Gene

KWMTBOMO05932  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002793

Annotation

endoplasmic_reticulum_oxidoreduction_1-like_precursor_[Bombyx_mori]

Location

Bomo_Chr10(+):14662095-14680301      View in EpiBrowser

Full name

Ero1-like protein      

Alternative Name

Endoplasmic reticulum oxidoreductin-1-like protein

Location in the cell

Extracellular   Reliability : 1.702 Nuclear   Reliability : 1.718

CDS

ATGGCGCGGACATCCACAGAGATGCCACAGAAAAGTTATTGTGTTGTGTTTATTTTATTTGCTCTAGCGATAGTACAGGCGGTTGGTTACGACACGGAGCTAACGAAGCCTTGCGACAGTACAGCCTGCTTCGATGAGCTCCACGGGTCCTTGGGGGACTGCTCCTGTAAAGTCGACACAATTGACTTCTTCAATAATGTGAAGATCTTTCCCCGCATCCAGAGTATAGTCACGAAAGACTACTTCCGTTTTTATAAGGTTAATTTAAAAAAGGAATGCCCGTTCTGGGCTGATGACAGTAGGTGTGCAATGAAATACTGCCATATAAAGACTTGCACGAAGGAAAGTGTACCTGGCTATGAAACTGGATATAATAATGAGTATGTAGATGAAACGCCTGCCACCAAATACTCTAAAGAAGCACAGTCCGACTGTAAGTCTGATTTGGATCACGATCCTCAGTTGAGCTATTTGAATATGACCATTAGTGCTGCCAACCAGTATGAAATAGCAAAATGGAAAGTTCACGATGATGCACATGATAATTTTTGTGAAAGTGATGACCGTGATGCTGATGCAGATTATGTTGATTTAACATTAAACCCAGAGAGGTATACAGGATATAAAGGGCCATCTGCACACAGAATTTGGAGGAGTATTTATCAAGAAAACTGCTTTCGTCCAAAATTAAATCCATACGAATCATTCCCTTATGTGTTAAGTTCAGATCTGAGTAACCTGTGTTTAGAAAAACGAGTGTTTTATAGAGCTATATCTGGACTCCATACAAGTATTAATATACATTTATGTTCAAAATTTCTTTTGTCAGAAAAAAGCTTAGGTTTTGTTGCTCCTCCGGAAGGAGAGTGGGGTCCAAACTTAGAAGAGTTTCAAAGGAGATTTGATCCCTCTCAAACTATGGGTGAAAGTACAAATTGGTTAAAAAATCTATATTTTGTGTACTTATTAGAAATGAGGGCATTAGCAAAAGCTGGGCCATATTTAGAACAAGAAGAATATTTTACGGGAAACCCAACAGAAGATGAAGAGACCCGACAGGCGATCAGCAACATGTTGGGTGTTATATACTCATTTCCTGAGCATTTCAATGAGTCTTCCATGTTCAAAGGAGGCAGCCAAGTGGAGACACTGAAAAATGAGTTTCGTGATCATTTCCGTAATATTTCCAGGATCATGGACTGTGTTGGCTGTGATAAATGCAAGTTGTGGGGTAAACTCCAAACTCAGGGTCTCGGGACTGCTTTGAAAATATTGTTCTCGGATAAATGGAATAGCCCCGAAGCAGATCCCTCAAGTGGGAAACTACCATTAAGACATAAGTCACATAAAAAGCTACAAAGAACAGAGATTGTGGCCCTGTTCAATGCATTTGCTAGATTATCAAACAGTATTCGAGAACTGGAAAATTTCAGAATCATGCTTAGGTCGAATCGAGATGAAAGTTTATTTGTCACGTGCCAGCTTATTGAAGTGTAA

Protein

MARTSTEMPQKSYCVVFILFALAIVQAVGYDTELTKPCDSTACFDELHGSLGDCSCKVDTIDFFNNVKIFPRIQSIVTKDYFRFYKVNLKKECPFWADDSRCAMKYCHIKTCTKESVPGYETGYNNEYVDETPATKYSKEAQSDCKSDLDHDPQLSYLNMTISAANQYEIAKWKVHDDAHDNFCESDDRDADADYVDLTLNPERYTGYKGPSAHRIWRSIYQENCFRPKLNPYESFPYVLSSDLSNLCLEKRVFYRAISGLHTSINIHLCSKFLLSEKSLGFVAPPEGEWGPNLEEFQRRFDPSQTMGESTNWLKNLYFVYLLEMRALAKAGPYLEQEEYFTGNPTEDEETRQAISNMLGVIYSFPEHFNESSMFKGGSQVETLKNEFRDHFRNISRIMDCVGCDKCKLWGKLQTQGLGTALKILFSDKWNSPEADPSSGKLPLRHKSHKKLQRTEIVALFNAFARLSNSIRELENFRIMLRSNRDESLFVTCQLIEV

Description

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity).

Cofactor

FAD

Subunit

May function both as a monomer and a homodimer.

Similarity

Belongs to the EROs family.

Keywords

Complete proteome   Disulfide bond   Electron transport   Endoplasmic reticulum   FAD   Flavoprotein   Glycoprotein   Membrane   Oxidoreductase   Redox-active center   Reference proteome   Signal   Transport  

Feature

chain  Ero1-like protein

Uniprot

B8Y9B6   B8Y9B7   H9IZV8   A0A3S2P8J9   A0A0L7L5B5   A0A2H1X222   + More
A0A212EWW5   A0A194QR25   A0A194Q447   A0A2A4IUV4   A0A2J7QT53   A0A2J7QT51   A0A232F337   A0A0N0U3V4   A0A088AUZ0   K7ISD7   A0A2A3E833   A0A1B6C188   E2BCF6   A0A158N925   A0A195FTI4   A0A026VVV6   A0A151J7P6   A0A151WNQ0   F4WHH6   A0A151I6X8   E0VC42   A0A1B6FD23   A0A1B6IJN4   T1HPH1   A0A0P4VV13   E2A327   A0A224XP88   A0A0C9PTU8   D6W7V7   U4U9G2   N6TSI6   A0A0A9VX61   A0A0K8TPM8   A0A0A9VYW6   A0A0A9W2U9   A0A0K8SIA3   A0A023EU82   Q17J67   A0A1S4F0Q7   A0A336MIC1   A0A1Q3FFH4   A0A336MHH0   B0WB59   U5ETA6   A0A1Q3FFD8   U5EX41   A0A182G527   A0A0L7QL43   A0A0L0CDR1   A0A1L8DUA8   A0A182G4I8   A0A0K8W7W4   A0A1B0CX39   A0A034VHT1   B4PHQ6   A0A182LYV0   A0A0A1WIB5   A0A3B0JBM9   A0A182TPY3   A0A293MVS8   Q7QCV3   D6WXL9   Q9V3A6   A0A182XHQ5   A0A182USK6   A0A182LGI4   A0A182HTN3   B4LB92   B4L9D2   W8BLB0   A0A2H8TWB3   B3M4W0   A0A182W002   A0A182QL73   A0A195BVQ4   B4J1F1   A0A0J9RNR9   A0A182P271   A0A1Y1MUH4   B4H7V7   B5DRX3   B4HU11   A0A182RNX4   B3NG46   A0A182IWA6   A0A1A9WLK3   A0A1I8QCH5   A0A182N775   A0A084VZZ7   A0A182KCS8   A0A0G2YI10   A0A1A9YIH1   A0A182Y448   A0A2M4BLU4  

EC Number

1.8.4.-

Pubmed

26556347    19121390    26227816    22118469    26354079    28648823    + More
20075255    20798317    21347285    24508170    30249741    21719571    20566863    27129103    18362917    19820115    23537049    25401762    26823975    26369729    24945155    17510324    26483478    26108605    25348373    17994087    17550304    25830018    12364791    10671517    10731132    12537572    20966253    24495485    22936249    28004739    15632085    24438588    25244985   

EMBL

FJ502246    ACL54850.1    FJ502247    ACL54851.1    BABH01019060    RSAL01000002    + More
RVE55000.1    RVE55053.1    JTDY01002812    KOB70673.1    ODYU01012861    SOQ59371.1    AGBW02011867    OWR45998.1    KQ461175    KPJ07947.1    KQ459472    KPJ00119.1    NWSH01006341    PCG63501.1    NEVH01011202    PNF31772.1    PNF31771.1    NNAY01001180    OXU24837.1    KQ435883    KOX69758.1    KZ288356    PBC27211.1    GEDC01030628    GEDC01030031    GEDC01025685    GEDC01016183    GEDC01005881    GEDC01002076    JAS06670.1    JAS07267.1    JAS11613.1    JAS21115.1    JAS31417.1    JAS35222.1    GL447257    EFN86692.1    ADTU01009051    KQ981268    KYN43930.1    KK107785    QOIP01000004    EZA47800.1    RLU24120.1    KQ979640    KYN20038.1    KQ982907    KYQ49473.1    GL888161    EGI66330.1    KQ978451    KYM93926.1    DS235047    EEB10948.1    GECZ01021674    JAS48095.1    GECU01020581    JAS87125.1    ACPB03017117    GDKW01001943    JAI54652.1    GL436266    EFN72162.1    GFTR01006585    JAW09841.1    GBYB01004758    JAG74525.1    KQ971307    EFA11035.1    KB632243    ERL90554.1    APGK01057129    KB741277    ENN71296.1    GBHO01042807    GDHC01015422    GDHC01015232    JAG00797.1    JAQ03207.1    JAQ03397.1    GDAI01001246    JAI16357.1    GBHO01042805    JAG00799.1    GBHO01042806    GBRD01012784    JAG00798.1    JAG53042.1    GBRD01012788    JAG53038.1    GAPW01001132    JAC12466.1    CH477234    EAT46740.1    UFQT01001318    SSX30016.1    GFDL01008752    JAV26293.1    UFQS01001286    UFQT01001286    SSX10122.1    SSX29844.1    DS231877    EDS42124.1    GANO01002008    JAB57863.1    GFDL01008782    JAV26263.1    GANO01002690    JAB57181.1    JXUM01042865    KQ561341    KXJ78916.1    KQ414934    KOC59304.1    JRES01000645    KNC29629.1    GFDF01004056    JAV10028.1    JXUM01042515    JXUM01042516    KQ561327    KXJ78973.1    GDHF01005051    JAI47263.1    AJWK01033182    GAKP01017285    JAC41667.1    CM000159    EDW93365.1    AXCM01001634    GBXI01016154    JAC98137.1    OUUW01000002    SPP77442.1    GFWV01019491    MAA44219.1    AAAB01008859    EAA07773.5    KQ971362    EFA08867.1    AF125280    AE014296    BT021422    APCN01000570    CH940647    EDW68656.1    CH933816    EDW17307.1    GAMC01008752    JAB97803.1    GFXV01006770    MBW18575.1    CH902618    EDV40534.1    AXCN02000328    KQ976405    KYM91876.1    CH916366    EDV95842.1    CM002912    KMY97518.1    GEZM01020390    JAV89281.1    CH479219    EDW34747.1    CH379070    EDY74250.1    CH480817    EDW50432.1    CH954178    EDV50875.1    ATLV01019059    KE525259    KFB43541.1    KP322129    AKI88008.1    GGFJ01004861    MBW54002.1   

Proteomes

UP000005204    UP000283053    UP000037510    UP000007151    UP000053240    UP000053268    + More
UP000218220    UP000235965    UP000215335    UP000053105    UP000005203    UP000002358    UP000242457    UP000008237    UP000005205    UP000078541    UP000053097    UP000279307    UP000078492    UP000075809    UP000007755    UP000078542    UP000009046    UP000015103    UP000000311    UP000007266    UP000030742    UP000019118    UP000008820    UP000002320    UP000069940    UP000249989    UP000053825    UP000037069    UP000092461    UP000002282    UP000075883    UP000268350    UP000075902    UP000007062    UP000000803    UP000076407    UP000075903    UP000075882    UP000075840    UP000008792    UP000009192    UP000007801    UP000075920    UP000075886    UP000078540    UP000001070    UP000075885    UP000008744    UP000001819    UP000001292    UP000075900    UP000008711    UP000075880    UP000091820    UP000095300    UP000075884    UP000030765    UP000075881    UP000092443    UP000076408   

PRIDE

B8Y9B6    B8Y9B7    H9IZV8    Q9V3A6   

Pfam

PF04137   ERO1

Interpro

IPR037192   ERO1-like_sf        + More
IPR007266   Ero1       

SUPFAM

SSF110019   SSF110019       

ProteinModelPortal

B8Y9B6   B8Y9B7   H9IZV8   A0A3S2P8J9   A0A0L7L5B5   A0A2H1X222   + More
A0A212EWW5   A0A194QR25   A0A194Q447   A0A2A4IUV4   A0A2J7QT53   A0A2J7QT51   A0A232F337   A0A0N0U3V4   A0A088AUZ0   K7ISD7   A0A2A3E833   A0A1B6C188   E2BCF6   A0A158N925   A0A195FTI4   A0A026VVV6   A0A151J7P6   A0A151WNQ0   F4WHH6   A0A151I6X8   E0VC42   A0A1B6FD23   A0A1B6IJN4   T1HPH1   A0A0P4VV13   E2A327   A0A224XP88   A0A0C9PTU8   D6W7V7   U4U9G2   N6TSI6   A0A0A9VX61   A0A0K8TPM8   A0A0A9VYW6   A0A0A9W2U9   A0A0K8SIA3   A0A023EU82   Q17J67   A0A1S4F0Q7   A0A336MIC1   A0A1Q3FFH4   A0A336MHH0   B0WB59   U5ETA6   A0A1Q3FFD8   U5EX41   A0A182G527   A0A0L7QL43   A0A0L0CDR1   A0A1L8DUA8   A0A182G4I8   A0A0K8W7W4   A0A1B0CX39   A0A034VHT1   B4PHQ6   A0A182LYV0   A0A0A1WIB5   A0A3B0JBM9   A0A182TPY3   A0A293MVS8   Q7QCV3   D6WXL9   Q9V3A6   A0A182XHQ5   A0A182USK6   A0A182LGI4   A0A182HTN3   B4LB92   B4L9D2   W8BLB0   A0A2H8TWB3   B3M4W0   A0A182W002   A0A182QL73   A0A195BVQ4   B4J1F1   A0A0J9RNR9   A0A182P271   A0A1Y1MUH4   B4H7V7   B5DRX3   B4HU11   A0A182RNX4   B3NG46   A0A182IWA6   A0A1A9WLK3   A0A1I8QCH5   A0A182N775   A0A084VZZ7   A0A182KCS8   A0A0G2YI10   A0A1A9YIH1   A0A182Y448   A0A2M4BLU4  

PDB

3AHQ     E-value=1.14319e-110,     Score=1023

KEGG

100270768    K10950 ERO1-like protein alpha [EC:1.8.4.-] | (RefSeq) Ero1; endoplasmic reticulum oxidoreduction 1-

PATHWAY

04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0016671   GO:0003756   GO:0005783   GO:0016021   GO:0015035   GO:0005789   GO:0034975   GO:0051085   GO:0016491   GO:0005525   GO:0030131   GO:0005488   GO:0005622   GO:0007264   GO:0008026   GO:0016597   GO:0055114  

PANTHER

PTHR12613  

Subcellular location

Endoplasmic reticulum membrane  

SignalP

Position:   1 - 27,         Likelihood:  0.988151

 

 

Length:

498

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

18.47324

Exp number, first 60 AAs:

18.47146

Total prob of N-in:

0.99425

POSSIBLE N-term signal

sequence

inside

1  -  12

TMhelix

13  -  30

outside

31  -  498

 

 

Pi

262.535718

Theta

202.241178

Tajima's D

1.081951

CLR

0.090698

CSRT

0.686015699215039

Interpretation

Uncertain