SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO05733  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA006813
Annotation
Nuclear_pore_complex_protein_Nup155_[Papilio_xuthus]
Full name
Nuclear pore complex protein Nup154       + More
Nuclear pore complex protein Nup155      
Alternative Name
154 kDa nucleoporin
Nucleoporin Nup154
Tulipan
155 kDa nucleoporin
Nucleoporin Nup155
Location in the cell
Nuclear   Reliability : 1.442 PlasmaMembrane   Reliability : 1.462
 

Sequence

CDS
ATGCAGCTAGAATCTTTGGAGCTGGCTGGCTGTACGCTTGACCGGTACATTAGCTTTGATAATTCGCGCCCTTCCTTTTTGGAGTTAACTGGCATTGCAGCACAACGGAGTCCAACATGCAGTGGGTTAAATGCTGGCGATTACCGCAACCTTGCTGCTCTCCTGAACCATCCTAACTTGTCCCAGTTGAAAATTCTCAACAAAGTGCCTCTGCCACCAGAGATTATGGAACACTTTGCTCATATGCAATGCCATTGTTTAATGGGAGTTTTCCCTGAAATTAGCAGAGTTTGGCTTGCAATAGACAGCAATATATATGTTTGGGCATTTGAACATGGGAGCGATGTTGCATATTTCGATGGATTAGGAGAAACCATAGTCAGTGTTGGCTTAGTTAAACCAAAACCAGGGGTGTTTCAGAATTTTGTCAAGTATTTGCTTGTTCTCACGACAACAGTGGAAATTGTTGTATTAGGTGTGACATTTTCATCAAACAAAAGCGATTCTCCAAGAGAATTTCAAGAAATACATCTTGTCTCAGAACCTGTCTTTGTTCTGCCAACTGATGGTGTGTCAATGATGTGTGTTAAATCCACTTCAAGAGGTCGAATATTTATGGGAGGTAAAGATGGCTGTCTGTATGAAATAACCTATCAGGCACAATTAGGATGGTTTGGTAAACATTGCAAGAAAGTGAACCATTCCACCAGCACTCTTTCATTCCTAGTACCATCATTTCTAAATGCCGCATTATATGACGAGGATCCGATAGTAAAAATTGAAGTTGATGATTCCCGGAACATTTTGTATACACTCAGTGAAAAAGGCTGTATAGAAGTATTTGATCTTGGCAAGGATGGTGACAGCCTCAGTCGAGTTGTAAGGCTAACACAAGGAAAGATTGTATCTGCAGCTGTGGATATAGTGAAAACTTTGGAAGTAAGCAACTTCAAACCTGTCATAGCAATTTCTGCTGTAGATGAATCAGAGTCTGACCATTTGAATTTAGTAGCAGTCACACAGACTGGAGCAAGATTATATTTTAGCACGGGAAGTGGAGATACAAACCAAAGTGGTATACAGAGACCACAGTACTTGACAATGCTGCATGTAAGGCTGCCCCCTGGATTCACTCCTAATTCATCAGTGTTAAAGCCAAAACAAGTTCACAGTGCTGTTTACGAAAATGGTTCCCTGGTAATGATATGTTCATCCGGCGGCGGCGAGGCGGAGACTCTGTGGTGCTTGTCTCGCGTCATCCCGGGCAGCGCGGCCTTCAGCGAGGCGCACACCGTGCTGGCGCTGGACGGGCCCGCCTGGGCGCTTACTGCGCTGCCTCACCAGCATGCCGCTCACATATCCAACGCTCTTCTCACTAAAAAAGAAGTGTGGTGTGTCTCGCGATGGGCAGTAGTGACAGGGGCGGGAGCCTGTATCATAACAGCCGGAGCTGCTCCAGACATACTACGAACATTACTTAGAGACTGTCGGGGTCCTGAAGCACATGCTGTCAAGGACTTCTTTCAGCTGCACAGTGTAGAACAAGCATGCGCATGCGCCTTGTATTTGGCGTGCGAGGATACCACCAGCAGTGACCTCTCAATCAGCGAGTGGGCTACCAGAGCATTCTTCTTATATGGGACCCAGATGACTCCTGCTCCAATCTATCAGCACTCTTCACAGATGCCTTCCAGTATAGGTTCACCCAAATTTTCACCGCGACAAATGTCAACGCCCATGTCGAGAGGACCGCAGGGTCAAATTCAGGGACCGCAAGCAAACAAATTCAATCAGTCGTACCAACAACACATGAACCAGTCATTCCCGGGGTCGCCGAACCACTCGATGATGACGCAACAGCCGCAATACTCTATGAGTCCGACCCCGTACAACCAGACGTCGTTCAACGGAAACATCACTCAGCAACAAAGAGACCCTAACTACCCTGTGCCAATTGAATTTAGTGCGAAACACAACGGCCTCTATATTTACGTCGGTCGAATACTGTTGCCGATATGGAATTTAAAATGCGTCTCGAAATCCCAGACTCCGGACAGTAAAGAATTCATGTCTAGTCAAGTGACAGGCGAGGACTGTGCGTACATAGCCAAGAAATTGCAACGTGTGGCGGCGTTCATGCAGCGCACATTAGCGCCGCAACATTCTGAAGAGTACACATCGCTAAATGCATTGAAGTTATTTGTCTCAATGGCAATAGAAATGTTGAATCTATGGAGAGTACTATGTGAGCACCAGTTTCACGTGATAGCCGCGAGCCTGCCCGCAGATCAGCAGAATGCTCTTCAAGCAGCAAGTTTTAGAGAATTACTGGTTGGCGGTCAGGAAGTAGCATGCTTACTTCTAGGATCTTTGGTGGCAGGATATCTGCGTGACAATGCTTCTGTCGATGGAATTTCACAGAAACTACGACAATTATGTCCAACATTATACAGACAAGAAGACGCTACTTGCTCCAAGGCCAACGAACTCTTGATGTTTGCCAAACAACAAAAGAATCCCACGGAAAGGGAAGAAATGTTGCAGCATGCCCTAAAACTGTGTAAAGATGTGGCCCCAAATGTGAACCTGCCATTGGTTTGTTCGAAACTGGCATCTGTTGGGTTTTACTCGGGGGTGGTGGAACTGTGCGCTACTTGTGCCTGCAAACTCGATCCTCAGGATAAAGCACTGCATTACTATAAAAGTGATCAGCCCACGCAAGATCGAGAAGGACATCTAGCTTATTACAGAAGAATGGAAATTTATCGCGAAGTGTGTGCTGCTCTGGAGCGTCTTTACGAGCGCAGCAACGAAGCGCCGGGCGCCGAGCCCTCCCCGCACCGAGCGCCCTCGCAGCACTCCGCCGACGCTGACGTCACTCTGTCCCCAGCTGATGCCAACTATCAAGGTAGAAAGCTGGTGTGGGAGTGCTTGTCACGAGATGACGAACTGCTGCATGTCGCCGTTTATGAATGGCTAGTCTCCAAGAATCTCGGTTCGGAATTATTGTCGCTGGGGAGGGCGCCGCCTGCGTCATTGCGGACGTACCTGCAGGCGGCGGCTAGATCGGCGCCGCCCGCAGCTTCCCTCCACCTACTGGACCTGCTGTGGAAGGTCTTAGAGAAGTGCGGAGATCATCTCGCAGCTGCACAAGTCCTAGAGGGACTCGCTACTAGACCGGGGTCGGGCGCGACGCTGGCGCAGCGCATGTCGTGGCTGTGCGCGGGCGTGGTGTGCGTGCGCGGCGCGGGCGCGGGCGGCGGGGAGGTGGTGCGGCGGCTGGAGGAGGCGGGCGAGGTGGCGCGCGTGCAGCGGGCCGTGCGCGCCGCCGCCGCCGCCCTGCCCGCCGCGCGCCGCCCCCCGCCGCCGCACATGCAGCGCCTGGACGACGAGCTGCTCGAGATCACGCAGCTGTATGAGGAGTACGCGGACCGCTACAACCTGTGGGAGTGCAAGCTGGCCATCGTGCAGTGCTCGGGGCACAACGACGCGCTGCTGGTCGAGAACATCTGGAGCAACATTCTGGCGGAGGCGGAGGCGGCCGCCAGCGCCCTGCCCGCGCCCGACGAGAGGCTGGCCTCGGTGCTCAGTAAAATCACCACTCTGGGACGCGAATATGTCAACACCGGACATTGTTTCCCCTTGTATTTCATTGCACGCCAGTTAGAAATAATGAGTTGTAAACTTCGAGCGGATCAGAGCATGGTGTTCAAAGCGATTCTAAGTATCGGAGTCTCGCTTGAACAAGTACTGGATATTTACATCAAGCTGGTGAGCGTGAACGAGCGCGTGTGGCTGGGCTGCGGCGAGGAGACGCACGCGTGCGGCGCGGCGGCGCGGCTGCTGGAGGCGGCGCGCGCGCACGTGCAGCCGCTCGCAGCGCACGTGCGGCGCCGCGCGCTCGCCCGCTGCAAGGACCTACACGAAGCCGCCCTGTCCGCGCTTCAGGCTCGTCCCAACACACAACACCTGATAGAAAGGTTGTCAGTCGCACAGGCGCACCTAGATCGTATGGATTAA
Protein
MQLESLELAGCTLDRYISFDNSRPSFLELTGIAAQRSPTCSGLNAGDYRNLAALLNHPNLSQLKILNKVPLPPEIMEHFAHMQCHCLMGVFPEISRVWLAIDSNIYVWAFEHGSDVAYFDGLGETIVSVGLVKPKPGVFQNFVKYLLVLTTTVEIVVLGVTFSSNKSDSPREFQEIHLVSEPVFVLPTDGVSMMCVKSTSRGRIFMGGKDGCLYEITYQAQLGWFGKHCKKVNHSTSTLSFLVPSFLNAALYDEDPIVKIEVDDSRNILYTLSEKGCIEVFDLGKDGDSLSRVVRLTQGKIVSAAVDIVKTLEVSNFKPVIAISAVDESESDHLNLVAVTQTGARLYFSTGSGDTNQSGIQRPQYLTMLHVRLPPGFTPNSSVLKPKQVHSAVYENGSLVMICSSGGGEAETLWCLSRVIPGSAAFSEAHTVLALDGPAWALTALPHQHAAHISNALLTKKEVWCVSRWAVVTGAGACIITAGAAPDILRTLLRDCRGPEAHAVKDFFQLHSVEQACACALYLACEDTTSSDLSISEWATRAFFLYGTQMTPAPIYQHSSQMPSSIGSPKFSPRQMSTPMSRGPQGQIQGPQANKFNQSYQQHMNQSFPGSPNHSMMTQQPQYSMSPTPYNQTSFNGNITQQQRDPNYPVPIEFSAKHNGLYIYVGRILLPIWNLKCVSKSQTPDSKEFMSSQVTGEDCAYIAKKLQRVAAFMQRTLAPQHSEEYTSLNALKLFVSMAIEMLNLWRVLCEHQFHVIAASLPADQQNALQAASFRELLVGGQEVACLLLGSLVAGYLRDNASVDGISQKLRQLCPTLYRQEDATCSKANELLMFAKQQKNPTEREEMLQHALKLCKDVAPNVNLPLVCSKLASVGFYSGVVELCATCACKLDPQDKALHYYKSDQPTQDREGHLAYYRRMEIYREVCAALERLYERSNEAPGAEPSPHRAPSQHSADADVTLSPADANYQGRKLVWECLSRDDELLHVAVYEWLVSKNLGSELLSLGRAPPASLRTYLQAAARSAPPAASLHLLDLLWKVLEKCGDHLAAAQVLEGLATRPGSGATLAQRMSWLCAGVVCVRGAGAGGGEVVRRLEEAGEVARVQRAVRAAAAALPAARRPPPPHMQRLDDELLEITQLYEEYADRYNLWECKLAIVQCSGHNDALLVENIWSNILAEAEAAASALPAPDERLASVLSKITTLGREYVNTGHCFPLYFIARQLEIMSCKLRADQSMVFKAILSIGVSLEQVLDIYIKLVSVNERVWLGCGEETHACGAAARLLEAARAHVQPLAAHVRRRALARCKDLHEAALSALQARPNTQHLIERLSVAQAHLDRMD

Summary

Description
Component of the nuclear pore complex (PubMed:17410542). Has a role in the organization of the inner nuclear membrane proteins at the nuclear envelope (PubMed:22718353). In germ cells, plays a role in the nuclear localization of components of the dpp signaling pathways, such as Medea and phosphorylated Mad (PubMed:21696798). Binds to chromatin, and together with Nup62 and Nup93-1, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells (PubMed:22718353, PubMed:26341556). Has a role in female fertility including egg chamber development; in nurse cells, has a role in the organization of F-actin in subcortical and cytoplasmic actin filaments important for the transfer of cytoplasm from nurse cells to the growing oocytes (PubMed:9732281, PubMed:10511559, PubMed:17410542, PubMed:17277377). Has a role in male spermatogenesis and fertility (PubMed:9732281, PubMed:10511559). Has a role in germ line cell proliferation (PubMed:21696798).
Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.
Subunit
Interacts (via N-terminus) with Nup93-1 (PubMed:22718353). Interacts with Nup35 (PubMed:22718353). Interacts with cup (PubMed:17277377).
Interacts with GLE1 and NUP35/NUP53. Able to form a heterotrimer with GLE1 and NUPL2 in vitro (By similarity). Forms a complex with NUP35, NUP93, NUP205 and lamin B (By similarity).
Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro. Forms a complex with NUP35, NUP93, NUP205 and lamin B.
Similarity
Belongs to the non-repetitive/WGA-negative nucleoporin family.
Keywords
Chromosome   Complete proteome   Cytoplasm   Membrane   mRNA transport   Nuclear pore complex   Nucleus   Protein transport   Reference proteome   Translocation   Transport   Disulfide bond   Glycoprotein   Phosphoprotein   3D-structure   Alternative splicing   Atrial fibrillation   Disease mutation   Isopeptide bond   Ubl conjugation  
Feature
chain  Nuclear pore complex protein Nup154
splice variant  In isoform 2.
sequence variant  In ATFB15; fails to accumulate at various foci of the nuclear envelope and is diffusely distributed in the cytoplasm; shows significantly reduced permeability of the nuclear envelope compared to wild-type; dbSNP:rs587777339.
EMBL
KQ460398    KPJ15054.1    KQ459606    KPI91439.1    AGBW02013719    OWR42917.1    + More
NWSH01000130    PCG79234.1    ODYU01005260    SOQ45936.1    BABH01030920    BABH01030921    GBYB01003356    GBYB01013329    JAG73123.1    JAG83096.1    AAZX01000576    NNAY01000426    OXU28488.1    KK107997    QOIP01000013    EZA46992.1    RLU15247.1    ADTU01021605    KQ978273    KYM95793.1    KQ982691    KYQ52258.1    KQ976641    KYM78767.1    KQ980765    KYN13411.1    DS235366    EEB15317.1    KQ981744    KYN36228.1    NEVH01008206    PNF34664.1    GL442888    EFN62815.1    GFDL01014698    JAV20347.1    DS231817    EDS39688.1    GAKP01007794    JAC51158.1    UFQS01000266    UFQT01000266    SSX02233.1    SSX22610.1    SSX02235.1    SSX22612.1    GL450241    EFN81296.1    GANO01000575    JAB59296.1    KB631760    ERL85886.1    KQ414705    KOC63217.1    GG666529    EEN58615.1    KZ288191    PBC34501.1    KQ435687    KOX81376.1    GECZ01001684    JAS68085.1    KB202752    ESO88145.1    KQ971314    EEZ97868.2    CH902620    EDV32454.1    UFQT01002397    SSX33365.1    GEZM01030665    JAV85435.1    CH954177    EDV58941.1    CM000157    EDW88030.1    GEDC01026829    JAS10469.1    CM002910    KMY89676.1    CH477229    EAT47017.1    CH480818    EDW52541.1    AAAB01008964    EAA12437.4    AAPE02020438    AAPE02020439    AAPE02020440    APGK01009472    APGK01009473    APGK01009474    APGK01009475    APGK01009476    APGK01009477    APGK01009478    APGK01009479    KB737952    ENN82823.1    ABGA01167514    ABGA01167515    ABGA01167516    ABGA01167517    ABGA01167518    ABGA01167519    ABGA01167520    ABGA01167521    ABGA01167522    ABGA01167523    Y17111    AF051397    AF051398    AF051396    AE014134    AF160944    AAC05385.1    AAC05386.1    AAC06247.1    AAC06248.1    AAD46884.1    AAF53051.1    CAA76635.1    KQ759893    OAD62095.1    AMGL01035186    GABZ01000296    JAA53229.1    NDHI03003396    PNJ67043.1    CH940649    EDW63290.1    GFFV01000356    JAV39589.1    JH881428    ELR54397.1    AK145717    BAE26607.1    AK129217    BAC98027.1    AC107747    AAGW02030447    AAGW02030448    AAGW02030449    AAGW02030450    AF322375    AABR07008413    AABR07008414    CH474048    EDL75690.1    CH471119    EAW55958.1    AJ007558    AF165926    AB018334    BC039257    AL117585    CABD030105545    CABD030105546    CABD030105547    CABD030105548    CABD030105549    CABD030105550    CABD030105551    CABD030105552    GAMS01005320    JAB17816.1    AACZ04053631    AACZ04053632    GABC01007734    GABF01008724    GABD01004593    GABE01005623    NBAG03000430    JAA03604.1    JAA13421.1    JAA28507.1    JAA39116.1    PNI25611.1    KN123819    KFO23085.1    GAMT01005065    GAMR01003352    GAMQ01001821    GAMP01004097    JAB06796.1    JAB30580.1    JAB40030.1    JAB48658.1    BC050919    AAH50919.1    AQIA01058446    AQIA01058447    AQIA01058448    AQIA01058449    AQIA01058450    JSUE03035764    JSUE03035765    JSUE03035766    JSUE03035767    JSUE03035768    JSUE03035769    JSUE03035770    JSUE03035771    JSUE03035772    JSUE03035773    CM001281    EHH54205.1    JU321860    JU472862    JV044517    CM001256    AFE65616.1    AFH29666.1    AFI34588.1    EHH18476.1    AEYP01001369    AEYP01001370    AEYP01001371    AEYP01001372    AEYP01001373    AEYP01001374    AEYP01001375    AEYP01001376    AEYP01001377    AEYP01001378    JH171771    GEBF01000601    EHB12695.1    JAO03032.1    HAAF01000733    CCP72559.1    BC047162    CM004466    AAH47162.1    OCU02591.1    AGTP01040422    AGTP01040423   
Pfam
PF03177   Nucleoporin_C        + More
PF08801   Nucleoporin_N
PF01979   Amidohydro_1
PF00069   Pkinase
Interpro
IPR014908   Nucleoporin_Nup133/Nup155_N        + More
IPR017593   Allantoinase       
IPR011059   Metal-dep_hydrolase_composite       
IPR004870   Nucleoporin_Nup155       
IPR006680   Amidohydro-rel       
IPR007187   Nucleoporin_Nup133/Nup155_C       
IPR032466   Metal_Hydrolase       
IPR002195   Dihydroorotase_CS       
IPR036322   WD40_repeat_dom_sf       
IPR017986   WD40_repeat_dom       
IPR001680   WD40_repeat       
IPR011044   Quino_amine_DH_bsu       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR000719   Prot_kinase_dom       
IPR011047   Quinoprotein_ADH-like_supfam       
IPR018391   PQQ_beta_propeller_repeat       
IPR017441   Protein_kinase_ATP_BS       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
SUPFAM
SSF51338   SSF51338        + More
SSF51556   SSF51556       
SSF50978   SSF50978       
SSF50969   SSF50969       
SSF50998   SSF50998       
SSF56112   SSF56112       
Gene 3D
PDB
5IJO     E-value=0,     Score=1862

Ontologies

Topology

Subcellular location
Nucleus   Increased localization to chromatin before interphase (PubMed:22718353). Distributed along filamentous structures that extend radially on the nuclear side of the pore complex (PubMed:17410542).   With evidence from 3 publications.
Nuclear pore complex   Increased localization to chromatin before interphase (PubMed:22718353). Distributed along filamentous structures that extend radially on the nuclear side of the pore complex (PubMed:17410542).   With evidence from 3 publications.
Chromosome   Increased localization to chromatin before interphase (PubMed:22718353). Distributed along filamentous structures that extend radially on the nuclear side of the pore complex (PubMed:17410542).   With evidence from 3 publications.
Nucleus membrane   Increased localization to chromatin before interphase (PubMed:22718353). Distributed along filamentous structures that extend radially on the nuclear side of the pore complex (PubMed:17410542).   With evidence from 3 publications.
Cytoplasm   Increased localization to chromatin before interphase (PubMed:22718353). Distributed along filamentous structures that extend radially on the nuclear side of the pore complex (PubMed:17410542).   With evidence from 3 publications.
Length:
1339
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.677829999999996
Exp number, first 60 AAs:
0
Total prob of N-in:
0.01803
outside
1  -  1339
 
 

Population Genetic Test Statistics

Pi
301.182819
Theta
190.532429
Tajima's D
1.258134
CLR
0.062509
CSRT
0.726463676816159
Interpretation
Uncertain
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