Gene

KWMTBOMO05745  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006881

Annotation

PREDICTED:_cGMP-dependent_protein_kinase?_isozyme_1-like_[Bombyx_mori]

Location

Bomo_Chr10(+):9226705-9239567      View in EpiBrowser

Full name

cGMP-dependent protein kinase      

Location in the cell

Cytoplasmic   Reliability : 2.317

CDS

ATGGTGATATGTCCCCCGTTTAAGTGGTCATCTAAGGGTGGTTTTAATTTAAGTAATATTTCGAACGGCCTTGACAAGAAGACCCGCCGTGAAACCATTATCGGATTACCTGACAATGACACGGACTTTAAGCGAGTCAACAGCGAAGAACGAACTTCGACTAGTGTAAAACTCGTTCAACACATCCAAATACCTCCGCAAGCGGACAAAAAAAATAGCAAGATAAGTGTTGAAAGTGGGGAATCAGTCTCTACTTTCAGTAATGACCACAACCGTAAAAGTAGTACTGGTCGTAAAACCATATCAGAAATAGTTAGAGGGGATCCGGAAAAACGTGAGAAGCAACGCAGGAAAAGAGGGATTATTGCTCCACATCCTACATTTGACGCAGCACGCTCACTGACTGACTTACAGTATGATGTCTTTGAAAAAGATGAAAGGTCGGCAGAGCAAATCCGAAAGGCTATTATGATGAATGATTTCTTAAGAAATTTAATGGATGATGAAAGACTCAACGCTGTAGTTGGTGCAATGATGACACAAGATTTCGAAGCTGGAAGTCTCATCATTCGTGAAGGAGAGAGTGGAAGTCATCTGTTTGTTTCGGCTTCAGGACAATTTGAAGCGTTAAAAAGTGGCCAAGTCGTTAAGAACTTTGGACCAGGCGAAGTTTTTGGTGAACTGGCAATCTTATATAAAGCCAAACGATTCGCTTCAATACGATGTATAACCGAGGCGAGGGTGTGGACATTAGAGAGAAGAGTCTTTCAAAAAATCATGGTTCGAAGTGAACGCCAGGAACAGGAAGACAATATTCGTTTTCTTTCTTCTGTGCCGCTTCTGCAAGAAATACACCATATTGAATTAGCACAAATATCCGATTTCTTAAAAAGAGAATTCTTCTCCACCGGTACAGCGGTGGTCAGACAAGGCGATCGTGGAGATAAGTTCTACATTATTCGCGGTGGGGAGGTGGTTGTTACGAAGCGTGAAGGGGATGATGGAGAAAAACGGATCGGAGTGTTGAAACGCGGTGATTACTTCGGGGAGCAAGCATTGCTGTACGAAGACCGACGCCTTGCGACAGTAACTGCTTTGCCGCCGGGCGTGGAATGCCTGACTCTGGATCGCGGACCGTTCACTGAATTTCTTGGAAATTTGGAGAAATTGAAGAACATACGCCACTCAGTGCCCCGTCCATCGCAGCAGAAGAAAACATCTCAAGTTAAAAGCGAATTCGAGTATGTTGAACTTAAAGATCTAGAAATAGTGGGAACGATGGGTGTAGGTGGCTTCGGTCGTGTTGAGTTAGTGCAGTACAAGCCTGCACCGAAACTAACGTTCGCCCTGAAATGTCTCAAGAAAATCGAGATGGTACAGCAACAGCAACAAGAGCATGCGTACAATGAGAAGAATATCATGATGAGTTGTAAGAGCCCGTTTATATGCAGATTGTATCGCACATTCAAAGATAAAAAATACATTTATTTTCTAATGGAACCGGTATTGGGTGGCGACGTGTGGACTATACTACAGAAACAGCGTTTCTTTCCAGAAAACGTTGCTAAGTTCATAGCCGCCTGCGTCACAGAAGCTTTCCAATACTTGCATTCGAAAGATATCATTTACAGAGACCTCAAACCCGAAAATCTAATGCTCGATAAATACGGCTACATCAAATTGGTCGACTTCGGATTTGCTAAACGTATTTCGCCGAATAGTAAGACATGGACGTTTGCCGGAACACCCGAGTACGTTGCGCCAGAAATCGTACTAAACAAGGGTCACGACCGGGCAGTTGACTGTTGGGCTTTGGGCGTATTGATCCATGAGCTACTCGTCGGCAACTCTCCGTTCCGTGCCCGGGGCGGGGATCACATGAAAACCTACACTCTAATATTGAAAGGAATCGATGTAGTAGATTTTCACCCGAGAGTTTTGAAGTCTGCTCAAATGCTCATACGCAAGCTATGCAAAGCTGTGCCCAGTGAAAGGCTCGGATACCTCAAAAATGGCATGGCTGATGTCAAAAATCACAAATGGTTCCTCGGATTCGACTGGGACGGTCTCCGAGAAAAAAGACTGAAAGCGCCATTAATTCAAGCAGTAGCCAACGACCTTGACCTGTCCAACTTCGAAAAATACCCACAAGAGAAACTGCCACCAGACGAAACGTCTGGCTGGGACTTAGATTTCTGA

Protein

MVICPPFKWSSKGGFNLSNISNGLDKKTRRETIIGLPDNDTDFKRVNSEERTSTSVKLVQHIQIPPQADKKNSKISVESGESVSTFSNDHNRKSSTGRKTISEIVRGDPEKREKQRRKRGIIAPHPTFDAARSLTDLQYDVFEKDERSAEQIRKAIMMNDFLRNLMDDERLNAVVGAMMTQDFEAGSLIIREGESGSHLFVSASGQFEALKSGQVVKNFGPGEVFGELAILYKAKRFASIRCITEARVWTLERRVFQKIMVRSERQEQEDNIRFLSSVPLLQEIHHIELAQISDFLKREFFSTGTAVVRQGDRGDKFYIIRGGEVVVTKREGDDGEKRIGVLKRGDYFGEQALLYEDRRLATVTALPPGVECLTLDRGPFTEFLGNLEKLKNIRHSVPRPSQQKKTSQVKSEFEYVELKDLEIVGTMGVGGFGRVELVQYKPAPKLTFALKCLKKIEMVQQQQQEHAYNEKNIMMSCKSPFICRLYRTFKDKKYIYFLMEPVLGGDVWTILQKQRFFPENVAKFIAACVTEAFQYLHSKDIIYRDLKPENLMLDKYGYIKLVDFGFAKRISPNSKTWTFAGTPEYVAPEIVLNKGHDRAVDCWALGVLIHELLVGNSPFRARGGDHMKTYTLILKGIDVVDFHPRVLKSAQMLIRKLCKAVPSERLGYLKNGMADVKNHKWFLGFDWDGLREKRLKAPLIQAVANDLDLSNFEKYPQEKLPPDETSGWDLDF

Catalytic Activity

ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

Uniprot

H9JBI6   A0A194Q8U7   A0A194RGH7   A0A212EPV0   Q7Q1G7   A0A182NBV8   + More
A0A182KTW9   A0A1S4H219   A0A182XGB0   A0A182UPU4   A0A182GH35   A0A182HRS9   Q16JU3   A0A182QN18   A0A182RW91   A0A182YDF6   A0A182K172   A0A1Q3FYH9   A0A182J1F8   A0A084WG62   A0A182F2Y8   A0A2M4CZT4   A0A182MF89   W5JFH4   T1DTC1   A0A2J7QD19   A0A1L8DKA5   A0A1L8DLC7   A0A067QNL1   A0A336M1D1   A0A1B0GJ39   A0A1J1HYE5   A0A2J7RN62   A0A067QRD6   D7EJR5   A0A1B6FHY7   N6UMB8   A0A1Y1KIP8   T1PAE9   A0A1I8MH66   A0A1B0GHS1   E0W2T9   A0A1L8DLB2   A0A1I8P6Z8   A0A1I8P6X5   A0A0L0BRX8   A0A1B0DDW7   W8B2Y0   A0A034V629   A0A034V171   A0A034V633   A0A034V164   A0A0A1WUK9   A0A0K8WA20   A0A1B6M946   A0A0P6ABA0   A0A0P5QQS0   B4JDS9   B4N0R8   A0A182F0V1   A0A182K5Y2   A0A1A9W6T0   A0A182RK93   A0A023F244   A0A1B0G2D9   A0A131XYI8   A0A182GN03   A0A182YPT9   A0A0P4VKD7   A0A182WFK8   W5JLZ2   A0A182QJD3   A0A336M6T3   B3MLR5   A0A182X604   A0A1B0B0N6   A0A182UVH2   Q7Q8J6   B7PRK0   A0A1S4GZE3   A0A3B0JBL4   A0A182KMH2   A0A182IBN5   A0A1A9ZH72   A0A084VFG3   A0A1A9XCE2   A0A1A9VXF4   A0A224X8L8   A0A182NTB8   Q178W2   A0A3B0K889   A0A182J8D1   A0A182MBA8   Q29LM5   B4GPQ3   T1HXG4   A0A1W4V258   E2AD78   B4KF83  

EC Number

2.7.11.12

Pubmed

19121390    26354079    22118469    12364791    20966253    26483478    + More
17510324    25244985    24438588    20920257    23761445    24845553    18362917    19820115    23537049    28004739    25315136    20566863    26108605    24495485    25348373    25830018    17994087    25474469    27129103    15632085    20798317   

EMBL

BABH01030939    KQ459302    KPJ01829.1    KQ460398    KPJ15036.1    AGBW02013402    + More
OWR43487.1    AAAB01008980    EAA14287.4    JXUM01063087    JXUM01063088    JXUM01063089    KQ562230    KXJ76351.1    APCN01001743    CH477991    EAT34556.1    AXCN02000691    GFDL01002416    JAV32629.1    ATLV01023451    ATLV01023452    KE525343    KFB49206.1    GGFL01006180    MBW70358.1    AXCM01004047    ADMH02001647    ETN61559.1    GAMD01001054    JAB00537.1    NEVH01015828    PNF26488.1    GFDF01007198    JAV06886.1    GFDF01006909    JAV07175.1    KK853196    KDR09980.1    UFQS01000240    UFQT01000240    SSX01880.1    SSX22257.1    AJWK01019266    AJWK01019267    CVRI01000036    CRK93045.1    NEVH01002545    PNF42262.1    KK853110    KDR11233.1    DS497714    EFA12840.1    GECZ01019953    JAS49816.1    APGK01017657    KB740047    ENN81836.1    GEZM01087471    JAV58667.1    KA645125    AFP59754.1    AJWK01005555    AJWK01005556    AJWK01005557    AJWK01005558    AJWK01005559    AAZO01007281    DS235879    EEB19945.1    GFDF01006954    JAV07130.1    JRES01001455    KNC22797.1    AJVK01005478    AJVK01005479    AJVK01005480    GAMC01013648    JAB92907.1    GAKP01021934    JAC37018.1    GAKP01021931    JAC37021.1    GAKP01021929    JAC37023.1    GAKP01021936    JAC37016.1    GBXI01011745    JAD02547.1    GDHF01004624    JAI47690.1    GEBQ01007539    JAT32438.1    GDIP01031941    JAM71774.1    GDIQ01117324    JAL34402.1    CH916368    EDW03449.1    CH963920    EDW77681.1    GBBI01003065    JAC15647.1    CCAG010023722    GEFM01003717    JAP72079.1    JXUM01075500    JXUM01075501    JXUM01075502    JXUM01075503    JXUM01075504    KQ562889    KXJ74903.1    GDKW01003639    JAI52956.1    ADMH02000752    ETN65166.1    AXCN02000716    UFQT01000541    SSX25091.1    CH902620    EDV30786.1    JXJN01006782    AAAB01008944    EAA10189.4    ABJB010244403    ABJB010250096    ABJB010477177    ABJB010561205    ABJB010605367    ABJB010770811    ABJB010782958    ABJB010814706    ABJB010954984    ABJB011089181    DS773104    EEC09222.1    OUUW01000004    SPP79747.1    APCN01000712    ATLV01012389    KE524787    KFB36707.1    GFTR01007719    JAW08707.1    CH477358    EAT42737.1    SPP79748.1    AXCM01004170    CH379060    EAL34020.2    CH479187    EDW39575.1    ACPB03012641    GL438684    EFN68626.1    CH933807    EDW13066.2   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000007062    UP000075884    + More
UP000075882    UP000076407    UP000075903    UP000069940    UP000249989    UP000075840    UP000008820    UP000075886    UP000075900    UP000076408    UP000075881    UP000075880    UP000030765    UP000069272    UP000075883    UP000000673    UP000235965    UP000027135    UP000092461    UP000183832    UP000007266    UP000019118    UP000095301    UP000009046    UP000095300    UP000037069    UP000092462    UP000001070    UP000007798    UP000091820    UP000092444    UP000075920    UP000007801    UP000092460    UP000001555    UP000268350    UP000092445    UP000092443    UP000078200    UP000001819    UP000008744    UP000015103    UP000192221    UP000000311    UP000009192   

PRIDE

H9JBI6   

Pfam

PF00027   cNMP_binding        + More
PF00069   Pkinase
PF00664   ABC_membrane
PF00005   ABC_tran

Interpro

IPR002374   cGMP_dep_kinase        + More
IPR018490   cNMP-bd-like       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR014710   RmlC-like_jellyroll       
IPR035014   STKc_cGK       
IPR000719   Prot_kinase_dom       
IPR000961   AGC-kinase_C       
IPR018488   cNMP-bd_CS       
IPR000595   cNMP-bd_dom       
IPR017441   Protein_kinase_ATP_BS       
IPR003439   ABC_transporter-like       
IPR017871   ABC_transporter_CS       
IPR036640   ABC1_TM_sf       
IPR011527   ABC1_TM_dom       
IPR027417   P-loop_NTPase       
IPR003593   AAA+_ATPase       

SUPFAM

SSF51206   SSF51206        + More
SSF56112   SSF56112       
SSF52540   SSF52540       
SSF90123   SSF90123       

Gene 3D

2.60.120.10     1.20.1560.10    

CDD

cd05572  STKc_cGK
cd00038  CAP_ED

ProteinModelPortal

H9JBI6   A0A194Q8U7   A0A194RGH7   A0A212EPV0   Q7Q1G7   A0A182NBV8   + More
A0A182KTW9   A0A1S4H219   A0A182XGB0   A0A182UPU4   A0A182GH35   A0A182HRS9   Q16JU3   A0A182QN18   A0A182RW91   A0A182YDF6   A0A182K172   A0A1Q3FYH9   A0A182J1F8   A0A084WG62   A0A182F2Y8   A0A2M4CZT4   A0A182MF89   W5JFH4   T1DTC1   A0A2J7QD19   A0A1L8DKA5   A0A1L8DLC7   A0A067QNL1   A0A336M1D1   A0A1B0GJ39   A0A1J1HYE5   A0A2J7RN62   A0A067QRD6   D7EJR5   A0A1B6FHY7   N6UMB8   A0A1Y1KIP8   T1PAE9   A0A1I8MH66   A0A1B0GHS1   E0W2T9   A0A1L8DLB2   A0A1I8P6Z8   A0A1I8P6X5   A0A0L0BRX8   A0A1B0DDW7   W8B2Y0   A0A034V629   A0A034V171   A0A034V633   A0A034V164   A0A0A1WUK9   A0A0K8WA20   A0A1B6M946   A0A0P6ABA0   A0A0P5QQS0   B4JDS9   B4N0R8   A0A182F0V1   A0A182K5Y2   A0A1A9W6T0   A0A182RK93   A0A023F244   A0A1B0G2D9   A0A131XYI8   A0A182GN03   A0A182YPT9   A0A0P4VKD7   A0A182WFK8   W5JLZ2   A0A182QJD3   A0A336M6T3   B3MLR5   A0A182X604   A0A1B0B0N6   A0A182UVH2   Q7Q8J6   B7PRK0   A0A1S4GZE3   A0A3B0JBL4   A0A182KMH2   A0A182IBN5   A0A1A9ZH72   A0A084VFG3   A0A1A9XCE2   A0A1A9VXF4   A0A224X8L8   A0A182NTB8   Q178W2   A0A3B0K889   A0A182J8D1   A0A182MBA8   Q29LM5   B4GPQ3   T1HXG4   A0A1W4V258   E2AD78   B4KF83  

PDB

6C0T     E-value=1.29085e-109,     Score=1016

KEGG

101735910    K07376 cGMP-dependent protein kinase 1 [EC:2.7.11.12] | (RefSeq) cGMP-dependent protein kinase, isoz

GO

GO:0005524   GO:0004692   GO:0030553   GO:0016021   GO:0042626   GO:0005737   GO:0007526   GO:0004672   GO:0006468   GO:0004674   GO:0004568   GO:0006032   GO:0006541   GO:0016812   GO:0016597  

Length:

732

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01645

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00034

outside

1  -  732

 

 

Pi

209.152869

Theta

169.563349

Tajima's D

0.71727

CLR

0.219907

CSRT

0.579471026448678

Interpretation

Uncertain