Gene

KWMTBOMO05789  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006920

Annotation

Leucine-rich_repeats_and_immunoglobulin-like_domains_protein_3_[Papilio_machaon]

Location

Bomo_Chr10(-):10039724-10054175      View in EpiBrowser

Full name

Leucine-rich repeats and immunoglobulin-like domains protein 3      

Location in the cell

Nuclear   Reliability : 1.689 PlasmaMembrane   Reliability : 1.164

CDS

ATGGGAGACTCTCGATTGTTATTGTTTATAACAATGAGCTTGTTCCTTAGTTCATCGACTCTGGGGGAAATTTACTTTTGCCCATTAGAATGCGCCTGTCTGCATTTATATGTCGATTGTTCAAAGAAGAATTTGGTGTCTGTGCCAAAAATTCCTGAGTGGGCGGAGCAATTGGACCTCAGTCATAATAAACTAAATAATGTCACGAATGAATTGAATACGCTATCGAATTTAAAAGTATTAAAACTCGACAAGAATAATATGAACAATATACCGAACCTCCAGTTGGACGAAATACTAGAACTAAACCTCAATAGAAATAACATTGTATCAATAGACACGAATCATTTTCCGGAAAATAGCTCTTTGAAAATATTAAATCTCAACAGTAATCACATAATGACGATACATGAAGGAGCTATTGATAATTTATCCAACTTGGAAGTATTGAAATTAAACAGAAATGAGATTAAATCTCTCCCAAATCATTTATTCAAGTATCAAACAAATTTGAGAATTCTAGAACTGAATCACAATAAATTGCATGTTATCAATGCACTGCTTTTTCAAGGATTATCAAATTTGACTACTTTGAAACTTAGATTTAACAACATAGATAAAATAATGGATGGTGCCTTTTTCGGATTTAAATCAATGAACCTATTGCAATTGGATCATAATAAAATCAGAGGTATATCAAAAGGGTGGATGTATGGCCTTGAATCTTTGACAACATTATCTATGTCCAACAACTTGATATCTAATATTGATCTAGGAAGCTGGGAACTGTGTGCAAATTTAGAGGTTCTTGATTTATCACACAATCATTTGATAGAAATAGAGGGGCGTACCTTTCAACACCTAATAAACCTTGAAACATTAAATCTTAGTAACAATAATATATCATCTATTTCACAAGAGTCCTTCAGTTATATGGCTCATCTTAAAGCACTTTATTTGAATAACAACAAAATTTCTTGGACTGTAGAAGACATGTCTGGGCCTTTCTCAAAATTACAAAATTTACACTTCTTTAACTTAGCAAGTAATCATATAAAGTCTATAAACTCCAGGGCATTTGATGGTCTTTCCAATCTATTGGAGTTAAATTTGGCTGGAAATAACATAACATCTATTCAGCAGCATGCATTTAATTCTATGACAAACCTGAAAAAACTACACATGAACTCGTCATCGCTACTCTGTGACTGTAATTTGTTATGGATTGTTAAATGGATAAAAGAAAAAGCTGAGCAAAAATTTATCACTGCTACTTGTGCATACCCCTCTGAAGTCAGAGGTGTGTCAATTACAAAACTGAAAGAGGAAAACTGTGGAGATTCGCCAAAACCAAAAATTGTAGAGCATCCTAAAACACAGCTTGCAATTAAAGGGCGTTCTGCTAGTCTAAGTGGTCAACCTCGTGCAACATCTACCCTAATTATACCTAACATCTCACAAGGAGATTCTGGTAAATACCAATGTGTTGTAACAAATAATTTTGGAACTACATATTCTTCAAAAGCAAAAATGAATATTGTCACATTCCCTAGGTTTATAAAAACACCAACAAATGTGACTGTTAAAACTGGTGAAACTGTCACACTGAACTGTGCAGCTACTGGAGACCCTACTCCAGAGATATCATGGAAAAAAGATGGGGGGAATGACTTCCCTGCAGCTAGAGAAAGAAGAATGAATGTTATGCCGGATGATCATTTATTTTTTATTGTTAATGTAAAGACAACAGATATTGGTGTTTACAGTTGCGCTGCAAAAAATCCTGCCGGCACTATTGTGGCTAATGCTACATTGACAGTATTACAAGAACCTTCATTTGCTAAGGTAATGGAAAACAAAGAAGTCATCAGTGGAGACTCAGTTGTTTTACAATGTATGATTTCGGGATCACCTAAGCCAGTTTTGAAATGGCTAAAAGATGATACTCCAGTTGTCCCTGGCGAAAGACATTTCTTAGTTAATGATGACCAACTATTGATCATAACAGGAGTACAATCTGACGATGCTGGTAAATATGATTGTGAGATCACAAATGAACTGGGAACTAAGAAACATATGACTCAGCTACAAGTATTGCCACCTGTAGCAATTATGGTTAATGAGGAAGATATGACTGGCATCATAATTATAACTGTAGTGTGTTGTGCTGTTGGAACTTCAATAATATGGGTAGTAATTATATATCATACCCGTAGGCGTATGGCAACTGCAGTGCGTATTCCTACAGAAAGTTTGAAAAGAACACATATAGTGCACAGTGACAGTGATTCTCCACAAATGTTTTCAGACAATGTTTCAGAACATTCATCATGTAAGGATAGTGGGACTGGTGATTCTGCTAAACAAACGAGCTTTGATGGTGTTCCTATGGAAAGGATTGAACAAGTACACTTTGAGCCTCCTGCCACCAACCGGAGCTATTCTCCTGTGCCTGAGGCTCATAAACTTCTTCCATCTTCCTTTAAACCATCAATTCAATCCGGATATCCAGGACAGGCAGCTTACGGTGGAATGCCACCAGGCCAATTAGAAATTGGACATGGACCGTACCCTTCCATTGGAGTTGGGGGTACTATTACGCCCCAAGTACAGCAGTGGTTCCGAGCTGTAGATAAAGATCAATCTGGATTCATTACTTCGACAGAACTAAGATCAGCGTTGGTGAACGCTCAAGGTCAAACTTTTTCCGAAACTGCTTGCAATCTGATGATTGGTATGTTCGACAAAGACCGCAACGGGCAGATTAATCTCGATGAATTTGATAAGCTTTATACTTACGTGAATCAATGGTTAGCTGTATTCAAAACCTACGATACGGATCAATCTGGTTTCATAGATGAAGGCGAACTTTCTAAAGCTCTGACACAAATGGGATTCCGGTTCTCACCAGAGTTTATAAATATTTTAACGAAACGGAGTAACACAAATGATGGAAAAATTTCCGTGGACCAGTTTATTGTGATGTGCGTTCAGATACAACGTTTCACTGAAGCATTTCGAGTACGCGATACCGAACAAAATGGGACGGTTACCATAGCCTTTGAAGACTTCCTTACTATTGCCCTGAGCTGTTCTATTTGA

Protein

MGDSRLLLFITMSLFLSSSTLGEIYFCPLECACLHLYVDCSKKNLVSVPKIPEWAEQLDLSHNKLNNVTNELNTLSNLKVLKLDKNNMNNIPNLQLDEILELNLNRNNIVSIDTNHFPENSSLKILNLNSNHIMTIHEGAIDNLSNLEVLKLNRNEIKSLPNHLFKYQTNLRILELNHNKLHVINALLFQGLSNLTTLKLRFNNIDKIMDGAFFGFKSMNLLQLDHNKIRGISKGWMYGLESLTTLSMSNNLISNIDLGSWELCANLEVLDLSHNHLIEIEGRTFQHLINLETLNLSNNNISSISQESFSYMAHLKALYLNNNKISWTVEDMSGPFSKLQNLHFFNLASNHIKSINSRAFDGLSNLLELNLAGNNITSIQQHAFNSMTNLKKLHMNSSSLLCDCNLLWIVKWIKEKAEQKFITATCAYPSEVRGVSITKLKEENCGDSPKPKIVEHPKTQLAIKGRSASLSGQPRATSTLIIPNISQGDSGKYQCVVTNNFGTTYSSKAKMNIVTFPRFIKTPTNVTVKTGETVTLNCAATGDPTPEISWKKDGGNDFPAARERRMNVMPDDHLFFIVNVKTTDIGVYSCAAKNPAGTIVANATLTVLQEPSFAKVMENKEVISGDSVVLQCMISGSPKPVLKWLKDDTPVVPGERHFLVNDDQLLIITGVQSDDAGKYDCEITNELGTKKHMTQLQVLPPVAIMVNEEDMTGIIIITVVCCAVGTSIIWVVIIYHTRRRMATAVRIPTESLKRTHIVHSDSDSPQMFSDNVSEHSSCKDSGTGDSAKQTSFDGVPMERIEQVHFEPPATNRSYSPVPEAHKLLPSSFKPSIQSGYPGQAAYGGMPPGQLEIGHGPYPSIGVGGTITPQVQQWFRAVDKDQSGFITSTELRSALVNAQGQTFSETACNLMIGMFDKDRNGQINLDEFDKLYTYVNQWLAVFKTYDTDQSGFIDEGELSKALTQMGFRFSPEFINILTKRSNTNDGKISVDQFIVMCVQIQRFTEAFRVRDTEQNGTVTIAFEDFLTIALSCSI

Description

May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).

Subunit

Interacts with EGFR, ERBB2 and ERBB4 (in vitro).

Keywords

Alternative splicing   Cell membrane   Complete proteome   Cytoplasmic vesicle   Developmental protein   Disulfide bond   Glycoprotein   Immunoglobulin domain   Leucine-rich repeat   Membrane   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Leucine-rich repeats and immunoglobulin-like domains protein 3
splice variant  In isoform 2.

Uniprot

A0A194RBK8   A0A194QEA5   A0A0L7LRL8   A0A2H1W9I2   A0A2A4JQA6   A0A2W1BU19   + More
A0A194RCI6   A0A2J7PXZ3   A0A2J7PY00   A0A2P8ZLE5   E2BGQ9   A0A0N8A6G9   A0A0P5HNG9   A0A026VY36   D6W6K8   A0A0J7NT49   A0A088AUX2   A0A146L7E5   A0A0P6AM67   A0A164W9T3   A0A0P6GUV0   A0A2A3E803   E1ZVE8   V4BQX8   A0A1B6GRF4   A0A1B6E3N8   R7V016   K7IXQ9   A0A151WKY9   A0A0T6BC00   A0A195BGE0   A0A195DQZ1   A0A195FD24   I3M049   F4X8H7   H0VJB6   A0A151IIY4   A0A158NBN2   F6W7K8   A0A2K6F4G2   A0A3Q7WZW6   A0A2Y9GYK9   A0A3Q7V3Q9   G3SKZ9   G3U7I2   G3RJB5   A0A0P5RBF1   A0A2U3X4L7   D2H328   H2NHW0   Q6UXM1   H2Q6D1   A0A2Y9KYJ8   G1S5Q1   A0A3Q7PYL0   E1BN69   A0A2Y9FNH4   M3XSK0   F1SKD7   A0A383ZXC5   G1T9T3   F6YDB3   A0A232ES86   A0A1S2ZBA6   A0A2J8KVQ9   W5NIH5   W5NIH3   A0A1S3FF81   A0A1L8GYN2   A0A1L8GUD1   A0A287AI53   A0A3Q3KMT6   H3CN76   A0A1S3SHC9   A0A3B4CUF8   A0A3B3TED3   A0A3Q3KMV7   A0A1S3N0F3   A0A3Q1F4B6   A0A147BU85   A0A131XVU3   W5P3P1   A0A131XF45   W5LKM1   A0A1B6MI28   A0A1B6KHJ9   L7MIH9   I3JUG3  

Pubmed

26354079    26227816    28756777    29403074    20798317    24508170    + More
30249741    18362917    19820115    26823975    23254933    20075255    21719571    21993624    21347285    19892987    22398555    20010809    15203213    12975309    14702039    16136131    19393038    20431018    28648823    27762356    15496914    29240929    29652888    20809919    28049606    25329095    25576852    25186727   

EMBL

KQ460398    KPJ14997.1    KQ459302    KPJ01796.1    JTDY01000239    KOB78115.1    + More
ODYU01006887    SOQ49134.1    NWSH01000905    PCG73590.1    KZ149900    PZC78572.1    KPJ14995.1    NEVH01020852    PNF21218.1    PNF21219.1    PYGN01000023    PSN57328.1    GL448204    EFN85129.1    GDIP01177785    JAJ45617.1    GDIQ01230832    JAK20893.1    KK107638    QOIP01000004    EZA48386.1    RLU23208.1    KQ971307    EFA10831.1    LBMM01001902    KMQ95575.1    GDHC01015537    JAQ03092.1    GDIP01027507    JAM76208.1    LRGB01001274    KZS13085.1    GDIQ01028504    JAN66233.1    KZ288356    PBC27181.1    GL434492    EFN74858.1    KB202283    ESO91319.1    GECZ01004789    JAS64980.1    GEDC01004745    JAS32553.1    AMQN01005574    AMQN01005575    AMQN01005576    KB296320    ELU11894.1    KQ982981    KYQ48549.1    LJIG01002086    KRT84854.1    KQ976500    KYM83242.1    KQ980581    KYN15330.1    KQ981673    KYN38308.1    AGTP01085485    AGTP01085486    AGTP01085487    GL888932    EGI57246.1    AAKN02014756    KQ977445    KYN02610.1    ADTU01011228    CABD030083438    CABD030083439    GDIQ01122668    JAL29058.1    ACTA01002073    ACTA01010073    GL192457    EFB28898.1    ABGA01160822    ABGA01160823    ABGA01160824    ABGA01160825    ABGA01160826    ABGA01160827    NDHI03003457    PNJ44445.1    AY505340    AY358288    AY358295    AK074921    AACZ04012982    ADFV01002192    ADFV01002193    AEYP01080416    AEYP01080417    AEMK02000033    AAMC01103647    AAMC01103648    NNAY01002474    OXU21223.1    NBAG03000333    PNI39111.1    AHAT01037175    CM004470    OCT88950.1    CM004471    OCT87435.1    GEGO01001101    JAR94303.1    GEFM01004383    JAP71413.1    AMGL01081444    AMGL01081445    GEFH01003609    JAP64972.1    GEBQ01004448    JAT35529.1    GEBQ01029343    JAT10634.1    GACK01002040    JAA62994.1    AERX01012898    AERX01012899   

Proteomes

UP000053240    UP000053268    UP000037510    UP000218220    UP000235965    UP000245037    + More
UP000008237    UP000053097    UP000279307    UP000007266    UP000036403    UP000005203    UP000076858    UP000242457    UP000000311    UP000030746    UP000014760    UP000002358    UP000075809    UP000078540    UP000078492    UP000078541    UP000005215    UP000007755    UP000005447    UP000078542    UP000005205    UP000002281    UP000233160    UP000286642    UP000248481    UP000007646    UP000001519    UP000245340    UP000008912    UP000001595    UP000005640    UP000002277    UP000248482    UP000001073    UP000286641    UP000009136    UP000248484    UP000000715    UP000008227    UP000261681    UP000001811    UP000008143    UP000215335    UP000079721    UP000018468    UP000081671    UP000186698    UP000261640    UP000007303    UP000087266    UP000261440    UP000261540    UP000257200    UP000002356    UP000018467    UP000005207   

PRIDE

Q6UXM1    F1SKD7   

Pfam

PF13202   EF-hand_5        + More
PF13855   LRR_8
PF13499   EF-hand_7
PF07679   I-set
PF13405   EF-hand_6
PF01462   LRRNT
PF01463   LRRCT
PF13516   LRR_6
PF13306   LRR_5

Interpro

IPR003599   Ig_sub        + More
IPR000483   Cys-rich_flank_reg_C       
IPR007110   Ig-like_dom       
IPR013783   Ig-like_fold       
IPR032675   LRR_dom_sf       
IPR002048   EF_hand_dom       
IPR011992   EF-hand-dom_pair       
IPR013098   Ig_I-set       
IPR001611   Leu-rich_rpt       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR003598   Ig_sub2       
IPR018247   EF_Hand_1_Ca_BS       
IPR000372   LRRNT       
IPR036179   Ig-like_dom_sf       
IPR026906   LRR_5       

SUPFAM

SSF47473   SSF47473        + More
SSF48726   SSF48726       

Gene 3D

2.60.40.10     3.80.10.10    

ProteinModelPortal

A0A194RBK8   A0A194QEA5   A0A0L7LRL8   A0A2H1W9I2   A0A2A4JQA6   A0A2W1BU19   + More
A0A194RCI6   A0A2J7PXZ3   A0A2J7PY00   A0A2P8ZLE5   E2BGQ9   A0A0N8A6G9   A0A0P5HNG9   A0A026VY36   D6W6K8   A0A0J7NT49   A0A088AUX2   A0A146L7E5   A0A0P6AM67   A0A164W9T3   A0A0P6GUV0   A0A2A3E803   E1ZVE8   V4BQX8   A0A1B6GRF4   A0A1B6E3N8   R7V016   K7IXQ9   A0A151WKY9   A0A0T6BC00   A0A195BGE0   A0A195DQZ1   A0A195FD24   I3M049   F4X8H7   H0VJB6   A0A151IIY4   A0A158NBN2   F6W7K8   A0A2K6F4G2   A0A3Q7WZW6   A0A2Y9GYK9   A0A3Q7V3Q9   G3SKZ9   G3U7I2   G3RJB5   A0A0P5RBF1   A0A2U3X4L7   D2H328   H2NHW0   Q6UXM1   H2Q6D1   A0A2Y9KYJ8   G1S5Q1   A0A3Q7PYL0   E1BN69   A0A2Y9FNH4   M3XSK0   F1SKD7   A0A383ZXC5   G1T9T3   F6YDB3   A0A232ES86   A0A1S2ZBA6   A0A2J8KVQ9   W5NIH5   W5NIH3   A0A1S3FF81   A0A1L8GYN2   A0A1L8GUD1   A0A287AI53   A0A3Q3KMT6   H3CN76   A0A1S3SHC9   A0A3B4CUF8   A0A3B3TED3   A0A3Q3KMV7   A0A1S3N0F3   A0A3Q1F4B6   A0A147BU85   A0A131XVU3   W5P3P1   A0A131XF45   W5LKM1   A0A1B6MI28   A0A1B6KHJ9   L7MIH9   I3JUG3  

PDB

4U7M     E-value=7.08465e-68,     Score=657

KEGG

101739812    no KO assigned | (RefSeq) leucine-rich repeats and immunoglobulin-like domains protein 3

GO

GO:0005509   GO:0016021   GO:0032474   GO:0030659   GO:0005615   GO:0031012   GO:0005886   GO:0005515   GO:0008173   GO:0008168   GO:0000160   GO:0005216   GO:0006811   GO:0006541   GO:0016812   GO:0016597  

Subcellular location

Cell membrane   Detected in cytoplasmic vesicles when coexpressed with ERBB4.   With evidence from 1 publications.
Cytoplasmic vesicle membrane   Detected in cytoplasmic vesicles when coexpressed with ERBB4.   With evidence from 1 publications.

SignalP

Position:   1 - 22,         Likelihood:  0.996707

 

 

Length:

1033

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

25.95096

Exp number, first 60 AAs:

3.14039

Total prob of N-in:

0.14645

outside

1  -  711

TMhelix

712  -  734

inside

735  -  1033

 

 

Pi

236.425944

Theta

178.691513

Tajima's D

-1.360933

CLR

0.876088

CSRT

0.0776961151942403

Interpretation

Uncertain