Gene

KWMTBOMO05743  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006878

Annotation

PREDICTED:_integrin_beta_subunit_1_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr10(+):9125075-9137700      View in EpiBrowser

Full name

Integrin beta       + More
Integrin beta-PS      

Alternative Name

Position-specific antigen beta subunit
Protein myospheroid
Protein olfactory C

Location in the cell

Extracellular   Reliability : 3.541

CDS

ATGCAAAAGCTTACGTTTGCCTATTCCCGGGCTCAAGATTATCCCGTCGATCTGTACTATCTTATGGATCTCAGTAGGTCCATGAAGAACGACAAAGAGAAGCTCAGTGCTTTGGGCAGTCTGCTCTCGGCGACGATGAGGAACATGACATCCAATTTTAGGATCGGCTTCGGATCTTTCGTAGACAAACTCGTTATGCCGTATGTTTCAACGGTGCCTAAGAATCTCATCTCTCCGTGCGACAACTGCGCCGCGCCTTACGGTTTCCGCAATCAAATGTCGCTCAGTAAGGATACTGACTTCTTTGAAAAAGCAGTCGCACAAGCGGACGTTTCTGGTAACTTGGACGCGCCCGAAGGAGGGTTCGACGCGATCATGCAGGCGGTCGTGTGCCGCCAACAGATCGGCTGGAGGGACCAGGCCCGTCGGCTGCTCGTCTTCTCGACCGACGCCGGCTTCCATTACGCCGGGGACGGAAAGCTCGGCGGTATAGTGCAGCCTAATGACGGCCAATGTCACATGGAAAACAACGCTTACACACACTCGACCCTTCAAGATTACCCCAGTATTTCACAGATCAACCTGAAAGTGAAAAAAAATGCTATAAACGTGATATTCGCGGTAACAGCCGAACAGATCAGCGTGTACGAAGAGTTGAGCAAACACATCGAGGGGTCCAGCAGCGGCATCCTCAGTGAGGACTCCGACAACGTTGTCGATCTCGTACGGGAGCAATACAATAAAATTACGTCAACCGTTGAAATGAAGGACTCATCGAGTGACGCCGTTCAAATTGTGTATTACTCATCGTGTCTCGGCGGCAAGGATCTCGTGCAAACAAATAAATGTGACGGACTCAAGGTCGGAGACATGGTGGAGTTCACAGCAGAGATTACATTGAAGGAATGTCCTAAAGATCGAAACAAATGGAAACAATTATTCGAAATATCCCCTGTGGGTATATCGGACAGTCTACAGGTGGAGTTGGAGTTGCTTTGCGACTGTCCTTGTGAACGGCCGGGACATTTCGCGTACAACGCGAGTCCGCTGGTGTGCAGCGGCGAGGGCGTGTCGGCGTGCGGCGTGTGCCTGTGCAGCCCGGGCCGCTTCGGGAAGAGCTGCGAGTGCTCCGCGCAGGGCGGCGTGTCCGTCGAGCAGGAGCGCGGCTGCCGCCCCACCAACGCCACCTCCAGCCCGCTCTGCTCCAACCGCGGGACCTGCATCTGCGGCGTCTGCGAGTGCAACAAGATGGAAGACCCCACTAAGGTAATATCGGGCCCGTTCTGCGAGTGCGACAACTTCACGTGCGACCGCTACAAGGGGCAGCTGTGCTCGGGCCACGGCACGTGCGTGTGCGGCAAGTGCAGCTGCGAGCCGGACTACGGCGGGCCCGCCTGCCAGTGCCTCAAGGACACCAAAGTGTGCATGTCGCCAGAGAACAACAAGATTTGTAGTGGCAACGGCAAATGTGTGTGCGGCCAGTGCGTGTGCAACGTGGACGACGACAAACACTATTCTGGAATGTACTGCGAGAAATGCCCAACTTGCCCCGGCCACTGCGGAGACTTCAAAGACTGCGTCCTCTGCGAGGTGCACAAGCGCGGCCCCAAGTACAACCCCGACACGGACGGCTGCGGCAATTGCGCGCTCCTGCCGATCATAGAGGAAGGCAGGATCGAAGCCAACGAAACTCTCAACGAGCACTTGTGCAGTTTCTACGACGACGAGGACTGTTTGTACGTGTACGTCTATTCTTACCAAGACACTCGGAAAGTGGTCATCAGGGCGCAGAAGGAACGAGAATGCCCTAAAAAGGTACCAATCTTGGGTATAGTCCTGGGCGTGATCGCCGCCATAGTGCTGGTCGGGCTGGCGCTGTTGATGCTATGGAAGATGGCCACCACCATACACGACCGACGCGAGTTCGCACGCTTCGAAAAGGAACGTATGATGGCCAAATGGGATACGGGCGAGAATCCGATTTACAAGCAAGCGACGTCGACGTTCAAGAATCCAACTTACGCCGGAAAATAA

Protein

MQKLTFAYSRAQDYPVDLYYLMDLSRSMKNDKEKLSALGSLLSATMRNMTSNFRIGFGSFVDKLVMPYVSTVPKNLISPCDNCAAPYGFRNQMSLSKDTDFFEKAVAQADVSGNLDAPEGGFDAIMQAVVCRQQIGWRDQARRLLVFSTDAGFHYAGDGKLGGIVQPNDGQCHMENNAYTHSTLQDYPSISQINLKVKKNAINVIFAVTAEQISVYEELSKHIEGSSSGILSEDSDNVVDLVREQYNKITSTVEMKDSSSDAVQIVYYSSCLGGKDLVQTNKCDGLKVGDMVEFTAEITLKECPKDRNKWKQLFEISPVGISDSLQVELELLCDCPCERPGHFAYNASPLVCSGEGVSACGVCLCSPGRFGKSCECSAQGGVSVEQERGCRPTNATSSPLCSNRGTCICGVCECNKMEDPTKVISGPFCECDNFTCDRYKGQLCSGHGTCVCGKCSCEPDYGGPACQCLKDTKVCMSPENNKICSGNGKCVCGQCVCNVDDDKHYSGMYCEKCPTCPGHCGDFKDCVLCEVHKRGPKYNPDTDGCGNCALLPIIEEGRIEANETLNEHLCSFYDDEDCLYVYVYSYQDTRKVVIRAQKERECPKKVPILGIVLGVIAAIVLVGLALLMLWKMATTIHDRREFARFEKERMMAKWDTGENPIYKQATSTFKNPTYAGK

Description

Integrin alpha-PS1/beta-PS is a receptor for laminin (PubMed:7972082). Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m (PubMed:7924982, PubMed:7972082, PubMed:9660786). Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle (PubMed:15469969). Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium (PubMed:15469969). The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not (PubMed:15469969). Required for rhea/talin correct cellular localization in the midgut (PubMed:15469969). Required for many embryonic (dorsal closure and somatic muscle attachments) and postembryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development) (PubMed:8119134, PubMed:7924982, PubMed:7972082, PubMed:10821184). Involved in the function and/or development of the olfactory system (PubMed:10821184). In the testes, essential for shv-dependent maintenance of somatic hub cells and their localization to the apical tip (PubMed:27191715). Plays a role in timely border cell migration during oogenesis (PubMed:19035354).

Subunit

Heterodimer of an alpha and a beta subunit. Beta-PS associates with either alpha-PS1, alpha-PS2, alpha-PS3, alpha-PS4 or alpha-PS5.

Miscellaneous

The absence of the beta-PS subunit results in detachment and rounding up of the muscles, thus the gene encoding beta-PS is called myospheroid.

Similarity

Belongs to the integrin beta chain family.

Keywords

Behavior   Cell adhesion   Cell membrane   Complete proteome   Developmental protein   Disulfide bond   Flight   Glycoprotein   Integrin   Membrane   Olfaction   Phosphoprotein   Receptor   Reference proteome   Repeat   Sensory transduction   Signal   Transmembrane   Transmembrane helix   Vision  

Feature

chain  Integrin beta

Uniprot

A0A076JVB8   D1MBK3   H9JBI3   A0A2H1WGL4   F8TAD6   D2DMM8   + More
Q86G85   A0A023UG44   A0A2A4K6E0   A0A1E1WNR2   A0A212EPU0   A2TIK8   C6KE04   A0A3S2P1P8   U5EVW7   A0A1L8DMI8   A0A1L8DMS5   A0A1L8DMF7   A0A1L8DMT3   A0A1L8DMJ4   A0A1L8DMR9   A0A336MBS4   A0A336M8L1   A0A1B6GQB5   A0A0B5H7U8   A0A1B6MUI8   A0A2J7PDP2   E0W1M5   A0A2J7PDN9   A0A067REY1   A0A0N8B5P6   A0A0P5EN75   A0A1I8MIF1   A0A1B6CMD9   A0A0P5IU01   T1P7N9   A0A1I8MIE7   A0A1B0AX62   A0A1A9X588   A0A1A9X8U0   A0A1A9UUR6   E9GI17   A0A1I8PZ80   A0A2S2QNA7   A0A182IJP6   A0A069DXI6   A0A2M4CU18   A0A2M4CU05   A0A0K8UTI8   A0A224XBJ4   A0A034V7S9   B4JNC9   A0A0P6AIE1   B4NEJ2   A0A084VH17   Q16M01   A0A1S4FW80   A0A2A3E010   T1GNV7   A0A0M5J132   A0A1W4VWF1   B4L1D3   A0A158NM60   E2A6Z5   J9K6Z1   A0A182HIV0   A0A026X3M7   A0A2M4BDV9   A0A182Q0X5   A0A2M4A9N8   A0A2M4A9A0   A0A2M4BDW1   B4M7J6   B3MRJ4   A0A182XDN2   A0A1I8PFU3   A0A182PFW1   A0A1W4VID4   A0A0Q9WXU2   A0A3Q0JA47   A0A1Q3FMG1   A0A151WGW9   A0A182V657   A0A182YH54   A0A182W5K9   B0WHR4   Q7QE55   A0A182TIH0   A0A1B0AK61   Q9NAS7   A0A146KXD2   A0A182RHJ6   F4WYP6   E2B3R7   E9J4K4   X2JAU0   P11584   U4USQ6   X2JE30   A0A151JTC0  

Pubmed

25064490    19121390    21856307    12974949    22118469    20708011    + More
20566863    24845553    25315136    21292972    26334808    25348373    17994087    24438588    17510324    21347285    20798317    24508170    30249741    25244985    12364791    14747013    17210077    11437913    26823975    21719571    21282665    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    3128792    8119134    12537569    7924982    7972082    9660786    10821184    15469969    17893096    19035354    19349973    27191715    23537049   

EMBL

KJ511854    AII79413.1    GU129932    ACY74431.1    BABH01030933    BABH01030934    + More
ODYU01008525    SOQ52209.1    HQ829425    ADW20295.1    FJ599745    ACU32665.1    AY237588    AAO85806.1    KJ462516    AHY00655.1    NWSH01000130    PCG79230.1    GDQN01007634    GDQN01002429    JAT83420.1    JAT88625.1    AGBW02013402    OWR43484.1    EF202843    ABM91320.1    GQ178290    ACS66819.1    RSAL01000053    RVE50105.1    GANO01001694    JAB58177.1    GFDF01006408    JAV07676.1    GFDF01006407    JAV07677.1    GFDF01006529    JAV07555.1    GFDF01006410    JAV07674.1    GFDF01006406    JAV07678.1    GFDF01006409    JAV07675.1    UFQT01000673    SSX26379.1    SSX26380.1    GECZ01005141    JAS64628.1    KJ535130    AJF38203.1    GEBQ01000406    JAT39571.1    NEVH01026386    PNF14450.1    DS235872    EEB19531.1    PNF14449.1    KK852510    KDR22327.1    GDIQ01245981    GDIQ01227794    GDIQ01210291    GDIQ01207807    GDIQ01206458    GDIQ01203248    GDIQ01191690    GDIQ01132238    GDIQ01113476    GDIP01089236    JAK41434.1    JAM14479.1    GDIQ01269713    JAJ82011.1    GEDC01022664    GEDC01007821    JAS14634.1    JAS29477.1    GDIP01253007    GDIQ01269714    GDIQ01227795    GDIQ01227793    GDIQ01225644    GDIQ01210290    GDIQ01191691    JAI70394.1    JAK41435.1    KA644626    AFP59255.1    JXJN01005087    JXJN01005088    GL732545    EFX80954.1    GGMS01009837    MBY79040.1    GBGD01000492    JAC88397.1    GGFL01004659    MBW68837.1    GGFL01004658    MBW68836.1    GDHF01022317    JAI29997.1    GFTR01008112    JAW08314.1    GAKP01019606    JAC39346.1    CH916371    EDV92222.1    GDIP01030205    JAM73510.1    CH964239    EDW82161.2    ATLV01013123    KE524840    KFB37261.1    CH477885    EAT35362.1    KZ288518    PBC25100.1    CAQQ02145466    CAQQ02145467    CP012528    ALC49048.1    CH933810    EDW06654.2    ADTU01020302    GL437208    EFN70798.1    ABLF02015963    ABLF02015965    ABLF02015966    ABLF02015969    ABLF02015970    ABLF02052007    APCN01004101    KK107019    QOIP01000007    EZA62678.1    RLU20975.1    GGFJ01002095    MBW51236.1    AXCN02002227    GGFK01004007    MBW37328.1    GGFK01003991    MBW37312.1    GGFJ01002056    MBW51197.1    CH940653    EDW62763.2    CH902622    EDV34399.1    KRF93760.1    GFDL01006333    JAV28712.1    KQ983145    KYQ47058.1    DS231939    EDS27931.1    AAAB01008847    EAA06838.2    AJ292755    CAC00630.1    GDHC01018354    JAQ00275.1    GL888455    EGI60681.1    GL445398    EFN89654.1    GL768105    EFZ12250.1    AE014298    AHN59470.1    J03251    AY113499    KB632349    ERL93211.1    AHN59468.1    KQ981960    KYN31910.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000235965    UP000009046    + More
UP000027135    UP000095301    UP000092460    UP000091820    UP000092443    UP000078200    UP000000305    UP000095300    UP000075880    UP000001070    UP000007798    UP000030765    UP000008820    UP000242457    UP000015102    UP000092553    UP000192221    UP000009192    UP000005205    UP000000311    UP000007819    UP000075840    UP000053097    UP000279307    UP000075886    UP000008792    UP000007801    UP000076407    UP000075885    UP000079169    UP000075809    UP000075903    UP000076408    UP000075920    UP000002320    UP000007062    UP000075902    UP000092445    UP000075900    UP000007755    UP000008237    UP000000803    UP000030742    UP000078541   

PRIDE

D1MBK3    H9JBI3    X2JAU0    P11584    X2JE30   

Pfam

PF08725   Integrin_b_cyt        + More
PF17205   PSI_integrin
PF00362   Integrin_beta
PF07965   Integrin_B_tail
PF07974   EGF_2
PF18372   I-EGF_1

Interpro

IPR036349   Integrin_bsu_tail_dom_sf        + More
IPR012896   Integrin_bsu_tail       
IPR002369   Integrin_bsu_VWA       
IPR013111   EGF_extracell       
IPR033760   Integrin_beta_N       
IPR032695   Integrin_dom_sf       
IPR036465   vWFA_dom_sf       
IPR014836   Integrin_bsu_cyt_dom       
IPR015812   Integrin_bsu       
IPR040622   I-EGF_1       

SUPFAM

SSF53300   SSF53300        + More
SSF69687   SSF69687       
SSF69179   SSF69179       

Gene 3D

3.40.50.410    

ProteinModelPortal

A0A076JVB8   D1MBK3   H9JBI3   A0A2H1WGL4   F8TAD6   D2DMM8   + More
Q86G85   A0A023UG44   A0A2A4K6E0   A0A1E1WNR2   A0A212EPU0   A2TIK8   C6KE04   A0A3S2P1P8   U5EVW7   A0A1L8DMI8   A0A1L8DMS5   A0A1L8DMF7   A0A1L8DMT3   A0A1L8DMJ4   A0A1L8DMR9   A0A336MBS4   A0A336M8L1   A0A1B6GQB5   A0A0B5H7U8   A0A1B6MUI8   A0A2J7PDP2   E0W1M5   A0A2J7PDN9   A0A067REY1   A0A0N8B5P6   A0A0P5EN75   A0A1I8MIF1   A0A1B6CMD9   A0A0P5IU01   T1P7N9   A0A1I8MIE7   A0A1B0AX62   A0A1A9X588   A0A1A9X8U0   A0A1A9UUR6   E9GI17   A0A1I8PZ80   A0A2S2QNA7   A0A182IJP6   A0A069DXI6   A0A2M4CU18   A0A2M4CU05   A0A0K8UTI8   A0A224XBJ4   A0A034V7S9   B4JNC9   A0A0P6AIE1   B4NEJ2   A0A084VH17   Q16M01   A0A1S4FW80   A0A2A3E010   T1GNV7   A0A0M5J132   A0A1W4VWF1   B4L1D3   A0A158NM60   E2A6Z5   J9K6Z1   A0A182HIV0   A0A026X3M7   A0A2M4BDV9   A0A182Q0X5   A0A2M4A9N8   A0A2M4A9A0   A0A2M4BDW1   B4M7J6   B3MRJ4   A0A182XDN2   A0A1I8PFU3   A0A182PFW1   A0A1W4VID4   A0A0Q9WXU2   A0A3Q0JA47   A0A1Q3FMG1   A0A151WGW9   A0A182V657   A0A182YH54   A0A182W5K9   B0WHR4   Q7QE55   A0A182TIH0   A0A1B0AK61   Q9NAS7   A0A146KXD2   A0A182RHJ6   F4WYP6   E2B3R7   E9J4K4   X2JAU0   P11584   U4USQ6   X2JE30   A0A151JTC0  

PDB

4UM8     E-value=5.38539e-129,     Score=1183

KEGG

100313947    K05719 integrin beta 1 | (RefSeq) integrin beta subunit 1

PATHWAY

04145    Phagosome - Bombyx mori (domestic silkworm)
04512    ECM-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0007229   GO:0007155   GO:0016021   GO:0009986   GO:0005178   GO:0008305   GO:0033627   GO:0007160   GO:0005925   GO:0016477   GO:0007298   GO:0021551   GO:0007015   GO:0016328   GO:0031252   GO:0035160   GO:0007508   GO:0003344   GO:1990430   GO:0007431   GO:0007377   GO:0016203   GO:0035099   GO:0006930   GO:0090129   GO:0007411   GO:0030718   GO:0005927   GO:0009925   GO:0007608   GO:0007419   GO:0051492   GO:0046982   GO:0008340   GO:0007391   GO:0035001   GO:0008360   GO:0034446   GO:0042734   GO:0045211   GO:0043034   GO:0045214   GO:0030425   GO:0030336   GO:0048803   GO:0005886   GO:0007417   GO:0031589   GO:0007157   GO:0016340   GO:0007475   GO:0005887   GO:0007494   GO:0007629   GO:0007601   GO:0007517   GO:0016339   GO:0016324  

PANTHER

PTHR10082  

Subcellular location

Membrane  
Apical cell membrane  
Lateral cell membrane  
Basal cell membrane  

Length:

677

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.06252

Exp number, first 60 AAs:

0.13298

Total prob of N-in:

0.01282

outside

1  -  607

TMhelix

608  -  630

inside

631  -  677

 

 

Pi

231.637573

Theta

163.768458

Tajima's D

0.944177

CLR

0.45611

CSRT

0.651767411629419

Interpretation

Uncertain