Gene

KWMTBOMO05775

Pre Gene Modal

BGIBMGA006929

Annotation

5-hydroxytryptamine_receptor_[Bombyx_mori]

Location

Bomo_Chr10(+):9754318-9761359      View in EpiBrowser

Full name

5-hydroxytryptamine receptor      

Alternative Name

Serotonin receptor

Location in the cell

PlasmaMembrane   Reliability : 4.797

CDS

ATGGAGGGCGCGGAAGGGCAAGAGGAGCTAGATTGGGAAGCGCTGTACCTGCGCCTCCCGTTGCAGAACTGCTCATGGAACTCCACAGGATGGGAGCCGAACTGGAACGTGACTGTGGTGCCCAATACAACCTGGTGGCAGGCATCCGCGCCCTTCGACACGCCCGCTGCCCTGGTTCGCGCCGCAGCCAAAGCCGTCGTGCTCGGCTTACTTATTTTAGCTACTGTTGTTGGTAATGTGTTCGTGATAGCTGCAATATTGTTAGAGAGACACCTCCGTAGTGCGGCCAACAATCTGATCCTGTCCTTGGCCGTGGCTGACTTGCTAGTGGCCTGTTTGGTGATGCCCCTCGGCGCGGTATACGAAGTCGCGCAAAGATGGACCCTCGGACCAGAACTTTGCGATATGTGGACTTCAGGCGATGTCCTGTGTTGTACTGCTTCTATCCTACATCTAGTCGCTATTGCACTCGACAGGTACTGGGCTGTGACCAACATTGACTACATACACGCCCGTACAGCTAAGCGGGTGGGTATGATGATCGCCTGTGTATGGACTGTTAGTTTTTTTGTGTGCATAGCTCCGTTGTTGGGATGGAAAGATCCGGACTGGAACCGACGCGTATCCGAAGATCTTAGATGCGTGGTCAGTCAAGACGTTGGATACCAGATTTTTGCGACGGCTTCATCATTCTATGTGCCGGTTCTGATTATTTTAATTTTATACTGGCGGATATATCAAACCGCTAGGAAAAGAATACGTCGAAGACGTGGAGCTACAGCCCGCGGCGGAGTTGGACCCCCGCCCGTGCCTGCCGGCGGAGCACTGGTCGCCGCCGGGGGCAGCGGAGGTATTGCGGCGGCAGTCGTCGCCGTTATCGGACGACCTCTTCCAACGATATCTGAAACGACCACGACCGGTTTCACGAATGTTTCATCGAACAACACGAGCCCCGAAAAACAATCTTGTGCCAACGGCCTCGAGGCAGATCCGCCGACCACGGGTTACGGTGCTGTAGCAGCGGCATACTATCCGTCGCTCGTGCGTCGCAAGCCCAAAGAAGCCGCTGACTCTAAACGGGAAAGAAAAGCGGCTAAGACATTAGCTATAATCACTGGAGCCTTTGTGGCATGCTGGCTTCCTTTCTTCGTGTTAGCGATTCTCGTTCCGACGTGTGATTGTGAAGTGAGTCCCGTGCTGACTTCGCTGTCTCTCTGGCTTGGATATTTCAATTCTACTTTGAATCCTGTAATATATACGGTGTTCAGTCCCGAGTTTAGACACGCGTTTCAGCGTCTGCTGTGCGGTCGACGGGTGCGCCGCCGCCGCGCCCCGCAGTAG

Protein

MEGAEGQEELDWEALYLRLPLQNCSWNSTGWEPNWNVTVVPNTTWWQASAPFDTPAALVRAAAKAVVLGLLILATVVGNVFVIAAILLERHLRSAANNLILSLAVADLLVACLVMPLGAVYEVAQRWTLGPELCDMWTSGDVLCCTASILHLVAIALDRYWAVTNIDYIHARTAKRVGMMIACVWTVSFFVCIAPLLGWKDPDWNRRVSEDLRCVVSQDVGYQIFATASSFYVPVLIILILYWRIYQTARKRIRRRRGATARGGVGPPPVPAGGALVAAGGSGGIAAAVVAVIGRPLPTISETTTTGFTNVSSNNTSPEKQSCANGLEADPPTTGYGAVAAAYYPSLVRRKPKEAADSKRERKAAKTLAIITGAFVACWLPFFVLAILVPTCDCEVSPVLTSLSLWLGYFNSTLNPVIYTVFSPEFRHAFQRLLCGRRVRRRRAPQ

Description

This is a receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Cell membrane   Complete proteome   Disulfide bond   G-protein coupled receptor   Glycoprotein   Membrane   Receptor   Reference proteome   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  5-hydroxytryptamine receptor

Uniprot

H9JBN4   A0A0A7LUY8   Q17239   B9TXW0   Q0GMY1   A0A2W1BU56   + More
A0A2A4JW03   A0A2H1WHH4   A0A194RGE6   A0A194Q8S6   A0A212EYW7   A0A142F417   A0A0L7LLF3   K7IZ04   A0A1Y1KIA8   A0A139WBY7   A0A139WC03   D6X0M4   A0A0A9WDL6   A0A0A9WBR5   T1HY03   A0A0T6BC49   A0A182M0B5   E9RJV3   A0A1B3P5Y1   A0A1B3P987   B0F4P9   Q6QR16   A0A0P5DFZ2   Q32Z81   A0A0P5CSV0   A0A164WNP0   A0A0P5SNH1   A0A0P5AEP6   A0A0P5T634   A0A0P5VRY8   A0A0P6FFN5   A0A0P6CK70   A0A0P6CNP6   E9FYY1   A0A0P6BWY1   A0A0P5KXS2   A0A0P4Z017   B7Q8G2   A0A1I8NV00   A0A0P5JD95   A0A061QHX0   T1J8G2   A0A0P5ZCK7   A0A0N8E0H8   A0A0P5JVM6   A0A0P5IY22   B7P9P1   A0A0P5D1N7   A0A0N8D2A7   A0A0P5EFR1   A0A0P5LN14   A0A0P5IZ09   A0A2P6L4H1   A0A0P6GJL4   A0A210PSA3   Q2PGF5   A0A2P6L1I8   A0A0P5UJP3   A0A0P6A7T6  

Pubmed

19121390    9014328    16935223    28756777    26354079    22118469    + More
26974346    26227816    20075255    28004739    18362917    19820115    18054377    18025266    18316733    20068045    21843505    23604020    25401762    26823975    18083737    15116388    16949686    21292972    28812685    20100484   

EMBL

BABH01024408    KM236101    AIZ66400.1    X95604    EU402613    ABY85411.1    + More
DQ840516    ABI33827.1    KZ149900    PZC78578.1    NWSH01000528    PCG75868.1    ODYU01008709    SOQ52521.1    KQ460398    KPJ15006.1    KQ459302    KPJ01804.1    AGBW02011422    OWR46685.1    KT946787    AMQ67546.1    JTDY01000740    KOB76041.1    GEZM01085676    JAV59950.1    KQ971371    KYB25478.1    KYB25477.1    BK005866    DAA64503.1    GBHO01037715    GDHC01002643    JAG05889.1    JAQ15986.1    GBHO01037717    JAG05887.1    ACPB03016262    LJIG01002056    KRT84884.1    AXCM01000188    AB618099    BAJ83480.1    KU712069    AOG12999.1    KU710382    AOG14378.1    EU131667    ABX10973.1    AY528822    AAS18607.1    GDIP01156939    JAJ66463.1    AY661549    AAV48573.1    GDIP01182085    JAJ41317.1    LRGB01001151    KZS13434.1    GDIP01137534    JAL66180.1    GDIP01199875    JAJ23527.1    GDIP01132232    JAL71482.1    GDIP01097244    JAM06471.1    GDIQ01064907    JAN29830.1    GDIQ01090103    JAN04634.1    GDIQ01090150    JAN04587.1    GL732527    EFX87613.1    GDIP01008371    JAM95344.1    GDIQ01177765    JAK73960.1    GDIP01221090    JAJ02312.1    ABJB010142903    DS883764    EEC15134.1    GDIQ01203916    JAK47809.1    GBFC01000015    JAC59323.1    JH431954    GDIP01047797    JAM55918.1    GDIQ01073844    JAN20893.1    GDIQ01192905    JAK58820.1    GDIQ01232345    JAK19380.1    ABJB010719857    DS666028    EEC03313.1    GDIP01164135    JAJ59267.1    GDIP01075791    JAM27924.1    GDIP01148992    JAJ74410.1    GDIQ01176112    JAK75613.1    GDIQ01205559    JAK46166.1    MWRG01001886    PRD33470.1    GDIQ01044671    JAN50066.1    NEDP02005528    OWF39387.1    AB209935    BAE72141.1    MWRG01002621    PRD32421.1    GDIP01114201    JAL89513.1    GDIP01046107    JAM57608.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000037510    + More
UP000002358    UP000007266    UP000015103    UP000075883    UP000076858    UP000000305    UP000001555    UP000095300    UP000242188   

PRIDE

H9JBN4    Q17239   

Pfam

PF00001   7tm_1

Interpro

IPR000276   GPCR_Rhodpsn        + More
IPR017452   GPCR_Rhodpsn_7TM       
IPR002233   ADR_fam       
IPR001671   Melcrt_ACTH_rcpt       
IPR002231   5HT_rcpt       

ProteinModelPortal

H9JBN4   A0A0A7LUY8   Q17239   B9TXW0   Q0GMY1   A0A2W1BU56   + More
A0A2A4JW03   A0A2H1WHH4   A0A194RGE6   A0A194Q8S6   A0A212EYW7   A0A142F417   A0A0L7LLF3   K7IZ04   A0A1Y1KIA8   A0A139WBY7   A0A139WC03   D6X0M4   A0A0A9WDL6   A0A0A9WBR5   T1HY03   A0A0T6BC49   A0A182M0B5   E9RJV3   A0A1B3P5Y1   A0A1B3P987   B0F4P9   Q6QR16   A0A0P5DFZ2   Q32Z81   A0A0P5CSV0   A0A164WNP0   A0A0P5SNH1   A0A0P5AEP6   A0A0P5T634   A0A0P5VRY8   A0A0P6FFN5   A0A0P6CK70   A0A0P6CNP6   E9FYY1   A0A0P6BWY1   A0A0P5KXS2   A0A0P4Z017   B7Q8G2   A0A1I8NV00   A0A0P5JD95   A0A061QHX0   T1J8G2   A0A0P5ZCK7   A0A0N8E0H8   A0A0P5JVM6   A0A0P5IY22   B7P9P1   A0A0P5D1N7   A0A0N8D2A7   A0A0P5EFR1   A0A0P5LN14   A0A0P5IZ09   A0A2P6L4H1   A0A0P6GJL4   A0A210PSA3   Q2PGF5   A0A2P6L1I8   A0A0P5UJP3   A0A0P6A7T6  

PDB

4IAR     E-value=2.0266e-31,     Score=339

KEGG

693054    K04153 5-hydroxytryptamine receptor 1 | (RefSeq) Ser-4; serotonin receptor 4

PATHWAY

04080    Neuroactive ligand-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0004930   GO:0016021   GO:0005886   GO:0004993   GO:0005887   GO:0030594   GO:0007187   GO:0030425   GO:0007268   GO:0004715   GO:0004935   GO:0004977   GO:0007186   GO:0009190   GO:0016849   GO:0004568   GO:0006032   GO:0006541   GO:0016812   GO:0016597  

Subcellular location

Cell membrane  

Length:

446

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

161.90215

Exp number, first 60 AAs:

0.03203

Total prob of N-in:

0.02373

outside

1  -  64

TMhelix

65  -  87

inside

88  -  98

TMhelix

99  -  121

outside

122  -  135

TMhelix

136  -  157

inside

158  -  176

TMhelix

177  -  199

outside

200  -  223

TMhelix

224  -  246

inside

247  -  367

TMhelix

368  -  390

outside

391  -  399

TMhelix

400  -  422

inside

423  -  446

 

 

Pi

273.89768

Theta

206.573367

Tajima's D

0.778889

CLR

1.319238

CSRT

0.596370181490925

Interpretation

Uncertain