Gene

KWMTBOMO05762

Pre Gene Modal

BGIBMGA006801

Annotation

PREDICTED:_guanylate_cyclase_32E-like_[Bombyx_mori]

Location

Bomo_Chr10(-):9501246-9523167      View in EpiBrowser

Full name

Guanylate cyclase       + More
Receptor-type guanylate cyclase Gyc76C      

Alternative Name

DrGC-1

Location in the cell

PlasmaMembrane   Reliability : 2.638

CDS

ATGTGGCACGGTGCGCGGGTGTTGGTGTTCGCGGCGCTGGGCTTACTGGCTGGGCCTTCGCTTGCCCACAAGAAGTTCAATATCACCATTGGCTACTTACCGGCTCTTACCGGTGACTTGCGAGACAGACAAGGACTCACAGTCTCCGGGGCACTGTCGTTGGCACTTGAAGAGCTGAACAATGGAGTCGATCTGCTGCCGGATGTGGAGATTCACATGCAGTGGAACAACACGAAATATGACATGGTAACTTCCACCAGGCTCATCACCGAAATGAGTCGTGCAGGTGTAGTAGCCTTTTTCGGACCCGAAGGTCGCTGTGAAACTGAAGCCATAATTGCGCAATCCAGAAACTTGCCTATGATCTCTTACAAATGCTCAGACTACCAAGTATCTAGGCTACCAAACTTTGCTCGATTAGAGCCTCCGGGCGTTCAGGCGACAAAAGCGTTAATATCGTTGCTACGTTACTATAGATGGAACAAATTCTCTATATTGTATGAAGAATCTTGGATGACGGTAGCCCTGACGTTGGCGAACTATGCCAAGGATTTTAACATGACTGTAAACCATCAGAGTCCCGTCATAAATACTTTTAAATGTTGCGTAGAGAAAATGGCTTGCTGTGCACCCGGTTTCTGGTATCAGTTCATTCATGATACAAAAAACAAAACAAGAATTTACGTTTTCCTTGGGTCGACTTCGGGACTAATAGAGATGATGACCGCCATGGAGTCGCTGCAGTTATTCGCGAAGGGCGAGTACATGGTTATATTCGTGGACATGATGACGTACTCTCTTAAAGACTCTGCCAAGTATTTGTTGAAAATCGAAGATCGTTTATCGTCGACATTAATATGTCCGAACACGCCTGAATTTAAAAAGAGAGCCCAGTCGTTACTGGTGATAGCTTCGTCGGAACCATCCCCGGAATATGAAGAGTTTACGGCTAAAGTCAGGAAATACAATTCTCTAGAACCATTCAATTTTCCCGATGTCTTTGGCAGCAAGTACATTAAGTTTGTATCCATTTACGCTGCGTACTTGTATGATTCGGTGAAGCTCTATGCTAAAGCTCTAGATGAAATAATCAAGGAGGAAACTCAAAAGGAGCCCTTGACGCAGGCCAAGCTAACGAATATTGTCACTAACGGAACAGCCATTGTGGCGAAGATGATTAAAAGTTCGCCATACAAAAGTGTGTCCGGTTTGACGATACGTTTAGATGATCGTGGCGATTCCGAGGGAAACTTCTCCTTGCTCGCTTTCAAGCCGATCAACAACAAGATTGATAGAAACTGCAGTTACAGTATGATACCGGTTGCTCATTTCCAGCAAAACAGTAAAGAGTTTCCTGATTACAAACTGAATTCTCGTATACCGATCGATTGGCCTGACAGCGTGAAACCGGAGGACGAACCGTCTTGCGGTTTCAACAACGAGAAATGTCCAAGGCACAACTCGCTGATAACGTTGGCGTTACCGTTAGCGTTGACGGGAACGTTGGCGGTGACTTTGTTTTGTGTGTTATTCGTCACGGTCAGCAAATACCGAAAATGGAAGATCAAACAAGAAATAGAAGGTTTTCTTTGGGAAATAGACGCACAGGAAGTTACCGGATATTCCGACAACGGCCTCGTGTGCTCGCCCAGTAAGTTATGTCTAGCGAGCGGTATATCATACGAAATGTGCCCACAAAAATTCACCACGACGGCGCAATACAGAGGGAATTTAGTCAGGATAAAAACATTGAAGTTTTCTAAAAAGAAGGATATATCTCGGGACATAATGAAAGAGATGCGGCTGCTGCGCGAGCTGCGTCACGACAATCTCAACTCGTTCATCGGCGCCGTCGTGGAGCCGATGCGCGTGCTCATCCTCACCGACTACTGTGCCAAGGGGAGCTTGTATGATATAATAGAAAACGAAGATATCAAATTGGATCAGATGTTAATATCTTTGCTTATTCACGATCTCATTAAGGGTATGATCTTCATTCATTCATCGCCTTTAATATTTCACGGAAATCTCAAATCCTCGAATTGTGTAGTTACATCAAGATGGATGTTACAAGTAGCTGATTTTGATCTTCGTGAGCTGAAATATTGCGCTGAAAACAAGTTTATTGGAGAACATCAGTATTATAGAGGTTTGCTTTGGAAATCACCAGAGTTGTTGAGAGGATTAAACAACCCGAATGGCATCGTGGGCGGAACGCAAAAAGGTGACGTCTATGCGTTTGGGATTATTCTATACGAAGTGATAGCGAGAAAAGGCCCTTTCGGAAATGTCGCAATGGAGCCCAAAGATATAATAGACCGCTTGAAGCGGCCGAAGTTGGACGGCGAAGAGTTGTTTCGTCCGGACACGAGCAGCATCGACGGCGGCATCGACGACTACATCGTGTCGTGCATGAAGGACTGCTGGGCAGAAGATCCCAACACAAGACCTGACTTCCCTACGATTAGAACCAGACTAAAGAAGATGAAATCGGTACAGTAA

Protein

MWHGARVLVFAALGLLAGPSLAHKKFNITIGYLPALTGDLRDRQGLTVSGALSLALEELNNGVDLLPDVEIHMQWNNTKYDMVTSTRLITEMSRAGVVAFFGPEGRCETEAIIAQSRNLPMISYKCSDYQVSRLPNFARLEPPGVQATKALISLLRYYRWNKFSILYEESWMTVALTLANYAKDFNMTVNHQSPVINTFKCCVEKMACCAPGFWYQFIHDTKNKTRIYVFLGSTSGLIEMMTAMESLQLFAKGEYMVIFVDMMTYSLKDSAKYLLKIEDRLSSTLICPNTPEFKKRAQSLLVIASSEPSPEYEEFTAKVRKYNSLEPFNFPDVFGSKYIKFVSIYAAYLYDSVKLYAKALDEIIKEETQKEPLTQAKLTNIVTNGTAIVAKMIKSSPYKSVSGLTIRLDDRGDSEGNFSLLAFKPINNKIDRNCSYSMIPVAHFQQNSKEFPDYKLNSRIPIDWPDSVKPEDEPSCGFNNEKCPRHNSLITLALPLALTGTLAVTLFCVLFVTVSKYRKWKIKQEIEGFLWEIDAQEVTGYSDNGLVCSPSKLCLASGISYEMCPQKFTTTAQYRGNLVRIKTLKFSKKKDISRDIMKEMRLLRELRHDNLNSFIGAVVEPMRVLILTDYCAKGSLYDIIENEDIKLDQMLISLLIHDLIKGMIFIHSSPLIFHGNLKSSNCVVTSRWMLQVADFDLRELKYCAENKFIGEHQYYRGLLWKSPELLRGLNNPNGIVGGTQKGDVYAFGIILYEVIARKGPFGNVAMEPKDIIDRLKRPKLDGEELFRPDTSSIDGGIDDYIVSCMKDCWAEDPNTRPDFPTIRTRLKKMKSVQ

Description

Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:24284209). Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin (PubMed:21893139). Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity (PubMed:15282266, PubMed:24284209). Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscles and for localization of integrin beta-ps at developing dorsal muscle myotendinous junctions (PubMed:23213443). Required for invagination, migration and lumen shape of the embryonic salivary gland by regulating the localization of the integrin-binding protein rhea/Talin to the visceral mesoderm surrounding the gland and maintaining the laminin matrix (PubMed:23862019). Required in the developing wing to regulate extracellular matrix (ECM) organization by activating the cGMP-dependent protein kinase For which represses the activity of matrix metalloproteases such as Mmp2 and decreases ECM matrix reorganization (PubMed:26440503).

Catalytic Activity

GTP = 3',5'-cyclic GMP + diphosphate

Subunit

Interacts with the semaphorin 1A receptor PlexA; PlexA enhances Gyc76C catalytic activity. Interacts with the PDZ domain-containing protein kermit; kermit increases cell surface expression of Gyc76C.

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

ATP-binding   Cell membrane   cGMP biosynthesis   Complete proteome   Glycoprotein   GTP-binding   Lyase   Magnesium   Membrane   Metal-binding   Nucleotide-binding   Receptor   Reference proteome   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Guanylate cyclase

Uniprot

H9JBA6   H9JBJ6   A0A3S2LS11   A0A2H1WKG2   A0A194RAY4   A0A2A4J2G4   + More
A0A2W1BY57   A0A194Q8F6   A0A212F645   S4P787   A0A1L8DJG1   A0A1L8DJE6   A0A1L8DJP0   A0A1L8DJP4   A0A1L8DJR8   A0A1L8DJF6   D6X177   E0VCX6   A0A0L0C8M8   T1PCH4   W8AIX8   A0A1I8PNZ6   A0A1W4XT11   A0A1Y1M579   A0A034V957   A0A1J1IPW9   A0A1A9ZDW0   A0A1A9UKP9   Q16YZ6   A0A182HEV4   A0A1A9XJW6   A0A1B0C6N8   A0A0A1X4C8   A0A0A1WZK5   A0A084WB37   A0A1B0GF71   B4N3M7   A0A1B0CUZ5   A0A182WD90   A0A1A9W5X4   Q7PZZ3   A0A182PGB7   A0A182HPR9   A0A0M4EG81   A0A182X009   A0A182KT21   A0A182J455   B5DRL7   B4LGE0   A0A3B0J659   A0A182QXR8   B4KY29   A0A2M3YZT9   A4V243   Q7JQ32   B3M6J3   B4QQX8   B3NII0   A0A182FW72   A0A2M4A487   A0A2M4A468   B4PFY8   A0A2M4A4N6   B4IWW8   A0A1W4UDX7   K7J3D3   A0A2M4CIM0   A0A2M4CKB0   A0A2M4CLW1   A0A182RXD1   A0A0L7RJ80   A0A3L8DCZ8   A0A151X5N2   A0A088AVQ7   A0A158NJ88   A0A151JZJ7   A0A336LXX4   A0A182MXC5   A0A067QVM8   B4IIP9   A0A1B6EEF4   A0A1B6MKA2   A0A1B6F1B7   U4TZM5   N6UEX4   A0A2H8TK31   J9JNT2   A0A224XIA1   A0A2S2R4A9   A0A023F3B8   A0A3Q0J1D4   A0A2P8YZ06   A0A182YQ82   A0A0M8ZPG3   B0WSE8   E9J8Y6   A0A195BKT2   A0A151IK46   T1IAR7   A0A026WMG4  

EC Number

4.6.1.2

Pubmed

19121390    26354079    28756777    22118469    23622113    18362917    + More
19820115    20566863    26108605    25315136    24495485    28004739    25348373    17510324    26483478    25830018    24438588    17994087    12364791    20966253    15632085    23185243    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    7706258    7759483    15282266    23213443    21893139    23862019    24284209    26440503    22936249    17550304    20075255    30249741    21347285    24845553    23537049    25474469    29403074    25244985    21282665    24508170   

EMBL

BABH01030967    BABH01030968    BABH01030969    BABH01030970    BABH01030971    BABH01030972    + More
RSAL01000275    RVE43120.1    ODYU01009272    SOQ53570.1    KQ460398    KPJ15013.1    NWSH01003611    PCG66059.1    KZ149900    PZC78585.1    KQ459302    KPJ01808.1    AGBW02010077    OWR49210.1    GAIX01004724    JAA87836.1    GFDF01007498    JAV06586.1    GFDF01007496    JAV06588.1    GFDF01007499    JAV06585.1    GFDF01007497    JAV06587.1    GFDF01007500    JAV06584.1    GFDF01007501    JAV06583.1    KQ971372    EFA10586.2    DS235068    EEB11232.1    JRES01000760    KNC28587.1    KA645835    AFP60464.1    GAMC01020881    GAMC01020880    GAMC01020878    JAB85677.1    GEZM01043506    JAV79046.1    GAKP01019888    GAKP01019887    JAC39064.1    CVRI01000055    CRL01142.1    CH477506    EAT39830.1    JXUM01036120    JXUM01036121    JXUM01036122    JXUM01036123    JXUM01036124    JXUM01036125    JXUM01036126    JXUM01036127    KQ561084    KXJ79765.1    JXJN01026843    GBXI01015827    GBXI01008764    GBXI01005765    JAC98464.1    JAD05528.1    JAD08527.1    GBXI01010499    JAD03793.1    ATLV01022307    ATLV01022308    KE525331    KFB47431.1    CCAG010012768    CH964095    EDW79232.1    AJWK01029883    AJWK01029884    AJWK01029885    AJWK01029886    AJWK01029887    AJWK01029888    AJWK01029889    AAAB01008986    EAA00176.4    APCN01003270    CP012525    ALC45096.1    CH379070    EDY74228.1    CH940647    EDW70469.1    OUUW01000002    SPP77407.1    AXCN02001683    CH933809    EDW18731.1    GGFM01001015    MBW21766.1    AE014296    AAF49117.1    AAV50029.1    L35598    U23485    BT011062    AAA74408.1    AAA85858.1    AAR31133.1    CH902618    EDV40842.1    CM000363    CM002912    EDX11116.1    KMZ00596.1    CH954178    EDV52405.1    GGFK01002303    MBW35624.1    GGFK01002283    MBW35604.1    CM000159    EDW95285.1    GGFK01002453    MBW35774.1    CH916366    EDV97369.1    GGFL01001032    MBW65210.1    GGFL01001598    MBW65776.1    GGFL01001700    MBW65878.1    KQ414582    KOC70843.1    QOIP01000010    RLU18186.1    KQ982498    KYQ55696.1    ADTU01017581    ADTU01017582    ADTU01017583    ADTU01017584    ADTU01017585    ADTU01017586    ADTU01017587    KQ981427    KYN41775.1    UFQT01000216    SSX21841.1    KK853196    KDR09972.1    CH480844    EDW49820.1    GEDC01007580    GEDC01000969    JAS29718.1    JAS36329.1    GEBQ01016200    GEBQ01014835    GEBQ01003621    JAT23777.1    JAT25142.1    JAT36356.1    GECZ01025815    GECZ01004426    JAS43954.1    JAS65343.1    KB631805    ERL86282.1    APGK01029504    APGK01029505    APGK01029506    KB740735    ENN79171.1    GFXV01002712    MBW14517.1    ABLF02031542    ABLF02031545    ABLF02043285    GFTR01008655    JAW07771.1    GGMS01015560    MBY84763.1    GBBI01002797    JAC15915.1    PYGN01000278    PSN49479.1    KQ435922    KOX68415.1    DS232069    EDS33793.1    GL769162    EFZ10727.1    KQ976453    KYM85379.1    KQ977255    KYN04643.1    ACPB03019543    KK107167    EZA56309.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000218220    UP000053268    UP000007151    + More
UP000007266    UP000009046    UP000037069    UP000095301    UP000095300    UP000192223    UP000183832    UP000092445    UP000078200    UP000008820    UP000069940    UP000249989    UP000092443    UP000092460    UP000030765    UP000092444    UP000007798    UP000092461    UP000075920    UP000091820    UP000007062    UP000075885    UP000075840    UP000092553    UP000076407    UP000075882    UP000075880    UP000001819    UP000008792    UP000268350    UP000075886    UP000009192    UP000000803    UP000007801    UP000000304    UP000008711    UP000069272    UP000002282    UP000001070    UP000192221    UP000002358    UP000075900    UP000053825    UP000279307    UP000075809    UP000005203    UP000005205    UP000078541    UP000075884    UP000027135    UP000001292    UP000030742    UP000019118    UP000007819    UP000079169    UP000245037    UP000076408    UP000053105    UP000002320    UP000078540    UP000078542    UP000015103    UP000053097   

PRIDE

H9JBA6    H9JBJ6    Q7JQ32   

Pfam

PF07714   Pkinase_Tyr        + More
PF01094   ANF_receptor
PF00211   Guanylate_cyc
PF07701   HNOBA

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR001828   ANF_lig-bd_rcpt       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR000719   Prot_kinase_dom       
IPR028082   Peripla_BP_I       
IPR029787   Nucleotide_cyclase       
IPR001054   A/G_cyclase       
IPR018297   A/G_cyclase_CS       
IPR011645   HNOB_dom_associated       

SUPFAM

SSF53822   SSF53822        + More
SSF56112   SSF56112       
SSF55073   SSF55073       

Gene 3D

3.30.70.1230    

ProteinModelPortal

H9JBA6   H9JBJ6   A0A3S2LS11   A0A2H1WKG2   A0A194RAY4   A0A2A4J2G4   + More
A0A2W1BY57   A0A194Q8F6   A0A212F645   S4P787   A0A1L8DJG1   A0A1L8DJE6   A0A1L8DJP0   A0A1L8DJP4   A0A1L8DJR8   A0A1L8DJF6   D6X177   E0VCX6   A0A0L0C8M8   T1PCH4   W8AIX8   A0A1I8PNZ6   A0A1W4XT11   A0A1Y1M579   A0A034V957   A0A1J1IPW9   A0A1A9ZDW0   A0A1A9UKP9   Q16YZ6   A0A182HEV4   A0A1A9XJW6   A0A1B0C6N8   A0A0A1X4C8   A0A0A1WZK5   A0A084WB37   A0A1B0GF71   B4N3M7   A0A1B0CUZ5   A0A182WD90   A0A1A9W5X4   Q7PZZ3   A0A182PGB7   A0A182HPR9   A0A0M4EG81   A0A182X009   A0A182KT21   A0A182J455   B5DRL7   B4LGE0   A0A3B0J659   A0A182QXR8   B4KY29   A0A2M3YZT9   A4V243   Q7JQ32   B3M6J3   B4QQX8   B3NII0   A0A182FW72   A0A2M4A487   A0A2M4A468   B4PFY8   A0A2M4A4N6   B4IWW8   A0A1W4UDX7   K7J3D3   A0A2M4CIM0   A0A2M4CKB0   A0A2M4CLW1   A0A182RXD1   A0A0L7RJ80   A0A3L8DCZ8   A0A151X5N2   A0A088AVQ7   A0A158NJ88   A0A151JZJ7   A0A336LXX4   A0A182MXC5   A0A067QVM8   B4IIP9   A0A1B6EEF4   A0A1B6MKA2   A0A1B6F1B7   U4TZM5   N6UEX4   A0A2H8TK31   J9JNT2   A0A224XIA1   A0A2S2R4A9   A0A023F3B8   A0A3Q0J1D4   A0A2P8YZ06   A0A182YQ82   A0A0M8ZPG3   B0WSE8   E9J8Y6   A0A195BKT2   A0A151IK46   T1IAR7   A0A026WMG4  

PDB

3P86     E-value=1.03098e-25,     Score=293

KEGG

101745811    no KO assigned | (RefSeq) guanylate cyclase 32E-like

GO

GO:0004383   GO:0004672   GO:0016021   GO:0005524   GO:0035556   GO:0000166   GO:0006182   GO:0007165   GO:0007168   GO:0001653   GO:0005886   GO:0019934   GO:0038023   GO:0005887   GO:0030215   GO:0030510   GO:0009651   GO:0005525   GO:0007411   GO:0007428   GO:0008045   GO:0016199   GO:0046872   GO:0007526   GO:0030198   GO:0007435   GO:0006468   GO:0019752   GO:0030170   GO:0004568   GO:0006032   GO:0006541   GO:0016812   GO:0016597  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 22,         Likelihood:  0.983461

 

 

Length:

833

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

32.50022

Exp number, first 60 AAs:

6.07606

Total prob of N-in:

0.27728

outside

1  -  491

TMhelix

492  -  514

inside

515  -  833

 

 

Pi

195.171459

Theta

150.870816

Tajima's D

1.156291

CLR

0.589927

CSRT

0.702364881755912

Interpretation

Uncertain