Pre Gene Modal
BGIBMGA006876
Annotation
PREDICTED:_probable_argininosuccinate_lyase_[Bombyx_mori]
Full name
Argininosuccinate lyase
Alternative Name
Arginosuccinase
Delta crystallin II
Delta-2 crystallin
Delta crystallin II
Delta-2 crystallin
Location in the cell
Cytoplasmic Reliability : 1.56 PlasmaMembrane Reliability : 1.2
Sequence
CDS
ATGTCTTCAAGCAAATTTCAACTTTGGGGTGGGTGTTTTGAAGAGGAACCTTCCTCGGTGCTTCGACGTTTGAACGATTCTTTACCGGTGGACTTTAGATTATTTCGTGAAGATATACAAGGAAGTCGCGCGTGGGCAGAAGAATTATTTCAGAGCCACCATTTGTCGGCCAATGACAATCTTGCTATACAAAAAGGTCTTGACAGTGTCGAAAAAGAAATAGAACAAGAACTAACAGAAAACGGCAAGCTTAAAGATGCTGAAGAAGACATACATTCTGTGATCGAATGCAGGTTATTCAAGCACAGTGGCGATGCAGCCTTTCGTCTACACACAGCACGTAGTCGTAATGACCAGTCTGCCACTGACACCCGCCTTTGGATGCTTGCATCCTTGCCAAAGCTGACATCTGCTATTGTAGAACTTATAACGGTACTTGCCACTCGAGCTGAAAATGAGATAGATATTATATCTGCTGGCTATACTCATCTACAACGTGCTCAGCCAGTAAGATGGAGTCATTTTTTGTTGAGTCACGCATGGGCTCTCCGCGATGACGTAACAAGACTTGAGGAGCAAAGAAGTAGACTCTCACGTTGTCCACTCGGCAGCGGTGCGTTAGCAGGTTGCGCTCTAACCATTGACAGAAAAAGACTTGCGCTAAATCTTGGCTTTGACGATATAACGCCTAATTCCATGTTTGCGGTTGGTTCTCGGGATCACTTAGTGGAGTTCTTCAATTGGGCGTCATTATGTGCATTGCATCTTAGTCGTTTAGCAGAAGATCTTATCATTTATAGTTCTCAAGAATATGGGATTGTACGTTTCTCGGACCAATTCTCTACGGGATCAAGTCTGATGCCACAGAAAAGAAATCCAGACGGTCAGGAATTGATTAGAGGAGCAGCAGGCCTTTTCTTGGGCGAGGCTTTTGGTTTTAGTTGCGTTTTAAAAGGATTGCCCAGCACGTACAACAAAGACTTACAGTCTGATAAAGAACTACTATTTCGAACCTACGACAGATTACTTGACTGTCTTAAAATTTCAGCCGGGTCCATTCGCACAATGAAAGTGAATATTGATAGAGCCTTGAACTCTTTAGAACCCGGAATGTTGGCTACAGATTTAGCTCATATGCTAGTCCGCCGAGGAGTGCCGTTTCGCAAAGCACACCATCTTGTCGGGACTGCGCTTTTACGAGCCACCAACCTTGGATTGGATTTACGAAACCTGCCTTACTCTGAATATATCGCTATATGTCCTGAATTTGGTACAGAAGAAGAACTAAAAGCGGTTTTTTCATGGGAAGCAAGCGTAGAACAATACACCAGCTCCGGAGGAACTGCCAGAAAAGCTGTCATTAATCAGCTAGAAATTCTACACATTTGGTTACAAAAATACAATAAAGAATGCACTGTTTGA
Protein
MSSSKFQLWGGCFEEEPSSVLRRLNDSLPVDFRLFREDIQGSRAWAEELFQSHHLSANDNLAIQKGLDSVEKEIEQELTENGKLKDAEEDIHSVIECRLFKHSGDAAFRLHTARSRNDQSATDTRLWMLASLPKLTSAIVELITVLATRAENEIDIISAGYTHLQRAQPVRWSHFLLSHAWALRDDVTRLEEQRSRLSRCPLGSGALAGCALTIDRKRLALNLGFDDITPNSMFAVGSRDHLVEFFNWASLCALHLSRLAEDLIIYSSQEYGIVRFSDQFSTGSSLMPQKRNPDGQELIRGAAGLFLGEAFGFSCVLKGLPSTYNKDLQSDKELLFRTYDRLLDCLKISAGSIRTMKVNIDRALNSLEPGMLATDLAHMLVRRGVPFRKAHHLVGTALLRATNLGLDLRNLPYSEYIAICPEFGTEEELKAVFSWEASVEQYTSSGGTARKAVINQLEILHIWLQKYNKECTV
Summary
Description
Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein also functions as an enzymatically active argininosuccinate lyase.
Catalytic Activity
2-(N(omega)-L-arginino)succinate = fumarate + L-arginine
Biophysicochemical Properties
0.05 mM for N(omega)-(L-arginino)succinate
Subunit
Homotetramer.
Miscellaneous
Each of the four substrate-binding sites present in the homotetrameric assembly are shared between three of the four subunits.
Similarity
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
Keywords
3D-structure
Amino-acid biosynthesis
Arginine biosynthesis
Eye lens protein
Lyase
Feature
chain Argininosuccinate lyase
Uniprot
H9JBI1
A0A2H1WGL1
A0A2A4K5R0
A0A3S2P762
A0A212EWB4
A0A194RB40
+ More
A0A194PEH8 A0A0L7LQP3 K7IT31 D7EI90 A0A293M2T1 A0A2J7RE36 A0A2J7RE26 A0A067R1D7 F4RWN3 A0A1Y1LD32 E2BEB7 A0A0T6BA01 A0A1J5AG91 B4KEY6 A0A1A8CHK3 A0A251VVI5 A0A3B5A0V8 E9GME3 A0A3B3BN31 A0A2I9LNS4 A0A162BR53 A0A1A8PTR0 A0A1A8MWF8 I3JPW9 A0A1A8FAR8 A0A367KHR1 A0A3B3BNH6 A0A3Q3K723 A0A1A8IYY4 A0A3Q3JW57 A0A3P9L6C5 H2LB38 A0A1A8AS15 A0A3P9IQS7 A0A0N0BL18 A0A088A0P4 A0A3Q3NFX3 A0A2D0T0W4 A0A3Q2UZR9 M5EN90 A0A210Q843 A0A3P9DI09 A0A3P8P1X2 B3MM85 A0A3Q2CZE2 A0A0P5Y5X8 A0A3Q1I4Y5 A0A0P6E2C0 A0A2I4CWC5 A0A166N8X8 I2CZS7 A0A3Q1C8G9 A0A066WCQ8 A0A1A7XAX5 A0A1W4VYU5 A0A3S2PDN3 A0A3Q3AEI1 A0A0P5CU80 A0A1S3RHA0 A0A3Q3E203 A0A074RM57 X8JFW3 A0A3B5QR07 A0A0S7FSR8 A0A2U9B7E5 A0A3B5R9H8 A0A1Y2BEE6 A0A3B1IFK5 Q7Q410 A0A060XCT2 A0A1S4GY36 A0A182L1E8 A0A182HUM3 I1C579 A0A182WU09 A0A182UZ89 A0A182TPI4 A0A0C9M7E2 B4M9P7 A0A3B5LAJ5 H0Z4K4 A0A147B0M8 A0A3P8WRG2 A0A3Q2TRL9 B4JP52 A0A0L0SFM7 A0A3Q2R2P4 I0I1L5 A0A197KAA1 A0A3B4V8R9 C3XV03 A0A3B3XQA2 S4V5T6 P24058
A0A194PEH8 A0A0L7LQP3 K7IT31 D7EI90 A0A293M2T1 A0A2J7RE36 A0A2J7RE26 A0A067R1D7 F4RWN3 A0A1Y1LD32 E2BEB7 A0A0T6BA01 A0A1J5AG91 B4KEY6 A0A1A8CHK3 A0A251VVI5 A0A3B5A0V8 E9GME3 A0A3B3BN31 A0A2I9LNS4 A0A162BR53 A0A1A8PTR0 A0A1A8MWF8 I3JPW9 A0A1A8FAR8 A0A367KHR1 A0A3B3BNH6 A0A3Q3K723 A0A1A8IYY4 A0A3Q3JW57 A0A3P9L6C5 H2LB38 A0A1A8AS15 A0A3P9IQS7 A0A0N0BL18 A0A088A0P4 A0A3Q3NFX3 A0A2D0T0W4 A0A3Q2UZR9 M5EN90 A0A210Q843 A0A3P9DI09 A0A3P8P1X2 B3MM85 A0A3Q2CZE2 A0A0P5Y5X8 A0A3Q1I4Y5 A0A0P6E2C0 A0A2I4CWC5 A0A166N8X8 I2CZS7 A0A3Q1C8G9 A0A066WCQ8 A0A1A7XAX5 A0A1W4VYU5 A0A3S2PDN3 A0A3Q3AEI1 A0A0P5CU80 A0A1S3RHA0 A0A3Q3E203 A0A074RM57 X8JFW3 A0A3B5QR07 A0A0S7FSR8 A0A2U9B7E5 A0A3B5R9H8 A0A1Y2BEE6 A0A3B1IFK5 Q7Q410 A0A060XCT2 A0A1S4GY36 A0A182L1E8 A0A182HUM3 I1C579 A0A182WU09 A0A182UZ89 A0A182TPI4 A0A0C9M7E2 B4M9P7 A0A3B5LAJ5 H0Z4K4 A0A147B0M8 A0A3P8WRG2 A0A3Q2TRL9 B4JP52 A0A0L0SFM7 A0A3Q2R2P4 I0I1L5 A0A197KAA1 A0A3B4V8R9 C3XV03 A0A3B3XQA2 S4V5T6 P24058
EC Number
4.3.2.1
Pubmed
19121390
22118469
26354079
26227816
20075255
18362917
+ More
19820115 24845553 21536894 28004739 20798317 27112493 17994087 21292972 29451363 29248469 26447480 25186727 29674435 17554307 28812685 26659563 24810276 25359908 23542700 25329095 12364791 24755649 20966253 19578406 20360741 24487278 18563158 2269436 15966727 9369472 10029536 11258884 11698398 15320872
19820115 24845553 21536894 28004739 20798317 27112493 17994087 21292972 29451363 29248469 26447480 25186727 29674435 17554307 28812685 26659563 24810276 25359908 23542700 25329095 12364791 24755649 20966253 19578406 20360741 24487278 18563158 2269436 15966727 9369472 10029536 11258884 11698398 15320872
EMBL
BABH01030925
ODYU01008525
SOQ52203.1
NWSH01000130
PCG79254.1
RSAL01000254
+ More
RVE43439.1 AGBW02012023 OWR45785.1 KQ460398 KPJ15048.1 KQ459606 KPI91433.1 JTDY01000312 KOB77750.1 AAZX01008089 KQ972669 EFA11668.2 GFWV01009609 MAA34338.1 NEVH01005278 PNF39092.1 PNF39094.1 KK852817 KDR15772.1 GL883126 EGG03062.1 GEZM01062287 JAV69865.1 GL447768 EFN85962.1 LJIG01002774 KRT84166.1 MNXL01000045 OIO97938.1 CH933807 EDW11955.1 HADZ01015248 HAEA01009784 SBP79189.1 JWSX01002280 OUC05395.1 GL732552 EFX79352.1 GFWZ01000047 MBW20037.1 KM225766 AKC57326.1 HAEI01003455 HAEH01022081 SBR84656.1 HAEF01020029 HAEG01003989 SBR61188.1 AERX01016999 HAEB01008712 HAEC01011831 SBQ55239.1 PJQM01001674 RCI01764.1 HAED01016117 HAEE01001743 SBR02562.1 HADY01018545 HAEJ01011467 SBP57030.1 KQ435687 KOX81392.1 HE999557 LT671824 CCU99114.1 SHO78349.1 NEDP02004652 OWF44901.1 CH902620 EDV31845.1 GDIP01062504 JAM41211.1 GDIQ01069642 JAN25095.1 KV417524 KZP24769.1 JQ794876 AFJ74693.2 KK764649 KDN51732.1 HADW01013861 HADX01005181 SBP15261.1 CM012450 RVE64041.1 GDIP01165438 JAJ57964.1 AZST01000564 KEP48171.1 JATN01000318 EUC62176.1 GBYX01461519 GBYX01461515 JAO20055.1 CP026246 AWO99793.1 MCGO01000068 ORY33209.1 AAAB01008964 EAA12415.4 FR905214 CDQ77231.1 APCN01002465 CH476737 EIE83609.1 DF836397 GAN06016.1 CH940654 EDW57923.1 ABQF01026259 GCES01001967 JAR84356.1 CH916372 EDV99477.1 GG745337 KNE61175.1 AP012337 BAL99152.1 KV442017 OAQ34627.1 GG666468 EEN67929.1 KC513736 AGO20699.1 M35132
RVE43439.1 AGBW02012023 OWR45785.1 KQ460398 KPJ15048.1 KQ459606 KPI91433.1 JTDY01000312 KOB77750.1 AAZX01008089 KQ972669 EFA11668.2 GFWV01009609 MAA34338.1 NEVH01005278 PNF39092.1 PNF39094.1 KK852817 KDR15772.1 GL883126 EGG03062.1 GEZM01062287 JAV69865.1 GL447768 EFN85962.1 LJIG01002774 KRT84166.1 MNXL01000045 OIO97938.1 CH933807 EDW11955.1 HADZ01015248 HAEA01009784 SBP79189.1 JWSX01002280 OUC05395.1 GL732552 EFX79352.1 GFWZ01000047 MBW20037.1 KM225766 AKC57326.1 HAEI01003455 HAEH01022081 SBR84656.1 HAEF01020029 HAEG01003989 SBR61188.1 AERX01016999 HAEB01008712 HAEC01011831 SBQ55239.1 PJQM01001674 RCI01764.1 HAED01016117 HAEE01001743 SBR02562.1 HADY01018545 HAEJ01011467 SBP57030.1 KQ435687 KOX81392.1 HE999557 LT671824 CCU99114.1 SHO78349.1 NEDP02004652 OWF44901.1 CH902620 EDV31845.1 GDIP01062504 JAM41211.1 GDIQ01069642 JAN25095.1 KV417524 KZP24769.1 JQ794876 AFJ74693.2 KK764649 KDN51732.1 HADW01013861 HADX01005181 SBP15261.1 CM012450 RVE64041.1 GDIP01165438 JAJ57964.1 AZST01000564 KEP48171.1 JATN01000318 EUC62176.1 GBYX01461519 GBYX01461515 JAO20055.1 CP026246 AWO99793.1 MCGO01000068 ORY33209.1 AAAB01008964 EAA12415.4 FR905214 CDQ77231.1 APCN01002465 CH476737 EIE83609.1 DF836397 GAN06016.1 CH940654 EDW57923.1 ABQF01026259 GCES01001967 JAR84356.1 CH916372 EDV99477.1 GG745337 KNE61175.1 AP012337 BAL99152.1 KV442017 OAQ34627.1 GG666468 EEN67929.1 KC513736 AGO20699.1 M35132
Proteomes
UP000005204
UP000218220
UP000283053
UP000007151
UP000053240
UP000053268
+ More
UP000037510 UP000002358 UP000007266 UP000235965 UP000027135 UP000001072 UP000008237 UP000009192 UP000261400 UP000000305 UP000261560 UP000005207 UP000253551 UP000261600 UP000265180 UP000001038 UP000265200 UP000053105 UP000005203 UP000261640 UP000221080 UP000264840 UP000186303 UP000242188 UP000265160 UP000265100 UP000007801 UP000265020 UP000265040 UP000192220 UP000076532 UP000257160 UP000192221 UP000264800 UP000087266 UP000261660 UP000027456 UP000030108 UP000002852 UP000246464 UP000193642 UP000018467 UP000007062 UP000193380 UP000075882 UP000075840 UP000009138 UP000076407 UP000075903 UP000075902 UP000053815 UP000008792 UP000261380 UP000007754 UP000265120 UP000265000 UP000001070 UP000054350 UP000007880 UP000078512 UP000261420 UP000001554 UP000261480
UP000037510 UP000002358 UP000007266 UP000235965 UP000027135 UP000001072 UP000008237 UP000009192 UP000261400 UP000000305 UP000261560 UP000005207 UP000253551 UP000261600 UP000265180 UP000001038 UP000265200 UP000053105 UP000005203 UP000261640 UP000221080 UP000264840 UP000186303 UP000242188 UP000265160 UP000265100 UP000007801 UP000265020 UP000265040 UP000192220 UP000076532 UP000257160 UP000192221 UP000264800 UP000087266 UP000261660 UP000027456 UP000030108 UP000002852 UP000246464 UP000193642 UP000018467 UP000007062 UP000193380 UP000075882 UP000075840 UP000009138 UP000076407 UP000075903 UP000075902 UP000053815 UP000008792 UP000261380 UP000007754 UP000265120 UP000265000 UP000001070 UP000054350 UP000007880 UP000078512 UP000261420 UP000001554 UP000261480
PRIDE
Interpro
SUPFAM
SSF48557
SSF48557
Gene 3D
ProteinModelPortal
H9JBI1
A0A2H1WGL1
A0A2A4K5R0
A0A3S2P762
A0A212EWB4
A0A194RB40
+ More
A0A194PEH8 A0A0L7LQP3 K7IT31 D7EI90 A0A293M2T1 A0A2J7RE36 A0A2J7RE26 A0A067R1D7 F4RWN3 A0A1Y1LD32 E2BEB7 A0A0T6BA01 A0A1J5AG91 B4KEY6 A0A1A8CHK3 A0A251VVI5 A0A3B5A0V8 E9GME3 A0A3B3BN31 A0A2I9LNS4 A0A162BR53 A0A1A8PTR0 A0A1A8MWF8 I3JPW9 A0A1A8FAR8 A0A367KHR1 A0A3B3BNH6 A0A3Q3K723 A0A1A8IYY4 A0A3Q3JW57 A0A3P9L6C5 H2LB38 A0A1A8AS15 A0A3P9IQS7 A0A0N0BL18 A0A088A0P4 A0A3Q3NFX3 A0A2D0T0W4 A0A3Q2UZR9 M5EN90 A0A210Q843 A0A3P9DI09 A0A3P8P1X2 B3MM85 A0A3Q2CZE2 A0A0P5Y5X8 A0A3Q1I4Y5 A0A0P6E2C0 A0A2I4CWC5 A0A166N8X8 I2CZS7 A0A3Q1C8G9 A0A066WCQ8 A0A1A7XAX5 A0A1W4VYU5 A0A3S2PDN3 A0A3Q3AEI1 A0A0P5CU80 A0A1S3RHA0 A0A3Q3E203 A0A074RM57 X8JFW3 A0A3B5QR07 A0A0S7FSR8 A0A2U9B7E5 A0A3B5R9H8 A0A1Y2BEE6 A0A3B1IFK5 Q7Q410 A0A060XCT2 A0A1S4GY36 A0A182L1E8 A0A182HUM3 I1C579 A0A182WU09 A0A182UZ89 A0A182TPI4 A0A0C9M7E2 B4M9P7 A0A3B5LAJ5 H0Z4K4 A0A147B0M8 A0A3P8WRG2 A0A3Q2TRL9 B4JP52 A0A0L0SFM7 A0A3Q2R2P4 I0I1L5 A0A197KAA1 A0A3B4V8R9 C3XV03 A0A3B3XQA2 S4V5T6 P24058
A0A194PEH8 A0A0L7LQP3 K7IT31 D7EI90 A0A293M2T1 A0A2J7RE36 A0A2J7RE26 A0A067R1D7 F4RWN3 A0A1Y1LD32 E2BEB7 A0A0T6BA01 A0A1J5AG91 B4KEY6 A0A1A8CHK3 A0A251VVI5 A0A3B5A0V8 E9GME3 A0A3B3BN31 A0A2I9LNS4 A0A162BR53 A0A1A8PTR0 A0A1A8MWF8 I3JPW9 A0A1A8FAR8 A0A367KHR1 A0A3B3BNH6 A0A3Q3K723 A0A1A8IYY4 A0A3Q3JW57 A0A3P9L6C5 H2LB38 A0A1A8AS15 A0A3P9IQS7 A0A0N0BL18 A0A088A0P4 A0A3Q3NFX3 A0A2D0T0W4 A0A3Q2UZR9 M5EN90 A0A210Q843 A0A3P9DI09 A0A3P8P1X2 B3MM85 A0A3Q2CZE2 A0A0P5Y5X8 A0A3Q1I4Y5 A0A0P6E2C0 A0A2I4CWC5 A0A166N8X8 I2CZS7 A0A3Q1C8G9 A0A066WCQ8 A0A1A7XAX5 A0A1W4VYU5 A0A3S2PDN3 A0A3Q3AEI1 A0A0P5CU80 A0A1S3RHA0 A0A3Q3E203 A0A074RM57 X8JFW3 A0A3B5QR07 A0A0S7FSR8 A0A2U9B7E5 A0A3B5R9H8 A0A1Y2BEE6 A0A3B1IFK5 Q7Q410 A0A060XCT2 A0A1S4GY36 A0A182L1E8 A0A182HUM3 I1C579 A0A182WU09 A0A182UZ89 A0A182TPI4 A0A0C9M7E2 B4M9P7 A0A3B5LAJ5 H0Z4K4 A0A147B0M8 A0A3P8WRG2 A0A3Q2TRL9 B4JP52 A0A0L0SFM7 A0A3Q2R2P4 I0I1L5 A0A197KAA1 A0A3B4V8R9 C3XV03 A0A3B3XQA2 S4V5T6 P24058
PDB
1K7W
E-value=2.38595e-104,
Score=969
Ontologies
KEGG
PATHWAY
GO
PANTHER
Topology
Subcellular location
Cytoplasm
Length:
473
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.10629
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00405
outside
1 - 473
Population Genetic Test Statistics
Pi
270.900141
Theta
192.712119
Tajima's D
1.352156
CLR
0.262338
CSRT
0.750412479376031
Interpretation
Uncertain
