Gene

KWMTBOMO05796

Pre Gene Modal

BGIBMGA006915

Annotation

cytochrome_P450_CYP18B3_[Spodoptera_littoralis]

Location

Bomo_Chr10(-):10292906-10302930      View in EpiBrowser

Full name

Cytochrome P450 18a1      

Alternative Name

CYPXVIIIA1

Location in the cell

Cytoplasmic   Reliability : 2.716

CDS

ATGTACCTACCACCAGGACCATGGGGTGTACCGTTTCTTGGTTATCTTCCGTTCATGAAGAGCTCACCCCACGCCATGTATTCTAGAATGGCCGATAAATACGGTGAAATTTCTTCTATAAAACTTGGAAACCATTTAGTCGTCTGTCTCAATTCGCCGAAACTTGTGAAGGAACTCTTCAGTCGATCGGATTCTATCGCGAGACCAAGAACTCCGCTGAACGAAATCATGGAAGGACGAGGTATAGTACTGAGTGAAGGTATACTTTGGCAGAAACAGCGTCAATTTCTACATGAAAAATTCAGGGCTCTTGGAGTCAAGGTTTGGCCGAAACAGCGATTCGAGAAATTTATTATTATGGAAATCGAAGAATTTATAACTGACCTAATTAAATTGAATGGAGCTCCTGTTGATCCAACGCTTTTGCTCGGAAGACACGTACACAATATAATATGCCAATTGATGATGAGTTTCCGATTTGAAGAGGACGATCAAGAATTCGGTATATTTAATGAAAAAATCAGTCGTGGGATGAAGCTGTACGGATCGATACACGCTAGCGAATACGTGCGGCAGTACTTGAAACTGCCCGGAAAGAAAACAATTTTAGACGAAATGAAACGTAGCTTGGCCGACATCAGCGAATTTCATGCAAACAAGATCAGAGAACGTATTGATTATCGAGCAACCCATCCGTATGATGAACCTGCCGACCTTTTGGATTATTACTTGGACAATATTGAAGCTAGGAAATCAAGAAAACGTTTCCCTGATATATTCCCGGGAGTCGATCCAGAGAAACAAGTAGTACAAGTGATGAACGATCTCTTCTCCGCCGGAATGGAGACGTCGCGCACGACTCTCTCCTGGACCTTACTGATGATGATCCACGAGCCTGACGTGGCTGCGAAGGTCCGGGCCCAGCTCACAGAAACGGTCCATCCAGGAGAGCTCGTAACCCTCGATCATCGCCCCGAGCTGCCGTACCTCGAGGCTGTGCTGTTCGAGACATTACGATGCGTTTCACTCGTACCCTTAGGAACCACACATGTCAATACAACCGAATGGAAAGTGGACAAGTACGTCATCCCGAAAGGAGCACACATTATTCCCTTAATCGGCAAGATGAATAACGACCCCAAAGTATACCCGGAACCGGATAAATTCAAACCGGAACGTTTCTTGCGCGACGGCCAGTTTCACATCCCGGATAGCTACATGGCTTTCGGAGTTGGACAACGCTTGTGTCTGGGAATCCAATTGGCCAGGATGCAGCTATTTCTCTTCTTCGCCAACATTATGAATAGATTCGAGTTTTCGCTGCCCGAGGGCGCTGAGATGCCGCCTTTAGAGGGCTTCATGGCCGCAACACACACTCCATTACCTTATTCTTTGTGTTTCCACAAAATCGATAACTAA

Protein

MYLPPGPWGVPFLGYLPFMKSSPHAMYSRMADKYGEISSIKLGNHLVVCLNSPKLVKELFSRSDSIARPRTPLNEIMEGRGIVLSEGILWQKQRQFLHEKFRALGVKVWPKQRFEKFIIMEIEEFITDLIKLNGAPVDPTLLLGRHVHNIICQLMMSFRFEEDDQEFGIFNEKISRGMKLYGSIHASEYVRQYLKLPGKKTILDEMKRSLADISEFHANKIRERIDYRATHPYDEPADLLDYYLDNIEARKSRKRFPDIFPGVDPEKQVVQVMNDLFSAGMETSRTTLSWTLLMMIHEPDVAAKVRAQLTETVHPGELVTLDHRPELPYLEAVLFETLRCVSLVPLGTTHVNTTEWKVDKYVIPKGAHIIPLIGKMNNDPKVYPEPDKFKPERFLRDGQFHIPDSYMAFGVGQRLCLGIQLARMQLFLFFANIMNRFEFSLPEGAEMPPLEGFMAATHTPLPYSLCFHKIDN

Description

Probably involved in steroid hormones biosynthesis.

Cofactor

heme

Similarity

Belongs to the cytochrome P450 family.

Keywords

Complete proteome   Developmental protein   Endoplasmic reticulum   Heme   Iron   Membrane   Metal-binding   Microsome   Monooxygenase   Oxidoreductase   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Cytochrome P450 18a1

Uniprot

H9JBM0   A0A2W1BU59   A0A248QHI9   T1WLS4   A0A2A4JAT0   A0A1V0D9E9   + More
A0A194Q8B8   A0A194QQQ7   A0A346IHW6   A0A1W6L1D2   A0A026WDY9   A0A154PF58   A0A310S7A8   A0A1L8E4A7   A0A194QW87   A0A1L8E418   A0A212FF58   A0A1L1ZLT7   A0A088ASU9   A0A1V0D9E4   A0A0K0LB80   E2B7S1   A0A2J7Q892   A0A1I8M232   A0A2R7WAK1   A0A2A3E9H0   A0A023F621   A0A224XI67   A0A1W4USK2   Q95078   A0A3B0JW02   B4L7K1   A0A1A9V5F7   B4JJR2   A0A336MGX6   A0A1A9ZTL1   B4I6V9   B4M2S8   B4ND97   B4NUN4   A0A0L0CHZ8   A0A1B0FA69   B4PWD9   B3NUM8   A0A1I8P5A2   Q29FZ2   B3MVQ7   A0A0A1WG55   M9T368   W8AMG1   B0W1X3   A0A067RDG2   A0A1A9XAW2   A0A1B0B547   Q17BQ1   A0A0K8UW89   A0A0A9YXX1   A0A0C9R0V4   U5EUU5   A0A0M8ZRY0   A0A1D2NIB6   A0A158ND43   A0A195BNJ2   A0A182RKU1   A0A182R1A8   A0A182K5Y9   A0A182NN32   W5J7Q3   A0A182YEM8   A0A182F8T8   A0A194Q8D1   A0A182IXK9   E0VMV7   A0A0M4F9T8   A0A182LRV4   A0A182VPZ6   E1ZW76   A0A0C5BXD7   A0A084VYR6   A0A151I688   A0A182PDH2   A0A195F8D5   F4X710   A0A2H1W1C9   A0A0L7LD89   A0A3S2MA15   A3RKJ4   A0A0U2DUF3   A0A0L7R6U1   A0A2A4J994   A0A2W1BU05   Q0KH48   B0FLU7   A0A286QUG6   X5D9A2   A0A1W4XAM0   V5K5J2   A0A0K1YW92   A0A1Y1LM62   E9G4T8  

EC Number

1.14.-.-

Pubmed

19121390    28756777    28881445    22984814    26354079    24508170    + More
30249741    22118469    20798317    25315136    25474469    9256362    17322555    10731132    12537572    8413299    17994087    26108605    17550304    15632085    25830018    24495485    24845553    17510324    25401762    26823975    27289101    21347285    20920257    23761445    25244985    20566863    24438588    21719571    26227816    16884680    24361403    24267698    28004739    21292972   

EMBL

BABH01024452    KZ149900    PZC78549.1    KX443452    ASO98027.1    JQ979045    + More
AGU36299.1    NWSH01002327    PCG68522.1    KY212059    ARA91623.1    KQ459302    KPJ01782.1    KQ461175    KPJ07832.1    MH138180    AXP17121.1    KX609518    ARN17925.1    KK107260    QOIP01000001    EZA54128.1    RLU27313.1    KQ434890    KZC10452.1    KQ774645    OAD52306.1    GFDF01000635    JAV13449.1    KPJ07831.1    GFDF01000678    JAV13406.1    AGBW02008863    OWR52347.1    KR058859    ALG65076.1    KY212058    ARA91622.1    KM217007    AIW79970.1    GL446201    EFN88284.1    NEVH01016967    PNF24798.1    KK854379    PTY15275.1    KZ288312    PBC28377.1    GBBI01002060    JAC16652.1    GFTR01006918    JAW09508.1    U44753    AM411848    AM411849    AM411850    AM411851    AM411852    AM411853    AM411854    AM411855    AM411856    AM411857    AM411858    AM411859    AM411860    AE014298    S66112    OUUW01000003    SPP77899.1    CH933814    EDW05714.1    CH916370    EDV99814.1    UFQT01000959    SSX28189.1    CH480823    EDW56057.1    CH940651    EDW65982.1    CH964239    EDW82806.1    CH984138    EDX16681.1    JRES01000348    KNC32028.1    CCAG010001311    CM000162    EDX02757.1    CH954180    EDV46625.1    CH379065    EAL31437.1    CH902625    EDV35052.1    GBXI01016278    JAC98013.1    KC701467    AGI92302.1    GAMC01019403    JAB87152.1    DS231824    EDS27409.1    KK852530    KDR21921.1    JXJN01008607    CH477318    EAT43716.1    GDHF01021694    JAI30620.1    GBHO01005737    GDHC01007258    JAG37867.1    JAQ11371.1    GBYB01000511    JAG70278.1    GANO01001300    JAB58571.1    KQ435936    KOX68309.1    LJIJ01000032    ODN04952.1    ADTU01012323    KQ976438    KYM86820.1    AXCN02002216    ADMH02002005    ETN60006.1    KPJ01783.1    DS235327    EEB14713.1    CP012528    ALC49375.1    AXCM01000572    GL434776    EFN74585.1    KP001118    AJN91163.1    ATLV01018418    KE525233    KFB43110.1    KQ978496    KYM93624.1    KQ981744    KYN36452.1    GL888828    EGI57772.1    ODYU01005660    SOQ46746.1    JTDY01001692    KOB73146.1    RSAL01000003    RVE54859.1    BABH01024447    EF421988    AK343215    AK343216    AK343217    ABO07438.1    BAM73898.1    BAM73899.1    BAM73900.1    KP058448    AKP80583.1    KQ414646    KOC66607.1    PCG68521.1    PZC78548.1    AM086639    CAJ31114.1    EU334832    ABY53102.1    KX443451    ASO98026.1    KF701122    AHW57292.1    KF044259    AGT57831.1    KP859375    AKZ17685.1    GEZM01051744    JAV74723.1    GL732532    EFX85356.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000053097    UP000279307    + More
UP000076502    UP000007151    UP000005203    UP000008237    UP000235965    UP000095301    UP000242457    UP000192221    UP000000803    UP000268350    UP000009192    UP000078200    UP000001070    UP000092445    UP000001292    UP000008792    UP000007798    UP000000304    UP000037069    UP000092444    UP000002282    UP000008711    UP000095300    UP000001819    UP000007801    UP000002320    UP000027135    UP000092443    UP000092460    UP000008820    UP000053105    UP000094527    UP000005205    UP000078540    UP000075900    UP000075886    UP000075881    UP000075884    UP000000673    UP000076408    UP000069272    UP000075880    UP000009046    UP000092553    UP000075883    UP000075920    UP000000311    UP000030765    UP000078542    UP000075885    UP000078541    UP000007755    UP000037510    UP000283053    UP000053825    UP000192223    UP000000305   

PRIDE

H9JBM0    Q95078    A3RKJ4   

Pfam

PF00067   p450        + More
PF00069   Pkinase

Interpro

IPR002401   Cyt_P450_E_grp-I        + More
IPR001128   Cyt_P450       
IPR017972   Cyt_P450_CS       
IPR036396   Cyt_P450_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR000719   Prot_kinase_dom       
IPR016024   ARM-type_fold       
IPR008069   Cyt_P450_E_grp-I_CYP2D-like       

SUPFAM

SSF48264   SSF48264        + More
SSF56112   SSF56112       
SSF48371   SSF48371       

Gene 3D

1.10.630.10    

ProteinModelPortal

H9JBM0   A0A2W1BU59   A0A248QHI9   T1WLS4   A0A2A4JAT0   A0A1V0D9E9   + More
A0A194Q8B8   A0A194QQQ7   A0A346IHW6   A0A1W6L1D2   A0A026WDY9   A0A154PF58   A0A310S7A8   A0A1L8E4A7   A0A194QW87   A0A1L8E418   A0A212FF58   A0A1L1ZLT7   A0A088ASU9   A0A1V0D9E4   A0A0K0LB80   E2B7S1   A0A2J7Q892   A0A1I8M232   A0A2R7WAK1   A0A2A3E9H0   A0A023F621   A0A224XI67   A0A1W4USK2   Q95078   A0A3B0JW02   B4L7K1   A0A1A9V5F7   B4JJR2   A0A336MGX6   A0A1A9ZTL1   B4I6V9   B4M2S8   B4ND97   B4NUN4   A0A0L0CHZ8   A0A1B0FA69   B4PWD9   B3NUM8   A0A1I8P5A2   Q29FZ2   B3MVQ7   A0A0A1WG55   M9T368   W8AMG1   B0W1X3   A0A067RDG2   A0A1A9XAW2   A0A1B0B547   Q17BQ1   A0A0K8UW89   A0A0A9YXX1   A0A0C9R0V4   U5EUU5   A0A0M8ZRY0   A0A1D2NIB6   A0A158ND43   A0A195BNJ2   A0A182RKU1   A0A182R1A8   A0A182K5Y9   A0A182NN32   W5J7Q3   A0A182YEM8   A0A182F8T8   A0A194Q8D1   A0A182IXK9   E0VMV7   A0A0M4F9T8   A0A182LRV4   A0A182VPZ6   E1ZW76   A0A0C5BXD7   A0A084VYR6   A0A151I688   A0A182PDH2   A0A195F8D5   F4X710   A0A2H1W1C9   A0A0L7LD89   A0A3S2MA15   A3RKJ4   A0A0U2DUF3   A0A0L7R6U1   A0A2A4J994   A0A2W1BU05   Q0KH48   B0FLU7   A0A286QUG6   X5D9A2   A0A1W4XAM0   V5K5J2   A0A0K1YW92   A0A1Y1LM62   E9G4T8  

PDB

6CSD     E-value=3.26557e-48,     Score=485

KEGG

101740852    no KO assigned | (RefSeq) cytochrome P450 18a1-like

GO

GO:0005506   GO:0016705   GO:0020037   GO:0004497   GO:0016021   GO:0005524   GO:0004672   GO:0016712   GO:0005789   GO:0035210   GO:0035074   GO:0007480   GO:0007304   GO:0046344   GO:0008395   GO:0007552   GO:0070330   GO:0046872   GO:0006805   GO:0005737   GO:0006082   GO:0055114   GO:0043231   GO:0042738   GO:0051861   GO:0000160   GO:0005216   GO:0006811   GO:0006541   GO:0016812   GO:0016597  

Subcellular location

Endoplasmic reticulum membrane  
Microsome membrane  

Length:

472

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.16253

Exp number, first 60 AAs:

0.0305

Total prob of N-in:

0.00170

outside

1  -  472

 

 

Pi

196.465249

Theta

181.320179

Tajima's D

-1.208699

CLR

1517.596663

CSRT

0.0998450077496125

Interpretation

Uncertain