Gene

KWMTBOMO05877  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002938

Annotation

PREDICTED:_nitric_oxide_synthase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr10(-):13157318-13180770      View in EpiBrowser

Full name

Nitric oxide synthase       + More
Nitric oxide synthase-like protein      
Nitric oxide synthase, salivary gland      

Alternative Name

Inducible nitric oxide synthase-like protein
dNOS

Location in the cell

Cytoplasmic   Reliability : 2.374

CDS

ATGGATATACCTGGTCGAGGTGATACCCCGCGGACGGCGGAAGAAGTGTTCAAGGATGCTCAGGCATTCCTCACACAATACTACGCTTCAATCAAGCGAGAGAACTCAGAAGCCCACAAAGCGAGGTTAGACGAAGTGAAGAGGGAATTGAAAGAAAAAGGAACGTATCAACTTAAAACTTCGGAATTGGTGTTCGGGGCCAAGTTGGCTTGGCGTAATGCGACCAGGTGCATCGGAAGAATACAGTGGAAAAAGTTACAGATATTCGATTGCAGAGAAGTGACCACAGCAAGCGGTATGTTCGAAGCATTGTGCAATCACATCAAATACGCTACGAATAAAGGAAATATTCGTTCAGCAATAACGATCTTCCCACAACGCACCGACGGTAAACATGACTACAGAATATGGAATCCGCAGCTTATCAATTATGCAGGATACCAGGAGCCAGATGGAAGCATTATAGGAGATCCAGCACGAGTTGAATTTACAGAGATTTGTATGAAACTTGGATGGAAAGCGCCGCGCACCCCATGGGACATTTTGCCGCTCGTACTCTCTGCTGACGGAAAAGATCCTGAATTCTTTGAACTACCCAAAGAAATAGTTATGGAAGTGCAATTCGAACATCCTGAATATGACTGGTTCAAAGACATGGGTTGGAAATGGTATGCTTTGCCGGCTGTTTCCAACATGAGGCTTGACTGCGGGGGCCTAGAGTTCACAGCTAATTCCTTCAACGGCTGGTACATGGGCACTGAGATCGGATGCAGGAACCTCTGCGATGAGAGTCGACTGAATATTGTTGAGGCTGTAGCCAAGAAAATGGGTCTAGACACAAACTCGTTTGTTTCTCTGTGGAAAGATAAGGCATTAGTTGAAGTTAATATAGCGGTACTGCACAGTTTCCATAGAGATAACGTGTCCATTGTTGATCATCACTCCGCGTCCGAACAGTTCCAGAAGCATTTAGAAAATGAAAATAAAAGCAGGGGCGGATGTCCAGCTGATTGGATATGGATCGTTCCACCGATGTCTTCATCGTTAACCACAGTGTTCCACCAAGAAATGGCCTTGTATTACATCAGACCGTCATATGATTATCAGGAACCACCATGGAAGACTCACCAATGGACAAAGTCTGACGGCACTAAGACCGTCCACAGGAAGTTCCACTTCAAACAGATCGCCAGAGCAGTTAAGTTCACTTCCAAACTGTTCGGACGGGCGCTCTCCAAGCGCATCAAAGCGACTATTCTCTACGCAACAGAGACGGGCAAATCTGAACACTACGCCAAAGAATTAGGAACTATTTTCGGACACGCTTTCAACGCGCAGGTACATTGCATGTCGGAATATGATATGTTTTCTATAGAACATGAGACTTTAGTTCTCATAGTGGCTTCCACGTTCGGCAATGGAGAACCTCCAGCTAACGGAGTCGATTTTGCAGAGCATCTATTTCAAATGCTTTATAATGAGACAAACAATAATCGAGGAGATGGTACAAATGACTTAGGCTCTGGTACGTTCAAGACACCAACACCAAAATCACTGATGAGATCAAACAGTATGATGACACCGAGCTTTGAATATAAGCGGCAATTAACGAGATTAGAGTCTAACAAAAGTAGCGTGGCCGGTGCATCATCTATAGAACAAATAGGACCTCTTAGCAACGTTTGTTTCGCTGTATTTGGTCTGGGGTCGAGTGCGTACCCAAAATTCTGTCATTTCGGTAAAACAGTTGACAAAATCCTTGGTGATTTAGGCGGCGAAAGAATATTAGAACTGGCATGTGGTGATGAATTGTACGGACAAGAACAACAGTTTCGCGCTTGGTCTTCGAAAATATTTCAGGTTGCCTGTGAAACGTTTTGCTTAGATGAAAACGACATGGTAAAAGATGCAAAGAAAGCTTTGGGTGACGTACCGCTGACAGAAGAGACAGTACGTTTCGGAAAATATCAGGGAGATACAAAGCTAAAGGCAGCTCTGGAGGCCAGCTTCAGAAAACAGCTCATTACTTGTAAAGTTAAAGAGAATAAAAACCTAGGGGACTTCTCAGCGGATCGGGCCACAGTATTTGTTGATATGCAACCAGAAACTGAATTCAAATACGATCCAGGAGATCACGTCGGAGTTTTGGCTTGTAATAGAAAAGAAATAGTAGATGCAGTACTAGAGAGGATGAAAGATGTTGACGACTATGATAAAACTGTTCAATTACAAGTGATGAAGGAGACGTTGACACCTACAGGTGCTATAAAGACATGGGAGCAACATGAAAGATTACCAGCGGTAACGATACGACAGATATTTACGAGATTTCTTGACATCACGACACCACCGTCAACGACTGTACTGAAATACTTATCTAAAGCTTGCACTGACCAGAATGATGCTGCCCAACTTAAAGAATTAGCCATAGATTCCAACAAATACGACGACTGGAGGCATCTCCACTATCCACACTTGGCCGAAGTACTAGCGCAGTTCCCTTCATGTCGACCTCAAGCATCTTTGCTAGCGGCCCTACTACCATCGTTACAGCCGAGGTTCTACTCCATATCTTCATCACCACTAGCGCATCCTCATAGAATTCACATCACATGCGCTGTTGTTGTTTACAGGACACAGAACGGACAAGGCCCGATGCATTATGGAGTATGCTCTACATACCTACAAAATCTAAAACCGGAGGACGAAGCCCTAGTTTTCATAAGACGTGCACCAAGCTTCCATATGCCTAAAGATTTATCAGCACCGCTTATTCTTGTCGGCCCCGGCTCTGGTATAGCGCCGTTCAGAGGATTTTGGCATCACAGAAAGCATCAGATCAAGAATTTGATACCGAACAAACAAAAACCAGGTCCTGTCTGGTTGTTCTTCGGTTGCCGAAACAGAGGAATGGATTTGTATAAAGAAGAAAAAGAAAAAGCGTTAGCCGATGGAGTATTGAGCAAAGTTTTCTTGGCACTTTCTAGGGAAGACTCTGTTGAAAAGAAACACATCCAAACGCTACTGGAGGACGAGGGTGCCGAAATCTCACGGATGCTTCTAGACGAAAACGGACATTTCTACGTTTGTGGTGATTGTAAAATGGCTGAAGAAGTTCAACAGAAATTAAAAGAAATCATGAAGAAACATGCCAAAATGACTGAGCAAGAATATGAAGAGTTCATCTTGAACTTGATGGATGAAAACAGATACCACGAAGATATCTTCGGGATCACTCTGAGAACAGCAGAAGTTCAAAGTGCATCAAGAGAATTCGCTAAAAGGACAAGGCAGGAATCACAGAAGTCACAAACTTAA

Protein

MDIPGRGDTPRTAEEVFKDAQAFLTQYYASIKRENSEAHKARLDEVKRELKEKGTYQLKTSELVFGAKLAWRNATRCIGRIQWKKLQIFDCREVTTASGMFEALCNHIKYATNKGNIRSAITIFPQRTDGKHDYRIWNPQLINYAGYQEPDGSIIGDPARVEFTEICMKLGWKAPRTPWDILPLVLSADGKDPEFFELPKEIVMEVQFEHPEYDWFKDMGWKWYALPAVSNMRLDCGGLEFTANSFNGWYMGTEIGCRNLCDESRLNIVEAVAKKMGLDTNSFVSLWKDKALVEVNIAVLHSFHRDNVSIVDHHSASEQFQKHLENENKSRGGCPADWIWIVPPMSSSLTTVFHQEMALYYIRPSYDYQEPPWKTHQWTKSDGTKTVHRKFHFKQIARAVKFTSKLFGRALSKRIKATILYATETGKSEHYAKELGTIFGHAFNAQVHCMSEYDMFSIEHETLVLIVASTFGNGEPPANGVDFAEHLFQMLYNETNNNRGDGTNDLGSGTFKTPTPKSLMRSNSMMTPSFEYKRQLTRLESNKSSVAGASSIEQIGPLSNVCFAVFGLGSSAYPKFCHFGKTVDKILGDLGGERILELACGDELYGQEQQFRAWSSKIFQVACETFCLDENDMVKDAKKALGDVPLTEETVRFGKYQGDTKLKAALEASFRKQLITCKVKENKNLGDFSADRATVFVDMQPETEFKYDPGDHVGVLACNRKEIVDAVLERMKDVDDYDKTVQLQVMKETLTPTGAIKTWEQHERLPAVTIRQIFTRFLDITTPPSTTVLKYLSKACTDQNDAAQLKELAIDSNKYDDWRHLHYPHLAEVLAQFPSCRPQASLLAALLPSLQPRFYSISSSPLAHPHRIHITCAVVVYRTQNGQGPMHYGVCSTYLQNLKPEDEALVFIRRAPSFHMPKDLSAPLILVGPGSGIAPFRGFWHHRKHQIKNLIPNKQKPGPVWLFFGCRNRGMDLYKEEKEKALADGVLSKVFLALSREDSVEKKHIQTLLEDEGAEISRMLLDENGHFYVCGDCKMAEEVQQKLKEIMKKHAKMTEQEYEEFILNLMDENRYHEDIFGITLRTAEVQSASREFAKRTRQESQKSQT

Description

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Involved in the induction of immune gene expression.
Produces nitric oxide (NO).
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Nitric oxide limits plasmodium development in the midgut.
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Truncated isoforms (isoform 3-isoform 6) are able to form intracellular complexes with the full-length protein and serve as dominant negative inhibitors of the enzyme activity.

Catalytic Activity

H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide

Cofactor

heme
FAD
FMN

Similarity

Belongs to the NOS family.

Keywords

Calmodulin-binding   Complete proteome   FAD   Flavoprotein   FMN   Heme   Iron   Metal-binding   NADP   Oxidoreductase   Reference proteome   Alternative splicing   3D-structure  

Feature

chain  Nitric oxide synthase
splice variant  In isoform 2.

Uniprot

Q8T8C0   H9J0A2   O77104   A0A194QQW5   A0A194Q846   A0A212FFL3   + More
A0A2W1BP40   A0A2A4JQF6   A0A2D1CSB0   A0A2H1WQB8   H9TN28   A0A3G2BAG7   A0A194QRD1   A0A2W1BRS1   A0A2A4JQY7   A0A2H1VQU4   A0A2A4JPA3   B1B557   A0A0L7L9D5   B7XH76   A0A2J7R7T5   D6WZB5   E0VG92   Q5FAN1   A0A2A3EKD6   A0A195CZ09   A0A0K0LIZ9   E9IZA1   A5HVZ7   A0A0K0LJ45   A0A195AU06   A0A310SCF2   A0A195FWG3   A0A151JCF9   A0A0L7R7J7   A0A026VVR0   A0A151WVV3   A0A154PDZ1   F4WUY7   Q16UY1   A0A1S4GYE8   Q7PNE2   D4N4H3   A5HVZ6   I2CZU9   O61608   A0A1Y9GKC1   A0A084W4T8   E2AAP2   A0A1Y9J085   A0A1Y9IVD5   A0A0N0BC93   D2YYH5   G8XR43   E2BIM4   D2J3S3   A0A2M4BAZ3   A0A2M4CJI3   A0A182UH37   A0A0U3BM43   A0A2M4A368   A0A1S4GYH2   A0A2M4A372   A0A2M4A3A5   A0A2M4CJ25   A0A182PCN0   A0A240SXC8   A0A182Y3I0   G0M6G3   W8BTS8   A0A240SWJ7   A0A182Q6X7   Q6E5V9   B4MU51   A0A226E7L0   B4KKM7   A0A3B0JN27   A0A023FA12   Q26240   A0A034WS92   B4JPU3   Q27571   B4LS74   Q29KP6   A0A0M5IY53   D5I3H5   A0A182V798   A0A2P2IBF2   A0A1W4W517   B4P121   B3MJW2   B3N527   B4HWW1   T1HIL3   A0A1I8Q4X2   J9JN78   A0A0J9TKU3   A0A2S2Q521   A0A3B0JLK8   A0A145P6C8  

EC Number

1.14.13.39

Pubmed

12000645    19121390    9736646    26354079    22118469    28756777    + More
29035888    18505883    26227816    19437615    18362917    19820115    20566863    21282665    24508170    21719571    17510324    12364791    20026409    9576947    10333518    24438588    20798317    25244985    24495485    15235013    17994087    25474469    9022713    25348373    7568075    11526108    10731132    12537572    12804606    15632085    20959144    17550304    22936249    27033466   

EMBL

AB071182    AB485775    AB017521    BAB33296.1    BAB85836.1    BAH23563.1    + More
BABH01019194    BABH01019195    AF062749    AAC61262.1    KQ461175    KPJ07898.1    KQ459302    KPJ01712.1    AGBW02008807    OWR52517.1    KZ149998    PZC75365.1    NWSH01000856    PCG73834.1    MF162295    ATN45429.1    ODYU01010272    SOQ55265.1    JF502067    AFG22596.1    MG770226    AYM26646.1    KPJ07899.1    PZC75366.1    PCG73832.1    ODYU01003891    SOQ43213.1    PCG73831.1    AB360590    AB485776    BAG12563.1    BAH23564.1    JTDY01002100    KOB72118.1    AB477987    BAH14964.1    NEVH01006727    PNF36893.1    KQ971372    EFA10400.2    DS235133    EEB12398.1    AB204558    BAD89803.1    KZ288232    PBC31491.1    KQ977141    KYN05369.1    KJ425527    AJA40862.1    GL767121    EFZ14055.1    AB304920    BAF63161.1    KJ425525    AJA40859.1    KQ976738    KYM75666.1    KQ761346    OAD57843.1    KQ981200    KYN45005.1    KQ979038    KYN23479.1    KQ414639    KOC66824.1    KK107770    EZA47847.1    KQ982691    KYQ52059.1    KQ434874    KZC09634.1    GL888378    EGI62001.1    CH477609    EAT38354.1    AAAB01008964    EAA12335.2    GQ429217    ADD63793.1    AB304919    BAF63160.1    JQ793785    AFJ74715.1    AF130134    AF130124    AF130125    AF130126    AF130127    AF130128    AF130129    AF130130    AF130131    AF130132    AF130133    APCN01000801    APCN01000802    ATLV01020382    ATLV01020383    KE525299    KFB45232.1    GL438137    EFN69492.1    KQ435922    KOX68681.1    AB485762    BAI67609.1    EU863412    ACJ54486.1    GL448516    EFN84471.1    GQ865598    ACZ60615.1    GGFJ01000837    MBW49978.1    GGFL01001306    MBW65484.1    KU306112    ALT10385.1    GGFK01001851    MBW35172.1    GGFK01001849    MBW35170.1    GGFK01001946    MBW35267.1    GGFL01001077    MBW65255.1    JXJN01001049    JXJN01001050    JXJN01001051    JXJN01001052    JXJN01001053    JXJN01001054    JXJN01001055    JXJN01001056    JXJN01001057    JXJN01001058    FR875156    CCC18661.1    GAMC01014036    JAB92519.1    AXCN02000784    AY552549    AAT46681.1    CH963852    EDW75640.1    LNIX01000006    OXA52596.1    CH933807    EDW12691.1    OUUW01000006    SPP81742.1    GBBI01000949    JAC17763.1    U59389    GAKP01002324    GAKP01002323    JAC56628.1    CH916372    EDV98923.1    U25117    AF215700    AF215691    AF215692    AF215693    AF215694    AF215695    AF215696    AF215697    AF215698    AF215699    AE014134    BT010016    CH940649    EDW64760.2    CH379061    EAL33128.1    CP012523    ALC38686.1    GQ862349    ACY56317.1    IACF01005756    LAB71339.1    CM000157    EDW87996.1    CH902620    EDV32417.1    CH954177    EDV58972.1    CH480818    EDW52506.1    ACPB03007893    ABLF02036032    ABLF02036036    ABLF02036037    CM002910    KMY89625.1    GGMS01003650    MBY72853.1    SPP81743.1    KU529650    AMV91694.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000218220    UP000037510    + More
UP000235965    UP000007266    UP000009046    UP000005203    UP000242457    UP000078542    UP000078540    UP000078541    UP000078492    UP000053825    UP000053097    UP000075809    UP000076502    UP000007755    UP000008820    UP000007062    UP000076408    UP000075840    UP000030765    UP000000311    UP000076407    UP000075920    UP000053105    UP000008237    UP000075902    UP000075885    UP000092460    UP000092443    UP000075886    UP000007798    UP000198287    UP000009192    UP000268350    UP000015103    UP000001070    UP000000803    UP000008792    UP000001819    UP000092553    UP000075903    UP000192221    UP000002282    UP000007801    UP000008711    UP000001292    UP000095300    UP000007819   

PRIDE

Q8T8C0    H9J0A2    B1B557    O61608    Q26240    Q27571    + More

Pfam

PF00175   NAD_binding_1        + More
PF02898   NO_synthase
PF00667   FAD_binding_1
PF00258   Flavodoxin_1

Interpro

IPR017938   Riboflavin_synthase-like_b-brl        + More
IPR004030   NOS_N       
IPR017927   FAD-bd_FR_type       
IPR001433   OxRdtase_FAD/NAD-bd       
IPR023173   NADPH_Cyt_P450_Rdtase_alpha       
IPR008254   Flavodoxin/NO_synth       
IPR001094   Flavdoxin-like       
IPR012144   NOS_euk       
IPR029039   Flavoprotein-like_sf       
IPR036119   NOS_N_sf       
IPR003097   CysJ-like_FAD-binding       
IPR001709   Flavoprot_Pyr_Nucl_cyt_Rdtase       
IPR039261   FNR_nucleotide-bd       

SUPFAM

SSF56512   SSF56512        + More
SSF63380   SSF63380       
SSF52343   SSF52343       
SSF52218   SSF52218       

Gene 3D

1.20.990.10     3.40.50.80     3.40.50.360    

ProteinModelPortal

Q8T8C0   H9J0A2   O77104   A0A194QQW5   A0A194Q846   A0A212FFL3   + More
A0A2W1BP40   A0A2A4JQF6   A0A2D1CSB0   A0A2H1WQB8   H9TN28   A0A3G2BAG7   A0A194QRD1   A0A2W1BRS1   A0A2A4JQY7   A0A2H1VQU4   A0A2A4JPA3   B1B557   A0A0L7L9D5   B7XH76   A0A2J7R7T5   D6WZB5   E0VG92   Q5FAN1   A0A2A3EKD6   A0A195CZ09   A0A0K0LIZ9   E9IZA1   A5HVZ7   A0A0K0LJ45   A0A195AU06   A0A310SCF2   A0A195FWG3   A0A151JCF9   A0A0L7R7J7   A0A026VVR0   A0A151WVV3   A0A154PDZ1   F4WUY7   Q16UY1   A0A1S4GYE8   Q7PNE2   D4N4H3   A5HVZ6   I2CZU9   O61608   A0A1Y9GKC1   A0A084W4T8   E2AAP2   A0A1Y9J085   A0A1Y9IVD5   A0A0N0BC93   D2YYH5   G8XR43   E2BIM4   D2J3S3   A0A2M4BAZ3   A0A2M4CJI3   A0A182UH37   A0A0U3BM43   A0A2M4A368   A0A1S4GYH2   A0A2M4A372   A0A2M4A3A5   A0A2M4CJ25   A0A182PCN0   A0A240SXC8   A0A182Y3I0   G0M6G3   W8BTS8   A0A240SWJ7   A0A182Q6X7   Q6E5V9   B4MU51   A0A226E7L0   B4KKM7   A0A3B0JN27   A0A023FA12   Q26240   A0A034WS92   B4JPU3   Q27571   B4LS74   Q29KP6   A0A0M5IY53   D5I3H5   A0A182V798   A0A2P2IBF2   A0A1W4W517   B4P121   B3MJW2   B3N527   B4HWW1   T1HIL3   A0A1I8Q4X2   J9JN78   A0A0J9TKU3   A0A2S2Q521   A0A3B0JLK8   A0A145P6C8  

PDB

5G0P     E-value=8.15695e-159,     Score=1442

KEGG

692510    K13240 nitric-oxide synthase, brain [EC:1.14.13.39] | (RefSeq) NOS1, BmNOS, BmNOS1, NOS, iNOS-LP; ni

PATHWAY

00220    Arginine biosynthesis - Bombyx mori (domestic silkworm)
00330    Arginine and proline metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0050661   GO:0050660   GO:0006809   GO:0046872   GO:0010181   GO:0020037   GO:0004517   GO:0005516   GO:0016491   GO:0005829   GO:0032496   GO:0012506   GO:0031284   GO:0005634   GO:0009725   GO:0005886   GO:0006527   GO:0007263   GO:0003958   GO:0007444   GO:0046620   GO:0008156   GO:0005777   GO:0007416   GO:0007399   GO:0008285   GO:0002027   GO:0005506   GO:0016597   GO:0055114  

Length:

1105

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.43567

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00002

outside

1  -  1105

 

 

Pi

241.07294

Theta

189.089799

Tajima's D

0.913215

CLR

0.0233

CSRT

0.633918304084796

Interpretation

Uncertain