Gene

KWMTBOMO05862

Pre Gene Modal

BGIBMGA006892

Annotation

fringe_[Bombyx_mori]

Location

Bomo_Chr10(-):12812419-12828505      View in EpiBrowser

Full name

Beta-1,3-N-acetylglucosaminyltransferase       + More
Fringe glycosyltransferase      

Alternative Name

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Location in the cell

Extracellular   Reliability : 1.722 PlasmaMembrane   Reliability : 1.365

CDS

ATGGGCGGACGAAGAATGCTTAAGGCCGCAGCTGTGCTGTTAGCCTTAGGATACTGCAGCTTATTAGTATACCAAGGAGGAGTCAACTTCAACTTCCAAGAAAGTCGGGCAGGTGTTGTGCAAGTGGCCGATCTATCAATTGAATCCATTACTAAAACAAGTGTTGACGATATTGAACTAAACAAAAACATTACCTTAAACGATATTTTTATTAGTGTTAAAACAACTAAACATTATCAGTACACAAGATTACCGATCATCTTGAAGACTTGGTTCCAGTTAGCAAAAGAACAGACATGGTTCTTCACGGACACAGAAACGAAACAACACCAAAATCAGACGAATGGCCACATGGTGAATACAAATTGCTCTGCGTCGCACCAACGTAAACATCTATGCTGCAAAATGTCCGTTGAATATGACCGGTTTCTCGAGAGTGGTAAAAAATGGTTCTGTCACTTTGACGACGACAACTACGTAAATGTTCCTCGTTTGGTGAGCGTGCTACAAACCTACAAGCACCAAGAAGATTGGTATCTAGGTAGAACGTCTGTTTACGAGCCGGTCAAAATATACAAGAAACCAACGAATAAGTTAATGTTTTCGTTCTGGTTCGCCACCGGCGGCGCTGGATTCTGCATAAGCAGAAGTTTAGCTCTTAAAATGCTACCTGTTGCAAGCGGTGGAAGATTTATAAGTATTTGTGAAGGCATACGGTTACCGGATGACGTGTCTATAGGATTTATTATAGAGCATCTAATGAAGAAGAATTTGACTCTGGTCCCGGAGTTTCATTCTCACTTGGAGCAGATGAAGCTTCTTCCTCCGGAGACATTTAGGGATCAGATCTCCTTTAGCTATGCCAAAGCGAAGGACGAATGGAATGTCGTGAACGTTCCTGGATTTGACACTAGATACGATCCTACGAGGTTCCTATCGCTGCACTGTTTCCTCTTCCCCCATTTTAAGTTTTGCCCGAGATAA

Protein

MGGRRMLKAAAVLLALGYCSLLVYQGGVNFNFQESRAGVVQVADLSIESITKTSVDDIELNKNITLNDIFISVKTTKHYQYTRLPIILKTWFQLAKEQTWFFTDTETKQHQNQTNGHMVNTNCSASHQRKHLCCKMSVEYDRFLESGKKWFCHFDDDNYVNVPRLVSVLQTYKHQEDWYLGRTSVYEPVKIYKKPTNKLMFSFWFATGGAGFCISRSLALKMLPVASGGRFISICEGIRLPDDVSIGFIIEHLMKKNLTLVPEFHSHLEQMKLLPPETFRDQISFSYAKAKDEWNVVNVPGFDTRYDPTRFLSLHCFLFPHFKFCPR

Description

Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity; extends the O-linked fucose on the Notch EGF repeats. Boundary-specific cell-signaling molecule that is responsible for dorsal-ventral cell interactions during wing development.

Catalytic Activity

Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.

Cofactor

Mn(2+)

Similarity

Belongs to the glycosyltransferase 31 family.

Keywords

Complete proteome   Developmental protein   Direct protein sequencing   Disulfide bond   Glycosyltransferase   Golgi apparatus   Manganese   Membrane   Metal-binding   Reference proteome   Signal-anchor   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Fringe glycosyltransferase

Uniprot

B1B559   H9JBJ7   A0A194QSD1   A0A194QE32   Q86MC1   A0A3S2P1N5   + More
A0A212ERS1   A0A2A4KAZ7   A0A0L7LAM4   A0A2H1WI07   E0V9K3   D6WZR0   A0A1B6EG05   A0A1X9ITA0   A0A146KVY3   A0A3L8DM07   A0A1B6MFN1   A0A1W4XWQ6   A0A0C9RXE9   A0A385JF78   A0A1B6FY57   A0A1B6JPC6   A0A1L8E2N9   A0A158NVD6   A0A1L8E260   A0A1E1WJH4   A0A1Y1MH03   T1J8T0   B3M6V8   L7LYZ5   A0A2L2YIP4   A0A1E1XJT3   A0A131YIM3   B4N3W0   B4LB70   A0A0J9RZ83   B4IAH5   Q24342   T1PLW7   B4PEN1   B3NIT5   B4L9F1   A0A1W4V986   A0A154PRH7   A0A0M4EJM5   B4J1C8   A0A3B0JT71   A0A0L0CL82   Q2M156   A0A1A9UVV0   A0A0L7QUB4   E2BQD2   A0A1A9W5R5   A0A034VEH4   A0A131XRV5   K7IX37   A0A151XEC5   A0A195DB56   A0A2M4CRE8   A0A2M4CSN0   A0A195F560   A0A0A1WQE2   A0A0K8VWC2   A0A0K8UL99   A0A0K8WLY6   A0A195BQK5   A0A293LPY3   A0A1B0G6C4   A0A0N7ZC89   A0A2M4ADJ3   A0A1Z5L9J1   W8BZA4   A0A0P5SJE9   A0A0P5Q132   A0A0P5JZ49   A0A0P5VM74   A0A0P5P663   A0A0P5HER5   A0A090B452   A0A0P5K5L9   A0A1Y9GLM6   A0A0P5UYG9   A0A0P5PB56   A0A1I8NIK1   A0A0P5PXR5   A0A1J1IAR5   Q49QW2   A0A0P5YMN0   A0A2C9KU68   A0A1V9XXE1   A0A195CEV8   A0A2H8TZY8   J9JPB6   A0A2S2P0B8  

EC Number

2.4.1.222

Pubmed

18505883    19121390    26354079    12743367    22118469    26227816    + More
20566863    18362917    19820115    27966611    26823975    30249741    21347285    28004739    17994087    25576852    26561354    29209593    26830274    22936249    7954826    10731132    12537572    12537569    9187150    9019410    10935626    10935637    10899003    10985380    17550304    26108605    15632085    20798317    25348373    29652888    20075255    25830018    28528879    24495485    25315136    15562597    28327890   

EMBL

AB360592    BAG12565.1    BABH01024608    BABH01024609    KQ461175    KPJ07890.1    + More
KQ459302    KPJ01721.1    AY228759    AAO38754.1    RSAL01000003    RVE54805.1    AGBW02012941    OWR44193.1    NWSH01000014    PCG80832.1    JTDY01001954    KOB72460.1    ODYU01008774    SOQ52667.1    DS234994    EEB10059.1    KQ971372    EFA09659.1    GEDC01000426    JAS36872.1    KY020091    APR62737.1    GDHC01019387    JAP99241.1    QOIP01000006    RLU21222.1    GEBQ01005244    JAT34733.1    GBYB01012576    JAG82343.1    MG213853    AXY96275.1    GECZ01030456    GECZ01014786    JAS39313.1    JAS54983.1    GECU01006719    JAT00988.1    GFDF01001319    JAV12765.1    ADTU01027099    ADTU01027100    ADTU01027101    ADTU01027102    ADTU01027103    ADTU01027104    ADTU01027105    ADTU01027106    ADTU01027107    ADTU01027108    GFDF01001320    JAV12764.1    GDQN01003919    JAT87135.1    GEZM01031077    JAV85079.1    JH431963    CH902618    EDV39794.1    GACK01008975    JAA56059.1    IAAA01027008    LAA08011.1    GFAA01003961    JAT99473.1    GEDV01010247    JAP78310.1    CH964095    EDW79315.1    CH940647    EDW68634.1    CM002912    KMZ00898.1    CH480826    EDW44288.1    L35770    AE014296    AY070927    KA649311    KA649777    AFP64406.1    CM000159    EDW95105.1    CH954178    EDV52581.1    CH933816    EDW17326.1    KQ435078    KZC14509.1    CP012525    ALC45177.1    CH916366    EDV95819.1    OUUW01000002    SPP76889.1    JRES01000234    KNC33118.1    CH379069    EAL30719.1    KQ414735    KOC62233.1    GL449738    EFN82096.1    GAKP01018984    GAKP01018982    JAC39968.1    GEFM01006976    GEGO01001507    JAP68820.1    JAR93897.1    AAZX01000615    KQ982254    KYQ58721.1    KQ981082    KYN09644.1    GGFL01003695    MBW67873.1    GGFL01003660    MBW67838.1    KQ981820    KYN35209.1    GBXI01013562    JAD00730.1    GDHF01009145    JAI43169.1    GDHF01025046    JAI27268.1    GDHF01000439    JAI51875.1    KQ976424    KYM88244.1    GFWV01005158    MAA29888.1    CCAG010000604    CCAG010000605    GDRN01070981    JAI63776.1    GGFK01005533    MBW38854.1    GFJQ02002995    JAW03975.1    GAMC01011991    JAB94564.1    GDIP01142761    LRGB01002100    JAL60953.1    KZS09219.1    GDIQ01141493    JAL10233.1    GDIQ01193071    JAK58654.1    GDIP01098110    JAM05605.1    GDIQ01139541    JAL12185.1    GDIQ01227913    JAK23812.1    AB851458    BAP63967.1    GDIQ01194465    JAK57260.1    APCN01002268    APCN01002269    APCN01002270    GDIP01108349    JAL95365.1    GDIQ01152784    JAK98941.1    GDIQ01121940    JAL29786.1    CVRI01000047    CRK97336.1    AY676138    AAV84108.1    GDIP01055664    JAM48051.1    MNPL01002546    OQR78175.1    KQ977827    KYM99424.1    GFXV01008041    MBW19846.1    ABLF02039501    ABLF02039532    ABLF02039539    GGMR01010205    MBY22824.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000283053    UP000007151    UP000218220    + More
UP000037510    UP000009046    UP000007266    UP000279307    UP000192223    UP000005205    UP000007801    UP000007798    UP000008792    UP000001292    UP000000803    UP000002282    UP000008711    UP000009192    UP000192221    UP000076502    UP000092553    UP000001070    UP000268350    UP000037069    UP000001819    UP000078200    UP000053825    UP000008237    UP000091820    UP000002358    UP000075809    UP000078492    UP000078541    UP000078540    UP000092444    UP000076858    UP000075840    UP000095301    UP000183832    UP000076420    UP000192247    UP000078542    UP000007819   

PRIDE

B1B559    H9JBJ7    Q24342   

Pfam

PF02434   Fringe        + More
PF01530   zf-C2HC
PF02820   MBT

Interpro

IPR003378   Fringe-like        + More
IPR017374   Fringe       
IPR002515   Znf_C2H2C       
IPR004092   Mbt       

ProteinModelPortal

B1B559   H9JBJ7   A0A194QSD1   A0A194QE32   Q86MC1   A0A3S2P1N5   + More
A0A212ERS1   A0A2A4KAZ7   A0A0L7LAM4   A0A2H1WI07   E0V9K3   D6WZR0   A0A1B6EG05   A0A1X9ITA0   A0A146KVY3   A0A3L8DM07   A0A1B6MFN1   A0A1W4XWQ6   A0A0C9RXE9   A0A385JF78   A0A1B6FY57   A0A1B6JPC6   A0A1L8E2N9   A0A158NVD6   A0A1L8E260   A0A1E1WJH4   A0A1Y1MH03   T1J8T0   B3M6V8   L7LYZ5   A0A2L2YIP4   A0A1E1XJT3   A0A131YIM3   B4N3W0   B4LB70   A0A0J9RZ83   B4IAH5   Q24342   T1PLW7   B4PEN1   B3NIT5   B4L9F1   A0A1W4V986   A0A154PRH7   A0A0M4EJM5   B4J1C8   A0A3B0JT71   A0A0L0CL82   Q2M156   A0A1A9UVV0   A0A0L7QUB4   E2BQD2   A0A1A9W5R5   A0A034VEH4   A0A131XRV5   K7IX37   A0A151XEC5   A0A195DB56   A0A2M4CRE8   A0A2M4CSN0   A0A195F560   A0A0A1WQE2   A0A0K8VWC2   A0A0K8UL99   A0A0K8WLY6   A0A195BQK5   A0A293LPY3   A0A1B0G6C4   A0A0N7ZC89   A0A2M4ADJ3   A0A1Z5L9J1   W8BZA4   A0A0P5SJE9   A0A0P5Q132   A0A0P5JZ49   A0A0P5VM74   A0A0P5P663   A0A0P5HER5   A0A090B452   A0A0P5K5L9   A0A1Y9GLM6   A0A0P5UYG9   A0A0P5PB56   A0A1I8NIK1   A0A0P5PXR5   A0A1J1IAR5   Q49QW2   A0A0P5YMN0   A0A2C9KU68   A0A1V9XXE1   A0A195CEV8   A0A2H8TZY8   J9JPB6   A0A2S2P0B8  

PDB

2J0B     E-value=9.88774e-67,     Score=642

KEGG

100144549    K05948 fringe [EC:2.4.1.222] | (RefSeq) Fng; fringe

PATHWAY

00514    Other types of O-glycan biosynthesis - Bombyx mori (domestic silkworm)
04330    Notch signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0016757   GO:0016020   GO:0033829   GO:0008375   GO:0036066   GO:0008593   GO:0016021   GO:0007389   GO:0030173   GO:0046872   GO:0006493   GO:0036099   GO:0045747   GO:0035017   GO:0008587   GO:0005797   GO:0001745   GO:0048100   GO:0048190   GO:0036011   GO:0005783   GO:0007293   GO:0030707   GO:0005795   GO:0005794   GO:0007450   GO:0007476   GO:0048749   GO:0005737   GO:0005634   GO:0006355   GO:0008270   GO:0019805   GO:0016491   GO:0005216   GO:0006811   GO:0006541   GO:0016812   GO:0016597  

Subcellular location

Golgi apparatus membrane  

Length:

327

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

29.78765

Exp number, first 60 AAs:

18.02404

Total prob of N-in:

0.49153

POSSIBLE N-term signal

sequence

outside

1  -  9

TMhelix

10  -  32

inside

33  -  200

TMhelix

201  -  220

outside

221  -  327

 

 

Pi

25.282205

Theta

191.611767

Tajima's D

0.636407

CLR

0.205229

CSRT

0.556622168891555

Interpretation

Uncertain