Gene

KWMTBOMO05754  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006806

Annotation

PREDICTED:_NIF3-like_protein_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr10(-):9415824-9422534      View in EpiBrowser

Full name

NIF3-like protein 1       + More
Probable cytosolic iron-sulfur protein assembly protein Ciao1      

Alternative Name

Protein anon-35F/36A

Location in the cell

Cytoplasmic   Reliability : 1.414 Golgi   Reliability : 1.043

CDS

ATGTCAACTGAGAAATTCTGTGCAGTGTCTTTGGAAAGAGTAGTAACAGTACTTGAAAAATTTGCTCCAAAAGAATTGGCAGAGAGTTGGGATAACACTGGTTTGTTGGTGGAACCTTACACACCGAGACAAATAACCAAAATTTTGTTAACTAACGACTTAACAGAAGATGTGGCCTTGGAAGCTGAAATTCTGGCGTGTGAGATGATTATTTCATATCATCCTCCGATATTTGCGCCTTTGAAGTCTATTGTTCAGCGTTCGTGGAAAGAACGGGTTGTATCTTATTTATTAGAAAAACGAATCGCCCTGTACTCGCCACATACTAGTTGGGATAGTGTGCAAGGCGGGGTCAATGACTGGTTGGCATCTGCTTTCTCTGTCGCAGAGTCTAAGCCAATTTTACAATCAAACAACCCCGACTTCGGAGCCGGCAGATTACTTCATTTGAGCACCGGAATCCCATTATCTGATGCAGTAAACAGAATTAAGGAACTTACACGACTCTCCCATGTCCGCATCGCTGCCGCAAAGGGAAAGTCTATGACGCACACCGTTCAGAGGGTAGCGTTATGTGCCGGATCCGGAAGTTCGGTATTAAAGGGAGTCGATGCTGATCTTTATTTGACAGGCGAAATGCTTCATCACGACGTACTTGATGCAGCTCAAAAAGGTATAACAGTTATATTAACGAATCATTCGGACTCCGAAAGAGGGTTCTTGCGAGGATTTGCAAATTATTTACATAAAAATTTGAATGAAGAAGTTGAGGTTTTCGTAAGCAAAGTCGACAAAGATCCTTTGATAACTGTGTAA

Protein

MSTEKFCAVSLERVVTVLEKFAPKELAESWDNTGLLVEPYTPRQITKILLTNDLTEDVALEAEILACEMIISYHPPIFAPLKSIVQRSWKERVVSYLLEKRIALYSPHTSWDSVQGGVNDWLASAFSVAESKPILQSNNPDFGAGRLLHLSTGIPLSDAVNRIKELTRLSHVRIAAAKGKSMTHTVQRVALCAGSGSSVLKGVDADLYLTGEMLHHDVLDAAQKGITVILTNHSDSERGFLRGFANYLHKNLNEEVEVFVSKVDKDPLITV

Description

Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.

Subunit

Homodimer. Interacts with COPS2. Interacts with THOC7.

Similarity

Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
Belongs to the WD repeat CIA1 family.

Keywords

Complete proteome   Reference proteome  

Feature

chain  NIF3-like protein 1

Uniprot

Q09GP9   A0A2W1BY67   A0A2A4JPP4   A0A3S2PFQ5   A0A194RAZ4   A0A212FAJ7   + More
I4DPQ9   A0A194Q8F4   S4PIU1   A0A1Y1NMB9   A0A026W7L8   K7ITJ5   E2A1X2   F4X187   E2BZE2   A0A0L7QX42   Q16HG3   A0A195CW66   A0A151WPG5   A0A1W4X908   A0A154NZ85   A0A158NFI7   A0A1Q3F0G9   B0WSH9   A0A0C9RIL3   A0A232F013   A0A195DQE0   A0A151JYK8   A0A182G867   U5ERY1   A0A195BDN2   A0A2A3EQK6   A0A0N0U7R7   E0VU56   A0A088A0Q2   R4G3U5   A0A1I8N5X4   W5JGF2   A0A034VLS1   A0A139WBU3   A0A0C9QZB1   G3NXR2   A0A0A1XB78   G3NXQ2   A0A0K8VP49   A0A023F7G3   A0A182JES3   W8BMZ3   A0A0V0G9T9   A0A084VJG4   A0A2M4CGC4   A0A0N7Z9M2   A0A182RGK0   A0A182J6N0   Q9NK57   A0A1A9YNU0   B4Q704   A0A1I8NUI7   A0A1B0G5J6   B4JAB4   A0A2C9GQU8   A0A0L0CJY1   D3TRD3   A0A069DRD8   A0A182UJ81   A0A1C7CZL6   Q7Q029   A0A182V1W6   A0A1B0AEA6   A0A0L8HAA7   B4I220   A0A226PAG4   A0A293LRX7   A0A2R5L8X4   T1DQA5   A0A182Y1Y7   B4MZQ8   A0A2M4BVL9   A0A2M4AT12   A0A2M4AT60   B4NXP1   A0A1B0DRC5   A0A2M3Z6M3   A0A3B0KB77   A0A182ML18   A0A182FK90   B4LTD1   E9IGK1   B4KI25   A0A131XTH7   V5HCH1   B7PB02   N6TP69   U4U9Y0   B3N6D3   A0A1W4VXE3   A0A182PW72   B4GQN5   A0A0M4DZG1   Q29NM8  

Pubmed

19121390    28756777    26354079    22118469    22651552    23622113    + More
28004739    24508170    20075255    20798317    21719571    17510324    21347285    28648823    26483478    20566863    25315136    20920257    23761445    25348373    18362917    19820115    25830018    25474469    24495485    24438588    27129103    10471707    10731132    12537572    12537569    17994087    22936249    26108605    20353571    26334808    20966253    12364791    14747013    17210077    24621616    25244985    17550304    21282665    25765539    23537049    15632085   

EMBL

BABH01030956    BABH01030957    DQ904010    ABI73988.1    KZ149900    PZC78595.1    + More
NWSH01000887    PCG73678.1    RSAL01000053    RVE50118.1    KQ460398    KPJ15023.1    AGBW02009454    OWR50766.1    AK403726    BAM19899.1    KQ459302    KPJ01817.1    GAIX01000069    JAA92491.1    GEZM01002932    JAV97057.1    KK107361    EZA51993.1    GL435845    EFN72566.1    GL888528    EGI59759.1    GL451589    EFN78952.1    KQ414705    KOC63187.1    CH478175    EAT33684.1    KQ977279    KYN04399.1    KQ982893    KYQ49585.1    KQ434783    KZC04947.1    ADTU01014525    GFDL01013992    JAV21053.1    DS232072    EDS33909.1    GBYB01013072    JAG82839.1    NNAY01001506    OXU23758.1    KQ980662    KYN14699.1    KQ981494    KYN40944.1    JXUM01047491    KQ561521    KXJ78296.1    GANO01002617    JAB57254.1    KQ976514    KYM82290.1    KZ288201    PBC33552.1    KQ435687    KOX81401.1    DS235780    EEB16912.1    ACPB03016329    GAHY01001361    JAA76149.1    ADMH02001582    ETN61980.1    GAKP01014696    JAC44256.1    KQ971372    KYB25409.1    GBYB01006057    JAG75824.1    GBXI01006242    JAD08050.1    GDHF01011686    JAI40628.1    GBBI01001401    JAC17311.1    GAMC01015526    JAB91029.1    GECL01001334    JAP04790.1    ATLV01013559    KE524867    KFB38108.1    GGFL01000131    MBW64309.1    GDKW01000155    JAI56440.1    AE014134    AY069556    CM000361    CM002910    EDX05212.1    KMY90503.1    CCAG010017734    CH916368    EDW03785.1    APCN01003282    JRES01000290    KNC32713.1    EZ423985    ADD20261.1    GBGD01002434    JAC86455.1    AAAB01008986    EAA00104.3    KQ418711    KOF86226.1    CH480820    EDW54577.1    AWGT02000109    OXB76891.1    GFWV01005871    MAA30601.1    GGLE01001817    MBY05943.1    GAMD01001275    JAB00316.1    CH963920    EDW77843.2    GGFJ01007976    MBW57117.1    GGFK01010541    MBW43862.1    GGFK01010633    MBW43954.1    CM000157    EDW89666.1    AJVK01019877    GGFM01003425    MBW24176.1    OUUW01000006    SPP82311.1    AXCM01005707    CH940649    EDW63901.2    GL763048    EFZ20289.1    CH933807    EDW11307.2    GEFM01005183    JAP70613.1    GANP01009409    JAB75059.1    ABJB010608500    DS674167    EEC03774.1    APGK01014197    APGK01014198    KB739226    ENN82329.1    KB632191    ERL89827.1    CH954177    EDV58102.1    CH479187    EDW39907.1    CP012523    ALC37978.1    CH379059    EAL34190.3   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000007151    UP000053268    + More
UP000053097    UP000002358    UP000000311    UP000007755    UP000008237    UP000053825    UP000008820    UP000078542    UP000075809    UP000192223    UP000076502    UP000005205    UP000002320    UP000215335    UP000078492    UP000078541    UP000069940    UP000249989    UP000078540    UP000242457    UP000053105    UP000009046    UP000005203    UP000015103    UP000095301    UP000000673    UP000007266    UP000007635    UP000075880    UP000030765    UP000075900    UP000000803    UP000092443    UP000000304    UP000095300    UP000092444    UP000001070    UP000075840    UP000037069    UP000075902    UP000075882    UP000007062    UP000075903    UP000092445    UP000053454    UP000001292    UP000198419    UP000076408    UP000007798    UP000002282    UP000092462    UP000268350    UP000075883    UP000069272    UP000008792    UP000009192    UP000001555    UP000019118    UP000030742    UP000008711    UP000192221    UP000075885    UP000008744    UP000092553    UP000001819   

PRIDE

Q09GP9    Q9NK57   

Pfam

PF01784   NIF3        + More
PF00400   WD40

Interpro

IPR036069   GTP_cyclohydrolase_I/Nif3_sf        + More
IPR002678   GTP_cyclohydrolase_I/Nif3       
IPR017221   GTP_cyclohydrolase_I_bac       
IPR017222   NIF3L1_animal       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR036322   WD40_repeat_dom_sf       
IPR019775   WD40_repeat_CS       
IPR028608   CIAO1/Cia1       
IPR020472   G-protein_beta_WD-40_rep       

SUPFAM

SSF102705   SSF102705        + More
SSF50978   SSF50978       

Gene 3D

2.130.10.10    

ProteinModelPortal

Q09GP9   A0A2W1BY67   A0A2A4JPP4   A0A3S2PFQ5   A0A194RAZ4   A0A212FAJ7   + More
I4DPQ9   A0A194Q8F4   S4PIU1   A0A1Y1NMB9   A0A026W7L8   K7ITJ5   E2A1X2   F4X187   E2BZE2   A0A0L7QX42   Q16HG3   A0A195CW66   A0A151WPG5   A0A1W4X908   A0A154NZ85   A0A158NFI7   A0A1Q3F0G9   B0WSH9   A0A0C9RIL3   A0A232F013   A0A195DQE0   A0A151JYK8   A0A182G867   U5ERY1   A0A195BDN2   A0A2A3EQK6   A0A0N0U7R7   E0VU56   A0A088A0Q2   R4G3U5   A0A1I8N5X4   W5JGF2   A0A034VLS1   A0A139WBU3   A0A0C9QZB1   G3NXR2   A0A0A1XB78   G3NXQ2   A0A0K8VP49   A0A023F7G3   A0A182JES3   W8BMZ3   A0A0V0G9T9   A0A084VJG4   A0A2M4CGC4   A0A0N7Z9M2   A0A182RGK0   A0A182J6N0   Q9NK57   A0A1A9YNU0   B4Q704   A0A1I8NUI7   A0A1B0G5J6   B4JAB4   A0A2C9GQU8   A0A0L0CJY1   D3TRD3   A0A069DRD8   A0A182UJ81   A0A1C7CZL6   Q7Q029   A0A182V1W6   A0A1B0AEA6   A0A0L8HAA7   B4I220   A0A226PAG4   A0A293LRX7   A0A2R5L8X4   T1DQA5   A0A182Y1Y7   B4MZQ8   A0A2M4BVL9   A0A2M4AT12   A0A2M4AT60   B4NXP1   A0A1B0DRC5   A0A2M3Z6M3   A0A3B0KB77   A0A182ML18   A0A182FK90   B4LTD1   E9IGK1   B4KI25   A0A131XTH7   V5HCH1   B7PB02   N6TP69   U4U9Y0   B3N6D3   A0A1W4VXE3   A0A182PW72   B4GQN5   A0A0M4DZG1   Q29NM8  

PDB

2FYW     E-value=1.45248e-22,     Score=261

KEGG

767622    no KO assigned | (RefSeq) NIF3-like protein

GO

GO:0016787   GO:0097361   GO:0016226   GO:0005737   GO:0005634   GO:0042802   GO:0005739  

PANTHER

PTHR13799   PTHR19920  

Subcellular location

Cytoplasm  
Nucleus  

Length:

271

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00414

Exp number, first 60 AAs:

0.00016

Total prob of N-in:

0.04648

outside

1  -  271

 

 

Pi

202.511202

Theta

162.638438

Tajima's D

0.808793

CLR

0.535836

CSRT

0.6033198340083

Interpretation

Uncertain