Gene

KWMTBOMO05777

Pre Gene Modal

BGIBMGA006926

Annotation

PREDICTED:_intraflagellar_transport_protein_81_homolog_[Bombyx_mori]

Location

Bomo_Chr10(-):9818578-9820135      View in EpiBrowser

Full name

Intraflagellar transport protein 81 homolog      

Alternative Name

Carnitine deficiency-associated protein expressed in ventricle 1

Location in the cell

Nuclear   Reliability : 2.221

CDS

ATGGTGAAACAAAAGGTGAAACAGCTCCTGGGGGATACGGTTTTGAGAGGCGAAGAACTCAAGAAATATGTGAATTCGTTACGAACAAAGAGTACGGTATATAAAAGGCAAAGAGCCAATCTTTTGGCATTGAAGAGTGAAGCAGGAATTCTAGCACGCACTATACAAATAATTAGTGTTGCGGATCCTACTGTAGAAATGGCTTTAGTAAACCATAAGAAAATGATTATTGATGACGAAAAGGATCTCTTGAGCAAAGACGACGACAACAGCATGGACTTAGGAAAGAAGTCTTTCCACGATTTATCTCAGATAGTTGCAAAAACAGCGCAAAAACTGTCTGAAGTGCGTCAAGAGATTCAGCCACTCGCCGACAAAATTAAGCCGGTCAAAGAAGAGTTTCAATCAGTCCAACAGCAATACGAACAAAGGAAGCGAGTGTACGAGGCAACGTCCATTAATATAGCCTCACAAATGGAGCCACTCAAGAATCAAGTGAAAACTCTGACCGACCAATTGAACAGCAAAGAGGACGAATGGAAAAACTTGAGGCAAAAAATAACGAAGGCCGAAAGTTTACAAGAGATCGTAATGTACGAAATGAAAAATTCTATGCAGTCCCCGAGGAAGCCATCGAAAATGGAGGCCCTGAAGTTAAAAGTTTCGGATTTGAAACGAATCGTTGAGAATTTGGAAAAGGAGCAAACGGCTATCAGTTCTCGTCAGGGTGTAGTTGAAGAGCAAACTAATTTATGGGAGAACACGTTGAAATTGCTCCGATGTAAGATGGCCGCCCGTAATGCGCCCGCTGCACGCCAGGGACGAATGCACATCACACAACATTCACAAATGCTTACACTTACATAA

Protein

MVKQKVKQLLGDTVLRGEELKKYVNSLRTKSTVYKRQRANLLALKSEAGILARTIQIISVADPTVEMALVNHKKMIIDDEKDLLSKDDDNSMDLGKKSFHDLSQIVAKTAQKLSEVRQEIQPLADKIKPVKEEFQSVQQQYEQRKRVYEATSINIASQMEPLKNQVKTLTDQLNSKEDEWKNLRQKITKAESLQEIVMYEMKNSMQSPRKPSKMEALKLKVSDLKRIVENLEKEQTAISSRQGVVEEQTNLWENTLKLLRCKMAARNAPAARQGRMHITQHSQMLTLT

Description

Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling.
Isoform CDV-1: May be involved in cardiac hypertrophy caused by carnitine deficiency.
Isoform CDV-1R: May play a role in development of the testis and spermatogenesis.

Subunit

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT81, and IFT88 (PubMed:19253336). Interacts with IFT74; the interaction is direct: within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium. Interacts with tubulin; the interaction is direct (By similarity). Interacts with RABL2/RABL2A; binding is equal in the presence of GTP or GDP (PubMed:23055941). Interacts with IFT88 (PubMed:19253336). Interacts (via the IFT74/IFT81 heterodimer) with RABL2B (By similarity).

Similarity

Belongs to the IFT81 family.

Keywords

Acetylation   Alternative initiation   Cell projection   Cilium   Coiled coil   Complete proteome   Developmental protein   Differentiation   Phosphoprotein   Reference proteome   Spermatogenesis  

Feature

chain  Intraflagellar transport protein 81 homolog
splice variant  In isoform CDV-1.

Uniprot

H9JBN1   A0A2A4JVN2   A0A2W1BZA7   A0A2H1X0I8   A0A3S2MA26   A0A194RCJ5   + More
A0A212ENT4   A0A194Q8F0   A0A0L7LTE9   A0A067QZX2   A0A2J7Q9D1   A0A2P8ZMQ4   E0W292   A0A210QUC2   A7SUB4   A0A2B4SCJ9   A0A1S3K063   A0A1B6E6H5   K1P7L7   A0A2G8L761   A0A2G8JQ43   A0A1I8GRH7   A0A267DQE4   A0A3P8VUB2   A0A267H7T7   A0A2L2YH96   W4XIJ8   A0A2C9K3X9   A0A1I8I9Q5   A0A1I8GTR3   A0A0B7B437   A0A0B7B4J9   F2UEF9   Q7QKF1   A0A182VG43   A0A1S4FVH9   A0A0L0HW19   T2M8U1   A0A3Q3AFD2   X1Z4C8   R7UNL3   A0A3P8NBK3   A0A3Q3BHA7   A0A3P8NBI6   A0A3P9AZI5   A0A3P8NBG3   A0A1L8HQQ1   A0A3B4ZPW6   I3KG30   A0A1W4W5E8   A0A3Q4H262   A0A1W4WH59   A0A3B4THB5   A0A0C9R6E4   A0A2D0QXV5   A0A3B4THE3   A0A1L8I137   A0A3B4XP82   A0A3M6V4W6   A0A3Q2U373   A0A0K2TAW8   G3PJH0   B3RM19   A0A2I4D7I8   A0A226DN84   A0A146ZA80   G5AWM7   A0A182H4U0   A0A0N8EUN2   A0A3B5PW21   K3XA89   M3ZQ61   L9KS83   A0A3P9PQS7   E1C6R0   A0A3P9HR24   A0A091K8Y7   A0A3Q0EKG0   A0A3P9MN77   A0A1V4JSH3   K9IN50   O35594   A0A1U7UGT3   A0A091GUT0   A0A3B3X4Z1   A0A087XBM8   H2YNA5   A0A3B3U9P2   A0A2Y9KHA4   A0A3P4RQW1   A0A3Q3X3K2  

Pubmed

19121390    28756777    26354079    22118469    26227816    24845553    + More
29403074    20566863    28812685    17615350    22992520    29023486    26392545    24487278    26561354    15562597    12364791    14747013    17210077    17510324    24065732    23254933    25186727    27762356    30382153    18719581    21993625    26483478    23542700    23385571    15592404    17554307    9187371    11130971    12549821    16141072    15489334    10210276    19253336    21183079    23055941   

EMBL

BABH01024416    NWSH01000528    PCG75869.1    KZ149900    PZC78577.1    ODYU01012516    + More
SOQ58870.1    RSAL01000003    RVE54877.1    KQ460398    KPJ15005.1    AGBW02013613    OWR43165.1    KQ459302    KPJ01803.1    JTDY01000121    KOB78735.1    KK853149    KDR10696.1    NEVH01016383    PNF25190.1    PYGN01000015    PSN57775.1    DS235874    EEB19748.1    NEDP02001821    OWF52341.1    DS469810    EDO32714.1    LSMT01000117    PFX26819.1    GEDC01003755    JAS33543.1    JH817661    EKC19637.1    MRZV01000188    PIK56102.1    MRZV01001432    PIK37901.1    NIVC01003566    PAA50779.1    NIVC01000012    PAA94343.1    IAAA01025374    LAA07503.1    AAGJ04044690    HACG01040943    CEK87808.1    HACG01040942    CEK87807.1    GL832970    EGD75009.1    AAAB01008799    EAA03674.3    KQ257450    KND05085.1    HAAD01002155    CDG68387.1    AMQN01007815    KB301444    ELU05522.1    CM004467    OCT98416.1    AERX01019884    GBYB01002326    GBYB01014539    JAG72093.1    JAG84306.1    CM004466    OCU02076.1    RCHS01000098    RMX60935.1    HACA01005356    CDW22717.1    DS985241    EDV28885.1    LNIX01000015    OXA46468.1    GCES01023073    JAR63250.1    JH167272    EHB01438.1    JXUM01025640    JXUM01025641    JXUM01025642    JXUM01025643    JXUM01025644    JXUM01025645    JXUM01025646    KQ560729    KXJ81112.1    GEBF01001107    JAO02526.1    GL376563    KB320685    ELW65523.1    AADN05000505    KK547596    KFP32806.1    LSYS01006629    OPJ75054.1    GABZ01004823    JAA48702.1    Y10495    Y10496    AF203441    AF203431    AF203432    AF203433    AF203434    AF203435    AF203436    AF203437    AF203438    AF203439    AF203440    AF354757    AK013424    AK042372    BC055721    KL510607    KFO86272.1    AYCK01014931    AYCK01014932    CYRY02042694    VCX36556.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000007151    UP000053268    + More
UP000037510    UP000027135    UP000235965    UP000245037    UP000009046    UP000242188    UP000001593    UP000225706    UP000085678    UP000005408    UP000230750    UP000095280    UP000215902    UP000265120    UP000007110    UP000076420    UP000007799    UP000007062    UP000075903    UP000053201    UP000264800    UP000014760    UP000265100    UP000264840    UP000265160    UP000186698    UP000261400    UP000005207    UP000192223    UP000261580    UP000261420    UP000221080    UP000261360    UP000275408    UP000265000    UP000007635    UP000009022    UP000192220    UP000198287    UP000006813    UP000069940    UP000249989    UP000002852    UP000011518    UP000242638    UP000000539    UP000265200    UP000189704    UP000265180    UP000190648    UP000000589    UP000261480    UP000028760    UP000007875    UP000261500    UP000248482    UP000261620   

PRIDE

H9JBN1    O35594   

Pfam

PF18383   IFT81_CH

Interpro

IPR041146   IFT81_CH        + More
IPR029600   IFT81       
IPR002912   ACT_dom       

ProteinModelPortal

H9JBN1   A0A2A4JVN2   A0A2W1BZA7   A0A2H1X0I8   A0A3S2MA26   A0A194RCJ5   + More
A0A212ENT4   A0A194Q8F0   A0A0L7LTE9   A0A067QZX2   A0A2J7Q9D1   A0A2P8ZMQ4   E0W292   A0A210QUC2   A7SUB4   A0A2B4SCJ9   A0A1S3K063   A0A1B6E6H5   K1P7L7   A0A2G8L761   A0A2G8JQ43   A0A1I8GRH7   A0A267DQE4   A0A3P8VUB2   A0A267H7T7   A0A2L2YH96   W4XIJ8   A0A2C9K3X9   A0A1I8I9Q5   A0A1I8GTR3   A0A0B7B437   A0A0B7B4J9   F2UEF9   Q7QKF1   A0A182VG43   A0A1S4FVH9   A0A0L0HW19   T2M8U1   A0A3Q3AFD2   X1Z4C8   R7UNL3   A0A3P8NBK3   A0A3Q3BHA7   A0A3P8NBI6   A0A3P9AZI5   A0A3P8NBG3   A0A1L8HQQ1   A0A3B4ZPW6   I3KG30   A0A1W4W5E8   A0A3Q4H262   A0A1W4WH59   A0A3B4THB5   A0A0C9R6E4   A0A2D0QXV5   A0A3B4THE3   A0A1L8I137   A0A3B4XP82   A0A3M6V4W6   A0A3Q2U373   A0A0K2TAW8   G3PJH0   B3RM19   A0A2I4D7I8   A0A226DN84   A0A146ZA80   G5AWM7   A0A182H4U0   A0A0N8EUN2   A0A3B5PW21   K3XA89   M3ZQ61   L9KS83   A0A3P9PQS7   E1C6R0   A0A3P9HR24   A0A091K8Y7   A0A3Q0EKG0   A0A3P9MN77   A0A1V4JSH3   K9IN50   O35594   A0A1U7UGT3   A0A091GUT0   A0A3B3X4Z1   A0A087XBM8   H2YNA5   A0A3B3U9P2   A0A2Y9KHA4   A0A3P4RQW1   A0A3Q3X3K2  

KEGG

101746415    K19677 intraflagellar transport protein 81 | (RefSeq) intraflagellar transport protein 81 homolog

GO

GO:0030992   GO:0015631   GO:0005929   GO:0060271   GO:0042073   GO:0031514   GO:0005813   GO:0032006   GO:0048793   GO:0097228   GO:0035735   GO:0036064   GO:0008589   GO:0007283   GO:0097225   GO:0030154   GO:0007275  

PANTHER

PTHR15614  

Subcellular location

  

Length:

288

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05013

Exp number, first 60 AAs:

0.0463

Total prob of N-in:

0.07060

outside

1  -  288

 

 

Pi

192.635551

Theta

189.807183

Tajima's D

-0.413451

CLR

1.189397

CSRT

0.257837108144593

Interpretation

Uncertain