Gene

KWMTBOMO05948  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002907

Annotation

diapause_bioclock_protein_[Bombyx_mori]

Location

Bomo_Chr10(-):15258949-15270380      View in EpiBrowser

Full name

Superoxide dismutase [Cu-Zn]      

Location in the cell

Extracellular   Reliability : 2.648

CDS

ATGCTGCTTCAACTCACATTCCTGGCTGCGATCGCTCTGGCGACGGCTCATCATGGCTTCACCACGCCGTCCCGCGCCATTGCCTTTCTATCCACAGAAACGATTAGAGGCAACATCACATTCACTCAGGTTCAAGATGGGAAGGTCCACGTTCAGGGGGGCATCACTGGGCTGCCTCCGGGTGAATACGGCTTCCACGTCCATGAGAAGGGCGACCTAAGCGGCGGTTGTGTATCGACTGGATCTCATTTCAATCCTGAACATAAGGACCACGGTCATCCGAACGATGTTAACCGTCACGTCGGCGACCTTGGAAACGTGGTCTTTGACGAGAACCACTACAGCAGGATCGACCTGGTAGACGACCAGATCTCGCTATCGGGTCCGCACGGTATCATCGGCAGGGCGGTGGTGCTCCACGAGAAAGCTGATGATTACGGCAAGAGTGACCATCCGGACTCCAGGAAGACCGGCAACGCTGGCGGTCGAGTCGCTTGCGGTGTCATCGGAATTCTATAG

Protein

MLLQLTFLAAIALATAHHGFTTPSRAIAFLSTETIRGNITFTQVQDGKVHVQGGITGLPPGEYGFHVHEKGDLSGGCVSTGSHFNPEHKDHGHPNDVNRHVGDLGNVVFDENHYSRIDLVDDQISLSGPHGIIGRAVVLHEKADDYGKSDHPDSRKTGNAGGRVACGVIGIL

Description

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic Activity

2 H(+) + 2 superoxide = H2O2 + O2

Cofactor

Cu cation
Zn(2+)

Biophysicochemical Properties

Active between pH 5 and 10.

Subunit

Homodimer (Probable).

Similarity

Belongs to the Cu-Zn superoxide dismutase family.

Keywords

Antioxidant   Copper   Cytoplasm   Direct protein sequencing   Metal-binding   Oxidoreductase   Zinc  

Feature

chain  Superoxide dismutase [Cu-Zn]

Uniprot

Q4JHW1   Q3Y666   Q08J22   H9J072   H9BE67   I4DMD1   + More
A0A194QWK9   A0A0L7L5I0   A0A194Q551   A0A0K0KJ13   A0A2S0RQQ0   A0A2H4G7I9   A0A3S2MA90   A0A212F790   A0A3S5HJH3   A0A2H1W8P0   A0A194QSJ6   A0A2A4JF55   A0A194Q3L2   A0A088SGB6   A0A034WIM4   A0A0C9REV0   A0A034WL86   A0A0C9R2T7   A0A0K8U5U3   A0A0K8UZT3   A0A0A1XL41   M1J3Y8   A0A0A1XSI9   A0A2P5YCL6   A0A1U8IBS9   A0A0B0MPF5   A0A0D2TZK0   A0A182NQ77   A0A034WMM4   T1E7D6   A0A1Y9H174   A0A1Y9H7N9   A0A1Q3B854   E6Y8N8   A8CWF4   A0A2P5Q434   A0A1U8IBW9   A0A1B0CYC5   A0A1U7ZG86   A0A2M3ZD70   A0A2S3H514   A0A2T7F042   A0A1J1J1H2   A0A182QE62   A0A2M4AYQ5   A0A1I8JVG9   A0A1Y9IQV8   A0A182LGP2   A0A182UJ15   A7UTA9   A0A182HNW0   K3ZXQ6   A0A1Q3F7B4   A0A1J1IWP5   A0A240PME8   A0A182FCV9   A0A087YZB1   H6S1K6   A0A182WME1   W5JT45   A0A2M3ZDC7   A0A182J3Z1   A0A1S6PDB1   A0A1I8JSG9   A0A2M4BZQ2   A0A182P8U8   A0A1J1IYC6   C6K2H2   A0A182XET3   A0A125SL96   A0A182YC20   A0A1C7CZ12   A0A1I8JSX4   A0A182VG23   Q7Q9H5   L7S334   A0A2I4G8M7   A0A1I8JUZ9   A0A2C9GUF8   A0A1Y9IV76   A0A2M4BZW3   A9LNG3   C0HK70   Q6QVQ5   A9LNF7   A0A182RV04   A9LNH0   Q5EGZ2   A9LMH9   H9A9E0   A0A3F2YTW1   Q71S31   A0A182MMA7  

EC Number

1.15.1.1

Pubmed

16952188    19121390    22651552    26354079    26227816    22118469    + More
25220661    25348373    25830018    25893780    23257886    18194529    23663246    20966253    12364791    14747013    17210077    22580951    20920257    23761445    20799071    25244985    27145194    28185046   

EMBL

DQ086424    EF121772    EF121773    AAY86076.1    ABL63513.1    ABL63514.2    + More
DQ154907    AAZ80044.1    AB257197    LC424927    BAF34334.1    BBG40623.1    BABH01019014    JQ003185    AFC35302.1    AK402449    BAM19071.1    KQ461175    KPJ07956.1    JTDY01002860    KOB70586.1    KQ459472    KPJ00130.1    KM215270    AIJ00867.1    MF797882    AWA45436.1    KU356855    APW79687.1    RSAL01000002    RVE54993.1    AGBW02009903    OWR49600.1    MH374164    AZK16058.1    ODYU01006924    SOQ49202.1    KPJ07955.1    NWSH01001766    PCG70204.1    KPJ00128.1    KM384740    AIO11231.1    GAKP01003531    JAC55421.1    GBYB01006885    JAG76652.1    GAKP01003533    JAC55419.1    GBYB01001151    JAG70918.1    GDHF01030393    GDHF01027182    GDHF01019979    GDHF01018890    GDHF01015981    GDHF01011959    JAI21921.1    JAI25132.1    JAI32335.1    JAI33424.1    JAI36333.1    JAI40355.1    GDHF01020198    JAI32116.1    GBXI01002213    JAD12079.1    JX263432    AGE89778.1    GBXI01000467    JAD13825.1    KZ663361    PPS13340.1    JRRC01403715    KHG04013.1    CM001752    KJB80823.1    GAKP01003532    JAC55420.1    GAMD01003137    JAA98453.1    AXCN02001018    BDDD01000337    GAV64207.1    FJ589638    ACU52586.1    EU124625    ABV60343.1    KZ650042    PPD69244.1    AJWK01010399    AJWK01010400    AJWK01010401    AJWK01010402    AJWK01010403    GGFM01005701    MBW26452.1    CM008047    PAN15435.1    CM009750    PUZ73440.1    CVRI01000063    CRL04705.1    GGFK01012593    MBW45914.1    AAAB01008900    EDO64116.1    APCN01002794    AGNK02001362    CM003529    RCV14396.1    GFDL01011585    JAV23460.1    CRL04707.1    GU731670    ADN04915.1    ADMH02000552    ETN65899.1    GGFM01005727    MBW26478.1    KX925930    AQU42894.1    GGFJ01009404    MBW58545.1    CRL04706.1    GQ149102    ACS45202.1    KT594770    AMH40758.1    EAA09396.4    JX948790    AGC13159.1    AXCM01008451    GGFJ01009403    MBW58544.1    EU250773    ABX54855.1    AY524130    AAS17758.1    EU250767    ABX54849.1    EU250780    ABX54862.1    AY881165    AAW80441.1    EU247081    ABX26134.1    JN869247    AFC35179.1    AF318938    AAQ14591.1   

Proteomes

UP000005204    UP000053240    UP000037510    UP000053268    UP000283053    UP000007151    + More
UP000218220    UP000239757    UP000189702    UP000032304    UP000075884    UP000075886    UP000187406    UP000239050    UP000092461    UP000189703    UP000243499    UP000244336    UP000183832    UP000076407    UP000075903    UP000075882    UP000075902    UP000007062    UP000075840    UP000004995    UP000075880    UP000069272    UP000075920    UP000000673    UP000075885    UP000076408    UP000235220    UP000075883    UP000075900    UP000075881   

PRIDE

Q4JHW1    Q3Y666    Q08J22    H9J072   

Pfam

PF00080   Sod_Cu        + More
PF00335   Tetraspanin

Interpro

IPR024134   SOD_Cu/Zn_/chaperone        + More
IPR036423   SOD-like_Cu/Zn_dom_sf       
IPR018152   SOD_Cu/Zn_BS       
IPR001424   SOD_Cu_Zn_dom       
IPR018499   Tetraspanin/Peripherin       

SUPFAM

SSF49329   SSF49329       

Gene 3D

2.60.40.200    

CDD

cd00305  Cu-Zn_Superoxide_Dismutase

ProteinModelPortal

Q4JHW1   Q3Y666   Q08J22   H9J072   H9BE67   I4DMD1   + More
A0A194QWK9   A0A0L7L5I0   A0A194Q551   A0A0K0KJ13   A0A2S0RQQ0   A0A2H4G7I9   A0A3S2MA90   A0A212F790   A0A3S5HJH3   A0A2H1W8P0   A0A194QSJ6   A0A2A4JF55   A0A194Q3L2   A0A088SGB6   A0A034WIM4   A0A0C9REV0   A0A034WL86   A0A0C9R2T7   A0A0K8U5U3   A0A0K8UZT3   A0A0A1XL41   M1J3Y8   A0A0A1XSI9   A0A2P5YCL6   A0A1U8IBS9   A0A0B0MPF5   A0A0D2TZK0   A0A182NQ77   A0A034WMM4   T1E7D6   A0A1Y9H174   A0A1Y9H7N9   A0A1Q3B854   E6Y8N8   A8CWF4   A0A2P5Q434   A0A1U8IBW9   A0A1B0CYC5   A0A1U7ZG86   A0A2M3ZD70   A0A2S3H514   A0A2T7F042   A0A1J1J1H2   A0A182QE62   A0A2M4AYQ5   A0A1I8JVG9   A0A1Y9IQV8   A0A182LGP2   A0A182UJ15   A7UTA9   A0A182HNW0   K3ZXQ6   A0A1Q3F7B4   A0A1J1IWP5   A0A240PME8   A0A182FCV9   A0A087YZB1   H6S1K6   A0A182WME1   W5JT45   A0A2M3ZDC7   A0A182J3Z1   A0A1S6PDB1   A0A1I8JSG9   A0A2M4BZQ2   A0A182P8U8   A0A1J1IYC6   C6K2H2   A0A182XET3   A0A125SL96   A0A182YC20   A0A1C7CZ12   A0A1I8JSX4   A0A182VG23   Q7Q9H5   L7S334   A0A2I4G8M7   A0A1I8JUZ9   A0A2C9GUF8   A0A1Y9IV76   A0A2M4BZW3   A9LNG3   C0HK70   Q6QVQ5   A9LNF7   A0A182RV04   A9LNH0   Q5EGZ2   A9LMH9   H9A9E0   A0A3F2YTW1   Q71S31   A0A182MMA7  

PDB

2E46     E-value=5.88602e-75,     Score=709

KEGG

692772    K04565 superoxide dismutase, Cu-Zn family [EC:1.15.1.1] | (RefSeq) Time, ea4; time interval measurin

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0004784   GO:0016021   GO:0006801   GO:0005507   GO:0005576   GO:0005615   GO:0019430   GO:0005737   GO:0005525   GO:0030131   GO:0005488   GO:0005622   GO:0007264   GO:0008026   GO:0016597   GO:0055114  

PANTHER

PTHR10003  

Subcellular location

Cytoplasm  

SignalP

Position:   1 - 16,         Likelihood:  0.962064

 

 

Length:

172

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.942139999999999

Exp number, first 60 AAs:

0.94197

Total prob of N-in:

0.05313

outside

1  -  172

 

 

Pi

389.713984

Theta

193.104443

Tajima's D

2.694206

CLR

1.050301

CSRT

0.961101944902755

Interpretation

Uncertain