Gene

KWMTBOMO05847

Pre Gene Modal

BGIBMGA006899

Annotation

E2F_transcription_factor_4-like_protein_[Bombyx_mori]

Location

Bomo_Chr10(-):12457322-12461690      View in EpiBrowser

Full name

Transcription factor E2F4      

Transcription factor

E2F

Location in the cell

Nuclear   Reliability : 3.281

CDS

ATGACTGATTTAAAATACAAAAGATATGAAAAATCTTTGGGTTTGCTCACAACTAAATTTGTTTCATTATTACAGAAAGCAAAAGACGGTGTTTTGGATTTAAAAATTGCTACCAATTTATTGGCTGTTAGACAAAAACGAAGAATATATGATATTACTAATGTTTTAGAGGGAATTGGTTTGATTGAAAAACGAAGTAAAAATAGCATTCAATGGAGAGGAGCAGGTCCCGATTATGATAAAAATGAAATTGGTAAAAAGGTAATGGGATTAAGAAAACAATTAAGCTATTTGGATGAACATGAAAGATTATTAGATAGGCGATTACAGTGGATTAAACAAAGTACGAAAAATGTTTTAGACGAACCAGACAACCAAGATATGTGTTTTGTCATGGATACTGAAATCCAGCAATGTTTTCAGAATGATCTAGTTTTAGTTTTAGAAGCACCATTGGGTGCAAATTTATCTATTGGAACACAACCAAATAAGGACAGAGAATCAAATTTTTTACTTCACATTAAATCATCAGAATCAATGGGGGTTGTGTTGCTAAACGATAAGGAGGAGGAGGAAGAGGAGGAGTATGAAGACGAAGAGACAAATAGTAATAACGAAATGGAAGATAATAATATCAAATGTTTCAAAAACTCAGAAGAAGCATCATTAATAAATGATTGCCTTTTGCGACTTAGTCCTCCGGCTTCGAAGTACGATTTCCTGTTTTCCTTGAGCAACACAGAAGGATTATGCGAACTTTTTGATATTCCTTGTTGA

Protein

MTDLKYKRYEKSLGLLTTKFVSLLQKAKDGVLDLKIATNLLAVRQKRRIYDITNVLEGIGLIEKRSKNSIQWRGAGPDYDKNEIGKKVMGLRKQLSYLDEHERLLDRRLQWIKQSTKNVLDEPDNQDMCFVMDTEIQQCFQNDLVLVLEAPLGANLSIGTQPNKDRESNFLLHIKSSESMGVVLLNDKEEEEEEEYEDEETNSNNEMEDNNIKCFKNSEEASLINDCLLRLSPPASKYDFLFSLSNTEGLCELFDIPC

Description

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes. Component of the EDM complex, a complex specifically required for multiciliate cell differentiation: the EDM complex binds and activate genes required for centriole biogenesis. Activates genes required for centriole assembly (plk4, cep152) and genes specifically required for motile cilia formation (foxj1). Also promotes the deuterosome pathway of centriole biogenesis by activating expression of deup1, but not its paralog cep63.

Subunit

Component of the drtf1/e2f transcription factor complex. Component of the EDM complex, at least composed of e2f4, e2f5, mcidas and tfdp1.

Similarity

Belongs to the E2F/DP family.

Keywords

Activator   DNA-binding   Nucleus   Transcription   Transcription regulation  

Feature

chain  Transcription factor E2F4

Uniprot

H9JBK4   Q2F6B1   A0A2A4J5H0   A0A2H1WMS7   A0A194Q867   S4PM20   + More
A0A212ETI0   A0A0L7LLY6   A0A194QRB0   A0A0N8CXB6   R7UPI4   E9GHV8   A0A3M6U9E2   A0A0P5LSC5   T2MDG2   A0A0N8CQ48   A0A0P5U5I5   A0A0L8GJ81   A0A0P5BNP9   A0A0P5EAA5   A0A0P5MPJ1   A0A0P6D8M1   A0A3B3RHC9   A0A0P5DDT0   A0A0P5LCM0   A0A0P5XA82   A0A0P5D632   A0A0P6I8F9   A0A0N8C0R4   A0A1B6E4X6   A0A2J7PJX7   H2Y549   A0A1S3W4B8   A0A067RG63   B3S7H0   A0A2B4RKB0   A0A0B6Y4M0   A0A232EZJ7   V3ZU63   K7JUF1   A0A1L8GLJ2   B0JZ97   A0A2C9JLT3   A7SL09   R4GAJ8   A0A3B3RFV9   A0A1L8GEZ4   Q6DE14   Q5ZJU1   A0A2T7NI19   A0A218V6Q6   H2XV16   U3JX79   A0A3Q0JUK2   C3ZBS5   Q4H3N4   A0A1W4Z0S3   A0A1W4Z145   A0A3B4DUS4   A0A1V4K0R1   W4ZKV4   A0A1S3ISI7   H2TIK9   G1MUE9   V9KQT0   A0A0P5UHV6   F7DAT3  

Pubmed

19121390    26354079    23622113    22118469    26227816    23254933    + More
21292972    30382153    24065732    29240929    24845553    18719581    28648823    20075255    27762356    15562597    17615350    21881562    24934224    15592404    15642098    12481130    15114417    18563158    12203911    12736827    15269171    16141696    21551351    20838655    24402279    20431018   

EMBL

BABH01024576    BABH01024577    DQ311161    ABD36106.1    NWSH01003269    PCG66642.1    + More
ODYU01009378    SOQ53764.1    KQ459302    KPJ01732.1    GAIX01003770    JAA88790.1    AGBW02012562    OWR44812.1    JTDY01000585    KOB76568.1    KQ461175    KPJ07879.1    GDIP01089719    LRGB01002580    JAM13996.1    KZS06938.1    AMQN01006870    KB299425    ELU08013.1    GL732545    EFX80902.1    RCHS01002005    RMX50221.1    GDIQ01176127    JAK75598.1    HAAD01003738    CDG69970.1    GDIP01109863    JAL93851.1    GDIP01119558    JAL84156.1    KQ421607    KOF77018.1    GDIP01181997    JAJ41405.1    GDIP01146008    JAJ77394.1    GDIQ01176126    JAK75599.1    GDIQ01081866    JAN12871.1    GDIP01161421    JAJ61981.1    GDIQ01176125    JAK75600.1    GDIP01076563    JAM27152.1    GDIP01162456    JAJ60946.1    GDIQ01009088    JAN85649.1    GDIQ01126147    JAL25579.1    GEDC01004477    GEDC01004312    JAS32821.1    JAS32986.1    NEVH01024944    PNF16641.1    KK852704    KDR18049.1    DS985254    EDV21198.1    LSMT01000518    PFX16797.1    HACG01004163    CEK51028.1    NNAY01001524    OXU23690.1    KB202823    ESO87892.1    CM004472    OCT84714.1    BC159089    AAI59090.1    DS469693    EDO35612.1    AAWZ02023721    CM004473    OCT82442.1    BC077333    AAH77333.1    AADN05000561    JQ678847    AJ720343    AFF59224.1    CAG32002.1    PZQS01000012    PVD20792.1    MUZQ01000037    OWK61683.1    EAAA01002293    AGTO01010687    GG666603    EEN50312.1    AB210388    BAE06393.1    LSYS01005191    OPJ78050.1    AAGJ04044559    JW868185    AFP00703.1    GDIP01112662    JAL91052.1    AAMC01003338    AAMC01003339    AAMC01003340    AAMC01003341   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000037510    UP000053240    + More
UP000076858    UP000014760    UP000000305    UP000275408    UP000053454    UP000261540    UP000235965    UP000007875    UP000079721    UP000027135    UP000009022    UP000225706    UP000215335    UP000030746    UP000002358    UP000186698    UP000076420    UP000001593    UP000001646    UP000000539    UP000245119    UP000197619    UP000008144    UP000016665    UP000001554    UP000192224    UP000261440    UP000190648    UP000007110    UP000085678    UP000005226    UP000001645    UP000008143   

PRIDE

H9JBK4    Q2F6B1   

Pfam

PF02319   E2F_TDP        + More
PF16421   E2F_CC-MB

Interpro

IPR037241   E2F-DP_heterodim        + More
IPR003316   E2F_WHTH_DNA-bd_dom       
IPR036388   WH-like_DNA-bd_sf       
IPR036390   WH_DNA-bd_sf       
IPR015633   E2F       
IPR032198   E2F_CC-MB       
IPR028312   E2F4       

SUPFAM

SSF46785   SSF46785        + More
SSF144074   SSF144074       

Gene 3D

1.10.10.10    

CDD

cd14660  E2F_DD

ProteinModelPortal

H9JBK4   Q2F6B1   A0A2A4J5H0   A0A2H1WMS7   A0A194Q867   S4PM20   + More
A0A212ETI0   A0A0L7LLY6   A0A194QRB0   A0A0N8CXB6   R7UPI4   E9GHV8   A0A3M6U9E2   A0A0P5LSC5   T2MDG2   A0A0N8CQ48   A0A0P5U5I5   A0A0L8GJ81   A0A0P5BNP9   A0A0P5EAA5   A0A0P5MPJ1   A0A0P6D8M1   A0A3B3RHC9   A0A0P5DDT0   A0A0P5LCM0   A0A0P5XA82   A0A0P5D632   A0A0P6I8F9   A0A0N8C0R4   A0A1B6E4X6   A0A2J7PJX7   H2Y549   A0A1S3W4B8   A0A067RG63   B3S7H0   A0A2B4RKB0   A0A0B6Y4M0   A0A232EZJ7   V3ZU63   K7JUF1   A0A1L8GLJ2   B0JZ97   A0A2C9JLT3   A7SL09   R4GAJ8   A0A3B3RFV9   A0A1L8GEZ4   Q6DE14   Q5ZJU1   A0A2T7NI19   A0A218V6Q6   H2XV16   U3JX79   A0A3Q0JUK2   C3ZBS5   Q4H3N4   A0A1W4Z0S3   A0A1W4Z145   A0A3B4DUS4   A0A1V4K0R1   W4ZKV4   A0A1S3ISI7   H2TIK9   G1MUE9   V9KQT0   A0A0P5UHV6   F7DAT3  

PDB

1CF7     E-value=9.3738e-29,     Score=314

KEGG

693080    K04682 transcription factor E2F4/5 | (RefSeq) E2F transcription factor 4-like protein

PATHWAY

04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005667   GO:0003700   GO:0003677   GO:0046983   GO:0005634   GO:0000278   GO:0051726   GO:0043565   GO:0090575   GO:0045944   GO:0008134   GO:0000981   GO:0000122   GO:0006884   GO:0008015   GO:0000083   GO:0002064   GO:0042127   GO:1990841   GO:0019904   GO:0005654   GO:0009887   GO:0001228   GO:0000978   GO:0060271   GO:0000790   GO:0044458   GO:0098534   GO:1903251   GO:0006355   GO:0008270   GO:0005216   GO:0006811   GO:0006541   GO:0016812   GO:0016597  

PANTHER

PTHR12081   PTHR12081:SF42  

Subcellular location

Nucleus  

Length:

258

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00651

Exp number, first 60 AAs:

0.00287

Total prob of N-in:

0.19074

outside

1  -  258

 

 

Pi

17.599855

Theta

42.438539

Tajima's D

-2.040994

CLR

49.219853

CSRT

0.0113494325283736

Interpretation

Uncertain