    AK008540    AK008576    AK020692    AK148753    CH466520    AAL56658.1    ABS83527.1    BAB25730.1    BAB32175.1    BAE28656.1    EDL39802.1    AF139542    AAP97271.1    X61431    AK018720    AK027906    BC028874    GFDG01001239    JAV17560.1    JH000158    EGV99072.1    CAVP010059219    CDL95644.1    JH000707    RAZU01000050    EGW04166.1    RLQ77420.1    AEYP01049611    AEYP01049612    KB368080    ELV10283.1    BC059746    CR942430    AAH59746.1    CAJ82921.1    AMGL01054516    GAEP01000061    GBEW01000031    JAB54760.1    JAI10334.1    AF407578    AAK98608.2    KL884870    KGL72355.1    GANO01002567    JAB57304.1    ACTA01178760    KE163846    EPQ14090.1    UZAF01020241    VDO67836.1    M15886    BC114181    NNAY01004411    OXU17938.1    KJ463745    AIM41257.1    AAAB01008846    EAU77246.2    AAEX03011881    AC139867    AM000002    CAJ00737.1    EDL39803.1    AANG04001482    KB111613    ELK25707.1    APCN01001132    AKHW03006853    KYO18133.1    AB019792    DQ885192    JH884384    ELR45212.1    KL216593    KFV70311.1    KE124911    JARK01001347    EPB75203.1    EYC26092.1    CH933807    EDW11159.1    CH479188    EDW40222.1    FJ843607    ACO82288.1    KQ965737    KXS19973.1    AK417353    BAN20568.1    AAKN02006772    JN572541    AEP84099.1    JRES01001065    KNC25833.1    CVRI01000063    CRL04770.1    CP012523    ALC38216.1    GAMP01004713    JAB48042.1    AGCU01193249    KE164353    EPQ17373.1    KZ345082    PIO76060.1    GAMC01002165    JAC04391.1    MCFN01000471    OXB58400.1    AWGT02000228    OXB73161.1    KE317999    EPQ20752.1    LSYS01004331    OPJ79785.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000037510    UP000218220    + More
UP000283053    UP000276569    UP000273346    UP000002494    UP000000589    UP000002358    UP000001075    UP000025227    UP000000715    UP000081671    UP000011518    UP000286642    UP000002356    UP000095301    UP000001811    UP000053641    UP000002254    UP000008912    UP000038042    UP000268014    UP000009136    UP000248481    UP000002281    UP000215335    UP000286641    UP000245340    UP000189706    UP000076407    UP000007062    UP000011712    UP000248482    UP000286640    UP000075840    UP000050525    UP000008227    UP000053875    UP000024635    UP000079721    UP000009192    UP000008744    UP000265180    UP000070544    UP000002280    UP000085678    UP000095300    UP000005447    UP000037069    UP000183832    UP000245341    UP000092553    UP000233040    UP000233220    UP000007267    UP000192221    UP000198323    UP000198419    UP000190648   

PRIDE

H9J071    Q9NBL5    Q3ULV8    P11030    Q71U42    P31786    + More
G3H5D5    G3HTK8    Q8WN94    P07107    F6ZEV8    J9NTT2    P12026   

Pfam

PF00887   ACBP        + More
PF12697   Abhydrolase_6

Interpro

IPR022408   Acyl-CoA-binding_prot_CS        + More
IPR000582   Acyl-CoA-binding_protein       
IPR014352   FERM/acyl-CoA-bd_prot_sf       
IPR035984   Acyl-CoA-binding_sf       
IPR000073   AB_hydrolase_1       
IPR029058   AB_hydrolase       

SUPFAM

SSF47027   SSF47027        + More
SSF53474   SSF53474       

Gene 3D

1.20.80.10     3.40.50.1820    

CDD

cd00435  ACBP

ProteinModelPortal

H9J071   Q9NBL5   P31824   A0A194QRJ8   I4DIN1   I4DM59   + More
A0A194Q3L7   A0A3G1T1N8   A0A212F8S3   S4NRC4   Q6F456   Q6RVD2   A0A0L7LRA7   D2SNW2   A0A076FX45   A0A3S2PLN9   A0A0P0ELD1   A0A1V0M8B8   A0A2H1WH92   A0A3B0E215   Q3ULV8   A0A3L7HKD0   P11030   A0A250Y8P0   Q548W7   Q71U42   P31786   K7J2N9   A0A1L8EFR7   G3H5D5   W6NI80   G3HTK8   M3XPD9   A0A1S3FJG3   L8Y1P3   A0A3Q7WVT1   Q6PBE8   W5PSF3   P82934   U3FZT8   A0A1I8N243   Q8WN94   A0A099YUV9   U5ES18   Q9TQX6   G1LPH3   S7NCD3   A0A0N4X0X3   P07107   A0A2Y9HPH7   F6ZEV8   A0A232EHZ7   A0A3Q7N305   A0A2U3W938   A0A1U7QBI0   A0A088F9H6   A0A182XLT1   A0NCC5   J9NTT2   Q4VWZ5   A0A2I2U6R0   A0A2Y9LG21   A0A3Q7TUQ4   L5LHM2   A0A182IA89   A0A151M0V0   P12026   L8HQB5   A0A093IUI0   A0A016VGG7   A0A1S2ZUP3   B4KGV9   A0A2U3X363   B4GR37   C3V6N0   A0A3P9LVL2   A0A139ATS2   F6R7V5   A0A1S3K426   A0A1I8QE19   A0A337SLC2   R4WD32   H0UTW1   G5D6Q4   A0A0L0C0K1   A0A1J1IYJ7   A0A2U3YV59   A0A0M4DZW2   A0A2K5QQS7   U3EU42   A0A2K6UYW5   K7F621   S7Q296   A0A1W4V7D9   A0A2G9V2W1   W8BSQ3   A0A226MTB7   A0A226P018   S7QGY0   A0A1V4K5Z5  

PDB

2FDQ     E-value=7.07094e-19,     Score=224

KEGG

692574    K08762 diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein) | (RefSeq) ACB

GO

GO:0000062   GO:0008289   GO:0005886   GO:0006694   GO:0008021   GO:0005783   GO:0006637   GO:0007420   GO:0031670   GO:0005794   GO:0014009   GO:0046889   GO:0005615   GO:0043292   GO:0032228   GO:0005737   GO:0051281   GO:0005634   GO:0031999   GO:0030157   GO:0030156   GO:0046983   GO:0043588   GO:0036151   GO:0001942   GO:0005739   GO:0097038   GO:0036042   GO:0060291   GO:0021670   GO:0006641   GO:0007611   GO:0001662   GO:0042742   GO:0016787   GO:0046872   GO:0004784   GO:0005525   GO:0030131   GO:0005488   GO:0005622   GO:0007264   GO:0008026   GO:0016597  

Subcellular location

Endoplasmic reticulum   Golgi localization is dependent on ligand binding.   With evidence from 2 publications.
Golgi apparatus   Golgi localization is dependent on ligand binding.   With evidence from 2 publications.

Length:

91

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00119

Exp number, first 60 AAs:

0.0002

Total prob of N-in:

0.23434

outside

1  -  91

 

 

Pi

179.854886

Theta

144.123014

Tajima's D

0.964785

CLR

0.323236

CSRT

0.651117444127794

Interpretation

Uncertain