Gene

KWMTBOMO05749  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006807

Annotation

ribosomal_protein_S6_kinase_[Bombyx_mori]

Location

Bomo_Chr10(-):9295546-9303494      View in EpiBrowser

Full name

Non-specific serine/threonine protein kinase       + More
Ribosomal protein S6 kinase      

Location in the cell

Cytoplasmic   Reliability : 3.615

CDS

ATGGCAGGTGTTTTTGATTTAGATTTAGATGTGGATACAGTTACAGTAGCAGATTCAGATGAAGATGATATTATCGATGTCGATGAGGTGGACTATGAACCAGAATTACATGTGAACAGTATTGTGGAGGCAGAAGGATCAGAAACGATTCAACTTTGTGAAGATAATGTGAATCCAGGTCAATGTAAACGTCTTGGTCCTCAAGACTTTGAATTACGAAAAGTACTTGGAAAAGGAGGATATGGAAAAGTTTTTCAAGTTCGTAAAATCACAGGGCAAGATGCTGGTGCCCATTTTGCTATGAAAGTTCTTAAAAAAGCTTCCATAGTTCGAAATCAAAAAGATACTGCACATACCAAGGCTGAAAGGAATATATTGGAAGCTGTAAAGCATCCATTCATAGTAGAACTAGTGTATGCTTTCCAGACCGGTGGAAAGTTGTACTTAATTTTAGAATATTTAAGTGGTGGAGAGCTTTTTATGCACCTTGAAAGGGAGGGGATTTTCCTGGAAGATACAGCCTGTTTCTACCTATCAGAGATTATACTGGCCTTAGAACATTTGCATAGCTTAGGAATAATATATCGTGATTTAAAACCTGAAAATGTACTACTCGACGCTCAAGGACATGTCAAATTAACAGATTTTGGATTATGTAAGGAACACATCCAGGAGGGTATTGTAACCCACACATTCTGTGGAACCATCGAATATATGGCCCCAGAAATTTTAACTAGAAGTGGCCATGGTAAAGCTGTTGATTGGTGGAGTCTAGGAGCATTGATGTATGATATGCTGATAGGTCAGCCACCATACACTGGAGACAATCGTACGAAAACCATAGAAAAAATATTAAAAGGGAAACTTATGTTACCTGCCTACCTCACGCAAGACGCTCGTGATTTAATCAGACGTCTAATGAAGCGTTCAGAGACTCAGCGCCTGGGAGCCGCCGGGGCAGCGGCTGTTCGGGGTCACGCTTTCTTCAAACACGTACATTGGGATGATGTATTTGCTCGAAGATTAGAACCACCAATAAAACCAAGATTAACCAGTGAAGATGATGTATCACAATTCGACACAAGATTTACTTTACAAACACCAATTGATTCACCAGATGAATCTACTTTAAGTGAAAGTGCCAACTTAATGTTCCAGGGATTCACATACGTGGCGCCGTCTGTTATGGACGAGATCCACAAGCCCAGAGTTATAACGGCTCGTTCTCCTCGTCGTCCGAGACCGCATCATAACTTTACTATCCCGCCCGCCGCCGCTGCCCACAATCACACTCACGCTCAACAAGAGGACCTCATGGAAGTTCAAGGTTTACCTATATACAATAAATATTCGAAATTGAAATGA

Protein

MAGVFDLDLDVDTVTVADSDEDDIIDVDEVDYEPELHVNSIVEAEGSETIQLCEDNVNPGQCKRLGPQDFELRKVLGKGGYGKVFQVRKITGQDAGAHFAMKVLKKASIVRNQKDTAHTKAERNILEAVKHPFIVELVYAFQTGGKLYLILEYLSGGELFMHLEREGIFLEDTACFYLSEIILALEHLHSLGIIYRDLKPENVLLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLIGQPPYTGDNRTKTIEKILKGKLMLPAYLTQDARDLIRRLMKRSETQRLGAAGAAAVRGHAFFKHVHWDDVFARRLEPPIKPRLTSEDDVSQFDTRFTLQTPIDSPDESTLSESANLMFQGFTYVAPSVMDEIHKPRVITARSPRRPRPHHNFTIPPAAAAHNHTHAQQEDLMEVQGLPIYNKYSKLK

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

Feature

chain  Ribosomal protein S6 kinase

Uniprot

B4YQA2   A0A1J0FAY2   A0A2A4J5I1   S4PCN8   A0A194RBP8   A0A194QA08   + More
B0W6W6   Q17ND6   Q535V4   I1SV92   A0A182J791   D3TMG0   T1PDA1   D9YID1   U5EGG3   A0A182XYL1   A0A160U3N0   A0A182FDA2   A0A0K8TZM8   A0A034VR43   B4IZH1   A0A0K8TP32   A0A2J7QD46   A0A067QLI7   A0A182WJI2   B4KWC8   B3NC94   Q94533   A0A0J9RPX7   B4HUJ3   B4QIS8   B4PIX6   W8ANA8   A0A1W4UWP9   A0A3B0JAL1   Q29E52   P91656   A0A1I8P3P8   B4MML4   B3M3L7   B4LH55   V5GSM6   A0A160U2U2   A0A182XA31   A0A0Q9X1F0   A0A182UFW0   A0A023F437   A0A182I301   A0A069DZ19   A0A182KQZ6   Q7QJ74   A0A182RU24   A0A2M4CXV1   A0A0T6BFX1   A0A1B6CM79   A0A224XNM1   A0A0K1IK33   A0A0A9XVN0   A0A182PZZ2   T1IGN1   A0A2M4A563   A0A2M4CFV3   Q9GQB3   A0A2M4BJF7   A0A1Y1KGC1   A0A1L8DMU4   A0A2M3Z1I2   A0A2M3Z116   W5JN51   A0A2M3ZGB3   A0A1L8DML9   E0VG95   A0A195CD58   A0A1B0AU96   A0A1A9VTY4   A0A1A9WSK8   A0A158NQG4   A0A0P5ENK5   A0A3L8D8I5   K7IRN7   A0A0P5C5B1   A0A0P5C1C2   A0A0P5G770   A0A232EXK2   A0A2R5LCK8   A0A0P6DYK0   E9G367   H1ZYE3   A0A0J9RPP2   A0A0L7R8I2   A0A0M4EHN0   A0A154NYI2   A0A3R7LZY7   A0A2A3E3S6   V9IH09   E9JB08   A0A088A6F6   A0A151HYB7   A0A151WRS2   A0A1B0CC11  

EC Number

2.7.11.1

Pubmed

23622113    26354079    17510324    15788394    20353571    25315136    + More
22105664    25244985    25348373    17994087    26369729    24845553    8855259    10497130    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22936249    17550304    24495485    15632085    8942996    25474469    26334808    20966253    12364791    14747013    17210077    25401762    26823975    11310561    28004739    20920257    23761445    20566863    21347285    30249741    20075255    28648823    21292972    21282665   

EMBL

EU649693    ACF37495.1    KU987819    APC26146.1    NWSH01003259    PCG66673.1    + More
GAIX01004081    JAA88479.1    KQ460398    KPJ15032.1    KQ459302    KPJ01825.1    DS231850    EDS37112.1    CH477200    EAT48199.1    AY700377    AAW21700.1    JF746878    AEG64800.1    EZ422612    ADD18888.1    KA645913    AFP60542.1    GQ203802    ACU32444.1    GANO01003453    JAB56418.1    LN901440    CUT08902.1    GDHF01033342    GDHF01032397    GDHF01018786    JAI18972.1    JAI19917.1    JAI33528.1    GAKP01014365    GAKP01014364    JAC44587.1    CH916366    EDV97746.1    GDAI01001697    JAI15906.1    NEVH01015828    PNF26504.1    KK853196    KDR09984.1    CH933809    EDW18535.1    CH954178    EDV51052.1    U66562    AE014296    BT133257    AAC47312.4    AAF50742.1    AFC17501.1    CM002912    KMY97802.1    CH480817    EDW50614.1    CM000363    EDX09353.1    CM000159    EDW93546.1    GAMC01016282    GAMC01016280    GAMC01016278    GAMC01016276    JAB90275.1    OUUW01000002    SPP77493.1    CH379070    EAL30210.1    U67304    AAC47429.1    CH963847    EDW73420.1    CH902618    EDV40310.1    CH940647    EDW69545.1    GALX01001292    JAB67174.1    LN901441    CUT08903.1    KRF97762.1    GBBI01002486    JAC16226.1    APCN01000192    GBGD01001410    JAC87479.1    AAAB01008807    EAA04271.4    GGFL01005982    MBW70160.1    LJIG01001157    KRT85783.1    GEDC01022820    GEDC01000016    JAS14478.1    JAS37282.1    GFTR01006396    JAW10030.1    KP769804    KU057878    AKU04653.1    ALU11321.1    GBHO01020163    GDHC01021413    JAG23441.1    JAP97215.1    AXCN02000553    ACPB03012369    GGFK01002588    MBW35909.1    GGFL01000049    MBW64227.1    AF282407    AAG48248.1    GGFJ01004046    MBW53187.1    GEZM01087820    JAV58456.1    GFDF01006379    JAV07705.1    GGFM01001547    MBW22298.1    GGFM01001476    MBW22227.1    ADMH02000892    ETN64743.1    GGFM01006739    MBW27490.1    GFDF01006378    JAV07706.1    DS235133    EEB12401.1    KQ978023    KYM98013.1    JXJN01003570    ADTU01023313    GDIP01143794    JAJ79608.1    QOIP01000011    RLU16432.1    GDIP01180032    JAJ43370.1    GDIP01181779    JAJ41623.1    GDIQ01267079    LRGB01001574    JAJ84645.1    KZS11711.1    NNAY01001716    OXU23144.1    GGLE01003106    MBY07232.1    GDIQ01072197    JAN22540.1    GL732531    EFX86042.1    FR870165    FR870166    FR870167    FR870168    FR870169    FR870170    FR870171    FR870172    FR870173    FR870174    FR870175    FR870176    CCB63123.1    CCB63124.1    CCB63125.1    CCB63126.1    CCB63127.1    CCB63128.1    CCB63129.1    CCB63130.1    CCB63131.1    CCB63132.1    CCB63133.1    CCB63134.1    KMY97803.1    KQ414632    KOC67180.1    CP012525    ALC44115.1    KQ434783    KZC04729.1    QCYY01002747    ROT67855.1    KZ288405    PBC26144.1    JR047381    AEY60398.1    GL770707    EFZ10003.1    KQ976723    KYM76687.1    KQ982803    KYQ50550.1    AJWK01006063    AJWK01006064    AJWK01006065    AJWK01006066    AJWK01006067    AJWK01006068    AJWK01006069    AJWK01006070    AJWK01006071    AJWK01006072   

Proteomes

UP000218220    UP000053240    UP000053268    UP000002320    UP000008820    UP000075880    + More
UP000095301    UP000076408    UP000069272    UP000001070    UP000235965    UP000027135    UP000075920    UP000009192    UP000008711    UP000000803    UP000001292    UP000000304    UP000002282    UP000192221    UP000268350    UP000001819    UP000095300    UP000007798    UP000007801    UP000008792    UP000076407    UP000075902    UP000075840    UP000075882    UP000007062    UP000075900    UP000075886    UP000015103    UP000000673    UP000009046    UP000078542    UP000092460    UP000078200    UP000091820    UP000005205    UP000279307    UP000002358    UP000076858    UP000215335    UP000000305    UP000053825    UP000092553    UP000076502    UP000283509    UP000242457    UP000005203    UP000078540    UP000075809    UP000092461   

PRIDE

B4YQA2    Q94533    P91656    H1ZYE3   

Pfam

PF00433   Pkinase_C        + More
PF00069   Pkinase

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR016238   Ribosomal_S6_kinase       
IPR000961   AGC-kinase_C       
IPR017892   Pkinase_C       
IPR000719   Prot_kinase_dom       
IPR000435   Tektin       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

B4YQA2   A0A1J0FAY2   A0A2A4J5I1   S4PCN8   A0A194RBP8   A0A194QA08   + More
B0W6W6   Q17ND6   Q535V4   I1SV92   A0A182J791   D3TMG0   T1PDA1   D9YID1   U5EGG3   A0A182XYL1   A0A160U3N0   A0A182FDA2   A0A0K8TZM8   A0A034VR43   B4IZH1   A0A0K8TP32   A0A2J7QD46   A0A067QLI7   A0A182WJI2   B4KWC8   B3NC94   Q94533   A0A0J9RPX7   B4HUJ3   B4QIS8   B4PIX6   W8ANA8   A0A1W4UWP9   A0A3B0JAL1   Q29E52   P91656   A0A1I8P3P8   B4MML4   B3M3L7   B4LH55   V5GSM6   A0A160U2U2   A0A182XA31   A0A0Q9X1F0   A0A182UFW0   A0A023F437   A0A182I301   A0A069DZ19   A0A182KQZ6   Q7QJ74   A0A182RU24   A0A2M4CXV1   A0A0T6BFX1   A0A1B6CM79   A0A224XNM1   A0A0K1IK33   A0A0A9XVN0   A0A182PZZ2   T1IGN1   A0A2M4A563   A0A2M4CFV3   Q9GQB3   A0A2M4BJF7   A0A1Y1KGC1   A0A1L8DMU4   A0A2M3Z1I2   A0A2M3Z116   W5JN51   A0A2M3ZGB3   A0A1L8DML9   E0VG95   A0A195CD58   A0A1B0AU96   A0A1A9VTY4   A0A1A9WSK8   A0A158NQG4   A0A0P5ENK5   A0A3L8D8I5   K7IRN7   A0A0P5C5B1   A0A0P5C1C2   A0A0P5G770   A0A232EXK2   A0A2R5LCK8   A0A0P6DYK0   E9G367   H1ZYE3   A0A0J9RPP2   A0A0L7R8I2   A0A0M4EHN0   A0A154NYI2   A0A3R7LZY7   A0A2A3E3S6   V9IH09   E9JB08   A0A088A6F6   A0A151HYB7   A0A151WRS2   A0A1B0CC11  

PDB

4L46     E-value=1.69458e-148,     Score=1349

KEGG

100174852    K04688 ribosomal protein S6 kinase beta [EC:2.7.11.1] | (RefSeq) P70S6K, S6K; ribosomal protein S6 k

PATHWAY

04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)
04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0007165   GO:0004674   GO:0005840   GO:0005524   GO:0036099   GO:0045793   GO:0051124   GO:0004711   GO:0007525   GO:0030536   GO:2000331   GO:0048813   GO:0016239   GO:0006629   GO:0048010   GO:0048786   GO:0007520   GO:0008340   GO:1902669   GO:0035264   GO:0030307   GO:0008286   GO:0006979   GO:2001023   GO:0040018   GO:0008361   GO:0010508   GO:0045927   GO:0046622   GO:0005829   GO:0006468   GO:0007584   GO:0005654   GO:0005737   GO:0005634   GO:0035556   GO:0004672   GO:0004568   GO:0006032   GO:0006541   GO:0016812   GO:0016597  

Length:

454

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02837

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00198

outside

1  -  454

 

 

Pi

292.286657

Theta

217.19664

Tajima's D

0.936255

CLR

0

CSRT

0.645717714114294

Interpretation

Uncertain