Gene
KWMTBOMO05811
Pre Gene Modal
BGIBMGA006911
Annotation
PREDICTED:_protein_PTHB1_isoform_X2_[Bombyx_mori]
Full name
Protein PTHB1
Alternative Name
Bardet-Biedl syndrome 9 protein homolog
Parathyroid hormone-responsive B1 gene protein homolog
Parathyroid hormone-responsive B1 gene protein homolog
Location in the cell
Nuclear Reliability : 2.263
Sequence
CDS
ATGTCTATCTTTAAAGTCAAATATTGGTGGTCTACCGACAGTCTCCACACTAAGGAGACAGTGAGTGGATCCCAAAACGCTTATAGTCTAAAAGTGGACAGATTCAATTCTCACAGTGACAGTGACTGTATATTGTTAGCAGAGGAATCGACAATAAAAGTATTTAAACCTAATATAGAGCAAGAAAATTCACATACACTTTTAGAAAGTGAATTGGAAGATGTTATATTACAAATCGAAACAGGTAAATTTGTAAGCGAGATCGCGGACAGGCAGATAATTGTGCTACATGCGAGAAGCTACTCTATCTATCAGTTACTTAAACAGGAAGGTCATACAAACGCAGGCGAACAAAATAAACTTGAACCATTAGTTAGGCATGCGTTCACAAGAAAAGCTGACAGTTTGACGTGTGGTCCTTTTGGGAATATAAAAACCCGTGATTTTATATGTATCCAAGGCCTCGATGGAAGTTTAAGCTTCTTTGATCAGGATACATTTTTATTTCTATGTATTTTCAATGATGTCATTATTCCTGGACCGATATCTTACATTGCAAATTGCGATGCATTTGTTTTATGTAAGTCGACTTGGGTTTTAGAAATTTATAGCTACCAGCAACTACGAGAGTTCAGTGAGTTAAGCTTACGACAGAATAAACAAAATGTACCCCAATGGACGTACAGTGCCTGTGAAGAAATTACACAAATACAAGTCATTCAGACTAGCAGCAATTTTTCTAGTATCATAGCACTAGGAGAAAGACATCTTTGCTGTTTTCAAGACAACGGCTTAATGAAATTCATGATAAAATTCGATTATATGCCAATGTGTTTTAATAGTTATCTTATTGGATGGTATTACGAGCCAACTGCACGAATGTTAGTAATGGTAGCTTCAGATGATTGCAAATTATATGTTTACGAAAACACGACCTTACTATGGTCGTGTGATTTACTACATCCAGTTATCTCCATAGCGCGTTGTTTTCTAAAAAATCTTCCCGGAGGAATAGTGAGTTTATCAAATACTGGTATAGTAAACGTAGGCTATTTAGGCACGGAGCCCGATCTCAACGGTAACGCTAGAGCCATGATCAACGAGCCGATTGATCCGGAACAGATTCAAGCCGAATTGGACGAGGTTGAAAGTGCTCTCCAAAAACTTTTAGATGATAAAGACGAAGCGGCTACCAGCTTTTCATTAGTAGAACGAACAATAAATATAAAGGCGGACGTCGGGAAACCAGTTCAAAATTTGTTTCAAGAATTTTCTAAAGGAGACGAAGCTTTACATTTGCTTATGTGCCCTATCATAGTAATGATAACGTGCGATGATCCCAAAATTATACAAAACGTCCAAATATCATATGTTTGTTGTTTTCCGTTCGCTTGTTCAGAGTCTGCAATTTCATTAGACAGAATTAACGGCACGGAAATTATTGAGACGCAAGTTTTCTTGACTAGTCACTGTGATATTTCTGATACAAGGGTAGTAATAATGTTCACAATAACAGATTCCGCTGGGAAAATAGTCGTGCTATCACGTGAGATTTTGTTACCAATCAGTCTTTACTGCACACCTATCGAAATAATATCGGAAAATCAGTATATGTTAAGTGTTAGAACAAATAACCCTATTGTGGAATTTACACAAATATTTACAGACTTCAATGGGGAAGATTTGTCGAGTAATACCATTACGTTTGGGTATAGATCAACAAAGAATACCATTACACTTAAAATAAGAGACGACCACTACATAATCGAAGCGAATAATTTTACGGAAATTACAAGTGTATTGGATCATTTTCTCGTGAAGTTAATAGACCATCACAGGAGGATGTCCACAAAGGATTTTCGTTTTGATTTTCAATATGATAAAGAATTTAAAAAACAGCTCCTTCATAATTTTCTGAAGAGCATCGAAATACATGCGAAGGAACGCATTAAACTCAAAGGGTTTGAGGATGAGCTGATGACACTTCACGGACAATTTACTTTAATTCAAAAGAAACTACTTGTACAGTACGGGTCGTTGCCCCCAGGCGATTGCGAATCTCTCGAGTTCTTGATGAAGGATACACATCACCGACTCGTTAGCACGGTTCAAGAAATAGTGAAATGTAAAGACACTGTCTGCAATCTAGGTAGCACTTTGAGCACCGTCGGCCGATTGATTCTTTGTATATTAAAACAAGTGACGCACGACAGTCTCAAAATGAAATTGATAGAAGAGATGATGTCCGTCAATTCCTTGTATGAAGATTACCAGGAATGGGAAGAGGCCGCTGTCCAGGGAGTTTTTTACATTCTAAACACTTTATTAAAAAAATCCGATAAAGACAAGGAAAAATTGGCACCGGTTACCGAACAAGACGCGCTGTCGCAAATCAACGTGAAGCGTTGTTTGAAACAGACCAAAGTTATCCTCGAGATGATGTTTGAGGATGCGAGCGCCGAGGATCAAGACGGAAGAGTTGCTCGTACTGAAGAGCTAGTTGAAGTGATTTAA
Protein
MSIFKVKYWWSTDSLHTKETVSGSQNAYSLKVDRFNSHSDSDCILLAEESTIKVFKPNIEQENSHTLLESELEDVILQIETGKFVSEIADRQIIVLHARSYSIYQLLKQEGHTNAGEQNKLEPLVRHAFTRKADSLTCGPFGNIKTRDFICIQGLDGSLSFFDQDTFLFLCIFNDVIIPGPISYIANCDAFVLCKSTWVLEIYSYQQLREFSELSLRQNKQNVPQWTYSACEEITQIQVIQTSSNFSSIIALGERHLCCFQDNGLMKFMIKFDYMPMCFNSYLIGWYYEPTARMLVMVASDDCKLYVYENTTLLWSCDLLHPVISIARCFLKNLPGGIVSLSNTGIVNVGYLGTEPDLNGNARAMINEPIDPEQIQAELDEVESALQKLLDDKDEAATSFSLVERTINIKADVGKPVQNLFQEFSKGDEALHLLMCPIIVMITCDDPKIIQNVQISYVCCFPFACSESAISLDRINGTEIIETQVFLTSHCDISDTRVVIMFTITDSAGKIVVLSREILLPISLYCTPIEIISENQYMLSVRTNNPIVEFTQIFTDFNGEDLSSNTITFGYRSTKNTITLKIRDDHYIIEANNFTEITSVLDHFLVKLIDHHRRMSTKDFRFDFQYDKEFKKQLLHNFLKSIEIHAKERIKLKGFEDELMTLHGQFTLIQKKLLVQYGSLPPGDCESLEFLMKDTHHRLVSTVQEIVKCKDTVCNLGSTLSTVGRLILCILKQVTHDSLKMKLIEEMMSVNSLYEDYQEWEEAAVQGVFYILNTLLKKSDKDKEKLAPVTEQDALSQINVKRCLKQTKVILEMMFEDASAEDQDGRVARTEELVEVI
Summary
Description
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization (By similarity).
Subunit
Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts with LZTL1; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.
Keywords
Alternative splicing
Cell membrane
Cell projection
Cilium
Complete proteome
Cytoplasm
Cytoskeleton
Membrane
Protein transport
Reference proteome
Transport
Feature
chain Protein PTHB1
splice variant In isoform 3 and isoform 4.
splice variant In isoform 3 and isoform 4.
Uniprot
A0A2H1WKM0
F8SL48
A0A0L7KYG6
A0A194Q8A3
A0A212EUU0
A0A2J7QTW1
+ More
Q7Q5W5 A0A182TWC1 A0A182XPB6 A0A182URQ1 A0A182WLL9 D2CG54 A0A182NK21 A0A182KNX2 A0A182I1B2 W4XAU7 A0A182QYT0 A0A2D0T7D0 A0A091W3U4 A7STA0 A0A0C9PRB8 A0A3B3CFN9 A0A3B4EMP8 A0A2D0T7H0 A0A182LY43 A0A091IKZ3 A0A093HXT1 A0A2I0UDG0 A0A091W2Y7 A0A2D0T833 A0A091IWC2 A0A093RQ84 A0A3B4DAL8 A0A087QQV6 A0A182YKU5 A0A093H9A7 Q811G0-2 A0A0A0AL25 A0A1A8BAA0 A0A3Q2EE66 A0A1D5PGS0 A0A093BIM2 U3JJ66 H2MKZ4 A0A1A8SG82 A0A091ERS1 A0A1A8JRU2 A0A182GA54 A0A1S3HPP0 A0A1A7WGU5 A0A1A8BZS7 H2MKZ6 G1NHM3 A0A1A8VCQ6 A0A3Q3B2D2 A0A3P9IRY0 A0A1A7YUI9 A0A1A8LI84 H0Z4G6 A0A336MBG3 A0A1A8E5K2 A0A1A8I4H4 A0A182GWS0 A0A3B3Z2G7 Q811G0 A0A3B1IVI9 A0A3Q0G9M4 A0A3P8VPS2 A0A3Q2DBU9 A0A3B1JKL7 H0Z4G5 A0A336MGV4 A0A093C305 A0A3Q2UB44 A0A3B1IQZ0 A0A182JSH0 A0A3Q1G407 A0A091GJ20 A0A1A8BB88 A0A1A7WWS3 A0A218UZG6 A0A1A8BK77 U4U829 A0A336N0M3 A0A3P9Q2Y9 A0A1S4EYX2 E7F6E0 H0UV24 A0A091SY34 A0A3Q2U256 B3RRG2 M4AFV4 A0A3Q0GD40 A0A091M4W1 A0A369RSG1 W5KAP8
Q7Q5W5 A0A182TWC1 A0A182XPB6 A0A182URQ1 A0A182WLL9 D2CG54 A0A182NK21 A0A182KNX2 A0A182I1B2 W4XAU7 A0A182QYT0 A0A2D0T7D0 A0A091W3U4 A7STA0 A0A0C9PRB8 A0A3B3CFN9 A0A3B4EMP8 A0A2D0T7H0 A0A182LY43 A0A091IKZ3 A0A093HXT1 A0A2I0UDG0 A0A091W2Y7 A0A2D0T833 A0A091IWC2 A0A093RQ84 A0A3B4DAL8 A0A087QQV6 A0A182YKU5 A0A093H9A7 Q811G0-2 A0A0A0AL25 A0A1A8BAA0 A0A3Q2EE66 A0A1D5PGS0 A0A093BIM2 U3JJ66 H2MKZ4 A0A1A8SG82 A0A091ERS1 A0A1A8JRU2 A0A182GA54 A0A1S3HPP0 A0A1A7WGU5 A0A1A8BZS7 H2MKZ6 G1NHM3 A0A1A8VCQ6 A0A3Q3B2D2 A0A3P9IRY0 A0A1A7YUI9 A0A1A8LI84 H0Z4G6 A0A336MBG3 A0A1A8E5K2 A0A1A8I4H4 A0A182GWS0 A0A3B3Z2G7 Q811G0 A0A3B1IVI9 A0A3Q0G9M4 A0A3P8VPS2 A0A3Q2DBU9 A0A3B1JKL7 H0Z4G5 A0A336MGV4 A0A093C305 A0A3Q2UB44 A0A3B1IQZ0 A0A182JSH0 A0A3Q1G407 A0A091GJ20 A0A1A8BB88 A0A1A7WWS3 A0A218UZG6 A0A1A8BK77 U4U829 A0A336N0M3 A0A3P9Q2Y9 A0A1S4EYX2 E7F6E0 H0UV24 A0A091SY34 A0A3Q2U256 B3RRG2 M4AFV4 A0A3Q0GD40 A0A091M4W1 A0A369RSG1 W5KAP8
Pubmed
EMBL
ODYU01009197
SOQ53452.1
HQ645847
AEH16631.1
JTDY01004421
KOB68180.1
+ More
KQ459302 KPJ01767.1 AGBW02012322 OWR45224.1 NEVH01011193 PNF32019.1 AAAB01008960 EAA11471.4 DS497712 EFA12827.1 APCN01000049 AAGJ04009815 AAGJ04009816 AXCN02000497 KL410402 KFQ96453.1 DS469792 EDO33076.1 GBYB01003793 JAG73560.1 AXCM01000788 KL218786 KFP08193.1 KL206564 KFV83787.1 KZ505850 PKU44087.1 KK734671 KFR09987.1 KK501145 KFP12999.1 KL225500 KFW73019.1 KL225815 KFM03610.1 KL217271 KFV75990.1 AK053503 AK144730 BC030419 BC046426 BC054441 U85993 KL871995 KGL94253.1 HADY01024935 SBP63420.1 AADN05000034 KN126477 KFU89962.1 AGTO01021402 HAEH01016351 HAEI01014768 SBS17237.1 KK718893 KFO59297.1 HAEE01002084 SBR22104.1 JXUM01008551 JXUM01008552 JXUM01008553 KQ560264 KXJ83474.1 HADW01003349 SBP04749.1 HADZ01009226 SBP73167.1 HADY01018274 HAEJ01016521 SBS56978.1 HADX01011602 SBP33834.1 HAEF01006664 SBR44046.1 ABQF01014237 ABQF01014238 ABQF01014239 ABQF01014240 ABQF01014241 ABQF01014242 ABQF01014243 ABQF01014244 ABQF01014245 ABQF01014246 UFQS01000663 UFQT01000663 SSX05900.1 SSX26259.1 HAEA01012768 SBQ41248.1 HAED01006359 SBQ92394.1 JXUM01019820 JXUM01019821 JXUM01019822 JXUM01019823 JXUM01019824 KQ560556 KXJ81905.1 UFQT01001153 SSX29180.1 KL232453 KFV06622.1 KL448200 KFO81291.1 HADY01025421 SBP63906.1 HADW01008972 SBP10372.1 MUZQ01000082 OWK59215.1 HADZ01004081 SBP68022.1 KB631857 ERL86761.1 UFQT01002897 SSX34237.1 AL845419 FP245475 AAKN02032372 AAKN02032373 AAKN02032374 KK488946 KFQ62880.1 DS985243 EDV26341.1 KK518927 KFP65737.1 NOWV01000227 RDD37635.1
KQ459302 KPJ01767.1 AGBW02012322 OWR45224.1 NEVH01011193 PNF32019.1 AAAB01008960 EAA11471.4 DS497712 EFA12827.1 APCN01000049 AAGJ04009815 AAGJ04009816 AXCN02000497 KL410402 KFQ96453.1 DS469792 EDO33076.1 GBYB01003793 JAG73560.1 AXCM01000788 KL218786 KFP08193.1 KL206564 KFV83787.1 KZ505850 PKU44087.1 KK734671 KFR09987.1 KK501145 KFP12999.1 KL225500 KFW73019.1 KL225815 KFM03610.1 KL217271 KFV75990.1 AK053503 AK144730 BC030419 BC046426 BC054441 U85993 KL871995 KGL94253.1 HADY01024935 SBP63420.1 AADN05000034 KN126477 KFU89962.1 AGTO01021402 HAEH01016351 HAEI01014768 SBS17237.1 KK718893 KFO59297.1 HAEE01002084 SBR22104.1 JXUM01008551 JXUM01008552 JXUM01008553 KQ560264 KXJ83474.1 HADW01003349 SBP04749.1 HADZ01009226 SBP73167.1 HADY01018274 HAEJ01016521 SBS56978.1 HADX01011602 SBP33834.1 HAEF01006664 SBR44046.1 ABQF01014237 ABQF01014238 ABQF01014239 ABQF01014240 ABQF01014241 ABQF01014242 ABQF01014243 ABQF01014244 ABQF01014245 ABQF01014246 UFQS01000663 UFQT01000663 SSX05900.1 SSX26259.1 HAEA01012768 SBQ41248.1 HAED01006359 SBQ92394.1 JXUM01019820 JXUM01019821 JXUM01019822 JXUM01019823 JXUM01019824 KQ560556 KXJ81905.1 UFQT01001153 SSX29180.1 KL232453 KFV06622.1 KL448200 KFO81291.1 HADY01025421 SBP63906.1 HADW01008972 SBP10372.1 MUZQ01000082 OWK59215.1 HADZ01004081 SBP68022.1 KB631857 ERL86761.1 UFQT01002897 SSX34237.1 AL845419 FP245475 AAKN02032372 AAKN02032373 AAKN02032374 KK488946 KFQ62880.1 DS985243 EDV26341.1 KK518927 KFP65737.1 NOWV01000227 RDD37635.1
Proteomes
UP000037510
UP000053268
UP000007151
UP000235965
UP000007062
UP000075902
+ More
UP000076407 UP000075903 UP000075920 UP000007266 UP000075884 UP000075882 UP000075840 UP000007110 UP000075886 UP000221080 UP000053283 UP000001593 UP000261560 UP000261440 UP000075883 UP000054308 UP000053584 UP000053605 UP000053119 UP000054081 UP000053286 UP000076408 UP000053875 UP000000589 UP000053858 UP000265020 UP000000539 UP000016665 UP000001038 UP000052976 UP000069940 UP000249989 UP000085678 UP000001645 UP000265200 UP000007754 UP000261480 UP000018467 UP000189705 UP000265120 UP000075881 UP000257200 UP000053760 UP000197619 UP000030742 UP000242638 UP000000437 UP000005447 UP000265000 UP000009022 UP000002852 UP000253843
UP000076407 UP000075903 UP000075920 UP000007266 UP000075884 UP000075882 UP000075840 UP000007110 UP000075886 UP000221080 UP000053283 UP000001593 UP000261560 UP000261440 UP000075883 UP000054308 UP000053584 UP000053605 UP000053119 UP000054081 UP000053286 UP000076408 UP000053875 UP000000589 UP000053858 UP000265020 UP000000539 UP000016665 UP000001038 UP000052976 UP000069940 UP000249989 UP000085678 UP000001645 UP000265200 UP000007754 UP000261480 UP000018467 UP000189705 UP000265120 UP000075881 UP000257200 UP000053760 UP000197619 UP000030742 UP000242638 UP000000437 UP000005447 UP000265000 UP000009022 UP000002852 UP000253843
PRIDE
Interpro
SUPFAM
SSF50978
SSF50978
ProteinModelPortal
A0A2H1WKM0
F8SL48
A0A0L7KYG6
A0A194Q8A3
A0A212EUU0
A0A2J7QTW1
+ More
Q7Q5W5 A0A182TWC1 A0A182XPB6 A0A182URQ1 A0A182WLL9 D2CG54 A0A182NK21 A0A182KNX2 A0A182I1B2 W4XAU7 A0A182QYT0 A0A2D0T7D0 A0A091W3U4 A7STA0 A0A0C9PRB8 A0A3B3CFN9 A0A3B4EMP8 A0A2D0T7H0 A0A182LY43 A0A091IKZ3 A0A093HXT1 A0A2I0UDG0 A0A091W2Y7 A0A2D0T833 A0A091IWC2 A0A093RQ84 A0A3B4DAL8 A0A087QQV6 A0A182YKU5 A0A093H9A7 Q811G0-2 A0A0A0AL25 A0A1A8BAA0 A0A3Q2EE66 A0A1D5PGS0 A0A093BIM2 U3JJ66 H2MKZ4 A0A1A8SG82 A0A091ERS1 A0A1A8JRU2 A0A182GA54 A0A1S3HPP0 A0A1A7WGU5 A0A1A8BZS7 H2MKZ6 G1NHM3 A0A1A8VCQ6 A0A3Q3B2D2 A0A3P9IRY0 A0A1A7YUI9 A0A1A8LI84 H0Z4G6 A0A336MBG3 A0A1A8E5K2 A0A1A8I4H4 A0A182GWS0 A0A3B3Z2G7 Q811G0 A0A3B1IVI9 A0A3Q0G9M4 A0A3P8VPS2 A0A3Q2DBU9 A0A3B1JKL7 H0Z4G5 A0A336MGV4 A0A093C305 A0A3Q2UB44 A0A3B1IQZ0 A0A182JSH0 A0A3Q1G407 A0A091GJ20 A0A1A8BB88 A0A1A7WWS3 A0A218UZG6 A0A1A8BK77 U4U829 A0A336N0M3 A0A3P9Q2Y9 A0A1S4EYX2 E7F6E0 H0UV24 A0A091SY34 A0A3Q2U256 B3RRG2 M4AFV4 A0A3Q0GD40 A0A091M4W1 A0A369RSG1 W5KAP8
Q7Q5W5 A0A182TWC1 A0A182XPB6 A0A182URQ1 A0A182WLL9 D2CG54 A0A182NK21 A0A182KNX2 A0A182I1B2 W4XAU7 A0A182QYT0 A0A2D0T7D0 A0A091W3U4 A7STA0 A0A0C9PRB8 A0A3B3CFN9 A0A3B4EMP8 A0A2D0T7H0 A0A182LY43 A0A091IKZ3 A0A093HXT1 A0A2I0UDG0 A0A091W2Y7 A0A2D0T833 A0A091IWC2 A0A093RQ84 A0A3B4DAL8 A0A087QQV6 A0A182YKU5 A0A093H9A7 Q811G0-2 A0A0A0AL25 A0A1A8BAA0 A0A3Q2EE66 A0A1D5PGS0 A0A093BIM2 U3JJ66 H2MKZ4 A0A1A8SG82 A0A091ERS1 A0A1A8JRU2 A0A182GA54 A0A1S3HPP0 A0A1A7WGU5 A0A1A8BZS7 H2MKZ6 G1NHM3 A0A1A8VCQ6 A0A3Q3B2D2 A0A3P9IRY0 A0A1A7YUI9 A0A1A8LI84 H0Z4G6 A0A336MBG3 A0A1A8E5K2 A0A1A8I4H4 A0A182GWS0 A0A3B3Z2G7 Q811G0 A0A3B1IVI9 A0A3Q0G9M4 A0A3P8VPS2 A0A3Q2DBU9 A0A3B1JKL7 H0Z4G5 A0A336MGV4 A0A093C305 A0A3Q2UB44 A0A3B1IQZ0 A0A182JSH0 A0A3Q1G407 A0A091GJ20 A0A1A8BB88 A0A1A7WWS3 A0A218UZG6 A0A1A8BK77 U4U829 A0A336N0M3 A0A3P9Q2Y9 A0A1S4EYX2 E7F6E0 H0UV24 A0A091SY34 A0A3Q2U256 B3RRG2 M4AFV4 A0A3Q0GD40 A0A091M4W1 A0A369RSG1 W5KAP8
PDB
4YD8
E-value=7.43359e-51,
Score=510
Ontologies
GO
PANTHER
Topology
Subcellular location
Cell projection
Cilium membrane
Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Centriolar satellite
Cilium membrane
Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Centriolar satellite
Length:
837
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.26025
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00929
outside
1 - 837
Population Genetic Test Statistics
Pi
257.137534
Theta
195.986805
Tajima's D
1.094642
CLR
0.165917
CSRT
0.687265636718164
Interpretation
Uncertain
