Gene

KWMTBOMO05795

Pre Gene Modal

BGIBMGA006916

Annotation

cytochrome_P450_18a1_[Bombyx_mori]

Location

Bomo_Chr10(-):10228436-10231045      View in EpiBrowser

Full name

Cytochrome P450 18a1      

Alternative Name

CYPXVIIIA1

Location in the cell

Cytoplasmic   Reliability : 1.446 Mitochondrial   Reliability : 1.266

CDS

ATGCTGATCATTGTAACCTGCACGGCGTTGTTGTTGACTCAATTCCTGAAGCTAGTACGTGACATTCGCAAGTTGCCCCCGGGACCGTGGGGACCACCCGTCGTCGGCTACCTACCTTTTCTCGGAGTCCGGCACAAGACGTTCCTTCAATTGGCCAGAAACTATGGAGCTCTCTTCTCTGCGCGACTCGGAAACCAATTGACCATCGTTATGAGTGACTACAAAATTATCAGAGAAGCCTTCCGACGCGAAGAATTCACCGGTCGTCCCAGCACTCCCTTAATGCATACTTTAGATGGTCTTGGCATCATCAATAGCGAGGGCCGCCTCTGGAAAAATCAACGACGGTTCTTGCACGAAAAACTACGGGAGTTCGGCATGACTTACATGGGAAACGGCAAAAAACTAATGGAGGATAGAATCAAGAATGAAATCCACGAGCTGATTGTAAGCCTGCATCGAGCGCAAGGCGCACCTATTGACGTAAATCCTCTCCTTGCGCTGTGCGTGTCCAACGTTATCTGCGGTATCACGATGTCGGTCCGTTTTAGTAACGGCGATGTACGCTTCGAGAGACTCAATCATCTTATCGAAGAAGGAATGAGACTTTTCGGAGAAGTTCACTACGGAGAATACATTCCTCTGTATAATTATCTACCTGGAAAAGCTCTAGCTCAAGAAAAGGTCGCAAAAAATCGCGATGAAATGTTCGCGTTCTATCAAACATTGATAGACGAGCACCGCGAAACTCTGGACATCAATAATGCCAGAGACCTTATCGATGTCTACTTAATTGAAATCGAGAAGGCGAAGAGCGAGGGCAGGGCCGGCGAACTCTTCGAAGGAAGAGATCATGAATTACAATTAAAACAAATACTTGGAGATCTTTTCTCTGCTGGTATGGAAACCATAAAGTCGTCGCTTCTGTGGATGATAGTATTCATGTTGCGAAACCCAGACGTGAAAAGGCGTGTACAAGAAGAACTCGATGCGGTCATTGGCCGAGAACGTCTCCCTTCTATTGACGACATATCTAGTCTTCCATACACCGAAACTACAATTTTGGAAACGCTAAGATTATCAAGCATTGTTCCTTTGGCAACCACACATTCTCCGACTAGGGATGTGCAAATCAACGGCTATAAGATTCCGGCGGGTTCTCAGGTTATACCACTTATTAACTGCGTGCACATGGATCCGAATCTCTGGGATGAACCAAACAAATTCAATCCTAGTAGATTCATCGACGCGACCGGCAAGATAAGACGTCCGGAATATTTCATGCCATTCGGGGTCGGCCGAAGAATGTGTTTGGGCGACGTATTGGCCCGCAAAGAGATGTTCATGTTCTTTTCGTGTATGATGCACCAATTCGACTTGGAAATGGCTGAAGGTGACGCATTACCTTCGCTGGAGGGCATAGTAGGTGCTACAATTGCACCGAAAGCTTTTCGTGTGAAATTTTTGGCTCGTTCACCAGTACCCTTAGTACCGACTACGCTCTCTGCAGATAGCTCTCATCTTCGTCATGTCGGCTCACATTAA

Protein

MLIIVTCTALLLTQFLKLVRDIRKLPPGPWGPPVVGYLPFLGVRHKTFLQLARNYGALFSARLGNQLTIVMSDYKIIREAFRREEFTGRPSTPLMHTLDGLGIINSEGRLWKNQRRFLHEKLREFGMTYMGNGKKLMEDRIKNEIHELIVSLHRAQGAPIDVNPLLALCVSNVICGITMSVRFSNGDVRFERLNHLIEEGMRLFGEVHYGEYIPLYNYLPGKALAQEKVAKNRDEMFAFYQTLIDEHRETLDINNARDLIDVYLIEIEKAKSEGRAGELFEGRDHELQLKQILGDLFSAGMETIKSSLLWMIVFMLRNPDVKRRVQEELDAVIGRERLPSIDDISSLPYTETTILETLRLSSIVPLATTHSPTRDVQINGYKIPAGSQVIPLINCVHMDPNLWDEPNKFNPSRFIDATGKIRRPEYFMPFGVGRRMCLGDVLARKEMFMFFSCMMHQFDLEMAEGDALPSLEGIVGATIAPKAFRVKFLARSPVPLVPTTLSADSSHLRHVGSH

Description

Probably involved in steroid hormones biosynthesis.

Cofactor

heme

Similarity

Belongs to the cytochrome P450 family.

Keywords

Complete proteome   Developmental protein   Endoplasmic reticulum   Heme   Iron   Membrane   Metal-binding   Microsome   Monooxygenase   Oxidoreductase   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Cytochrome P450 18a1

Uniprot

A3RKJ4   B0FLU7   A0A286QUG6   A0A0U2DUF3   A0A2H1W1C9   A0A2W1BU05   + More
A0A2A4J994   A0A0L7LD89   Q0KH48   A0A212FF58   A0A1V0D9E4   A0A0C5BXD7   A0A194Q8D1   A0A3S2MA15   X5D9A2   A0A194QW87   A0A0L0CHZ8   A0A1I8M232   A0A1I8P5A2   W8AMG1   A0A0K8UW89   A0A0A1WG55   B4L7K1   B4ND97   Q29FZ2   A0A1A9ZTL1   A0A1B0FA69   B4I6V9   B4NUN4   A0A1A9V5F7   B3MVQ7   A0A1L8E418   B3NUM8   A0A182NN32   A0A1W4USK2   A0A1L8E4A7   Q95078   A0A1A9XAW2   A0A1B0B547   B4M2S8   B4PWD9   B4JJR2   B0W1X3   A0A182RKU1   A0A3B0JW02   A0A182YEM8   A0A182R1A8   A0A182LRV4   A0A182IXK9   Q17BQ1   A0A182VPZ6   A0A0M4F9T8   A0A084VYR6   A0A182PDH2   A0A286MXM9   A0A182K5Y9   K9LCG6   A0A182F8T8   W5J7Q3   U5EUU5   A0A336MGX6   A0A068F5Y4   A0A0C9R0V4   A0A2J7Q892   A0A026WDY9   A0A1W4XAM0   A0A310S7A8   A0A088ASU9   A0A1L1ZLT7   A0A1Y1LM62   A0A0K1YW92   A0A067RDG2   A0A2A3E9H0   A0A0T6B5W1   A0A139WCK2   A0A023F621   A0A1J1J042   E0VMV7   A0A1W6L1D2   A0A154PF58   A0A0M8ZRY0   A0A0K0LB80   A0A182SF83   A0A0M4H5B2   A0A224XI67   M9T368   A0A1L8E3Y4   A0A0A9YXX1   A0A151I688   E2B7S1   A0A2R7WAK1   A0A1B6IFL7   E1ZW76   A0A0L7R6U1   A0A195BNJ2   A0A158ND43  

EC Number

1.14.-.-

Pubmed

19121390    28881445    28756777    26227816    16884680    22118469    + More
26354079    24361403    26108605    25315136    24495485    25830018    17994087    15632085    9256362    17322555    10731132    12537572    8413299    17550304    25244985    17510324    24438588    19954531    25299618    20920257    23761445    25880816    24508170    30249741    28004739    24845553    18362917    19820115    25474469    20566863    26319543    25401762    26823975    20798317    21347285   

EMBL

BABH01024447    EF421988    AK343215    AK343216    AK343217    ABO07438.1    + More
BAM73898.1    BAM73899.1    BAM73900.1    EU334832    ABY53102.1    KX443451    ASO98026.1    KP058448    AKP80583.1    ODYU01005660    SOQ46746.1    KZ149900    PZC78548.1    NWSH01002327    PCG68521.1    JTDY01001692    KOB73146.1    AM086639    CAJ31114.1    AGBW02008863    OWR52347.1    KY212058    ARA91622.1    KP001118    AJN91163.1    KQ459302    KPJ01783.1    RSAL01000003    RVE54859.1    KF701122    AHW57292.1    KQ461175    KPJ07831.1    JRES01000348    KNC32028.1    GAMC01019403    JAB87152.1    GDHF01021694    JAI30620.1    GBXI01016278    JAC98013.1    CH933814    EDW05714.1    CH964239    EDW82806.1    CH379065    EAL31437.1    CCAG010001311    CH480823    EDW56057.1    CH984138    EDX16681.1    CH902625    EDV35052.1    GFDF01000678    JAV13406.1    CH954180    EDV46625.1    GFDF01000635    JAV13449.1    U44753    AM411848    AM411849    AM411850    AM411851    AM411852    AM411853    AM411854    AM411855    AM411856    AM411857    AM411858    AM411859    AM411860    AE014298    S66112    JXJN01008607    CH940651    EDW65982.1    CM000162    EDX02757.1    CH916370    EDV99814.1    DS231824    EDS27409.1    OUUW01000003    SPP77899.1    AXCN02002216    AXCM01000572    CH477318    EAT43716.1    CP012528    ALC49375.1    ATLV01018418    KE525233    KFB43110.1    MF684347    ASX93981.1    JF835057    AFH54193.1    ADMH02002005    ETN60006.1    GANO01001300    JAB58571.1    UFQT01000959    SSX28189.1    KJ702226    AID61380.1    GBYB01000511    JAG70278.1    NEVH01016967    PNF24798.1    KK107260    QOIP01000001    EZA54128.1    RLU27313.1    KQ774645    OAD52306.1    KR058859    ALG65076.1    GEZM01051744    JAV74723.1    KP859375    AKZ17685.1    KK852530    KDR21921.1    KZ288312    PBC28377.1    LJIG01009597    KRT82761.1    KQ971368    KYB25634.1    GBBI01002060    JAC16652.1    CVRI01000066    CRL05883.1    DS235327    EEB14713.1    KX609518    ARN17925.1    KQ434890    KZC10452.1    KQ435936    KOX68309.1    KM217007    AIW79970.1    KR012853    ALD15928.1    GFTR01006918    JAW09508.1    KC701467    AGI92302.1    GFDF01000647    JAV13437.1    GBHO01005737    GDHC01007258    JAG37867.1    JAQ11371.1    KQ978496    KYM93624.1    GL446201    EFN88284.1    KK854379    PTY15275.1    GECU01021999    JAS85707.1    GL434776    EFN74585.1    KQ414646    KOC66607.1    KQ976438    KYM86820.1    ADTU01012323   

Proteomes

UP000005204    UP000218220    UP000037510    UP000007151    UP000053268    UP000283053    + More
UP000053240    UP000037069    UP000095301    UP000095300    UP000009192    UP000007798    UP000001819    UP000092445    UP000092444    UP000001292    UP000000304    UP000078200    UP000007801    UP000008711    UP000075884    UP000192221    UP000000803    UP000092443    UP000092460    UP000008792    UP000002282    UP000001070    UP000002320    UP000075900    UP000268350    UP000076408    UP000075886    UP000075883    UP000075880    UP000008820    UP000075920    UP000092553    UP000030765    UP000075885    UP000075881    UP000069272    UP000000673    UP000235965    UP000053097    UP000279307    UP000192223    UP000005203    UP000027135    UP000242457    UP000007266    UP000183832    UP000009046    UP000076502    UP000053105    UP000075901    UP000078542    UP000008237    UP000000311    UP000053825    UP000078540    UP000005205   

PRIDE

A3RKJ4    Q95078   

Pfam

PF00067   p450        + More
PF00089   Trypsin

Interpro

IPR036396   Cyt_P450_sf        + More
IPR017972   Cyt_P450_CS       
IPR001128   Cyt_P450       
IPR002401   Cyt_P450_E_grp-I       
IPR009003   Peptidase_S1_PA       
IPR001254   Trypsin_dom       
IPR008067   Cyt_P450_E_grp-I_CYP2A-like       
IPR008069   Cyt_P450_E_grp-I_CYP2D-like       

SUPFAM

SSF48264   SSF48264        + More
SSF50494   SSF50494       

Gene 3D

1.10.630.10    

ProteinModelPortal

A3RKJ4   B0FLU7   A0A286QUG6   A0A0U2DUF3   A0A2H1W1C9   A0A2W1BU05   + More
A0A2A4J994   A0A0L7LD89   Q0KH48   A0A212FF58   A0A1V0D9E4   A0A0C5BXD7   A0A194Q8D1   A0A3S2MA15   X5D9A2   A0A194QW87   A0A0L0CHZ8   A0A1I8M232   A0A1I8P5A2   W8AMG1   A0A0K8UW89   A0A0A1WG55   B4L7K1   B4ND97   Q29FZ2   A0A1A9ZTL1   A0A1B0FA69   B4I6V9   B4NUN4   A0A1A9V5F7   B3MVQ7   A0A1L8E418   B3NUM8   A0A182NN32   A0A1W4USK2   A0A1L8E4A7   Q95078   A0A1A9XAW2   A0A1B0B547   B4M2S8   B4PWD9   B4JJR2   B0W1X3   A0A182RKU1   A0A3B0JW02   A0A182YEM8   A0A182R1A8   A0A182LRV4   A0A182IXK9   Q17BQ1   A0A182VPZ6   A0A0M4F9T8   A0A084VYR6   A0A182PDH2   A0A286MXM9   A0A182K5Y9   K9LCG6   A0A182F8T8   W5J7Q3   U5EUU5   A0A336MGX6   A0A068F5Y4   A0A0C9R0V4   A0A2J7Q892   A0A026WDY9   A0A1W4XAM0   A0A310S7A8   A0A088ASU9   A0A1L1ZLT7   A0A1Y1LM62   A0A0K1YW92   A0A067RDG2   A0A2A3E9H0   A0A0T6B5W1   A0A139WCK2   A0A023F621   A0A1J1J042   E0VMV7   A0A1W6L1D2   A0A154PF58   A0A0M8ZRY0   A0A0K0LB80   A0A182SF83   A0A0M4H5B2   A0A224XI67   M9T368   A0A1L8E3Y4   A0A0A9YXX1   A0A151I688   E2B7S1   A0A2R7WAK1   A0A1B6IFL7   E1ZW76   A0A0L7R6U1   A0A195BNJ2   A0A158ND43  

PDB

5E58     E-value=3.52594e-73,     Score=700

KEGG

100036578    K14985 26-hydroxylase [EC:1.14.-.-] | (RefSeq) Cyp18a1; cytochrome P450 18a1

PATHWAY

00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0005506   GO:0016705   GO:0016021   GO:0004497   GO:0020037   GO:0046872   GO:0035210   GO:0007304   GO:0046344   GO:0035074   GO:0007480   GO:0008395   GO:0005789   GO:0007552   GO:0055114   GO:0043231   GO:0042738   GO:0016712   GO:0006805   GO:0004252   GO:0005737   GO:0006082   GO:0070330   GO:0051861   GO:0000160   GO:0005216   GO:0006811   GO:0006541   GO:0016812   GO:0016597  

Subcellular location

Endoplasmic reticulum membrane  
Microsome membrane  

Length:

514

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.4632

Exp number, first 60 AAs:

0.12625

Total prob of N-in:

0.01562

outside

1  -  514

 

 

Pi

185.639059

Theta

171.104208

Tajima's D

0.30313

CLR

0.377874

CSRT

0.452177391130443

Interpretation

Uncertain