SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO05766
Pre Gene Modal
BGIBMGA006799
Annotation
PREDICTED:_guanylate_cyclase_32E-like_[Bombyx_mori]
Full name
Guanylate cyclase      
Location in the cell
Mitochondrial   Reliability : 1.16 PlasmaMembrane   Reliability : 1.402
 

Sequence

CDS
ATGAAATCCTCGATGCGGACGCTATTTCGTTTCAGTCTGTGTGTCGTGATGATGTCTCTGAAAGCCTCTAATGGAGAGAAGTTTACACTTGGTTACTTAACCGGATCACAACGACGTCCCGGAGACTTCACGTACCCTAAACCAGGAATAATGATTTCAGGTGCAATATCAATGGCTGTGGATGAAGTTAACAAAGAACTATTGGGGCCGATGGGACATTCCCTGGACTTCGTTGTAGCTGAAACATACGGACAAGAAGAAGAATCTATACGCCAGGTAGCAGCTTTGTGGGCGGCTAATGTGTCTGCGTTCATCGGTCCACAAGAGACGTGTGTGCACGAGGGCCGCATGGCCGCCGCTTTCAACTTACCCATGATTAGCTACTACTGTCGGGACGTGGCCAACTCAAACAAGCGTGTTTACCCGACGTTCGCTCGCACCAGGCCCTCAGATGTCGACATATCACGCTCCGTGGTCGCCGTGCTGAAGCATTTCAATTTCATGCATGTGGCCTTTGTTTACTTGAATGCGCCAAATCACGATTATACTCGACTTGCTTATGCCATAAAACAGGCAGCAAGAGAGAAACATATATCCGTACGTGCAATCCAGGCTTATACGCACCCTTATTACTATGAAAATAAGGAAGGGAACTTTTCCCGTAATCCGTTTTTGGATATCGTGCGAGACACATATAAGGATACAAGAATTTACGTGTCTGTGGGGTACTATCATGATCATATAGCCTTGATGCTGGCGCTAGACACGCTCCATCTGCTAGATTCAGGAGAGTATGCCGCTATTGGAGTCGACGTCGAAAAGTACGAATCTAACGAAGCTGTCCGGTATCTGTCCGGGCCTTTGCTGAAAGAGCCAATACCAAGAACTCTGCGCGCGTTTCGTTCATATCTTGCAGTCGCGCCGTCTCCGTCACCATCCTACCCTGCTTTTGCTTTAGAAGTGAACAGAAGGTTGCAGATGCCCCCGTTCAATTTTAACAATCCGCTGCAATTCCTTGGTGGTGGGAAAGTGATACCCGTTGAAGCAGCATGGCTTCACGATGCCATATGGGTATATGCTCGCGCTCTGGCTGATGCTCTGAGGTCCGGAGAAGATTCGCGCGACGGCAGAGCTATAGCATCTCGAATGCTGAACACTACCTACAAAAGCGTTATGGGTTACTGGGTGCATATGGATGAAAATGGCGACGCTGAAGATAACTACACCCTGCTGTCCATTGACCCGAGTAGACCGCCAGGACTCTACCCGCTCGCTGTGCTACATAAATCTTATCCGGAAGTACGGTTTTTGCGTGAACTGGAATGGCCGGGCGGACAAGCACCGCTTTCGGAGCCGCCTTGCGGTTTTAGGGGAGAAAAATGCGTCAGCCACATCGGAGCCTGGGCTCTGGGTGCATCGGGCGGGACTCTAGCATTGCTCGCACTAGCTGCTCTCGCCTTGTATCGGGGTTGGCGTTACGAGCAAGAATTAGACTCACTACTTTGGAAGATAGACTTCAGGGACCTGCACCTTCCTGACAAAGAACAGCGAGCCAACAAACTGAGTAGCAGCGCGGTGGCTCACATCAACAATACGACAAACGCCGCTGGTAACAACGAGAAGAATGGAGGAGGCAGCACCGGCGGGGTTCGCTCAAGTCAGGTGTCACTAAGTTCGAACCCCGACCTAGACTTCCGTTACTCGGCGATCTTCACTGAAGTAGCATTCTACCGCGGCAGACTCGTCGCTGTCAAGCGAGTTAGACGACACCACATCGACATCAATAGAGAAATCAAAAAGGAACTTAAAATTATGCGGGACCTTCAACATGACAACATAAACGGGTTTGTGGGAGCGTGTATCGAACCTCCCAATGTATGCGCTTTGTCGGAATATTGCACGAGAGGTAGTCTTAAGGATATACTCGAAAATGAAGATATTAAACTCGACAACATGTTTATAGCATCTTTAGTTGGCGATATTATTAGGGGTATGATATTTATTCACGAGTCACCGCTGCAGTACCACGGGTCTCTGCGTCCGTCTAACTGCTTGGTGGATGCTCGATGGGTAGTCAAGCTCTCTGACTTTGGATTGAAGGAGTTCAGGAGAGGAGAGCTGCCTCCTTCAGAACCAACGGCGTTGAGGTCGCATGTCGACAGTCTAGTTTACCTGTCGCCGGAGTTGCTCAGAGCAGCCGGTTGGGGCAAGGACGGTCCGGCCCGAGGCCCTGACCAGCACGGGTCGGCGTCGGCGGACGTGTACGCGTTCTCGCTGGTGCTGTACGAGCTGCACTCGCGACGCGGGCCCTTCGGAGCGGACGCGCCGCCCGCGCCGTGCCTGCTGCGCCGCCTCGCGCTGCCCGACCCCGCGCCTTACAGACCTCCACTAGAAGTACTAGCAGATAGATTTGATTGCGTTCGGGAATGTTGTTGCGAATGCTGGGCAGAGGATCCGGCTACCAGACCGGACTTCAAATCTATCAGGACTAGATTGAGGCCGTTGCGTAAAGGAATGAAACCAAACATATTCGATAATATGATAGCCATGATGGAGAAATATGCGAATAATCTAGAAGCTCTAGTTGACGAGCGAACTGATCAACTACAAGAGGAGAAAAAAAAGACTGAGGCCCTGCTAGAGGAAATGTTGCCAGCGCCCGTGGCGGAGCAGCTGAAGCGCGGGAAGCGAGTGATGCCAGAGAGTTATGATTCCGTTACTATATACTTCAGCGATATCGTGGGGTTCACAGCCATGTCCGCGGAGAGCACACCGCTGCAAGTTGTGGACTTCCTAAACGACCTCTACACGTGTTTCGACTCAATTTTAGAAAACTTTGACGTGTATAAAGTAGAAACTATCGGGGACGCCTATATGGTGGTATCGGGTTTGCCGATTAGAAACGGCATTATGCACGCAGGAGAAGTGGCGTCAATGGCCCTGGCCCTTTTGTCAGCAACACGTGCCTTCAGGGTCCGGCATCGACCAGAGCATCGGATAATGCTGCGTGTCGGCATTCATTCCGGTCCGGTTTGCGCGGGCGTCGTTGGTTTGAAGATGCCGCGATACTGTTTGTTTGGCGACACTGTGAACACGGCCAGTCGCTTGGAATCAACGGGAGCACCACTCAAGATTCACTGCAGCTCTGCGTGTAAAGCGCTGTTGGATCAGCTGGGCGGATACATATTGGAAGAGCGAGGGCTGGTGTCGATGAAGGGCAAGCGCGACCAGCTGACGTACTGGCTGGGCGGGGAGCAGGACAGCGCGCGCGCGCGGCGCCGGGAGCGGGCCGCCGCGCCGCCGCCGCACGCGCGCGGACAAAGGAGCTCGCTCAAAACTAAGAACTGGAAGAACCAAGTCGGGGGCTTGCACAGATGCTGCAGTTTGGAATCTCCGAAAAAGCTTCGTTTCGCTTCTGGCAATCATCTTGAATCTCATAACGACAATGTCATGCATCACAGAAGCGACGAATATCTAATGGAGATGATCGGCGAGAGTAGGCTGGTTCCAGGCGGAGACCTATTGGAAGCCCCCAGCCTTCGGCAAGAACAAACGAGCGTCTCGTGCCCCATCATCGAGCACACGGAAGCGCCCGCGACGGCGCCTCCTCTGCCGGACGTGAAGCCGTGCGACATTAAGCTGGTCATCAACGGGTGTTCGTTCGCAGAGCGCGACGGCGCCGGCGTCCCGCTACTGGCGGACGCCTGA
Protein
MKSSMRTLFRFSLCVVMMSLKASNGEKFTLGYLTGSQRRPGDFTYPKPGIMISGAISMAVDEVNKELLGPMGHSLDFVVAETYGQEEESIRQVAALWAANVSAFIGPQETCVHEGRMAAAFNLPMISYYCRDVANSNKRVYPTFARTRPSDVDISRSVVAVLKHFNFMHVAFVYLNAPNHDYTRLAYAIKQAAREKHISVRAIQAYTHPYYYENKEGNFSRNPFLDIVRDTYKDTRIYVSVGYYHDHIALMLALDTLHLLDSGEYAAIGVDVEKYESNEAVRYLSGPLLKEPIPRTLRAFRSYLAVAPSPSPSYPAFALEVNRRLQMPPFNFNNPLQFLGGGKVIPVEAAWLHDAIWVYARALADALRSGEDSRDGRAIASRMLNTTYKSVMGYWVHMDENGDAEDNYTLLSIDPSRPPGLYPLAVLHKSYPEVRFLRELEWPGGQAPLSEPPCGFRGEKCVSHIGAWALGASGGTLALLALAALALYRGWRYEQELDSLLWKIDFRDLHLPDKEQRANKLSSSAVAHINNTTNAAGNNEKNGGGSTGGVRSSQVSLSSNPDLDFRYSAIFTEVAFYRGRLVAVKRVRRHHIDINREIKKELKIMRDLQHDNINGFVGACIEPPNVCALSEYCTRGSLKDILENEDIKLDNMFIASLVGDIIRGMIFIHESPLQYHGSLRPSNCLVDARWVVKLSDFGLKEFRRGELPPSEPTALRSHVDSLVYLSPELLRAAGWGKDGPARGPDQHGSASADVYAFSLVLYELHSRRGPFGADAPPAPCLLRRLALPDPAPYRPPLEVLADRFDCVRECCCECWAEDPATRPDFKSIRTRLRPLRKGMKPNIFDNMIAMMEKYANNLEALVDERTDQLQEEKKKTEALLEEMLPAPVAEQLKRGKRVMPESYDSVTIYFSDIVGFTAMSAESTPLQVVDFLNDLYTCFDSILENFDVYKVETIGDAYMVVSGLPIRNGIMHAGEVASMALALLSATRAFRVRHRPEHRIMLRVGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRLESTGAPLKIHCSSACKALLDQLGGYILEERGLVSMKGKRDQLTYWLGGEQDSARARRRERAAAPPPHARGQRSSLKTKNWKNQVGGLHRCCSLESPKKLRFASGNHLESHNDNVMHHRSDEYLMEMIGESRLVPGGDLLEAPSLRQEQTSVSCPIIEHTEAPATAPPLPDVKPCDIKLVINGCSFAERDGAGVPLLADA

Summary

Catalytic Activity
GTP = 3',5'-cyclic GMP + diphosphate
Similarity
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Feature
chain  Guanylate cyclase
EC Number
4.6.1.2
EMBL
BABH01030972    BABH01030973    BABH01030974    BABH01030975    BABH01030976    BABH01030977    + More
BABH01030978    ODYU01009272    SOQ53571.1    KQ459302    KPJ01807.1    KZ149900    PZC78584.1    KQ460398    KPJ15011.1    NWSH01003452    PCG66272.1    KQ971372    KYB25441.1    KK853196    KDR09970.1    APCN01003268    AXCN02001689    AXCN02001690    AXCN02001691    GGFJ01000755    MBW49896.1    GFXV01001995    MBW13800.1    GGFJ01000912    MBW50053.1    GGMS01010609    MBY79812.1    ATLV01022305    KE525331    KFB47428.1    CH933809    EDW19701.1    CH940647    EDW70302.2    KQ414582    KOC70842.1    KRG06745.1    CH379070    KRT08740.1    UFQS01000960    UFQT01000960    SSX07957.1    SSX28191.1    AE014296    AAN11824.2    KZ288198    PBC33702.1    UFQT01000682    SSX26518.1    CH963847    EDW72635.1    GBXI01010719    JAD03573.1    GAMC01018040    JAB88515.1    EAL30246.2    CP012525    ALC44253.1    AFH04414.1    AY125819    AAM94353.1    GAKP01013806    GAKP01013805    JAC45147.1    GDHF01022686    GDHF01021784    GDHF01018518    GDHF01017400    GDHF01008872    GDHF01007272    JAI29628.1    JAI30530.1    JAI33796.1    JAI34914.1    JAI43442.1    JAI45042.1    CH480815    EDW41395.1    KRT08739.1    CM000159    KRK01805.1    KRT08738.1    EDW94422.1    AAF49811.2    CM000363    CM002912    EDX10367.1    KMY99403.1    CH954178    EDV51687.1    BT099705    ACV53069.1    AFH04413.1    CH916366    EDV97169.1    OUUW01000002    SPP76354.1    KMY99404.1    QOIP01000010    RLU17552.1    GL450717    EFN80626.1    KQ434874    KZC09673.1    NEVH01019373    PNF22650.1    KQS43891.1    KK107167    EZA56308.1    NNAY01000627    OXU27316.1    CH902618    EDV41339.1    KPU79065.1    DS235068    EEB11234.1    JXJN01002101    KQS43890.1    DS232069    EDS33792.1    AAAB01008986    EAA00177.4    GDUN01000540    JAN95379.1    CCAG010022945    CVRI01000022    CRK92072.1    ADMH02001641    ETN61648.1    KQ435922    KOX68414.1    GL438030    EFN69668.1    KQ981427    KYN41776.1    KQ980427    KYN16071.1    GDIQ01098767    JAL52959.1    GDIP01036282    JAM67433.1    GL732541    EFX81936.1    CH477506    EAT39831.1    GDIQ01013798    JAN80939.1    GDIP01018910    JAM84805.1    APGK01029511    APGK01029512    APGK01029513    APGK01029514    APGK01029515    APGK01029516    KB740735    KB631805    ENN79172.1    ERL86283.1    ACPB03019547    LRGB01002121    KZS09016.1    KQ976453    KYM85381.1    KQ982498    KYQ55698.1    KQ977238    KYN04686.1    AMQN01006542    AMQN01006543    KB298595    ELU09058.1   
Pfam
PF00211   Guanylate_cyc        + More
PF07714   Pkinase_Tyr
PF01094   ANF_receptor
PF07701   HNOBA
PF00069   Pkinase
Interpro
IPR011009   Kinase-like_dom_sf        + More
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR001828   ANF_lig-bd_rcpt       
IPR029787   Nucleotide_cyclase       
IPR000719   Prot_kinase_dom       
IPR001054   A/G_cyclase       
IPR028082   Peripla_BP_I       
IPR018297   A/G_cyclase_CS       
IPR036638   HLH_DNA-bd_sf       
IPR011598   bHLH_dom       
IPR011645   HNOB_dom_associated       
IPR001170   ANPR/GUC       
IPR000337   GPCR_3       
SUPFAM
SSF53822   SSF53822        + More
SSF55073   SSF55073       
SSF56112   SSF56112       
Gene 3D
PDB
3ET6     E-value=4.4398e-36,     Score=384

Ontologies

Topology

SignalP
Position:   1 - 25,         Likelihood:  0.753230
 
 
Length:
1235
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
3.83268
Exp number, first 60 AAs:
0.10709
Total prob of N-in:
0.11738
outside
1  -  1235
 
 

Population Genetic Test Statistics

Pi
198.023843
Theta
174.189971
Tajima's D
-1.532634
CLR
1.770515
CSRT
0.0554472276386181
Interpretation
Uncertain
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