Gene

KWMTBOMO05892

Pre Gene Modal

BGIBMGA002930

Annotation

PREDICTED:_uncharacterized_protein_LOC106718540_[Papilio_machaon]

Location

Bomo_Chr10(-):13541189-13566265      View in EpiBrowser

Full name

TRPL translocation defect protein 14      

Location in the cell

Nuclear   Reliability : 1.959

CDS

ATGGCCAATCAATCTCAGAAAATCGTTTACAAGCTGGTTCTTACTGGAGGACCCTGCGGCGGCAAAACAACGGGACAGTCACGTTTAAGTACCTTCTTCGAGAACCTAGGATGGAAGGTGTTCCGGGTGCCGGAAACGGCTACCGTCCTTCTCAGCGGAGGCATAAAGTTTGCAGACCTCAGTCCTGAAGAAGCCTCGAAATTCCAAGAGAACCTATTGAAAACGATGATACAGATTGAGAACACGTTCTTCGAACTCGGCAGAACTAGTCAGAGGAATTGTCTGATAATCTGCGATCGAGGAGCCATGGACGCTAGTGCATTTATATCGAAGGAGAAATGGGAGGCGATACTCGCATCTAACAACTGGAATAATGTCGAACTACGCGACAACAGATACAACCACATCATGCATATGGTATCCGCTGCTAACGGAGCTGAAGACTTCTATTCCACGGAGGATCATGCTTGCCGATCTGAAGGAGTGGAACTCGCCAGAGAGCTGGACTACAAGGCGGCCGCCGCTTGGATCGGTCACCCGTACTTCGACGTGATCGACAATTCGACAGATTTCGATAAAAAGATGAATCGTTTGATCGCGTGCGTCTGCCAGAAGATCGGCATCGATACCGGCGACCGGCTCAACGTCAACTCGAAGAAGCGCAAGTTCCTCATCAAGGCGCCTCTCGCTCCCGACTCGGAGTTCCCGCCCTTCCAAGACTTCGACGTCGTTCACAACTACCTGCAGAGCGATTTGCGGAAAGCACAAGTCCGGCTACGTAAACGCGGACAGAAGGGACACTGGTCGTACATACACACGTTAAGGAAGTTCCACCCCACCAACGGACAGTCCGTCGAGGTCCGCACGCAACTGACGCACCGAGATTATTTGAATCTGTTGCCGCAGCGCGATGACGCTCATCTGACCATCTTCAAGAAGCGTCGTTGTTTCATCTACAACAACCAGTACTATCAGTTGGACATTTACAGGCAACCGACGCATCCCAGATGTCGCGGTTTGGTTCTCCTAGAAACCTACAGCGCTGCTTACGATCAGACCATTTTGCTGGCTTCATTACCCAAGTTTCTGACCATTGAGAAAGAAGTCACCGGAGATCCAGCATATTCAATGTACAATCTGTCATTGAAAGAAGATTGGAAGACCTCGAAAAGGTACTACGCTGGCACTGAGTGCAATGGTCACACTAAGTTGACCAACGGTCATGGCAACGTCAAAATTTGCCATTCAAAGATGAACGGTCATAGTGAGGAGAAAATCGGGCTCGCCTGTGACAAAATCAACGGTTGCGAGAAATCTGAAGTCAGGAAAACCAACGGTCACCATCACGTCAACGGTCACGGCGTGAAAACCGATCGAAACGGTATCACGAGAAACGGTAACGCCCACACCAATGAACTGCAAGACATCAAACAAAGAATTGATCTCGGGTCGCCAAAGATTCAAAAGGTCGCCGTAAAGATTTAA

Protein

MANQSQKIVYKLVLTGGPCGGKTTGQSRLSTFFENLGWKVFRVPETATVLLSGGIKFADLSPEEASKFQENLLKTMIQIENTFFELGRTSQRNCLIICDRGAMDASAFISKEKWEAILASNNWNNVELRDNRYNHIMHMVSAANGAEDFYSTEDHACRSEGVELARELDYKAAAAWIGHPYFDVIDNSTDFDKKMNRLIACVCQKIGIDTGDRLNVNSKKRKFLIKAPLAPDSEFPPFQDFDVVHNYLQSDLRKAQVRLRKRGQKGHWSYIHTLRKFHPTNGQSVEVRTQLTHRDYLNLLPQRDDAHLTIFKKRRCFIYNNQYYQLDIYRQPTHPRCRGLVLLETYSAAYDQTILLASLPKFLTIEKEVTGDPAYSMYNLSLKEDWKTSKRYYAGTECNGHTKLTNGHGNVKICHSKMNGHSEEKIGLACDKINGCEKSEVRKTNGHHHVNGHGVKTDRNGITRNGNAHTNELQDIKQRIDLGSPKIQKVAVKI

Description

GTP-binding protein which is required for the light-dependent internalization of the TRPL ion channel from the rhabdomere on the apical surface of photoreceptor cells to the cell body and for the recycling of TRPL back to the rhabdomere in the dark. Binds to 3-phosphoinositide (PtdIns(3)P) and phosphatic acid and so may interact with membranes, particularly the early endosome membrane where PtdIns(3)P is predominantly localized. Plays a role in preventing photoreceptor degeneration.

Keywords

Alternative splicing   Complete proteome   Cytoplasm   GTP-binding   Lipid-binding   Nucleotide-binding   Protein transport   Reference proteome   Transport  

Feature

chain  TRPL translocation defect protein 14
splice variant  In isoform B.

Uniprot

H9J095   A0A3S2PLE6   A0A2W1BRT0   A0A194Q9L1   A0A194QQX5   A0A2H1WZ88   + More
A0A1E1WKB5   A0A0L7LGI3   A0A212EKQ7   A0A2A4J7V0   K7IVI6   V9IKM3   A0A0C9REA7   A0A158NF37   W8BQC4   F4WEK1   E2B3I4   A0A3L8E577   A0A0A1WZ18   A0A069DZ00   A0A224XP27   A0A0V0G872   A0A023F8F4   W8C8C8   A0A0P4VUQ1   A0A0K8VM66   A0A1B6MCV5   A0A034VQH4   A0A146KNE8   A0A0A9XJH2   U5ESV8   A0A1I8NZV2   A0A1B6CCI7   A0A1B6EQH2   A0A2J7R7P3   A0A088AVP1   A0A3B0JR84   Q7K556-2   N6VF79   A0A0K8WLJ6   A0A3B0JXP7   Q7K556   A0A1B6MK29   A0A0Q9WVZ4   A0A0J9RFM9   A0A1I8NHI9   B4NMY7   T1P9X6   A0A0N8P025   A0A0J9RFV7   A0A1B6F8A9   A0A1I8NZY2   A0A0P8Y2A9   A0A0R1DXL7   A0A336LYL4   A0A0Q5VKX2   A0A336LUP4   T1E1Z0   W8BCP0   A0A0R1DXK9   A0A0Q5VZN6   A0A0K8TNM6   Q7PPH7   A0A023ESP0   A0A1B6KRJ5   A0A1Q3FY97   A0A1Q3FY70   D6X271   E2AE06   A0A1B6F1F5   A0A0A1X3A5   A0A0R3NV51   A0A151WPS7   A0A195FMB3   A0A146LYV1   A0A2M4A876   A0A1B0FKW4   A0A0Q9WIN4   A0A3F2YQ92   A0A1B6LAB5   E0VTI1   A0A2M4A8D5   A0A1A9UXB5   A0A2M3Z122   A0A2M4A8T5   A0A0Q9WGD4   T1DP48   A0A195C438   A0A2M4CJV5   A0A1B6ELE5   A0A0K8VN37   A0A3F2YQA0   A0A2M4BML9   A0A2M4BNH6   A0A1A9WBI6   A0A034VTY1   A0A232F5X0   A0A0K8UUD6   A0A2M4CVE4  

Pubmed

19121390    28756777    26354079    26227816    22118469    20075255    + More
21347285    24495485    21719571    20798317    30249741    25830018    26334808    25474469    27129103    25348373    26823975    25401762    10731132    12537572    12537569    26509977    15632085    17994087    22936249    25315136    17550304    24330624    26369729    12364791    24945155    18362917    19820115    20566863    28648823   

EMBL

BABH01019163    RSAL01000003    RVE54786.1    KZ149998    PZC75376.1    KQ459302    + More
KPJ01700.1    KQ461175    KPJ07908.1    ODYU01012212    SOQ58399.1    GDQN01007297    GDQN01005833    GDQN01003743    GDQN01003535    JAT83757.1    JAT85221.1    JAT87311.1    JAT87519.1    JTDY01001200    KOB74562.1    AGBW02014216    OWR42082.1    NWSH01002572    PCG67949.1    JR049709    AEY61046.1    GBYB01011497    JAG81264.1    ADTU01013727    ADTU01013728    GAMC01007547    JAB99008.1    GL888103    EGI67364.1    GL445346    EFN89736.1    QOIP01000001    RLU27515.1    GBXI01010396    GBXI01004307    JAD03896.1    JAD09985.1    GBGD01001505    JAC87384.1    GFTR01006236    JAW10190.1    GECL01001754    JAP04370.1    GBBI01001081    JAC17631.1    GAMC01007546    JAB99009.1    GDKW01003169    JAI53426.1    GDHF01012371    JAI39943.1    GEBQ01006220    JAT33757.1    GAKP01013391    JAC45561.1    GDHC01021807    JAP96821.1    GBHO01023510    GBHO01023505    JAG20094.1    JAG20099.1    GANO01004656    JAB55215.1    GEDC01026121    JAS11177.1    GECZ01029568    JAS40201.1    NEVH01006727    PNF36857.1    OUUW01000001    SPP75856.1    AE013599    AY051446    AAK92870.1    CM000071    ENO01720.2    GDHF01023757    GDHF01000352    JAI28557.1    JAI51962.1    SPP75858.1    GEBQ01003669    JAT36308.1    CH964282    KRG00272.1    CM002911    KMY94848.1    EDW85726.2    KA645532    AFP60161.1    CH902619    KPU75940.1    KMY94847.1    GECZ01023425    JAS46344.1    KPU75941.1    CM000158    KRK00002.1    UFQT01000211    SSX21753.1    CH954179    KQS62087.1    SSX21752.1    GALA01001655    JAA93197.1    GAMC01007545    JAB99010.1    KRK00001.1    KQS62088.1    GDAI01001634    JAI15969.1    AAAB01008948    EAA10383.4    GAPW01001311    JAC12287.1    GEBQ01025937    JAT14040.1    GFDL01002537    JAV32508.1    GFDL01002536    JAV32509.1    KQ971371    EFA09905.2    GL438827    EFN68239.1    GECZ01025792    JAS43977.1    GBXI01009062    JAD05230.1    KRT02659.1    KQ982854    KYQ49817.1    KQ981490    KYN41382.1    GDHC01005865    JAQ12764.1    GGFK01003676    MBW36997.1    CCAG010015818    CCAG010015819    CH940648    KRF80485.1    GEBQ01019416    JAT20561.1    DS235766    EEB16687.1    GGFK01003704    MBW37025.1    GGFM01001463    MBW22214.1    GGFK01003707    MBW37028.1    KRF80484.1    GAMD01002265    JAA99325.1    KQ978287    KYM95622.1    GGFL01001361    MBW65539.1    GECZ01031048    JAS38721.1    GDHF01032911    GDHF01012324    JAI19403.1    JAI39990.1    GGFJ01005188    MBW54329.1    GGFJ01005187    MBW54328.1    GAKP01013390    JAC45562.1    NNAY01000837    OXU26256.1    GDHF01022176    JAI30138.1    GGFL01005061    MBW69239.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000053240    UP000037510    UP000007151    + More
UP000218220    UP000002358    UP000005205    UP000007755    UP000008237    UP000279307    UP000095300    UP000235965    UP000005203    UP000268350    UP000000803    UP000001819    UP000007798    UP000095301    UP000007801    UP000002282    UP000008711    UP000007062    UP000007266    UP000000311    UP000075809    UP000078541    UP000092444    UP000008792    UP000069272    UP000009046    UP000078200    UP000078542    UP000091820    UP000215335   

PRIDE

H9J095    Q7K556   

Pfam

PF13521   AAA_28        + More
PF01344   Kelch_1

Interpro

IPR038727   NadR/Ttd14_AAA_dom        + More
IPR033469   CYTH-like_dom_sf       
IPR027417   P-loop_NTPase       
IPR015915   Kelch-typ_b-propeller       
IPR006652   Kelch_1       
IPR011043   Gal_Oxase/kelch_b-propeller       

SUPFAM

SSF55154   SSF55154        + More
SSF52540   SSF52540       
SSF117281   SSF117281       
SSF50965   SSF50965       

Gene 3D

2.120.10.80    

ProteinModelPortal

H9J095   A0A3S2PLE6   A0A2W1BRT0   A0A194Q9L1   A0A194QQX5   A0A2H1WZ88   + More
A0A1E1WKB5   A0A0L7LGI3   A0A212EKQ7   A0A2A4J7V0   K7IVI6   V9IKM3   A0A0C9REA7   A0A158NF37   W8BQC4   F4WEK1   E2B3I4   A0A3L8E577   A0A0A1WZ18   A0A069DZ00   A0A224XP27   A0A0V0G872   A0A023F8F4   W8C8C8   A0A0P4VUQ1   A0A0K8VM66   A0A1B6MCV5   A0A034VQH4   A0A146KNE8   A0A0A9XJH2   U5ESV8   A0A1I8NZV2   A0A1B6CCI7   A0A1B6EQH2   A0A2J7R7P3   A0A088AVP1   A0A3B0JR84   Q7K556-2   N6VF79   A0A0K8WLJ6   A0A3B0JXP7   Q7K556   A0A1B6MK29   A0A0Q9WVZ4   A0A0J9RFM9   A0A1I8NHI9   B4NMY7   T1P9X6   A0A0N8P025   A0A0J9RFV7   A0A1B6F8A9   A0A1I8NZY2   A0A0P8Y2A9   A0A0R1DXL7   A0A336LYL4   A0A0Q5VKX2   A0A336LUP4   T1E1Z0   W8BCP0   A0A0R1DXK9   A0A0Q5VZN6   A0A0K8TNM6   Q7PPH7   A0A023ESP0   A0A1B6KRJ5   A0A1Q3FY97   A0A1Q3FY70   D6X271   E2AE06   A0A1B6F1F5   A0A0A1X3A5   A0A0R3NV51   A0A151WPS7   A0A195FMB3   A0A146LYV1   A0A2M4A876   A0A1B0FKW4   A0A0Q9WIN4   A0A3F2YQ92   A0A1B6LAB5   E0VTI1   A0A2M4A8D5   A0A1A9UXB5   A0A2M3Z122   A0A2M4A8T5   A0A0Q9WGD4   T1DP48   A0A195C438   A0A2M4CJV5   A0A1B6ELE5   A0A0K8VN37   A0A3F2YQA0   A0A2M4BML9   A0A2M4BNH6   A0A1A9WBI6   A0A034VTY1   A0A232F5X0   A0A0K8UUD6   A0A2M4CVE4  

KEGG

101744916    no KO assigned | (RefSeq) uncharacterized LOC101744916

GO

GO:0016874   GO:0070300   GO:0005829   GO:0005525   GO:0035091   GO:0015031   GO:0045494   GO:0071482   GO:0090316  

Subcellular location

  

Length:

494

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01614

Exp number, first 60 AAs:

0.01396

Total prob of N-in:

0.01182

outside

1  -  494

 

 

Pi

209.195739

Theta

171.074664

Tajima's D

0.688537

CLR

0.409937

CSRT

0.574671266436678

Interpretation

Uncertain