Gene

KWMTBOMO05812  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006946

Annotation

caspase-1_[Bombyx_mori]

Location

Bomo_Chr10(+):10669121-10670302      View in EpiBrowser

Full name

Caspase-1       + More
Caspase      

Alternative Name

drICE

Location in the cell

Extracellular   Reliability : 1.785 Nuclear   Reliability : 1.308

CDS

ATGGCTGATGAAGAAAAGAAAAACAATGGCTCTGGAACAGAACAAAGGAAAAACGGCAACGAAGACGAAGGCGACGCATGGGGCAGTCATGGATCTTCACAAGGGCGACGTTATGCGAAAATGCCTGTCGAAAGATATGCTCATTACTATAACATGAACCACAATAATCGTGGTATGGCGATCATTTTCAATCATGAACATTTTGAAATTCATAATCTAAAATCTCGCACGGGCACCAATGTGGACAGTGACAGCTTATCTAAAGTCCTGAGAGGCTTAGGTTTCAGTGTTACTGTTCTTCATAACCTAAGAGCTGAAGATATCAACAGATATATACAACAGATATCTGAAATGGATCACACAGATAATGATTGTCTGCTGGTTGCTGTGTTGAGTCATGGAGAATTAGGTATGTTGTATGCCAAAGACACTCATTATAAACCAGATAATCTGTGGTATTACTTCACTGCTGATAAATGTCCAACTCTAGCTGGAAAACCAAAGCTGTTCTTTATTCAAGCTTGCCAAGGTGATAAGTTAGATGGTGGAATAACATTATCCAACACTGAAACAGATGGTTCTTCGTCTTCATCCTACAGAATCCCAATTCATGCTGACTTTTTGATTGTGTTCTCAACGGTACCAGGTTATTACTCTTGGAGAAACACAACTCGTGGCTCTTGGTTTATGCAATCTCTTTGTGAAGAATTGAGAAACTATGGTACTCAAAGAGATATTCTTACACTCTTGACATTTGTTTGTCAGAGAGTTGCTTTAGATTTTGAGTCAAATACACCAGATATCACACCGATGCATCAACAAAAACAGGTACCTTGCATAAATAGTATGCTGACACGCCTTCTCTTGTTTGGAAAAAAATAA

Protein

MADEEKKNNGSGTEQRKNGNEDEGDAWGSHGSSQGRRYAKMPVERYAHYYNMNHNNRGMAIIFNHEHFEIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQISEMDHTDNDCLLVAVLSHGELGMLYAKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGSSSSSYRIPIHADFLIVFSTVPGYYSWRNTTRGSWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTRLLLFGKK

Description

Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity). Inhibited by the baculovirus anti-apoptotic protein p35. Cleaves p35 and nuclear immunophilin FKBP46.

Subunit

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 19/18 kDa (p19/18) and a 12 kDa (p12) subunit.
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 21 kDa (p21) and a 12 kDa (p12) subunit. Inactive pro-form can homodimerize. Dronc and Drice can form a stable complex (PubMed:10675329). Interacts with Diap2 (via BIR3 domain) to form a stable complex (PubMed:18166655).

Similarity

Belongs to the peptidase C14A family.

Keywords

3D-structure   Apoptosis   Direct protein sequencing   Hydrolase   Protease   Thiol protease   Zymogen   Complete proteome   Reference proteome  

Feature

chain  Caspase-1 subunit p19/18

Uniprot

H9JBQ1   Q8I9V7   F6K5R8   A0A1E1WPY0   B6EEC1   I2EC37   + More
Q2TVJ7   F6K5S3   A7L9Z3   G1ELA2   A9Q0J3   G0XQE9   C6YXH1   G0XQE8   A0A0L7KY59   K4PXX6   H6V6K4   Q8I955   A0A194QQQ6   A0A2A4JRA2   A0A194Q8Q5   A0A2H1VLH4   P89116   D9IVD4   S4PEK3   G0XQE5   J9PJR5   A0A212EUQ8   G5CV11   G0XQE6   K4Q332   G0XQE4   F8UU16   G0XQE7   A0A0K8TSG1   A0A1W4W9I1   K7J065   A0A232EYP6   A0A1W4W9I8   A0A154PEN4   O01382   A0A1B0DJJ8   B4HZF1   A0A336MXM6   B4R093   A0A0C9RND9   A0A1Q3EXQ9   A0A3L8DWL7   E2AAJ3   B4NBM1   B0W0K2   A0A1W4UCU4   B4KAN6   B4PPJ9   D6WFK4   B4M0P7   A0A139WKB8   A0A1B0G224   A0A1P7XV02   E2B4X5   D3TL84   A0A182PVZ2   A0A2J7PIQ1   A0A1A9ZSW0   A0A182XXX5   A0A1A9VDR7   A0A182RMT7   A0A088A747   A0A1B0B2Z4   F4WFL7   A0A1A9W5Q4   A0A3B0JG01   A0A1L2F0C2   A0A182H4R2   Q297T5   A0A182LYX6   A0A0M4EUT4   B3LWX5   B4G307   A0A151J4A4   A0A1I8M9Z6   A0A084VH01   A0A182Q649   A0A1J1IZC7   E9IB18   A0A182W5E0   A0A182N1J2   T1EA88   A0A182IX37   A0A151HYK2   A0A0J7N6M5   B5AK94   A0A1I8P6R3   A0A151WIC1   B4JRJ9   W5JK07   A0A2M3ZJ43   A0A2M4AW77   A0A1W4UNE7   B3NPN7  

EC Number

3.4.22.-

Pubmed

19121390    12324475    21740565    19027856    17541728    17603110    + More
26227816    26354079    8999805    23622113    22118469    22229544    26369729    20075255    28648823    9184225    10731132    12537572    12537569    10675329    18166655    17994087    30249741    20798317    17550304    18362917    19820115    20353571    25244985    21719571    26483478    15632085    25315136    24438588    21282665    20920257    23761445   

EMBL

BABH01024476    AF448494    AAN86250.1    HM234675    AEF30493.1    GDQN01002016    + More
JAT89038.1    FJ266474    ACI43910.1    JQ864206    AFJ97219.1    AY159381    AAO17788.1    HM234680    AEF30498.1    EF688063    HQ645847    ABS18284.1    AEH16632.1    JN113041    AEK12771.1    EF190236    ABO93468.1    HQ328953    AEK20810.1    EF211965    ACU11588.1    HQ328952    AEK20809.1    JTDY01004421    KOB68178.1    AB755808    BAM62940.1    JN794535    AFA43940.1    AF548387    AAO16241.1    KQ461175    KPJ07838.1    NWSH01000730    PCG74557.1    KQ459302    KPJ01774.1    ODYU01003219    SOQ41673.1    U81510    HM204505    ADK24087.1    GAIX01004462    JAA88098.1    HQ328949    AEK20806.1    JF798683    AEQ18745.1    AGBW02012322    OWR45225.1    JN410830    AEP25406.1    HQ328950    AEK20807.1    AB755807    BAM62939.1    HQ328948    AEK20805.1    JF906728    AEH76885.1    HQ328951    AEK20808.1    GDAI01000733    JAI16870.1    NNAY01001601    OXU23463.1    KQ434878    KZC09894.1    Y12261    AE014297    AY058451    AJVK01028708    AJVK01035047    CH480819    EDW53408.1    UFQT01001457    SSX30638.1    CM000364    EDX14899.1    GBYB01009880    JAG79647.1    GFDL01014948    JAV20097.1    QOIP01000003    RLU24837.1    GL438128    EFN69540.1    CH964232    EDW81185.1    DS231818    EDS41304.1    CH933806    EDW16773.1    CM000160    EDW98249.1    KQ971328    EFA01345.2    CH940650    EDW67339.1    KYB28363.1    CCAG010010758    KF955542    KF955543    KZ288416    AIS23518.1    AIS23519.1    PBC26031.1    GL445671    EFN89257.1    EZ422185    ADD18379.1    NEVH01024980    PNF16221.1    JXJN01007738    GL888120    EGI66994.1    OUUW01000005    SPP81055.1    KX463639    ANQ91917.1    JXUM01003922    JXUM01003923    KQ560165    KXJ84059.1    CM000070    EAL28120.3    AXCM01000181    CP012526    ALC46917.1    CH902617    EDV43814.1    CH479179    EDW24202.1    KQ980159    KYN17427.1    ATLV01013118    KE524840    KFB37245.1    AXCN02001449    CVRI01000063    CRL04900.1    GL762102    EFZ22232.1    GAMD01001223    JAB00368.1    KQ976719    KYM76754.1    LBMM01009157    KMQ88345.1    EU854472    ACF71490.1    KQ983089    KYQ47566.1    CH916373    EDV94389.1    ADMH02001211    ETN63643.1    GGFM01007846    MBW28597.1    GGFK01011728    MBW45049.1    CH954179    EDV56828.1   

Proteomes

UP000005204    UP000037510    UP000053240    UP000218220    UP000053268    UP000007151    + More
UP000192223    UP000002358    UP000215335    UP000076502    UP000000803    UP000092462    UP000001292    UP000000304    UP000279307    UP000000311    UP000007798    UP000002320    UP000192221    UP000009192    UP000002282    UP000007266    UP000008792    UP000092444    UP000242457    UP000008237    UP000075885    UP000235965    UP000092445    UP000076408    UP000078200    UP000075900    UP000005203    UP000092460    UP000007755    UP000091820    UP000268350    UP000069940    UP000249989    UP000001819    UP000075883    UP000092553    UP000007801    UP000008744    UP000078492    UP000095301    UP000030765    UP000075886    UP000183832    UP000075920    UP000075884    UP000075880    UP000078540    UP000036403    UP000095300    UP000075809    UP000001070    UP000000673    UP000008711   

PRIDE

H9JBQ1    Q8I9V7    O01382   

Interpro

IPR015917   Pept_C14A        + More
IPR016129   Caspase_his_AS       
IPR029030   Caspase-like_dom_sf       
IPR001309   Pept_C14_p20       
IPR002138   Pept_C14_p10       
IPR002398   Pept_C14       
IPR033139   Caspase_cys_AS       

SUPFAM

SSF52129   SSF52129       

CDD

cd00032  CASc

ProteinModelPortal

H9JBQ1   Q8I9V7   F6K5R8   A0A1E1WPY0   B6EEC1   I2EC37   + More
Q2TVJ7   F6K5S3   A7L9Z3   G1ELA2   A9Q0J3   G0XQE9   C6YXH1   G0XQE8   A0A0L7KY59   K4PXX6   H6V6K4   Q8I955   A0A194QQQ6   A0A2A4JRA2   A0A194Q8Q5   A0A2H1VLH4   P89116   D9IVD4   S4PEK3   G0XQE5   J9PJR5   A0A212EUQ8   G5CV11   G0XQE6   K4Q332   G0XQE4   F8UU16   G0XQE7   A0A0K8TSG1   A0A1W4W9I1   K7J065   A0A232EYP6   A0A1W4W9I8   A0A154PEN4   O01382   A0A1B0DJJ8   B4HZF1   A0A336MXM6   B4R093   A0A0C9RND9   A0A1Q3EXQ9   A0A3L8DWL7   E2AAJ3   B4NBM1   B0W0K2   A0A1W4UCU4   B4KAN6   B4PPJ9   D6WFK4   B4M0P7   A0A139WKB8   A0A1B0G224   A0A1P7XV02   E2B4X5   D3TL84   A0A182PVZ2   A0A2J7PIQ1   A0A1A9ZSW0   A0A182XXX5   A0A1A9VDR7   A0A182RMT7   A0A088A747   A0A1B0B2Z4   F4WFL7   A0A1A9W5Q4   A0A3B0JG01   A0A1L2F0C2   A0A182H4R2   Q297T5   A0A182LYX6   A0A0M4EUT4   B3LWX5   B4G307   A0A151J4A4   A0A1I8M9Z6   A0A084VH01   A0A182Q649   A0A1J1IZC7   E9IB18   A0A182W5E0   A0A182N1J2   T1EA88   A0A182IX37   A0A151HYK2   A0A0J7N6M5   B5AK94   A0A1I8P6R3   A0A151WIC1   B4JRJ9   W5JK07   A0A2M3ZJ43   A0A2M4AW77   A0A1W4UNE7   B3NPN7  

PDB

2NN3     E-value=1.47847e-136,     Score=1244

KEGG

692604    K04397 caspase 7 [EC:3.4.22.60] | (RefSeq) Caspase1, BmCaspase1, Ice; caspase-1

PATHWAY

04214    Apoptosis - fly - Bombyx mori (domestic silkworm)
04215    Apoptosis - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0004197   GO:0006915   GO:0005737   GO:0010623   GO:2001269   GO:0010165   GO:0046672   GO:0006508   GO:0012501   GO:0097200   GO:0035070   GO:0048515   GO:0045476   GO:1990525   GO:0016322   GO:0035103   GO:0097153   GO:0046668   GO:0008234   GO:0008408   GO:0003677   GO:0005216   GO:0006811   GO:0006541   GO:0016812   GO:0016597  

PANTHER

PTHR10454  

Length:

293

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.505399999999999

Exp number, first 60 AAs:

0.00044

Total prob of N-in:

0.10255

outside

1  -  293

 

 

Pi

235.723211

Theta

154.665156

Tajima's D

1.887408

CLR

1.517568

CSRT

0.861906904654767

Interpretation

Possibly Positive selection