Silkworm Genome Informatics Database

Gene

KWMTBOMO05881

Pre Gene Modal

BGIBMGA002936

Annotation

PREDICTED:_nitric_oxide_synthase-like_protein_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr10(-):13252144-13267970 View in EpiBrowser

Full name

Nitric oxide synthase

Location in the cell

Cytoplasmic Reliability : 1.911

CDS

ATGGCTCCCGGTGTCATTCAAAACTCTGAAACAATATTGACCGACTCCCTCGAAGTTATTACCGCGACGCATAATGGGGGTCTTATTAACGAACTGATGGTTGAATCTAATGTAAACAAAACGTGCCCAGTGGATCTACAGTTCATTAATGGAGCCCATGGGCAACATCAAGCTGTTAAGGCTGCTGAAGCGGATAAAGTTGAAGTCAAGAAGCCGGCTCGTAAAGTTACAAGACCCAAAGTGCTGAAGAACCACGAGTCCAGAGAATTATTGTACGACAGACTGTACGACACAACTTGTCCCAGAGTGCCGACGCTATGCAACGAGCGCTCGTGTCTTGGGAGTTTGATGGCCATCCCGGGACGAGGCGACGTGCCCCGAGACCCGGAGGAGGTGCTTAATGACGCAAAGGACTTTCTAGGCCAGTACTTCGCTTCTATACGGAGGGCCAATACTCCAGCTCATGAAGCTCGCTGGAAAATCGTACAAGAGGAAGTAGCTACGACTGGCACATACCAACTAACCACAACAGAACTGGTATTTGGAGCCAAGCTTGCATGGAGAAACGCTAGCCGTTGCATTGGCAGAATCCAGTGGTCAAAATTGCAGGTATGTTGA

Protein

MAPGVIQNSETILTDSLEVITATHNGGLINELMVESNVNKTCPVDLQFINGAHGQHQAVKAAEADKVEVKKPARKVTRPKVLKNHESRELLYDRLYDTTCPRVPTLCNERSCLGSLMAIPGRGDVPRDPEEVLNDAKDFLGQYFASIRRANTPAHEARWKIVQEEVATTGTYQLTTTELVFGAKLAWRNASRCIGRIQWSKLQVC

Description

Produces nitric oxide (NO).

Catalytic Activity

H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide

Cofactor

FAD
FMN
heme

Similarity

Belongs to the NOS family.

Uniprot

A0A2A4JQY7 A0A2W1BRS1 A0A194Q9M0 A0A194QRD1

EC Number

1.14.13.39

Pubmed

28756777 26354079

EMBL

NWSH01000856 PCG73832.1 KZ149998 PZC75366.1 KQ459302 KPJ01710.1 + More
KQ461175 KPJ07899.1

Proteomes

UP000218220 UP000053268 UP000053240

Pfam

PF00258   Flavodoxin_1        + More
PF00667   FAD_binding_1
PF02898   NO_synthase
PF00175   NAD_binding_1

Interpro

IPR004030   NOS_N        + More
IPR017938   Riboflavin_synthase-like_b-brl
IPR008254   Flavodoxin/NO_synth
IPR023173   NADPH_Cyt_P450_Rdtase_alpha
IPR001433   OxRdtase_FAD/NAD-bd
IPR017927   FAD-bd_FR_type
IPR029039   Flavoprotein-like_sf
IPR012144   NOS_euk
IPR001094   Flavdoxin-like
IPR001709   Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR039261   FNR_nucleotide-bd
IPR003097   CysJ-like_FAD-binding
IPR036119   NOS_N_sf

SUPFAM

SSF56512   SSF56512        + More
SSF63380   SSF63380
SSF52343   SSF52343
SSF52218   SSF52218

Gene 3D

1.20.990.10 3.40.50.80

ProteinModelPortal

A0A2A4JQY7 A0A2W1BRS1 A0A194Q9M0 A0A194QRD1

PDB

3NOS E-value=3.38289e-23, Score=264

KEGG

100144542 K13240 nitric-oxide synthase, brain [EC:1.14.13.39] | (RefSeq) NOS2, BmNOS2, Nsl; nitric oxide synth

PATHWAY

00220    Arginine biosynthesis - Bombyx mori (domestic silkworm)
00330    Arginine and proline metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0050661 GO:0006809 GO:0050660 GO:0046872 GO:0010181 GO:0005516 GO:0020037 GO:0004517 GO:0005506 GO:0016597 GO:0055114

Length:

205

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00509

Exp number, first 60 AAs:

0.00075

Total prob of N-in:

0.05232

outside

1 - 205

Pi

237.076977

Theta

177.752345

Tajima's D

1.326704

CLR

0.209164

CSRT

0.746612669366532

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics