Gene

KWMTBOMO05888

Annotation

PREDICTED:_NADPH_oxidase_4-like_[Bombyx_mori]

Location

Bomo_Chr10(-):13481522-13501135      View in EpiBrowser

Full name

NADPH oxidase 4      

Alternative Name

Kidney oxidase-1
Kidney superoxide-producing NADPH oxidase
Renal NAD(P)H-oxidase

Location in the cell

PlasmaMembrane   Reliability : 4.959

CDS

ATGAAAATAAAGACGTATCTTTGCGGCGGCTACGAATTCTTGAAGAGGAAATTCTTTTTTATATCATGGATCTCATTAGTGTTATTTCTTTTATGTAACACCTTTATTTATTATAAGGACGAGCAGCAATTTTTTTACGTTAGAAGAATTTTAGGGCTAGGATTATGTGTATCTCGAGCCACTGCGTCGGTACTGAATTTATGCAGCGCATTGCTACTGGTGCCGTTTTGCAAGAAACTAAATCAATTCCTGTACAGGATAATATCGAAATTATGGCCAACATTATTCTTCTATTGGCTGGAGAAAGCGAAAAGCTTTCATATGACTGTGGCGATCACATTGTCCATATTTGCAGTTGTGCATTCTGCTTCTCACTTTGTAAACTTTTGGAATTTCTCAAGAGGATACGACGAAGAATGGACCGAGATTAACTTTGCAAGCTACAAGGATGAGAATCCTCTCTGGCTATTGTTGAGCGTGGCGGGCATAACCGGCGTGTCAATGCTGCTCATAGTCTTGGGTATGAGCGCAACCTCTACTAGGGTTGTTCGACGAAATATGTACAATGTTTTTTGGTATACGCATCAATTGTATCTGATGTTTATGGTGTTACTTATTGTGCACCCATTAAGTGGTGTTCTCAAAGAAGAAGTAGTTAATAGTGAAGCTAGTCTATATTCTAGTCATATTGACCCGTGGTCAAATAACGTTACCTCGGAGGCAATTCCGAAATTTGCGCCCATACAATCGAAGACTTGGTGCTGGATAGCTGTACCATTGACGTGTTACTTAGTCGACATCCTGTGGAGGATATTGACAAGGAACAGGGCGAAGATCGAAATTTTAGAGGTTTACCAGTAA

Protein

MKIKTYLCGGYEFLKRKFFFISWISLVLFLLCNTFIYYKDEQQFFYVRRILGLGLCVSRATASVLNLCSALLLVPFCKKLNQFLYRIISKLWPTLFFYWLEKAKSFHMTVAITLSIFAVVHSASHFVNFWNFSRGYDEEWTEINFASYKDENPLWLLLSVAGITGVSMLLIVLGMSATSTRVVRRNMYNVFWYTHQLYLMFMVLLIVHPLSGVLKEEVVNSEASLYSSHIDPWSNNVTSEAIPKFAPIQSKTWCWIAVPLTCYLVDILWRILTRNRAKIEILEVYQ

Description

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (By similarity).

Subunit

Interacts with protein disulfide isomerase (By similarity). Interacts with, relocalizes and stabilizes CYBA/p22phox. Interacts with TLR4.
Interacts with, relocalizes and stabilizes CYBA/p22phox. Interacts with TLR4. Interacts with protein disulfide isomerase (By similarity).

Keywords

Alternative splicing   Cell junction   Cell membrane   Complete proteome   Disulfide bond   Endoplasmic reticulum   Glycoprotein   Membrane   NADP   Nucleus   Oxidoreductase   Polymorphism   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  NADPH oxidase 4
splice variant  In isoform 2.
sequence variant  In dbSNP:rs317139.

Uniprot

A0A0G3XQZ0   A0A2H1VMB3   A0A2W1BM57   A0A194QRD5   A0A212EKS1   A0A3S2LIV0   + More
A0A194Q8I0   A0A0L7LKE0   A0A182IN29   A0A1S3GRG5   A0A094L5F6   G3VR45   A0A286XLU3   A0A1Y9GLB7   A0A182QCC0   A0A182WV83   Q7PS77   A0A182LAU5   A0A151MVE9   A0A182UWS6   A0A3Q7TMY3   A0A182F7N9   A0A3Q7UCV7   A0A151MVL8   F6Z703   A0A0N7ZB91   G1LF61   A0A2U9B5E6   D2HYE3   A0A182XXF9   A0A384D7C7   K7GHR7   A0A3Q7XI85   A0A1S3NU63   A0A340XUK4   A0A2Y9G6W1   A0A340XR87   A0A1S3NUL7   A0A2U3WUA1   M3YG53   A0A2U3WUA5   A0A1S3NUM3   A0A2Y9G9C6   A0A2U3X7H2   A0A3Q7QVC9   A0A2Y9K8N1   A0A2Y9KKG5   A0A1Y9H2C9   K7AKP0   A0A2Y9TGR3   A0A2K6FB47   A0A2Y9TAZ9   H2R516   A0A182TKV8   A0A2K5ESJ7   A0A2K6FB25   A0A337SH74   Q9NPH5-6   B7Z523   A0A2K5ESJ6   M3XET3   A0A182P7A5   A0A084VGL7   A0A182JVD9   Q9NPH5   A0A1S3IZ67   Q6V1P7   A0A3F2Z119   L8IHJ1   F1MQX5   A0A2Y9TGQ9   F7CF27   F7CEN8   A0A2K5MB73   A0A2Y9TAZ5   A7E3L3   A0A2Y9TCL3   A0A2K5MB91   I3MB82   A0A2J8S648   Q5R5C5   A0A2I3HSI0   A0A2J8S680   G3THC6   B0WUN3   Q5R5C5-2   H2T6D9   A0A091DFJ6   A0A096MLX2   H2T6E3   A0A2I3LZD7   A0A2K5QKU7   A0A2I3NES7   A0A3Q0GAD5   A0A2K6E3J2   W5P107   S7NES5   A0A2J8MCD2  

EC Number

1.6.3.-

Pubmed

28756777    26354079    22118469    26227816    21709235    21993624    + More
12364791    14747013    17210077    20966253    22293439    17495919    20010809    25244985    17381049    16136131    17975172    10869423    11376945    11032835    15210697    15721269    14702039    16554811    15489334    15155719    15356101    14966267    15572675    16230378    16179589    16324151    15927447    16019190    23393389    24438588    22751099    19393038    16381931    17612411    21551351    20809919   

EMBL

KP666171    AKM16733.1    ODYU01003336    SOQ41957.1    KZ149998    PZC75371.1    + More
KQ461175    KPJ07904.1    AGBW02014216    OWR42086.1    RSAL01000003    RVE54790.1    KQ459302    KPJ01704.1    JTDY01000777    KOB75917.1    KL359819    KFZ64677.1    AEFK01119641    AEFK01119642    AEFK01119643    AEFK01119644    AEFK01119645    AEFK01119646    AEFK01119647    AEFK01119648    AEFK01119649    AEFK01119650    AAKN02037747    AAKN02037748    AAKN02037749    AAKN02037750    AAKN02037751    AAKN02037752    APCN01003125    AXCN02000040    AAAB01008844    EAA06046.6    AKHW03004889    KYO28533.1    KYO28534.1    GDRN01087748    JAI60992.1    ACTA01035104    ACTA01043103    ACTA01051103    ACTA01059103    ACTA01067103    ACTA01075103    ACTA01083103    ACTA01091103    ACTA01099103    ACTA01107103    CP026245    AWO99134.1    GL193693    EFB16026.1    AGCU01053606    AGCU01053607    AGCU01053608    AGCU01053609    AGCU01053610    AGCU01053611    AGCU01053612    AGCU01053613    AEYP01058592    AEYP01058593    AEYP01058594    AACZ04016362    AACZ04016363    GABF01003754    NBAG03000261    JAA18391.1    PNI57173.1    GABF01003753    JAA18392.1    PNI57175.1    AANG04002890    AF261943    AF254621    AB041035    AY288918    AJ704725    AJ704726    AJ704727    AJ704728    AJ704729    AK291830    AK298323    AP003400    AP001815    AP002404    BC040105    BC051371    AK298328    BAH12759.1    ATLV01012999    KE524833    KFB37111.1    AY354499    AAQ72353.1    JH881171    ELR56020.1    BR000275    FAA00342.1    AGTP01101097    AGTP01101098    AGTP01101099    AGTP01101100    AGTP01101101    AGTP01101102    AGTP01101103    AGTP01101104    NDHI03003605    PNJ16250.1    CR857676    CR858307    CR860937    ADFV01110741    ADFV01110742    ADFV01110743    ADFV01110744    ADFV01110745    ADFV01110746    ADFV01110747    PNJ16254.1    DS232107    EDS35018.1    KN122620    KFO29238.1    AHZZ02007286    AHZZ02007287    AMGL01060390    AMGL01060391    AMGL01060392    AMGL01060393    AMGL01060394    KE164192    EPQ15849.1    PNI57177.1   

Proteomes

UP000053240    UP000007151    UP000283053    UP000053268    UP000037510    UP000075880    + More
UP000081671    UP000007648    UP000005447    UP000075840    UP000075886    UP000076407    UP000007062    UP000075882    UP000050525    UP000075903    UP000286640    UP000069272    UP000002280    UP000008912    UP000246464    UP000076408    UP000261680    UP000007267    UP000286642    UP000087266    UP000265300    UP000248481    UP000245340    UP000000715    UP000245341    UP000286641    UP000248482    UP000075884    UP000002277    UP000248484    UP000233160    UP000075902    UP000233020    UP000011712    UP000005640    UP000075885    UP000030765    UP000075881    UP000085678    UP000075920    UP000009136    UP000008225    UP000233060    UP000005215    UP000001595    UP000001073    UP000007646    UP000002320    UP000005226    UP000028990    UP000028761    UP000233040    UP000189705    UP000233120    UP000002356   

PRIDE

Q9NPH5    B7Z523   

Pfam

PF01794   Ferric_reduct        + More
PF08030   NAD_binding_6
PF08022   FAD_binding_8

Interpro

IPR013112   FAD-bd_8        + More
IPR017927   FAD-bd_FR_type       
IPR017938   Riboflavin_synthase-like_b-brl       
IPR039261   FNR_nucleotide-bd       
IPR013121   Fe_red_NAD-bd_6       
IPR013130   Fe3_Rdtase_TM_dom       
IPR000778   Cyt_b245_heavy_chain       

SUPFAM

SSF63380   SSF63380        + More
SSF52343   SSF52343       

Gene 3D

3.40.50.80    

ProteinModelPortal

A0A0G3XQZ0   A0A2H1VMB3   A0A2W1BM57   A0A194QRD5   A0A212EKS1   A0A3S2LIV0   + More
A0A194Q8I0   A0A0L7LKE0   A0A182IN29   A0A1S3GRG5   A0A094L5F6   G3VR45   A0A286XLU3   A0A1Y9GLB7   A0A182QCC0   A0A182WV83   Q7PS77   A0A182LAU5   A0A151MVE9   A0A182UWS6   A0A3Q7TMY3   A0A182F7N9   A0A3Q7UCV7   A0A151MVL8   F6Z703   A0A0N7ZB91   G1LF61   A0A2U9B5E6   D2HYE3   A0A182XXF9   A0A384D7C7   K7GHR7   A0A3Q7XI85   A0A1S3NU63   A0A340XUK4   A0A2Y9G6W1   A0A340XR87   A0A1S3NUL7   A0A2U3WUA1   M3YG53   A0A2U3WUA5   A0A1S3NUM3   A0A2Y9G9C6   A0A2U3X7H2   A0A3Q7QVC9   A0A2Y9K8N1   A0A2Y9KKG5   A0A1Y9H2C9   K7AKP0   A0A2Y9TGR3   A0A2K6FB47   A0A2Y9TAZ9   H2R516   A0A182TKV8   A0A2K5ESJ7   A0A2K6FB25   A0A337SH74   Q9NPH5-6   B7Z523   A0A2K5ESJ6   M3XET3   A0A182P7A5   A0A084VGL7   A0A182JVD9   Q9NPH5   A0A1S3IZ67   Q6V1P7   A0A3F2Z119   L8IHJ1   F1MQX5   A0A2Y9TGQ9   F7CF27   F7CEN8   A0A2K5MB73   A0A2Y9TAZ5   A7E3L3   A0A2Y9TCL3   A0A2K5MB91   I3MB82   A0A2J8S648   Q5R5C5   A0A2I3HSI0   A0A2J8S680   G3THC6   B0WUN3   Q5R5C5-2   H2T6D9   A0A091DFJ6   A0A096MLX2   H2T6E3   A0A2I3LZD7   A0A2K5QKU7   A0A2I3NES7   A0A3Q0GAD5   A0A2K6E3J2   W5P107   S7NES5   A0A2J8MCD2  

PDB

5O0T     E-value=4.09008e-05,     Score=110

KEGG

101745551    K21423 NADPH oxidase 4 [EC:1.6.3.-] | (RefSeq) NADPH oxidase 4-like

PATHWAY

04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0016491   GO:0016021   GO:0050667   GO:0005634   GO:0010467   GO:0072341   GO:0006801   GO:0003015   GO:0061098   GO:0042554   GO:0045453   GO:0051897   GO:0016175   GO:0055007   GO:0070374   GO:2000573   GO:0007569   GO:0000902   GO:0048471   GO:0071333   GO:1990782   GO:0008285   GO:0043406   GO:0071944   GO:0006952   GO:0005886   GO:0055114   GO:0043020   GO:0005925   GO:0014911   GO:0034599   GO:0071320   GO:0001725   GO:0097038   GO:0005739   GO:0001666   GO:0016174   GO:0005730   GO:0016324   GO:0005789   GO:0019826   GO:0000166   GO:2000379   GO:0020037   GO:0071480   GO:0051496   GO:0050660   GO:0071560   GO:0006954   GO:0072593   GO:1903409   GO:0009055   GO:0043065  

Subcellular location

Endoplasmic reticulum membrane  
Cell membrane  
Cell junction  
Focal adhesion  
Nucleus  
Nucleolus  

Length:

286

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

136.24703

Exp number, first 60 AAs:

27.19228

Total prob of N-in:

0.40431

POSSIBLE N-term signal

sequence

outside

1  -  19

TMhelix

20  -  38

inside

39  -  50

TMhelix

51  -  73

outside

74  -  82

TMhelix

83  -  100

inside

101  -  104

TMhelix

105  -  127

outside

128  -  153

TMhelix

154  -  176

inside

177  -  187

TMhelix

188  -  210

outside

211  -  252

TMhelix

253  -  272

inside

273  -  286

 

 

Pi

195.327584

Theta

177.927721

Tajima's D

0.332707

CLR

0.180246

CSRT

0.464476776161192

Interpretation

Uncertain