Gene
KWMTBOMO05778
Pre Gene Modal
BGIBMGA006926
Annotation
PREDICTED:_intraflagellar_transport_protein_81_homolog_[Bombyx_mori]
Full name
Intraflagellar transport protein 81 homolog
Alternative Name
Carnitine deficiency-associated protein expressed in ventricle 1
Location in the cell
Cytoplasmic Reliability : 1.599 Nuclear Reliability : 1.396
Sequence
CDS
ATGACGGAGCAAATTAAGTTTATAGTTAAAGAAATTAATTCAACTTTAGGGAGGAACTACTATTTGATACAATTTGATGCCCTCGATGAGAAGCAATTACTTCAGTTGCTAGTTGATTTGCTTGTCAATTTGGGAGCTGGTGAAAAGTTGGACGTCAATGAAGACGATTCTGAAACGGTATCATTTCGTCTTCTAGAAATGCTAGGCAGTGTGAAATATCGGCCGCCGAGCACTGTTGAGCCAACGCGGTTTAGGTCCCAACTTCTCGCCGGTGACTCCAGAACTATTCATCATGTTTTACATTGGCTCTTGTCGAATAAGGAACAAGTTAAAAACACAGCATATCTCGCAAAGTATCTCAAAATACCAGATATACCTTCTGACGTAGTTCGTAACAATACGATACAAGACCTGCTGGATCAATATCAAAGTTTGATCGACGAGTTCAAAGACGCTCACAAAAGAACAAGAATGTTGGAAAAGGAGAACGCTTCTGAAATCATTAATGATATCAAAGAGATGGCAGTCGAGAGAGACATGGTTATAAAGAGATTAGAAAGTGTTCAGGTTAATTTGGTAGATGTTCATAATAAAGATGAGTTATTGAATTTAAGCAAAACGTTACGACTTCAACAAGAAAAAGCAAAAGAATTAGAGCTTCAGTTTGATACTCAACAGTCTCAATTGAATTTAGCTTCTGATCAGCTAAAACGATATTTAAATGTAATTCATGGTCAAAGCGCTGCTACGAAAACCCCTACGGATATCATTAAGCATTTACAAGAGGAAATACAATTGAACAGTTATTTGGTGAAAGAAAAATTACCACAAGAGGCAGCTCACATACAGAAGGAATTGAACATTATGCAAAACATCGCCGCCGAGCAACATCCTAGTCGATCGGATCTACATGTGGTTCAAGATAAGTGA
Protein
MTEQIKFIVKEINSTLGRNYYLIQFDALDEKQLLQLLVDLLVNLGAGEKLDVNEDDSETVSFRLLEMLGSVKYRPPSTVEPTRFRSQLLAGDSRTIHHVLHWLLSNKEQVKNTAYLAKYLKIPDIPSDVVRNNTIQDLLDQYQSLIDEFKDAHKRTRMLEKENASEIINDIKEMAVERDMVIKRLESVQVNLVDVHNKDELLNLSKTLRLQQEKAKELELQFDTQQSQLNLASDQLKRYLNVIHGQSAATKTPTDIIKHLQEEIQLNSYLVKEKLPQEAAHIQKELNIMQNIAAEQHPSRSDLHVVQDK
Summary
Description
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling.
Isoform CDV-1: May be involved in cardiac hypertrophy caused by carnitine deficiency.
Isoform CDV-1R: May play a role in development of the testis and spermatogenesis.
Isoform CDV-1: May be involved in cardiac hypertrophy caused by carnitine deficiency.
Isoform CDV-1R: May play a role in development of the testis and spermatogenesis.
Subunit
Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT74; the interaction is direct: within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium. Interacts with tubulin; the interaction is direct (By similarity). Interacts with RABL2/RABL2A; binding is equal in the presence of GTP or GDP. Interacts with IFT88 (By similarity). Interacts (via the IFT74/IFT81 heterodimer) with RABL2B (By similarity).
Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT81, and IFT88 (PubMed:19253336). Interacts with IFT74; the interaction is direct: within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium. Interacts with tubulin; the interaction is direct (By similarity). Interacts with RABL2/RABL2A; binding is equal in the presence of GTP or GDP (PubMed:23055941). Interacts with IFT88 (PubMed:19253336). Interacts (via the IFT74/IFT81 heterodimer) with RABL2B (By similarity).
Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT81, and IFT88 (PubMed:19253336). Interacts with IFT74; the interaction is direct: within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium. Interacts with tubulin; the interaction is direct (By similarity). Interacts with RABL2/RABL2A; binding is equal in the presence of GTP or GDP (PubMed:23055941). Interacts with IFT88 (PubMed:19253336). Interacts (via the IFT74/IFT81 heterodimer) with RABL2B (By similarity).
Similarity
Belongs to the IFT81 family.
Keywords
Acetylation
Cell projection
Cilium
Coiled coil
Complete proteome
Phosphoprotein
Reference proteome
Alternative initiation
Developmental protein
Differentiation
Spermatogenesis
Feature
chain Intraflagellar transport protein 81 homolog
splice variant In isoform CDV-1.
splice variant In isoform CDV-1.
Uniprot
A0A2H1X0I8
H9JBN1
A0A0L7LTE9
A0A212ENT4
A0A194Q8F0
A0A194RAX4
+ More
A0A3S2MA26 A0A2W1BZA7 A0A2J7Q9D1 A0A336KJJ8 A0A1S3FQ29 A0A3Q2GTS2 A0A2U4CL11 F6W5E6 A0A182FPZ1 A0A091NK86 A0A336KI23 W5JWG1 A0A336MJ98 A0A3Q2HY54 A0A2K6EJ80 A0A087TRS8 A0A091S7R9 A0A093NT90 A0A093HCQ5 A0A384AQF3 W5Q2D2 A0A182QHG2 G1MY01 F1RNN4 K9IN50 L5KSD7 A0A087RB25 A0A093RFB8 A0A2Y9EKJ5 A0A384AR08 A0A093BIT9 A0A091PSE4 A0A3Q1LJV4 A0A093J092 A0A1D5Q0F5 A0A091VIC8 A0A384AQJ0 A0A0A0A8U9 A2VDQ0 A0A0Q3RDV0 F6RS05 A0A384AQD0 A0A093F5U9 A0A091L834 A0A093FN67 G1SXY6 A0A091PLN0 A0A3Q7UN25 A0A091G421 A0A2Y9KIK7 A0A2Y9KUS6 A0A3B4FIK6 A0A2Y9QDJ0 P83829 A0A250Y486 G3WS27 A0A2Y9RD33 D4A562 U6CUW8 A0A340WMB1 G3WS28 G3WS26 A0A341CJ39 A0A094L3H6 A0A2U4CKT1 G3SMM2 A0A226NA30 M3XSR0 A0A091I7N8 A0A094NQA2 A0A341CIN4 A0A2I0M8M8 F7G3R6 A0A099Z512 A0A2U3ZB99 A0A091VQB1 A0A084W9G2 A0A2U3ZB89 A0A3Q3BHA7 A0A3P8NBI6 A0A3P9AZI5 A0A3P8NBG3 A0A3P8NBK3 A0A093JEL9 A0A3Q7RXN0 G3H240 H0WUG9 A0A091UMH8 G1M686 A0A091LIG6 O35594 I3KG30 A0A1S3A4H4 A0A226PZP5
A0A3S2MA26 A0A2W1BZA7 A0A2J7Q9D1 A0A336KJJ8 A0A1S3FQ29 A0A3Q2GTS2 A0A2U4CL11 F6W5E6 A0A182FPZ1 A0A091NK86 A0A336KI23 W5JWG1 A0A336MJ98 A0A3Q2HY54 A0A2K6EJ80 A0A087TRS8 A0A091S7R9 A0A093NT90 A0A093HCQ5 A0A384AQF3 W5Q2D2 A0A182QHG2 G1MY01 F1RNN4 K9IN50 L5KSD7 A0A087RB25 A0A093RFB8 A0A2Y9EKJ5 A0A384AR08 A0A093BIT9 A0A091PSE4 A0A3Q1LJV4 A0A093J092 A0A1D5Q0F5 A0A091VIC8 A0A384AQJ0 A0A0A0A8U9 A2VDQ0 A0A0Q3RDV0 F6RS05 A0A384AQD0 A0A093F5U9 A0A091L834 A0A093FN67 G1SXY6 A0A091PLN0 A0A3Q7UN25 A0A091G421 A0A2Y9KIK7 A0A2Y9KUS6 A0A3B4FIK6 A0A2Y9QDJ0 P83829 A0A250Y486 G3WS27 A0A2Y9RD33 D4A562 U6CUW8 A0A340WMB1 G3WS28 G3WS26 A0A341CJ39 A0A094L3H6 A0A2U4CKT1 G3SMM2 A0A226NA30 M3XSR0 A0A091I7N8 A0A094NQA2 A0A341CIN4 A0A2I0M8M8 F7G3R6 A0A099Z512 A0A2U3ZB99 A0A091VQB1 A0A084W9G2 A0A2U3ZB89 A0A3Q3BHA7 A0A3P8NBI6 A0A3P9AZI5 A0A3P8NBG3 A0A3P8NBK3 A0A093JEL9 A0A3Q7RXN0 G3H240 H0WUG9 A0A091UMH8 G1M686 A0A091LIG6 O35594 I3KG30 A0A1S3A4H4 A0A226PZP5
Pubmed
19121390
26227816
22118469
26354079
28756777
19892987
+ More
20920257 23761445 20809919 20838655 23258410 19393038 17431167 21993624 28087693 21709235 15057822 23371554 17495919 24438588 25186727 21804562 20010809 9187371 11130971 12549821 16141072 15489334 10210276 19253336 21183079 23055941 24621616
20920257 23761445 20809919 20838655 23258410 19393038 17431167 21993624 28087693 21709235 15057822 23371554 17495919 24438588 25186727 21804562 20010809 9187371 11130971 12549821 16141072 15489334 10210276 19253336 21183079 23055941 24621616
EMBL
ODYU01012516
SOQ58870.1
BABH01024416
JTDY01000121
KOB78735.1
AGBW02013613
+ More
OWR43165.1 KQ459302 KPJ01803.1 KQ460398 KPJ15003.1 RSAL01000003 RVE54877.1 KZ149900 PZC78577.1 NEVH01016383 PNF25190.1 UFQS01000447 UFQT01000447 SSX04058.1 SSX24423.1 KL384645 KFP89487.1 SSX04057.1 SSX24422.1 ADMH02000156 ETN67560.1 UFQT01001127 SSX29049.1 KK116440 KFM67817.1 KK944863 KFQ53528.1 KL224874 KFW65145.1 KL205919 KFV76782.1 AMGL01039250 AMGL01039251 AMGL01039252 AMGL01039253 AMGL01039254 AXCN02001629 AEMK02000096 GABZ01004823 JAA48702.1 KB030576 ELK14327.1 KL226265 KFM10679.1 KL442952 KFW94687.1 KL227573 KFV03554.1 KK665277 KFQ10842.1 KK566159 KFW04429.1 JSUE03007740 JSUE03007741 KK432673 KFQ89363.1 KL870823 KGL89405.1 BC133344 AAI33345.1 LMAW01001359 KQK83705.1 KK617713 KFV49544.1 KL301911 KFP51413.1 KK392992 KFV55734.1 AAGW02061447 AAGW02061448 AAGW02061449 KK675470 KFQ08520.1 KL447648 KFO75819.1 AY345164 AAQ23131.1 GFFV01001542 JAV38403.1 AEFK01071447 AEFK01071448 AEFK01071449 AABR07036349 AABR07036350 AABR07036351 AABR07036352 AABR07036353 AABR07072296 HAAF01002445 CCP74271.1 KL360976 KFZ65400.1 MCFN01000132 OXB64120.1 AEYP01033509 AEYP01033510 AEYP01033511 AEYP01033512 AEYP01033513 AEYP01033514 AEYP01033515 AEYP01033516 AEYP01033517 AEYP01033518 KL217497 KFO95775.1 KL285693 KFZ68586.1 AKCR02000030 PKK26020.1 KL889407 KGL76811.1 KK734180 KFR04880.1 ATLV01021757 KE525322 KFB46856.1 KL217402 KFV77294.1 JH000113 EGW07455.1 AAQR03124337 AAQR03124338 AAQR03124339 AAQR03124340 AAQR03124341 AAQR03124342 AAQR03124343 AAQR03124344 AAQR03124345 AAQR03124346 KL409758 KFQ91821.1 ACTA01032595 ACTA01040594 ACTA01048594 ACTA01056594 ACTA01064594 ACTA01072594 KK753734 KFP42641.1 Y10495 Y10496 AF203441 AF203431 AF203432 AF203433 AF203434 AF203435 AF203436 AF203437 AF203438 AF203439 AF203440 AF354757 AK013424 AK042372 BC055721 AERX01019884 AWGT02000001 OXB84942.1
OWR43165.1 KQ459302 KPJ01803.1 KQ460398 KPJ15003.1 RSAL01000003 RVE54877.1 KZ149900 PZC78577.1 NEVH01016383 PNF25190.1 UFQS01000447 UFQT01000447 SSX04058.1 SSX24423.1 KL384645 KFP89487.1 SSX04057.1 SSX24422.1 ADMH02000156 ETN67560.1 UFQT01001127 SSX29049.1 KK116440 KFM67817.1 KK944863 KFQ53528.1 KL224874 KFW65145.1 KL205919 KFV76782.1 AMGL01039250 AMGL01039251 AMGL01039252 AMGL01039253 AMGL01039254 AXCN02001629 AEMK02000096 GABZ01004823 JAA48702.1 KB030576 ELK14327.1 KL226265 KFM10679.1 KL442952 KFW94687.1 KL227573 KFV03554.1 KK665277 KFQ10842.1 KK566159 KFW04429.1 JSUE03007740 JSUE03007741 KK432673 KFQ89363.1 KL870823 KGL89405.1 BC133344 AAI33345.1 LMAW01001359 KQK83705.1 KK617713 KFV49544.1 KL301911 KFP51413.1 KK392992 KFV55734.1 AAGW02061447 AAGW02061448 AAGW02061449 KK675470 KFQ08520.1 KL447648 KFO75819.1 AY345164 AAQ23131.1 GFFV01001542 JAV38403.1 AEFK01071447 AEFK01071448 AEFK01071449 AABR07036349 AABR07036350 AABR07036351 AABR07036352 AABR07036353 AABR07072296 HAAF01002445 CCP74271.1 KL360976 KFZ65400.1 MCFN01000132 OXB64120.1 AEYP01033509 AEYP01033510 AEYP01033511 AEYP01033512 AEYP01033513 AEYP01033514 AEYP01033515 AEYP01033516 AEYP01033517 AEYP01033518 KL217497 KFO95775.1 KL285693 KFZ68586.1 AKCR02000030 PKK26020.1 KL889407 KGL76811.1 KK734180 KFR04880.1 ATLV01021757 KE525322 KFB46856.1 KL217402 KFV77294.1 JH000113 EGW07455.1 AAQR03124337 AAQR03124338 AAQR03124339 AAQR03124340 AAQR03124341 AAQR03124342 AAQR03124343 AAQR03124344 AAQR03124345 AAQR03124346 KL409758 KFQ91821.1 ACTA01032595 ACTA01040594 ACTA01048594 ACTA01056594 ACTA01064594 ACTA01072594 KK753734 KFP42641.1 Y10495 Y10496 AF203441 AF203431 AF203432 AF203433 AF203434 AF203435 AF203436 AF203437 AF203438 AF203439 AF203440 AF354757 AK013424 AK042372 BC055721 AERX01019884 AWGT02000001 OXB84942.1
Proteomes
UP000005204
UP000037510
UP000007151
UP000053268
UP000053240
UP000283053
+ More
UP000235965 UP000081671 UP000002281 UP000245320 UP000069272 UP000000673 UP000233160 UP000054359 UP000054081 UP000053584 UP000002356 UP000075886 UP000001645 UP000008227 UP000010552 UP000053286 UP000261681 UP000009136 UP000006718 UP000053858 UP000051836 UP000001811 UP000286640 UP000053760 UP000248482 UP000261460 UP000248483 UP000002494 UP000007648 UP000248480 UP000265300 UP000252040 UP000007646 UP000198323 UP000000715 UP000054308 UP000053872 UP000002280 UP000053641 UP000245340 UP000053605 UP000030765 UP000264840 UP000265100 UP000265160 UP000053875 UP000286641 UP000001075 UP000005225 UP000053283 UP000008912 UP000000589 UP000005207 UP000079721 UP000198419
UP000235965 UP000081671 UP000002281 UP000245320 UP000069272 UP000000673 UP000233160 UP000054359 UP000054081 UP000053584 UP000002356 UP000075886 UP000001645 UP000008227 UP000010552 UP000053286 UP000261681 UP000009136 UP000006718 UP000053858 UP000051836 UP000001811 UP000286640 UP000053760 UP000248482 UP000261460 UP000248483 UP000002494 UP000007648 UP000248480 UP000265300 UP000252040 UP000007646 UP000198323 UP000000715 UP000054308 UP000053872 UP000002280 UP000053641 UP000245340 UP000053605 UP000030765 UP000264840 UP000265100 UP000265160 UP000053875 UP000286641 UP000001075 UP000005225 UP000053283 UP000008912 UP000000589 UP000005207 UP000079721 UP000198419
Pfam
PF18383 IFT81_CH
ProteinModelPortal
A0A2H1X0I8
H9JBN1
A0A0L7LTE9
A0A212ENT4
A0A194Q8F0
A0A194RAX4
+ More
A0A3S2MA26 A0A2W1BZA7 A0A2J7Q9D1 A0A336KJJ8 A0A1S3FQ29 A0A3Q2GTS2 A0A2U4CL11 F6W5E6 A0A182FPZ1 A0A091NK86 A0A336KI23 W5JWG1 A0A336MJ98 A0A3Q2HY54 A0A2K6EJ80 A0A087TRS8 A0A091S7R9 A0A093NT90 A0A093HCQ5 A0A384AQF3 W5Q2D2 A0A182QHG2 G1MY01 F1RNN4 K9IN50 L5KSD7 A0A087RB25 A0A093RFB8 A0A2Y9EKJ5 A0A384AR08 A0A093BIT9 A0A091PSE4 A0A3Q1LJV4 A0A093J092 A0A1D5Q0F5 A0A091VIC8 A0A384AQJ0 A0A0A0A8U9 A2VDQ0 A0A0Q3RDV0 F6RS05 A0A384AQD0 A0A093F5U9 A0A091L834 A0A093FN67 G1SXY6 A0A091PLN0 A0A3Q7UN25 A0A091G421 A0A2Y9KIK7 A0A2Y9KUS6 A0A3B4FIK6 A0A2Y9QDJ0 P83829 A0A250Y486 G3WS27 A0A2Y9RD33 D4A562 U6CUW8 A0A340WMB1 G3WS28 G3WS26 A0A341CJ39 A0A094L3H6 A0A2U4CKT1 G3SMM2 A0A226NA30 M3XSR0 A0A091I7N8 A0A094NQA2 A0A341CIN4 A0A2I0M8M8 F7G3R6 A0A099Z512 A0A2U3ZB99 A0A091VQB1 A0A084W9G2 A0A2U3ZB89 A0A3Q3BHA7 A0A3P8NBI6 A0A3P9AZI5 A0A3P8NBG3 A0A3P8NBK3 A0A093JEL9 A0A3Q7RXN0 G3H240 H0WUG9 A0A091UMH8 G1M686 A0A091LIG6 O35594 I3KG30 A0A1S3A4H4 A0A226PZP5
A0A3S2MA26 A0A2W1BZA7 A0A2J7Q9D1 A0A336KJJ8 A0A1S3FQ29 A0A3Q2GTS2 A0A2U4CL11 F6W5E6 A0A182FPZ1 A0A091NK86 A0A336KI23 W5JWG1 A0A336MJ98 A0A3Q2HY54 A0A2K6EJ80 A0A087TRS8 A0A091S7R9 A0A093NT90 A0A093HCQ5 A0A384AQF3 W5Q2D2 A0A182QHG2 G1MY01 F1RNN4 K9IN50 L5KSD7 A0A087RB25 A0A093RFB8 A0A2Y9EKJ5 A0A384AR08 A0A093BIT9 A0A091PSE4 A0A3Q1LJV4 A0A093J092 A0A1D5Q0F5 A0A091VIC8 A0A384AQJ0 A0A0A0A8U9 A2VDQ0 A0A0Q3RDV0 F6RS05 A0A384AQD0 A0A093F5U9 A0A091L834 A0A093FN67 G1SXY6 A0A091PLN0 A0A3Q7UN25 A0A091G421 A0A2Y9KIK7 A0A2Y9KUS6 A0A3B4FIK6 A0A2Y9QDJ0 P83829 A0A250Y486 G3WS27 A0A2Y9RD33 D4A562 U6CUW8 A0A340WMB1 G3WS28 G3WS26 A0A341CJ39 A0A094L3H6 A0A2U4CKT1 G3SMM2 A0A226NA30 M3XSR0 A0A091I7N8 A0A094NQA2 A0A341CIN4 A0A2I0M8M8 F7G3R6 A0A099Z512 A0A2U3ZB99 A0A091VQB1 A0A084W9G2 A0A2U3ZB89 A0A3Q3BHA7 A0A3P8NBI6 A0A3P9AZI5 A0A3P8NBG3 A0A3P8NBK3 A0A093JEL9 A0A3Q7RXN0 G3H240 H0WUG9 A0A091UMH8 G1M686 A0A091LIG6 O35594 I3KG30 A0A1S3A4H4 A0A226PZP5
PDB
6IAN
E-value=3.12413e-15,
Score=198
Ontologies
GO
PANTHER
Topology
Subcellular location
Length:
309
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00059
Exp number, first 60 AAs:
0.00059
Total prob of N-in:
0.04566
outside
1 - 309
Population Genetic Test Statistics
Pi
185.628075
Theta
183.549392
Tajima's D
0.010483
CLR
0.30297
CSRT
0.369031548422579
Interpretation
Uncertain
