Gene

KWMTBOMO05895

Pre Gene Modal

BGIBMGA002929

Annotation

PREDICTED:_protoheme_IX_farnesyltransferase?_mitochondrial_[Bombyx_mori]

Location

Bomo_Chr10(-):13596089-13603865      View in EpiBrowser

Full name

Protoheme IX farnesyltransferase, mitochondrial       + More
Adenosylhomocysteinase      
Structural maintenance of chromosomes protein      

Alternative Name

Heme O synthase

Location in the cell

PlasmaMembrane   Reliability : 4.373

CDS

ATGTCATATTTAAAGGTGATACACTGTACCTTGTGCCTGAAACATGGATACGTGGGAGTTTACTCGAAACCAGTTTTATTTAAAATTACTAATAACACACTCTTCCAGCATCTTGCCAGAATATCAACAGCACAAAACTGGAGAAGTAAAGTTCCACTTAAAACTCAGACAACTGCAACGGTAAAGAATAAAGTCACCCAAGACACCAGAGTATGGAAGGAAACACCATCATATGACAGGAAGAGCAATACGGGACAGTATTGTTTGATGCTATCTAAATCACGGTTAACATCATTAGTTGTGTTGACGTCTATGGCAGGATACGCACTAGCACCTGCCCCGTTTCAACTTACTACCTTTGCATTCTGCGCTGTGGGTACTGGTCTAGTATCAGCTGCAGCAAACTCTATAAATCAGTATCATGAAGTACCATTTGATGCCCAAATGTCGAGGACAAAGAACAGGGTGCTTGTCAAAGGTTTATTAGAGCCCGTCCATGCAATAGGTTTTGCAGCATTGACAAGCAGCGTAGGCCTTGGCGTTTTGTATTTTGGGGTCAACCCCTTGACAGCTGCACTAGGAGCAGGAAACCTCATCCTCTACACCTCAGTGTACACTCCAATGAAAAGAATGTCCATACTTAACACCTGGCTTGGCTCTGTAGTTGGAGCCATACCCCCCTTGATGGGATGGGCGGGCTGTACCGGGGGACTGGACGCTGGCGCGCTGGTGCTGGGCGCCTTGCTCTACTCGTGGCAGTTTCCACACTTCAACGCGCTCTCTTGGAATTTGCGACCAGACTACTCGCGGGCCGGGTATCGAATGATGGCCGTCACTAATCCCGCACTATGCCGAAGGGTTGCGCTTAGACACACAGGAATAATCACAGCAACATGCCTGGTATCACCTTATATAGGCGTTACAAACACGTGGTTCGCACTTGAATCATTACCATTGAATATTTATTTTATGTATTTAGCATGGCAATTCTACCAAAAATCAGACAGCGCAAGTTCGCGGAAGCTATTCAGATTTTCTCTACTTCACCTACCAGCATTAATGTTGCTAATGCTAGTAAATAAGAAGTACTGGAGTTCGAGTGACACTCAAGAGCAGACCGACACCAAAATCCAGGACGTAGGCATATTAGACAAGAGAATTACAGTACTACCTCGAGGACCGGTCGTTGTGGCCCAAGGAAACGACAAACAGTGCTAA

Protein

MSYLKVIHCTLCLKHGYVGVYSKPVLFKITNNTLFQHLARISTAQNWRSKVPLKTQTTATVKNKVTQDTRVWKETPSYDRKSNTGQYCLMLSKSRLTSLVVLTSMAGYALAPAPFQLTTFAFCAVGTGLVSAAANSINQYHEVPFDAQMSRTKNRVLVKGLLEPVHAIGFAALTSSVGLGVLYFGVNPLTAALGAGNLILYTSVYTPMKRMSILNTWLGSVVGAIPPLMGWAGCTGGLDAGALVLGALLYSWQFPHFNALSWNLRPDYSRAGYRMMAVTNPALCRRVALRHTGIITATCLVSPYIGVTNTWFALESLPLNIYFMYLAWQFYQKSDSASSRKLFRFSLLHLPALMLLMLVNKKYWSSSDTQEQTDTKIQDVGILDKRITVLPRGPVVVAQGNDKQC

Description

Converts protoheme IX and farnesyl diphosphate to heme O.

Catalytic Activity

H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine

Cofactor

NAD(+)

Similarity

Belongs to the ubiA prenyltransferase family.
Belongs to the adenosylhomocysteinase family.
Belongs to the SMC family.

Uniprot

A0A194Q844   A0A194QWG6   A0A212EKQ8   A0A2H1WZH3   A0A2W1BK11   A0A1B6DZP8   + More
A0A336M9Y1   A0A1B6MME4   B4LRA0   A0A2S2QA70   A0A1B6JVW7   B4JPM9   B4Q8U2   B4NZA1   B3N976   A0A2S2NAR1   Q9VKZ1   B3MPR6   C4WVL8   X1WJJ8   A0A0K8TKQ5   A0A0P4VL84   A0A1W4UG35   A0A1B6GJ74   B4KJK0   A0A1J1HTJ9   A0A0Q9XGJ0   A0A0A1WJ35   A0A3Q0ITB6   A0A3Q0IMS8   A0A1I8MZW5   A0A139WBV5   B0WQ76   W8BZA2   A0A1I8PHB2   A0A1I8PH37   E2BI52   A0A1Y1MTJ7   Q17L26   A0A182H5U9   A0A1B0CSN5   A0A0A9Y1Q1   A0A0K8T0H1   A0A023ESP8   A0A0L7QSL8   A0A1L8DZE2   A0A0K8V5P4   U4UQS3   A0A3B0K7S5   A0A1Q3FGH6   B4NQQ9   N6TCT9   K7IRR7   A0A195CBD9   A0A1A9Y6Y1   A0A1A9UT82   A0A026WWR5   A0A1B0BD28   A0A1B0DH26   E9JB06   A0A1A9ZVN7   D3TLZ7   A0A088A3H8   Q29CJ3   A0A2J7Q212   A0A2A3E3B8   V9IMH2   A0A151WRV5   A0A182M2F1   F4W874   B4G792   A0A182P674   A0A182RUP9   A0A182LMY2   A0A158NQG6   A0A182IVC0   A0A182Q0L9   A0A154NYN4   A0A182I777   W5JCA3   A0A2M4ABX0   A0A182JSP7   A0A182XDC4   A0A084VYN8   A0A182F5S5   A0A1S4H085   A0A195DUL9   A0A2M4BK45   Q7PWQ5   A0A2M4BK01   A0A2M4BK20   A0A182URC7   T1DQE7   A0A2M4ACG3   A0A2M3Z0W1   A0A2M4AEV6  

EC Number

2.5.1.-
3.3.1.1

Pubmed

26354079    22118469    28756777    17994087    22936249    17550304    + More
10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    26369729    27129103    25830018    25315136    18362917    19820115    24495485    20798317    28004739    17510324    26483478    25401762    26823975    24945155    23537049    20075255    24508170    21282665    20353571    15632085    21719571    20966253    21347285    20920257    23761445    24438588    12364791   

EMBL

KQ459302    KPJ01698.1    KQ461175    KPJ07911.1    AGBW02014216    OWR42079.1    + More
ODYU01012212    SOQ58402.1    KZ149998    PZC75379.1    GEDC01006167    JAS31131.1    UFQT01000735    SSX26830.1    GEBQ01019669    GEBQ01002867    JAT20308.1    JAT37110.1    CH940649    EDW64570.2    GGMS01005318    MBY74521.1    GECU01004387    JAT03320.1    CH916372    EDV98859.1    CM000361    CM002910    EDX04507.1    KMY89492.1    CM000157    EDW88796.1    CH954177    EDV58511.1    GGMR01001606    MBY14225.1    AE014134    AY058639    AAF52915.1    AAL13868.1    CH902620    EDV32314.1    AK341579    BAH71938.1    ABLF02017103    GDAI01002651    JAI14952.1    GDKW01003457    JAI53138.1    GECZ01026209    GECZ01015673    GECZ01007298    JAS43560.1    JAS54096.1    JAS62471.1    CH933807    EDW13580.1    CVRI01000020    CRK90708.1    KRG03886.1    GBXI01015611    JAC98680.1    KQ971372    KYB25345.1    DS232036    EDS32736.1    GAMC01001913    JAC04643.1    GL448450    EFN84623.1    GEZM01024410    JAV87795.1    CH477219    EAT47401.1    JXUM01026687    KQ560764    KXJ80973.1    AJWK01026312    GBHO01018043    JAG25561.1    GBRD01006915    GDHC01013747    JAG58906.1    JAQ04882.1    GAPW01001295    JAC12303.1    KQ414758    KOC61461.1    GFDF01002280    JAV11804.1    GDHF01018087    GDHF01008834    JAI34227.1    JAI43480.1    KB632326    ERL92400.1    OUUW01000006    SPP81686.1    GFDL01008387    JAV26658.1    CH964295    EDW86698.2    APGK01034968    KB740923    ENN78114.1    KQ978023    KYM98015.1    KK107078    EZA60502.1    JXJN01012270    AJVK01015316    GL770707    EFZ09997.1    EZ422449    ADD18725.1    CH475462    EAL29304.3    NEVH01019374    PNF22622.1    KZ288403    PBC26205.1    JR052111    AEY61624.1    KQ982803    KYQ50548.1    AXCM01000336    GL887898    EGI69569.1    CH479180    EDW28346.1    ADTU01023315    ADTU01023316    AXCN02002086    KQ434783    KZC04733.1    APCN01003368    ADMH02001840    ETN60953.1    GGFK01004938    MBW38259.1    ATLV01018382    KE525231    KFB43082.1    AAAB01008984    KQ980322    KYN16573.1    GGFJ01004212    MBW53353.1    EAA14890.4    GGFJ01004211    MBW53352.1    GGFJ01004213    MBW53354.1    GAMD01001200    JAB00391.1    GGFK01005150    MBW38471.1    GGFM01001327    MBW22078.1    GGFK01005993    MBW39314.1   

Proteomes

UP000053268    UP000053240    UP000007151    UP000008792    UP000001070    UP000000304    + More
UP000002282    UP000008711    UP000000803    UP000007801    UP000007819    UP000192221    UP000009192    UP000183832    UP000079169    UP000095301    UP000007266    UP000002320    UP000095300    UP000008237    UP000008820    UP000069940    UP000249989    UP000092461    UP000053825    UP000030742    UP000268350    UP000007798    UP000019118    UP000002358    UP000078542    UP000092443    UP000078200    UP000053097    UP000092460    UP000092462    UP000092445    UP000005203    UP000001819    UP000235965    UP000242457    UP000075809    UP000075883    UP000007755    UP000008744    UP000075885    UP000075900    UP000075882    UP000005205    UP000075880    UP000075886    UP000076502    UP000075840    UP000000673    UP000075881    UP000076407    UP000030765    UP000069272    UP000078492    UP000007062    UP000075903   

PRIDE

Q9VKZ1   

Pfam

PF01040   UbiA        + More
PF00670   AdoHcyase_NAD
PF05221   AdoHcyase
PF00046   Homeodomain
PF02463   SMC_N
PF06470   SMC_hinge

Interpro

IPR006369   Protohaem_IX_farnesylTrfase        + More
IPR000537   UbiA_prenyltransferase       
IPR016315   Protohaem_IX_farnesylTrfase_mt       
IPR030470   UbiA_prenylTrfase_CS       
IPR000043   Adenosylhomocysteinase-like       
IPR015878   Ado_hCys_hydrolase_NAD-bd       
IPR042172   Adenosylhomocyst_ase-like_sf       
IPR034373   Adenosylhomocysteinase       
IPR020082   S-Ado-L-homoCys_hydrolase_CS       
IPR036291   NAD(P)-bd_dom_sf       
IPR017970   Homeobox_CS       
IPR001356   Homeobox_dom       
IPR009057   Homeobox-like_sf       
IPR036277   SMC_hinge_sf       
IPR003395   RecF/RecN/SMC_N       
IPR010935   SMC_hinge       
IPR024704   SMC       
IPR027120   Smc2_ABC       
IPR027417   P-loop_NTPase       

SUPFAM

SSF51735   SSF51735        + More
SSF46689   SSF46689       
SSF75553   SSF75553       
SSF52540   SSF52540       

Gene 3D

3.40.50.1480    

CDD

cd13957  PT_UbiA_Cox10
cd00401  SAHH
cd00086  homeodomain
cd03273  ABC_SMC2_euk

ProteinModelPortal

A0A194Q844   A0A194QWG6   A0A212EKQ8   A0A2H1WZH3   A0A2W1BK11   A0A1B6DZP8   + More
A0A336M9Y1   A0A1B6MME4   B4LRA0   A0A2S2QA70   A0A1B6JVW7   B4JPM9   B4Q8U2   B4NZA1   B3N976   A0A2S2NAR1   Q9VKZ1   B3MPR6   C4WVL8   X1WJJ8   A0A0K8TKQ5   A0A0P4VL84   A0A1W4UG35   A0A1B6GJ74   B4KJK0   A0A1J1HTJ9   A0A0Q9XGJ0   A0A0A1WJ35   A0A3Q0ITB6   A0A3Q0IMS8   A0A1I8MZW5   A0A139WBV5   B0WQ76   W8BZA2   A0A1I8PHB2   A0A1I8PH37   E2BI52   A0A1Y1MTJ7   Q17L26   A0A182H5U9   A0A1B0CSN5   A0A0A9Y1Q1   A0A0K8T0H1   A0A023ESP8   A0A0L7QSL8   A0A1L8DZE2   A0A0K8V5P4   U4UQS3   A0A3B0K7S5   A0A1Q3FGH6   B4NQQ9   N6TCT9   K7IRR7   A0A195CBD9   A0A1A9Y6Y1   A0A1A9UT82   A0A026WWR5   A0A1B0BD28   A0A1B0DH26   E9JB06   A0A1A9ZVN7   D3TLZ7   A0A088A3H8   Q29CJ3   A0A2J7Q212   A0A2A3E3B8   V9IMH2   A0A151WRV5   A0A182M2F1   F4W874   B4G792   A0A182P674   A0A182RUP9   A0A182LMY2   A0A158NQG6   A0A182IVC0   A0A182Q0L9   A0A154NYN4   A0A182I777   W5JCA3   A0A2M4ABX0   A0A182JSP7   A0A182XDC4   A0A084VYN8   A0A182F5S5   A0A1S4H085   A0A195DUL9   A0A2M4BK45   Q7PWQ5   A0A2M4BK01   A0A2M4BK20   A0A182URC7   T1DQE7   A0A2M4ACG3   A0A2M3Z0W1   A0A2M4AEV6  

KEGG

101742139    K02257 heme o synthase [EC:2.5.1.141] | (RefSeq) protoheme IX farnesyltransferase, mitochondrial

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0008495   GO:0048034   GO:0031966   GO:0070069   GO:1902600   GO:0022900   GO:0006783   GO:0008535   GO:0016491   GO:0019510   GO:0004013   GO:0006730   GO:0051287   GO:0016740   GO:0005739   GO:0005634   GO:0045333   GO:0043565   GO:0006355   GO:0005694   GO:0051276   GO:0005524   GO:0016765   GO:0016818   GO:0003676   GO:0008026   GO:0016597  

PANTHER

PTHR43448   PTHR23420  

Subcellular location

Mitochondrion membrane  
Nucleus  

Length:

405

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

141.81474

Exp number, first 60 AAs:

0.10948

Total prob of N-in:

0.85282

inside

1  -  95

TMhelix

96  -  118

outside

119  -  178

TMhelix

179  -  201

inside

202  -  212

TMhelix

213  -  232

outside

233  -  241

TMhelix

242  -  264

inside

265  -  291

TMhelix

292  -  314

outside

315  -  341

TMhelix

342  -  359

inside

360  -  405

 

 

Pi

212.230269

Theta

168.80409

Tajima's D

0.374697

CLR

0.045442

CSRT

0.476026198690066

Interpretation

Uncertain