Gene

KWMTBOMO05741  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006809

Annotation

kinesin_heavy_chain_[Bombyx_mori]

Location

Bomo_Chr10(-):9100979-9113074      View in EpiBrowser

Full name

Kinesin-like protein       + More
Kinesin heavy chain      

Location in the cell

Cytoplasmic   Reliability : 1.488 Cytoskeletal   Reliability : 1.52 Nuclear   Reliability : 1.012

CDS

ATGGCAGCCGATCGCGAGATTGCTGCTGAAGACAGTATCAGAGTGGTATGCCGATTTCGACCACTGAATGACTCTGAAGAAAAAGCTGGTTCAAAATTTATCGTGAAATTTCCATCTGGACCTGATGATAATTGCATTTCTATAGGGGGTAAAGTATACTTATTTGACAAAGTATTCAAACCCAATGCAACCCAAGAAAAAGTCTACAATGAAGCTGCCAAAAGCATTGTATCAGATGTTCTGGCAGGCTACAATGGAACTATATTTGCCTATGGTCAAACAAGTTCTGGGAAAACACATACCATGGAAGGTGTCATAGGAGATCCAGGAAAACAGGGTATTATACCAAGGATTGTCAATGACATATTCAATCACATTTATGCCATGGAAGAGAACTTGGAATTTCATATTAAAGTGTCATATTTTGAAATCTATATGGACAAGATCAGAGACTTGCTCGATGTGTCAAAAGTAAATCTCAGTGTCCATGAAGACAAAAATAGAGTCCCATTTGTAAAAGGTGCTACAGAACGATTTGTATCAAGCCCTGAAGAAGTTTTTGAAGTTATTGAGGAAGGCAAATCAAATAGACATATTGCAGTCACAAACATGAATGAACATTCATCACGATCTCACTCTGTCTTCCTTATAAATGTCAAACAAGAAAATTTGGAAAATCAAAAGAAACTCTCAGGAAAGCTCTATCTTGTGGACTTGGCTGGTTCTGAAAAGGTATCAAAAACTGGTGCTGAAGGCACTGTCCTGGATGAAGCTAAAAATATTAATAAATCACTTTCGGCATTGGGTAATGTAATTTCAGCATTAGCTGATGGAAATAAATCTCATATTCCATACAGAGATTCCAAACTAACTCGAATTTTACAAGAGTCACTTGGTGGTAATGCAAGAACCACAATTGTAATTTGCTGCTCACCTGCTTCATTTAATGAAAGCGAAACTAAAAGTACACTTGACTTTGGTAAAAGAGCTAAGACAGTCAAGAATGTTGTATGTGTCAATGAGGAATTGACAGCTGAGGAATGGAAACGTCGCTATGAAAGAGAAAAGGAGAAAGTGGCTAGGCTGAAGGGCAAGGTTGAAAAACTAGAAGCTGAACTGAATCGCTGGCGTTCTGGTGAGACTGTCAGACTAGAAGAGCAAGTAAATCTGCAGGAGATTGAAGCTGTTACTCCAGTAACATCATTTATTGAAGAAAAACCTCCAGCACCTCCTGTACCAGTGGCTGTCGCCAGTGTTGTCGAAGACGCCGCAATGCAGGCTAAGTTAGAAGCTCTCTACCAACAGCTGGATGACAAAGATGAAGAGATCAACCAACATTCTCAGCTTGTTGAGAAACTTAAGGAACAGATGATGGAACAAGAAGAATTAATTGCCTGCACAAGGCGCGATTATGAGGCGTTACAAGGAGACATGAATAGAATCCAACAAGAAAATGAAGCTGCTAAAGAAGAAGTCAAAGAAGTTCTACAAGCTCTTGAAGAGCTCGCCGTTAATTACGACCAGAAGTCGCAGGAGGTAGACAGCAAGAGCCGCGAGTGCGATCAGCTGTCTGAAGACTTGCAATCCAAACAGAGCGCCCTGACTAGTGCTACGGCAGAGCTGCAACAACTCCGTGATTTGTCTGCACATCAACGAAAACGTATCGCGGAATTATTGACAAACTTACTTCGAGATCTCGCCGAGATAGGAGCTGCCGTCGGAGGATCTGAGCTCGACTTCAAACTCAATGTAGACACTGTCGGGAAACTGGAAGAGGAGTTTACAGTGGCTCGTCTCCACATCAGCAAAATGAAAAGTGAAGTCAAAAATATTGTCCAACGATGCCATTCACTTGAATCTGCTAACATCGATGCCAATCAGAAGATTGAAGAATATGAGCGAACACTTGGTGAATGTCGCCTTTTGATCTCCCAACACGAAGCCCGTTGTGCTTCGCTAGCAGAGTCGATGCGTGAGGCCGAAAATAAGAAACGACAACTCGAGGAAGCTGCTGACGCTTTACGTGAAGAGTGTGCTCGCCTACAGGCGGCCGAGCGCGTACAGCTGGCGGCGGCGGAGGACTCGCAGGTCCGCGGCGCGCTGGAGGCCCAGCTGGAGCAGCTGCGCGCCGCGCACTCCACGCAGCTGTCTGCGCTGCGGGACGAGCTCGCCGCGCTGCAGCGACAACACCAGGACCTCAAGGACACGTACCAGGAGCTAACCCTGGCGCGGCAGCAGCTCCAGGACGACTACGAGAAGCTGAAGCGCGAGGAGGCCGACAAGTCCGCCAAACTGAAGGAACTCATTCAAAGCGTGGAGCGGCGTGAACAGGCTCGCGCTGATCTCAAGGGCTTGGAAGACACCGTGGCTAAGGAACTACAGACCCTGCACAATCTGCGTAAACTCTTTGTTCAAGACCTGCAGGCGAGGATAAAGAAATCGAACAATTCTGAAGAGGGCGCCGAGGAGGAAGGCGGTTCCCTTGCACAAAAACAAAAGATCTCGTTCTTGGAGAATAACCTGGAGCAACTGACGAAAGTCCACAAGCAGCTCGTGCGTGACAATGCCGACCTGCGATGCGAAGTGCCCAAGCTGGAGAAACGACTCCGAGCCACCATGGAACGTGTCAAGGCACTCGAGACAGCGCTCAAGGAAGCAAAAGACGGTGCAATGCGCGATCGCAAACGATACCAGTTCGAAGTGGACAGAATCAAGGAAGCCGTGCGCGCTAAAAATCTTGCTCGCCGCGGTCCACAGGCCCAAATCGCGAAGCCGATACGCGCGGGCGGCGGGCACCTGGCGGGCGGCGCGGGCGCGGGCGTGCTGCGACCCGCCGCCGCCGCGCAGGACATCAAGCGGAAGTCTATCATCGTCGGCGCTAGAGATGAAAGTTGA

Protein

MAADREIAAEDSIRVVCRFRPLNDSEEKAGSKFIVKFPSGPDDNCISIGGKVYLFDKVFKPNATQEKVYNEAAKSIVSDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDPGKQGIIPRIVNDIFNHIYAMEENLEFHIKVSYFEIYMDKIRDLLDVSKVNLSVHEDKNRVPFVKGATERFVSSPEEVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSALGNVISALADGNKSHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGKRAKTVKNVVCVNEELTAEEWKRRYEREKEKVARLKGKVEKLEAELNRWRSGETVRLEEQVNLQEIEAVTPVTSFIEEKPPAPPVPVAVASVVEDAAMQAKLEALYQQLDDKDEEINQHSQLVEKLKEQMMEQEELIACTRRDYEALQGDMNRIQQENEAAKEEVKEVLQALEELAVNYDQKSQEVDSKSRECDQLSEDLQSKQSALTSATAELQQLRDLSAHQRKRIAELLTNLLRDLAEIGAAVGGSELDFKLNVDTVGKLEEEFTVARLHISKMKSEVKNIVQRCHSLESANIDANQKIEEYERTLGECRLLISQHEARCASLAESMREAENKKRQLEEAADALREECARLQAAERVQLAAAEDSQVRGALEAQLEQLRAAHSTQLSALRDELAALQRQHQDLKDTYQELTLARQQLQDDYEKLKREEADKSAKLKELIQSVERREQARADLKGLEDTVAKELQTLHNLRKLFVQDLQARIKKSNNSEEGAEEEGGSLAQKQKISFLENNLEQLTKVHKQLVRDNADLRCEVPKLEKRLRATMERVKALETALKEAKDGAMRDRKRYQFEVDRIKEAVRAKNLARRGPQAQIAKPIRAGGGHLAGGAGAGVLRPAAAAQDIKRKSIIVGARDES

Description

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria.

Subunit

Oligomer composed of two heavy chains and two light chains.

Similarity

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.

Keywords

3D-structure   ATP-binding   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Microtubule   Motor protein   Nucleotide-binding   Reference proteome  

Feature

chain  Kinesin heavy chain

Uniprot

A1E129   A0A2A4K5P8   A0A3S2NKS5   A0A212EPR4   H9JBB4   A0A1Y1N570   + More
D6X1C8   A0A194PFF3   A0A069DWW9   A0A0K8TN52   A0A1Q3FWW6   A0A0A9X3R0   A0A023F5N3   A0A2H1WGM5   A0A023EX60   T1I4R3   A0A151WPK5   A0A1L8E594   A0A1W4X1K0   E9IEF5   A0A195CCK8   F4X5U6   A0A151I2Y7   A0A158NME6   A0A151JVB4   A0A151IWY5   U5EZ14   A0A154PM70   A0A067RH20   A0A0C9PIE2   E2A3V0   A0A0C9QJF5   A0A1J1HRC6   T1PG04   A0A0K8WG54   A0A034WEC7   A0A0L0BLG8   A0A336MPV3   W8AWA0   B4LIQ5   B4MJT9   B4J458   A0A026WI49   A0A1L8E5E5   A0A0A1WNS3   E2C2T0   A0A1W4UZC6   A0A3B0J2P4   A0A1I8QA59   A0A2C9GQ78   A0A182QDF6   A0A0M4E793   A0A182UWK0   Q7PG43   A0A182IS91   Q291R3   A0A0J9U3H8   A0A336MNG3   B4HSU7   V9IEQ4   V9ID03   A0A088A7G3   B3NPL9   P17210   A0A2A3EBS3   B4P6A5   B3MF77   A0A084VFN8   A0A2M4A1T3   A0A2M4CTD2   A0A2M3ZFY2   A0A182FJU3   A0A2M4BCB7   B4QHV8   A0A310SHR9   A0A2M4BCC4   A0A336MGS8   A0A0M8ZRZ4   B4GAD8   A0A0L7R2X6   J9JR93   A0A2J7Q5G0   A0A2S2P7U9   Q16YJ5   A0A0P5KFA1   A0A0N8CWE0   A0A0N8ENT8   A0A224XE87   A0A0P5A5I1   A0A162PI66   E9GMY8   E0W1M3   A0A182YK72   T1JMP3   A0A423TSE4   A0A0P5NFY1   A0A0P4VXG2   A0A286RXN7   A0A1D2NDP8   A0A0P5YSV4  

Pubmed

20368730    22118469    19121390    28004739    18362917    19820115    + More
26354079    26334808    26369729    25401762    25474469    24945155    21282665    21719571    21347285    24845553    20798317    25348373    26108605    24495485    17994087    24508170    25830018    12364791    14747013    17210077    15632085    22936249    2522352    10731132    12537572    12537569    1384131    16717129    17550304    18057021    24438588    17510324    21292972    20566863    25244985    27289101   

EMBL

EF092448    ABK92268.2    NWSH01000130    PCG79244.1    RSAL01000053    RVE50104.1    + More
AGBW02013402    OWR43483.1    BABH01030929    BABH01030930    GEZM01012253    JAV93042.1    KQ971372    EFA10675.1    KQ459606    KPI91429.1    GBGD01000316    JAC88573.1    GDAI01002025    JAI15578.1    GFDL01002978    JAV32067.1    GBHO01031874    JAG11730.1    GBBI01002238    JAC16474.1    ODYU01008525    SOQ52208.1    GAPW01000117    JAC13481.1    ACPB03022837    KQ982865    KYQ49760.1    GFDF01000167    JAV13917.1    GL762591    EFZ21057.1    KQ977957    KYM98450.1    GL888742    EGI58186.1    KQ976507    KYM82816.1    ADTU01020416    ADTU01020417    ADTU01020418    KQ981706    KYN37416.1    KQ980838    KYN12345.1    GANO01001614    JAB58257.1    KQ434978    KZC12981.1    KK852510    KDR22333.1    GBYB01000698    JAG70465.1    GL436500    EFN71894.1    GBYB01000697    GBYB01000699    GBYB01000700    JAG70464.1    JAG70466.1    JAG70467.1    CVRI01000020    CRK90599.1    KA647752    AFP62381.1    GDHF01002285    JAI50029.1    GAKP01006452    JAC52500.1    JRES01001693    KNC20950.1    UFQT01001491    SSX30803.1    GAMC01017549    GAMC01017547    GAMC01017545    GAMC01017544    JAB89008.1    CH940648    EDW61408.1    CH963846    EDW72378.1    CH916367    EDW02664.1    KK107238    EZA54784.1    GFDF01000188    JAV13896.1    GBXI01013593    JAD00699.1    GL452203    EFN77765.1    OUUW01000001    SPP73412.1    APCN01001131    AXCN02002225    CP012524    ALC42516.1    AAAB01008846    EAA45075.2    CM000071    EAL25049.2    CM002911    KMY94225.1    UFQT01000836    SSX27528.1    CH480816    EDW48111.1    JR040062    AEY58966.1    JR040061    AEY58965.1    CH954179    EDV55786.1    M24441    AE013599    AY094959    KZ288296    PBC28924.1    CM000158    EDW91955.1    CH902619    EDV37705.1    KPU76995.1    ATLV01012451    KE524793    KFB36782.1    GGFK01001453    MBW34774.1    GGFL01004402    MBW68580.1    GGFM01006589    MBW27340.1    GGFJ01001480    MBW50621.1    CM000362    EDX07329.1    KQ759878    OAD62245.1    GGFJ01001490    MBW50631.1    SSX27527.1    KQ435918    KOX68746.1    CH479181    EDW31890.1    KQ414664    KOC65183.1    ABLF02034945    NEVH01017559    PNF23823.1    GGMR01012649    MBY25268.1    CH477516    EAT39661.1    GDIQ01190351    GDIP01134181    JAK61374.1    JAL69533.1    GDIP01092327    JAM11388.1    GDIQ01008564    JAN86173.1    GFTR01008318    JAW08108.1    GDIP01203774    JAJ19628.1    LRGB01000512    KZS18869.1    GL732553    EFX79177.1    DS235872    EEB19529.1    JH431954    QCYY01001255    ROT79351.1    GDIQ01149369    JAL02357.1    GDRN01089631    GDRN01089630    GDRN01089629    JAI60619.1    KY974271    ASW35071.1    LJIJ01000076    ODN03371.1    GDIP01055139    JAM48576.1   

Proteomes

UP000218220    UP000283053    UP000007151    UP000005204    UP000007266    UP000053268    + More
UP000015103    UP000075809    UP000192223    UP000078542    UP000007755    UP000078540    UP000005205    UP000078541    UP000078492    UP000076502    UP000027135    UP000000311    UP000183832    UP000037069    UP000008792    UP000007798    UP000001070    UP000053097    UP000008237    UP000192221    UP000268350    UP000095300    UP000075840    UP000075886    UP000092553    UP000075903    UP000007062    UP000075880    UP000001819    UP000001292    UP000005203    UP000008711    UP000000803    UP000242457    UP000002282    UP000007801    UP000030765    UP000069272    UP000000304    UP000053105    UP000008744    UP000053825    UP000007819    UP000235965    UP000008820    UP000076858    UP000000305    UP000009046    UP000076408    UP000283509    UP000094527   

PRIDE

A1E129    H9JBB4    P17210   

Pfam

PF00225   Kinesin

Interpro

IPR027417   P-loop_NTPase        + More
IPR019821   Kinesin_motor_CS       
IPR027640   Kinesin-like_fam       
IPR001752   Kinesin_motor_dom       
IPR036961   Kinesin_motor_dom_sf       

SUPFAM

SSF52540   SSF52540       

Gene 3D

3.40.850.10    

ProteinModelPortal

A1E129   A0A2A4K5P8   A0A3S2NKS5   A0A212EPR4   H9JBB4   A0A1Y1N570   + More
D6X1C8   A0A194PFF3   A0A069DWW9   A0A0K8TN52   A0A1Q3FWW6   A0A0A9X3R0   A0A023F5N3   A0A2H1WGM5   A0A023EX60   T1I4R3   A0A151WPK5   A0A1L8E594   A0A1W4X1K0   E9IEF5   A0A195CCK8   F4X5U6   A0A151I2Y7   A0A158NME6   A0A151JVB4   A0A151IWY5   U5EZ14   A0A154PM70   A0A067RH20   A0A0C9PIE2   E2A3V0   A0A0C9QJF5   A0A1J1HRC6   T1PG04   A0A0K8WG54   A0A034WEC7   A0A0L0BLG8   A0A336MPV3   W8AWA0   B4LIQ5   B4MJT9   B4J458   A0A026WI49   A0A1L8E5E5   A0A0A1WNS3   E2C2T0   A0A1W4UZC6   A0A3B0J2P4   A0A1I8QA59   A0A2C9GQ78   A0A182QDF6   A0A0M4E793   A0A182UWK0   Q7PG43   A0A182IS91   Q291R3   A0A0J9U3H8   A0A336MNG3   B4HSU7   V9IEQ4   V9ID03   A0A088A7G3   B3NPL9   P17210   A0A2A3EBS3   B4P6A5   B3MF77   A0A084VFN8   A0A2M4A1T3   A0A2M4CTD2   A0A2M3ZFY2   A0A182FJU3   A0A2M4BCB7   B4QHV8   A0A310SHR9   A0A2M4BCC4   A0A336MGS8   A0A0M8ZRZ4   B4GAD8   A0A0L7R2X6   J9JR93   A0A2J7Q5G0   A0A2S2P7U9   Q16YJ5   A0A0P5KFA1   A0A0N8CWE0   A0A0N8ENT8   A0A224XE87   A0A0P5A5I1   A0A162PI66   E9GMY8   E0W1M3   A0A182YK72   T1JMP3   A0A423TSE4   A0A0P5NFY1   A0A0P4VXG2   A0A286RXN7   A0A1D2NDP8   A0A0P5YSV4  

PDB

2Y65     E-value=1.78546e-177,     Score=1602

KEGG

100144600    K10396 kinesin family member 5 | (RefSeq) Khc; kinesin heavy chain

PATHWAY

04144    Endocytosis - Bombyx mori (domestic silkworm)

GO

GO:0007018   GO:0008017   GO:0005524   GO:0003777   GO:0005874   GO:0003774   GO:0007411   GO:0045202   GO:0048489   GO:0098971   GO:0032839   GO:0008574   GO:0016887   GO:0005871   GO:0046785   GO:0098957   GO:0030478   GO:0061572   GO:0007097   GO:0007310   GO:0051299   GO:0048312   GO:0008103   GO:0007317   GO:0001754   GO:0005523   GO:0051012   GO:0035617   GO:0035371   GO:0045451   GO:0098937   GO:0070868   GO:0048741   GO:0048813   GO:0008345   GO:1904115   GO:0046843   GO:0007409   GO:0008088   GO:0048311   GO:0007315   GO:0005737   GO:0005829   GO:0010970   GO:0007303   GO:0016021   GO:0004553   GO:0004568   GO:0006032   GO:0006541   GO:0016812   GO:0016597  

PANTHER

PTHR24115  

Subcellular location

  

Length:

964

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.06941

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00117

outside

1  -  964

 

 

Pi

222.179805

Theta

179.129019

Tajima's D

0.706339

CLR

0.07966

CSRT

0.577721113944303

Interpretation

Uncertain