SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO05813
Pre Gene Modal
BGIBMGA006909
Annotation
PREDICTED:_DEP_domain-containing_protein_5_[Bombyx_mori]
Full name
GATOR complex protein Iml1      
Alternative Name
Increased minichromosome loss 1
Location in the cell
Nuclear   Reliability : 2.127
 

Sequence

CDS
ATGAAGTCCTTTAAACTCATTGTACATCAGTCTAGTTTTAGCCCCGAAGATTTGATTATCAACTTGAAAGACTATCCAGGGTTAAAGGAAAAAGATATAGTCGAAATTTATCATCCCGAAAATGACTACCCCCGATTATTACTACAAGTTACAAAAGTGGACGCCCCCGGACGCGGCAGAGATACAATTAGTGTGGAACAAAGTATTGCTACCACTTTCCAACTCCGAACGTTTGCTGATGTCTATGTAAATATAGTCAATGTGCAAGATGTGGCTTTGGATTCAGTGGAATTAACATTCAAAGACCAATATCTCGGAAGATCCGAAATGTGGAGACTTAAAAATCACCTAGTAAGCACCTGCGTTTATTTAAACAAGAAGATAGAATATTGTGGTGGTGCAATTAGATGTCAAGTATATGAAATGTGGTCACAAGGGGACAGAGTTGCTTGTGGGGTAATCACTGAAGACACAAAAATAGTGTTCAGATCATCAACTTCAATGGTCTACCTCTTCATTCAAATGTCTTCTGAAATGTGGGATTTTGACATCCATGGTGATCTGTACTTTGAAAAGGCAGTTAATGGTTTCCTCGCTGATTTGTTTGCCAAATGGAAGAAAAATGGCAGTAATCATGAAGTAACCATAGTTCTCTTTTCAAGAACTTTTTATAAAGCTAAGTCTTTAGAAGAATTTCCTCAACATATGCAAGAGTGCTTGCAAAAAGATTACAGGGGGAGATTTTATGAAGACTTTTACAGGGTTGCAGTACAAAATGAGAGATATGAAGACTGGTCAAATGTACTACTACAATTAAGAAGACTCTTTACTGATTATCAAAAGATTGTGCTTCAGTACCATGAAAGGCCTAACATGGACATACCCACAGCAATAAACTCCACTGCTGCACAAGGAAATTTCCTAGAAGTCCTTAACATGAGTTTGAATGTATTCGAAAAACATTACCTGGATAGATGTTTCGACAGAACGGGGCAGCTGAGTGTGGTAATAACCCCAGGAGTAGGTGTATTTGAAGTCGACAGAGAACTGACTAATGTTACAAAACAAAGAATCATTGACAATGGTGTTGGCAGTGACTTAGTTTGTGTAGGAGAACAACCTCTGCATGCTGTGCCTTTACTAAAGTTCCACAATAAAGACAATAATTTGAATTCAATTGATGATTATTCGATGCCACATTGGATTAATCTATCATTTTATTCTACAAATAAAAAAGTGGCTTATTCCAATTTCATACCAAGAATTAAATTGCCTCCACGAAAGAGCCAAGAACCATTACGTAAAATGTATGAAGATGAGAGGAAAGGTAAATTGTTGAAAGAAGATGAATGTATGCACAATTCTATATTTGATTATGATGCATACGACGCGCAAGTTTTTCAGTTACCCCCCGCTCACAGCACACGGGTACAAAGGGTCGCCAGGACTAAGAAAACTTCTGTGGCGGGTTTAGAAGGCTTAAATCGTAGGAGCCCTCCAGCTTCTACTTTGCATCACAGAAAAATGTCGGATCCGGACATCCATCATAGCCTTGGAGATCTTTTGACTTCTGGAAACAAGTCCGCAGGCTACGACGCGGGCAGTGACACAACGGACTCGCCGATGTCGACGAACCGACTCTCGCCGCGCAGTTCGATATCTTCAATCAAGCCCGTTATCAGGACGGGCAGGGCACTCATCAACCCCTTCGATCCCTCGCATGTCACTGTCAAACTGACCAGTAACCGTCGAAGGTGGACGCATATATTTCCGAAAGGTCCAACTGGCGTATTGATACAGCAACATCACTACCAGGCCCGTCCCGCTGGCGAGCCGGCCCGCAACGAAGAGCATCGCTGCGAAAGTAACACACCAAAGGATAATGGTTCCTCGATATTAAACAACAACCATTCTATATATCAGGTTGACGGCAACATTATGTCGCGGAAACGCATGATAAGTGCGTCAGGAACGTTAGCCGTGCTCGGCGTGTCCGGGGGGACTCCCTCCACGACCAACAATGCGTCGCTCGCGCTGCTGTGGGGGGCTACGGGCGAACAGGAGTGGACCCCCGCTCTGACGACAGGGGTCGACTGGAAGTCACTGACCATACCTGCCTGCCTTCCGATCACTACGGACTACTTTCCCGACAAGAGATCACTTCAAAACGATTATCTAGTATCGGATTATAATCTGTTACCGGACGACGTGAACGCCGATTTCGCACAGAACCGAGCTATATACAAAGATCCCCTGACCACAATGGAAGTATTCAAGGAGTTGGTCTCACAAAGATTAGCTCAGGGTTTCCAGCTGATTGTGGGTGTTAACGAGAATGAAGTAATCGAATCTCACTGTGCGTCAACGGCGACTCCCCCACCATCCAAAGTGGCCCCACAGTGCGGGAAACCAGCCAACGCAGCACCCACCAAGCGTTACCTGCTCTCGATTGGGAGGATCTTCCACAAACTTACGCTGGTCGGGTCCACCATCACCGTCACTAGATACAGACCCAGACATCCATATCCGCCATTCAATATACACTACCGTTATCGTTTCCACGCACCGAACCACGACACGTACGAGGTGTCGTGGGTTTCGTTCACGACAGAAAAACTGGAAACTTACTACTGGAACTACATGGACCATTACATTTGTACGCGCGGCGACAGTGATTTCGCACTAGTTGAGCCTCTGAAGTACTGGCGGTTCCGGACTCTACTATTGCCTCTCTACAATCCGGCAACGAAACAAATTCTCGAAGACGATTCGACCCACTGCGACATATATCCAACTCCGACGCGTCATGATTTGGACCAACTAACCGATAATTTCCTCAAAATGACCGAATTGTATTTCAATAAAGTCAAAAGGCCAAACAAACAGAGGATGGCGGGCGCGGGCTGCGGCGCTAGCGACGCGGCACTCACGCGGCGCCGACACTCCACCTCCATCCTCACGCGGAGCGCACAGGCAGGGGTATCGAGCTCTCCATTCAGAGAGCGCGTTGGCAGCACCCGGCTACCTGACCGGCCTCGCCTCCGGATGGAAGCTATGGCGACGAAAGCAGTGCTAGAAAGGACGCAATCCCAAACCGGAGAAGCGGATGACACTTATGATGACGGAGTTTCAGAACCGAAACTGAAAGCGAACGCGCCATTGTCGGATGTCGTAGATAGAATGCGACACCCGACTCTGGGCTTGGGTTTCCTACAACAGACGGTCAGTTTGCCCTCGCATACATTCGTTTCGATATACGCCATACATTGGCTCCAAGAAAACATGGAGGGAATGGATTATGAAAAGGCTGCCAGTCTTATGGAGAGATTATTGAATGAGAAAATGATTTGTCATGCTTCAGGCGACACCACAAAACGTTTCGTTGTCGGATACTACATGTATCACATACTACCACAAAAGAAAGATAAAGAATTACCAGACTACGTGAAGCCCCTAGGAGACCTCCAGAGCTTCGAAAACGAATGGATGGAAGTTGAGGTACTGGGGCCGCGTTCGCCGCTCATACAAGTGGACAAAGCGAGCGGCGCCATAGATATATCTGGTTCTAGTCCTCTGGCCGACGACACGGGCGTTCCCGCCTTCCTGTGCGATAATATTGATCCAAACTACATGCAAATCGATAGCGACAGCGAAATACCCTTGTACAAGAAAACCCACCTAGATATAGATGTGAATAATAAAAGCGACCGGATCGAATGGGGCCACGCACGATATCAAGCCACGTTCCGACCGGACCAAGCCTTCGAAATGTGCATACAGTGGACAGTCGCCAGCGGAAATATTGTTGCCGAACTGATATTCGGATGGGCTCGTAAAGCCTCGTCCAACTGTAAGCTACAAATGGTGCCTATTCCTGCGGACCCCCTCGCTTTACCATTCACCCTCAAATCAGACCCGTTGCGAGGTCCGATTTACATTCCTATGAACGTAGAACCATTGTTGAGAAATAAGACTGTTTTGTTTGAAGGCTTCCCGGAAGAGACATGGCTCCAGCGTTTGTTCCTATTCCAAGAGGCCATAGTGGGTCGTTTCGGCTTCGTGAAGTGCACGGTCGAGAGCACGTCGCACGAGTGGGAGCGCGGCACGCCCCGCGGCTCGCCCACCGGGGACCACCTGTACGTGCACGTGACCGGGAACATGTTCATACTCATACCGACGACGGTCAAGTCCGAGCAGAAGTCGTCGAAGGTCAAGCCGCCGAACAGAACGCTGTGTAACAAGTACCCTGTGCCGACAGAAGTTGCCAACAGTCCTCATGAAGCTTATATTTCTCGACATGTCGGGTACAAAACGAACGACTACAATAATAGCAGACGGATGGGATTTTTATGGTCTTGGAATCACATGATTTCAAAGAAATGGAAGGGTTCACAAACACCAGCCACAGGAGACGAAGGTTTCCAAATGCGAATGCTAAGGGATTTCAAACATTTCTGTGCCAATCAGGAACAGAGGCTTAGTCAATTTTGGGATCACTGCTGGGAACTAAAGGATAAATCCCGAGGAATGACATCTTGTTAA
Protein
MKSFKLIVHQSSFSPEDLIINLKDYPGLKEKDIVEIYHPENDYPRLLLQVTKVDAPGRGRDTISVEQSIATTFQLRTFADVYVNIVNVQDVALDSVELTFKDQYLGRSEMWRLKNHLVSTCVYLNKKIEYCGGAIRCQVYEMWSQGDRVACGVITEDTKIVFRSSTSMVYLFIQMSSEMWDFDIHGDLYFEKAVNGFLADLFAKWKKNGSNHEVTIVLFSRTFYKAKSLEEFPQHMQECLQKDYRGRFYEDFYRVAVQNERYEDWSNVLLQLRRLFTDYQKIVLQYHERPNMDIPTAINSTAAQGNFLEVLNMSLNVFEKHYLDRCFDRTGQLSVVITPGVGVFEVDRELTNVTKQRIIDNGVGSDLVCVGEQPLHAVPLLKFHNKDNNLNSIDDYSMPHWINLSFYSTNKKVAYSNFIPRIKLPPRKSQEPLRKMYEDERKGKLLKEDECMHNSIFDYDAYDAQVFQLPPAHSTRVQRVARTKKTSVAGLEGLNRRSPPASTLHHRKMSDPDIHHSLGDLLTSGNKSAGYDAGSDTTDSPMSTNRLSPRSSISSIKPVIRTGRALINPFDPSHVTVKLTSNRRRWTHIFPKGPTGVLIQQHHYQARPAGEPARNEEHRCESNTPKDNGSSILNNNHSIYQVDGNIMSRKRMISASGTLAVLGVSGGTPSTTNNASLALLWGATGEQEWTPALTTGVDWKSLTIPACLPITTDYFPDKRSLQNDYLVSDYNLLPDDVNADFAQNRAIYKDPLTTMEVFKELVSQRLAQGFQLIVGVNENEVIESHCASTATPPPSKVAPQCGKPANAAPTKRYLLSIGRIFHKLTLVGSTITVTRYRPRHPYPPFNIHYRYRFHAPNHDTYEVSWVSFTTEKLETYYWNYMDHYICTRGDSDFALVEPLKYWRFRTLLLPLYNPATKQILEDDSTHCDIYPTPTRHDLDQLTDNFLKMTELYFNKVKRPNKQRMAGAGCGASDAALTRRRHSTSILTRSAQAGVSSSPFRERVGSTRLPDRPRLRMEAMATKAVLERTQSQTGEADDTYDDGVSEPKLKANAPLSDVVDRMRHPTLGLGFLQQTVSLPSHTFVSIYAIHWLQENMEGMDYEKAASLMERLLNEKMICHASGDTTKRFVVGYYMYHILPQKKDKELPDYVKPLGDLQSFENEWMEVEVLGPRSPLIQVDKASGAIDISGSSPLADDTGVPAFLCDNIDPNYMQIDSDSEIPLYKKTHLDIDVNNKSDRIEWGHARYQATFRPDQAFEMCIQWTVASGNIVAELIFGWARKASSNCKLQMVPIPADPLALPFTLKSDPLRGPIYIPMNVEPLLRNKTVLFEGFPEETWLQRLFLFQEAIVGRFGFVKCTVESTSHEWERGTPRGSPTGDHLYVHVTGNMFILIPTTVKSEQKSSKVKPPNRTLCNKYPVPTEVANSPHEAYISRHVGYKTNDYNNSRRMGFLWSWNHMISKKWKGSQTPATGDEGFQMRMLRDFKHFCANQEQRLSQFWDHCWELKDKSRGMTSC

Summary

Description
An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27672113, PubMed:25512509). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:27672113, PubMed:25512509). The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy (PubMed:23723238, PubMed:27672113, PubMed:25512509). GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:27672113, PubMed:25512509). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:27672113, PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:27672113, PubMed:25512509).
Subunit
Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 (PubMed:27166823).
Similarity
Belongs to the IML1 family.
Keywords
Alternative splicing   Cell cycle   Cell division   Complete proteome   Meiosis   Mitosis   Reference proteome  
Feature
chain  GATOR complex protein Iml1
splice variant  In isoform B.
EMBL
NWSH01000730    PCG74553.1    PCG74555.1    PCG74552.1    PCG74554.1    RSAL01000003    + More
RVE54847.1    PCG74551.1    GDQN01006869    JAT84185.1    AGBW02012322    OWR45226.1    GDQN01007419    JAT83635.1    KQ461175    KPJ07848.1    KQ459302    KPJ01766.1    BABH01024477    BABH01024478    BABH01024479    GL446901    EFN87095.1    ADTU01005761    ADTU01005762    ADTU01005763    ADTU01005764    ADTU01005765    ADTU01005766    ADTU01005767    KQ414661    KOC65522.1    KZ288230    PBC31633.1    KQ435855    KOX70637.1    QOIP01000001    RLU26392.1    AAZX01006262    GL439108    EFN67807.1    NNAY01000061    OXU31405.1    KQ434899    KZC10817.1    KQ982691    KYQ52041.1    DS235763    EEB16663.1    GEZM01088826    JAV57876.1    GEZM01088831    JAV57870.1    GFDF01006419    JAV07665.1    KQ981200    KYN45026.1    GFDL01009194    JAV25851.1    KK107260    EZA54070.1    GBBI01003463    JAC15249.1    GFDL01009188    JAV25857.1    GEDC01030206    GEDC01013922    JAS07092.1    JAS23376.1    DS232000    EDS31142.1    CH477944    EAT34884.1    KQ971371    EFA09893.1    GGFK01004942    MBW38263.1    APGK01043371    APGK01043372    APGK01043373    KB741014    ENN75447.1    GBXI01007420    JAD06872.1    GAMC01013315    JAB93240.1    AAAB01008807    EAA45449.4    GDHC01003374    JAQ15255.1    CCAG010014092    CCAG010014093    GECZ01019853    JAS49916.1    GEZM01088836    JAV57860.1    GAMC01013313    JAB93242.1    JRES01000254    KNC32927.1    GEZM01088830    JAV57871.1    CVRI01000059    CRL03427.1    GEDC01028514    JAS08784.1    GECZ01000571    JAS69198.1    CRL03426.1    CH954178    KQS43078.1    KQS43074.1    GBXI01007145    JAD07147.1    AJWK01021990    AJWK01021991    GECZ01025621    JAS44148.1    CH379067    EAL31308.3    CH933816    KRG07618.1    CH940647    KRF84042.1    AE014296    AGB93955.1    CM000159    KRK00748.1    EDV50171.2    CM002912    KMY96843.1    KQS43082.1    KRG07617.1    KRT07390.1    KRT07392.1    KRF84044.1    KRK00749.1    OUUW01000009    SPP84863.1    EDW92846.2    CH902618    KPU77708.1    CH963847    EDW72802.2    AY075414    BT125948    AAL68237.1    ADX35927.1    AAN11486.1    KPU77717.1    KMY96845.1    KMY96844.1    EDW17128.2    KQS43081.1   
Pfam
PF12257   IML1        + More
PF00610   DEP
PF17976   zf-RING_12
PF00240   ubiquitin
PF17978   zf-RING_14
PF00814   Peptidase_M22
PF00583   Acetyltransf_1
Interpro
IPR036388   WH-like_DNA-bd_sf        + More
IPR027244   IML1       
IPR036390   WH_DNA-bd_sf       
IPR000591   DEP_dom       
IPR041565   Parkin_Znf-RING       
IPR000626   Ubiquitin_dom       
IPR036291   NAD(P)-bd_dom_sf       
IPR020904   Sc_DH/Rdtase_CS       
IPR029071   Ubiquitin-like_domsf       
IPR041170   Znf-RING_14       
IPR003977   Parkin       
IPR002867   IBR_dom       
IPR000182   GNAT_dom       
IPR016181   Acyl_CoA_acyltransferase       
IPR000905   Gcp-like_dom       
SUPFAM
SSF46785   SSF46785        + More
SSF51735   SSF51735       
SSF54236   SSF54236       
SSF55729   SSF55729       
Gene 3D
PDB
6CET     E-value=0,     Score=2021

Ontologies

Topology

Length:
1513
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0675400000000001
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00031
outside
1  -  1513
 
 

Population Genetic Test Statistics

Pi
201.534252
Theta
157.623861
Tajima's D
0.942118
CLR
0.132598
CSRT
0.63896805159742
Interpretation
Uncertain
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