Gene

KWMTBOMO05912

Pre Gene Modal

BGIBMGA014593

Annotation

PREDICTED:_alpha-ketoglutarate-dependent_dioxygenase_alkB_homolog_4_[Amyelois_transitella]

Location

Bomo_Chr10(+):14297606-14299577      View in EpiBrowser

Full name

DNA-(apurinic or apyrimidinic site) lyase      

Location in the cell

Nuclear   Reliability : 2.728

CDS

ATGAAACCGAGACCTTGCGGCTGCAAAGGTTGTAGGACGTGTTTGATCTGTGAAACACAATACGGTGCTGCAGACCTGAAATTGCAGTTGGAACTAGACAAAGAAAAAAGTTACGTCTACTGTCCGTATTGCAACAAAGCCTGGAAAGGATGGGACATCAATTCTTACAAAGAACATCCGAACCATCACGGGGAACCGTTGAGTTATCGCGGCGTCTATATTCACTTGGACTTTATAAGCGAGTTGGAAGAGCAAATCTTAATCGATAACATAGACGAAATACCTTGGGATAACTCACAGAGTGGCAGAAGGAAACAGAACTATGGACCTAAAGTCAACTTCAAAAAGAAAAAAATCGTTTCCGGAAATTTCGAGGGTTTTCCAAAGTTTTCGAAAATGCTACAAGACAGATTTGCGACCATCGAAATGTTGGACGGTTTTGAAGTAATAGAACAGTGTTCATTGGAGTATGATCCCACTAAAGGTGCATCAATAGACCCACATATCGACGACTGCTGGGTGTGGGGTGAGAGAATCGTCACCGTTAACTTTCTGTCTGACTCAGTCCTCACAATGACACGTTTCAAAGGAGCGAAAACCAAATACAATTTATGCTCTGCTGAAAATTACCTTCCAGTGTTGGATTTAGAAGGAAAAATTATCAGAAATAATAAGAACCAAAGATCCTCTTTAGATATATGTAAACCTGTGACTGATGTGGATGTGATTGTCAGAATACCAATGCCAAGACGCTCATTACTAGTGCTGTATGGAGAATCGAGATATCACTGGGAGCATTGTGTACTCAGACAAGATATTTCAGCAAGGAGAGTATGTATTGCATATAGAGAGTTCACTCCCCCATACATGAATGGAGAACATCAGGAACTCGGTAAAGAAATACGAAGGAAAGGCAAAATGTTTTGGGATCATACTGAAAAATACCAAATAAATGTTAACTTAAATGAAAAGTGTGATATATTAAATGGTATATAA

Protein

MKPRPCGCKGCRTCLICETQYGAADLKLQLELDKEKSYVYCPYCNKAWKGWDINSYKEHPNHHGEPLSYRGVYIHLDFISELEEQILIDNIDEIPWDNSQSGRRKQNYGPKVNFKKKKIVSGNFEGFPKFSKMLQDRFATIEMLDGFEVIEQCSLEYDPTKGASIDPHIDDCWVWGERIVTVNFLSDSVLTMTRFKGAKTKYNLCSAENYLPVLDLEGKIIRNNKNQRSSLDICKPVTDVDVIVRIPMPRRSLLVLYGESRYHWEHCVLRQDISARRVCIAYREFTPPYMNGEHQELGKEIRRKGKMFWDHTEKYQINVNLNEKCDILNGI

Catalytic Activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Similarity

Belongs to the iron/ascorbate-dependent oxidoreductase family.
Belongs to the DNA repair enzymes AP/ExoA family.

Uniprot

H9JYH3   S4PY47   A0A212F0E8   A0A0L7L5H6   A0A194Q428   A0A194QWH9   + More
A0A3S2M9W8   A0A2A4IS25   A0A1E1W9W6   A0A2P8YLC1   A0A067RDL2   A0A195FR85   A0A2Z5U5Y9   F4WCD9   A0A0J7L5P2   A0A158NJQ8   A0A151XJR4   A0A3L8DDI7   A0A195EKL8   A0A195C5I8   A0A088AJM4   A0A1W4X0M0   A0A2A3E6V0   A0A0N0U3C5   E2A974   A0A1Y1JW78   A0A232FDA1   K7IWU2   D6WUI0   A0A154PJG9   A0A0C9RY19   Q16S01   A0A026WRZ8   W5JC07   A0A1B0D6X1   B0WX57   A0A182UMS7   A0A182L5X8   A0A182U7L1   A0A182XCJ0   J3JTX3   A0A182M8W1   A0A1Y9GLD5   A0A2M4AVC4   Q7PLZ9   A0A1Q3FDK2   A0A182GCY5   A0A1B6GT67   A0A1S3D6Z8   A0A1S3D5F8   A0A182PZD2   A0A1L8DFG9   A0A182F239   A0A1B6IHI2   A0A1B6KZD8   A0A1B6E1Q0   A0A182NUY2   A0A023EMG1   A0A182RRH2   U5EXP1   E9GAJ0   A0A2J7PJU2   A0A146MDD7   A0A0A9WWW8   A0A0L7QPN7   A0A0P5HFF2   A0A182K535   A0A146M525   A0A164SGQ8   A0A0P5HV87   A0A0P5WT63   A0A0P5RVZ7   A0A0P5MM12   A0A0P5W0Q5   A0A0P6BHP3   A0A0P5IK22   A0A0P6DBI6   A0A0P5TCW9   A0A0P5FRD7   A0A0N8C076   A0A0P6JPK7   A0A0P5LJQ3   A0A0P5IDE5   A0A0P5XPY3   A0A182PB10   A0A0K8VL64   B4NYM3   B3N8I5   A0A0Q9WJH2   Q9VL81   A0A0P4VS12   T1I7G8   W8CB18   Q8MR16   A0A1B0GIS2   B3MUZ6   B4JR58   B4HWA8   A0A1W4W9T5   A0A182Y5M2  

EC Number

4.2.99.18

Pubmed

19121390    23622113    22118469    26227816    26354079    29403074    + More
24845553    26760975    21719571    21347285    30249741    20798317    28004739    28648823    20075255    18362917    19820115    17510324    24508170    20920257    23761445    20966253    22516182    12364791    14747013    17210077    26483478    24945155    21292972    26823975    25401762    17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    27129103    24495485    25244985   

EMBL

BABH01043572    GAIX01003918    JAA88642.1    AGBW02011105    OWR47203.1    JTDY01002796    + More
KOB70707.1    KQ459472    KPJ00099.1    KQ461175    KPJ07926.1    RSAL01000003    RVE54772.1    NWSH01008489    PCG62541.1    GDQN01007254    GDQN01000787    JAT83800.1    JAT90267.1    PYGN01000512    PSN45038.1    KK852704    KDR18060.1    KQ981305    KYN42797.1    FX985796    BBA93683.1    GL888070    EGI68119.1    LBMM01000455    KMQ98297.1    ADTU01001951    KQ982052    KYQ60663.1    QOIP01000009    RLU18213.1    KQ978739    KYN28815.1    KQ978292    KYM95446.1    KZ288349    PBC27438.1    KQ435916    KOX68751.1    GL437711    EFN70059.1    GEZM01099011    JAV53574.1    NNAY01000426    OXU28490.1    AAZX01000576    KQ971357    EFA08384.1    KQ434924    KZC11624.1    GBYB01014170    JAG83937.1    CH477692    EAT37208.1    KK107119    EZA58825.1    ADMH02001945    ETN60379.1    AJVK01003764    DS232158    EDS36318.1    BT126683    AEE61645.1    AXCM01000826    APCN01004535    GGFK01011399    MBW44720.1    AAAB01008980    EAA14576.4    GFDL01009408    JAV25637.1    JXUM01055135    KQ561852    KXJ77336.1    GECZ01004153    JAS65616.1    AXCN02000752    GFDF01008896    JAV05188.1    GECU01021312    JAS86394.1    GEBQ01023160    JAT16817.1    GEDC01005440    GEDC01004910    JAS31858.1    JAS32388.1    GAPW01003090    JAC10508.1    GANO01000855    JAB59016.1    GL732537    EFX83520.1    NEVH01024944    PNF16603.1    GDHC01000798    JAQ17831.1    GBHO01031370    GBHO01005272    GBRD01011692    JAG12234.1    JAG38332.1    JAG54132.1    KQ414821    KOC60441.1    GDIQ01233761    JAK17964.1    GDHC01019654    GDHC01004517    JAP98974.1    JAQ14112.1    LRGB01002019    KZS09615.1    GDIQ01227440    JAK24285.1    GDIP01082110    JAM21605.1    GDIQ01095501    JAL56225.1    GDIQ01156230    JAK95495.1    GDIP01093414    JAM10301.1    GDIP01029010    JAM74705.1    GDIQ01212863    JAK38862.1    GDIQ01080512    JAN14225.1    GDIQ01093456    JAL58270.1    GDIQ01251496    JAK00229.1    GDIQ01127651    JAL24075.1    GDIQ01001645    JAN93092.1    GDIQ01193570    JAK58155.1    GDIQ01214948    JAK36777.1    GDIP01070361    JAM33354.1    GDHF01012682    JAI39632.1    CM000157    EDW88687.1    CH954177    EDV58408.1    CH940649    KRF81070.1    AE014134    AAF52815.1    ADV37012.1    GDKW01000722    JAI55873.1    ACPB03005592    GAMC01000849    JAC05707.1    AY122185    AAM52697.1    AJWK01015363    AJWK01015364    CH902624    EDV33061.1    CH916372    EDV99388.1    CH480818    EDW52303.1   

Proteomes

UP000005204    UP000007151    UP000037510    UP000053268    UP000053240    UP000283053    + More
UP000218220    UP000245037    UP000027135    UP000078541    UP000007755    UP000036403    UP000005205    UP000075809    UP000279307    UP000078492    UP000078542    UP000005203    UP000192223    UP000242457    UP000053105    UP000000311    UP000215335    UP000002358    UP000007266    UP000076502    UP000008820    UP000053097    UP000000673    UP000092462    UP000002320    UP000075903    UP000075882    UP000075902    UP000076407    UP000075883    UP000075840    UP000007062    UP000069940    UP000249989    UP000079169    UP000075886    UP000069272    UP000075884    UP000075900    UP000000305    UP000235965    UP000053825    UP000075881    UP000076858    UP000075885    UP000002282    UP000008711    UP000008792    UP000000803    UP000015103    UP000092461    UP000007801    UP000001070    UP000001292    UP000192221    UP000076408   

PRIDE

H9JYH3    Q9VL81    Q8MR16   

Pfam

PF03171   2OG-FeII_Oxy        + More
PF03372   Exo_endo_phos

Interpro

IPR005123   Oxoglu/Fe-dep_dioxygenase        + More
IPR032857   ALKBH4       
IPR037151   AlkB-like_sf       
IPR004808   AP_endonuc_1       
IPR020847   AP_endonuclease_F1_BS       
IPR020848   AP_endonuclease_F1_CS       
IPR036691   Endo/exonu/phosph_ase_sf       
IPR005135   Endo/exonuclease/phosphatase       

SUPFAM

SSF56219   SSF56219       

Gene 3D

2.60.120.590     3.60.10.10    

ProteinModelPortal

H9JYH3   S4PY47   A0A212F0E8   A0A0L7L5H6   A0A194Q428   A0A194QWH9   + More
A0A3S2M9W8   A0A2A4IS25   A0A1E1W9W6   A0A2P8YLC1   A0A067RDL2   A0A195FR85   A0A2Z5U5Y9   F4WCD9   A0A0J7L5P2   A0A158NJQ8   A0A151XJR4   A0A3L8DDI7   A0A195EKL8   A0A195C5I8   A0A088AJM4   A0A1W4X0M0   A0A2A3E6V0   A0A0N0U3C5   E2A974   A0A1Y1JW78   A0A232FDA1   K7IWU2   D6WUI0   A0A154PJG9   A0A0C9RY19   Q16S01   A0A026WRZ8   W5JC07   A0A1B0D6X1   B0WX57   A0A182UMS7   A0A182L5X8   A0A182U7L1   A0A182XCJ0   J3JTX3   A0A182M8W1   A0A1Y9GLD5   A0A2M4AVC4   Q7PLZ9   A0A1Q3FDK2   A0A182GCY5   A0A1B6GT67   A0A1S3D6Z8   A0A1S3D5F8   A0A182PZD2   A0A1L8DFG9   A0A182F239   A0A1B6IHI2   A0A1B6KZD8   A0A1B6E1Q0   A0A182NUY2   A0A023EMG1   A0A182RRH2   U5EXP1   E9GAJ0   A0A2J7PJU2   A0A146MDD7   A0A0A9WWW8   A0A0L7QPN7   A0A0P5HFF2   A0A182K535   A0A146M525   A0A164SGQ8   A0A0P5HV87   A0A0P5WT63   A0A0P5RVZ7   A0A0P5MM12   A0A0P5W0Q5   A0A0P6BHP3   A0A0P5IK22   A0A0P6DBI6   A0A0P5TCW9   A0A0P5FRD7   A0A0N8C076   A0A0P6JPK7   A0A0P5LJQ3   A0A0P5IDE5   A0A0P5XPY3   A0A182PB10   A0A0K8VL64   B4NYM3   B3N8I5   A0A0Q9WJH2   Q9VL81   A0A0P4VS12   T1I7G8   W8CB18   Q8MR16   A0A1B0GIS2   B3MUZ6   B4JR58   B4HWA8   A0A1W4W9T5   A0A182Y5M2  

PDB

3THT     E-value=0.0399674,     Score=85

KEGG

101735902    K10766 alkylated DNA repair protein alkB homolog 4 [EC:1.14.11.-] | (RefSeq) alpha-ketoglutarate-dep

GO

GO:0070988   GO:0016491   GO:0046872   GO:0051213   GO:0070989   GO:0032451   GO:0008168   GO:0006281   GO:0004519   GO:0003677   GO:0016021   GO:0035167   GO:0016706   GO:0140078   GO:0005515   GO:0005488   GO:0016765   GO:0005634   GO:0006355   GO:0016818   GO:0003676   GO:0008026   GO:0016597   GO:0055114  

PANTHER

PTHR12463   PTHR22748  

Length:

331

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00054

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02734

outside

1  -  331

 

 

Pi

139.717756

Theta

133.092029

Tajima's D

0.982939

CLR

3.049485

CSRT

0.655517224138793

Interpretation

Uncertain