Gene

KWMTBOMO05729  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006815

Annotation

beta-galactosidase_[Bombyx_mori]

Location

Bomo_Chr10(-):8909424-8928145      View in EpiBrowser

Full name

Beta-galactosidase      

Alternative Name

Acid beta-galactosidase

Location in the cell

Lysosomal   Reliability : 1.365

CDS

ATGACTCTCTTAATTGCAACATTTGCATTACTGTGTTTTCTTGGACAAACGTATTCCTTAGAAGATTATGCGCCCGTGGTTATCCGAGTGACAAATGAAGATCATCAAAATAAACTTTCAAACGAGTTCAAGATGAAAGGACACAACATAAGCATCGTTGGAGACAAGTTTATGATAGACGGGAAGCCTCTACACATCATATCAGGGTCATTGCACTACTTCAGGGTCCCTGCAGTGTATTGGCGTGACCGACTGCATAAGTTCAAAGCCGCTGGTCTCAACACAGTTGCTACGTACGTAGAATGGAGTTACCATGAGCCCGAGGAGAAACAGTATAATTTCGAAGGAGATCGTGACTTGGTGAGATTTGTTCAGACAGCGGCCGAAGTAGGCTTGCACGTTCTACTAAGGGTTGGTCCTTACATCTGTGCTGAAAGAGATTTAGGAGGATTGCCGTATTGGCTACTCGGAAAGTATCCGAATATAAAACTTCGTACAACCGACAAAGATTTCATCGCGGAGAGCGACATATGGCTGAAGAAACTATTCGAACAAGTCTCACATTTGTTATTCGGAAATGGTGGACCTATTATCTTAGTACAGGTGGAGAATGAATACGGCAGTTATGATAGCGACCTGGCATACAAGGAAAAGATGCGGGATCTGATAAGCGCCCACGTTGGGGATAAGGCTTTGCTATACACCACAGATGGACCGAGCCTAGTCGGCGCCGGCATGATCCCAGGAGTGCACGCCACCATCGACTTCGGCGTTACATCACAACCAACGGAGCAGTTCGACAGCCTGTTCCACCTGAGGCCGGCTCCCGGGCCGCTCATGAACTCCGAATTCTACCCGGGCTGGCTGACGCACTGGGGCGAGCGTATGGCGCGCGTCGGCACCAACGACATTGTGCTCACATTGCGTAACATGATCGTTAATAAAATACACGTCAATTTTTATGTATTCTTTGGTGGAAGTAATTTTGAGTTCACATCAGGAGCGAATTTCGATGGAACGTACCAGCCCGACATAACCTCGTACGATTACGACGCTCCCCTCTCCGAAGCCGGCGACCCAACCCCAAAATATTACGCCATCAGAGAAACATTGAAACAGTTGAATTTCGTGGATGAGAAAATTGAGCCGCCACAGCCCAGCCCTAAAGGTCGGTATGGCGCCGTGCCCGTCGCAGCGAAACTCAGTATCATGTCCCCGAAGGGTCGCTGCGACTTGGGGAAACGATACGAGGACGTGTCGGGCGGAACTTTGCCGACTTTCGAAGAGTTGAGGCAACGGAGCGGCTTGGTTTTATACGAGACGACGCTCAACGAAACAGAGGGAGTCCTTGTCCTCAACAAGCCGCGCGACCTGGTCTTCGTCTTTGTGGATGGAAAACCACAAGGCGTATTGAGTCGGATGCACAAGAAATACCATTTGCGTATAAGTTCGACGGCCGGCAGTAAGCTGTCCCTCCTAGTCGAGAACCAAGGCCGTATTAATTACGGCACGCTACTACACGACCGTAAGGGAATTTTAAGTGAAGTTATTTACAACAATAAAGTTATTGGAGGCAAATGGAGTATTACTGGATATCCGCTAGAGACGGTTCAGTTTAACTCTTCTGTGAGCGAAGTTACCCAAGGCCCAACGTTTTATGAGGGTACATTTGTGTTACCAGAGGGTCAAAAACCATTGGATACGTTTTTGGATACTACGGGATGGGATAAGGGCTACGTTTGGGTGAACGGTCACAATCTAGGACGGTACTGGCCCGGAGTCGGTCCCCAGGTCACTCTCTACGTCCCCGGAGTTTGGCTGCTCGAAGCGCCGCAACCGAACGTGCTACAAATACTTGAACTGAACAAACCTTCGGACAGCTCAACCATGGAGTTCATAGACAATCCTATTCTAAACCGGACTGGAAATTTACACGCGTGGAAGTTTCCTTAG

Protein

MTLLIATFALLCFLGQTYSLEDYAPVVIRVTNEDHQNKLSNEFKMKGHNISIVGDKFMIDGKPLHIISGSLHYFRVPAVYWRDRLHKFKAAGLNTVATYVEWSYHEPEEKQYNFEGDRDLVRFVQTAAEVGLHVLLRVGPYICAERDLGGLPYWLLGKYPNIKLRTTDKDFIAESDIWLKKLFEQVSHLLFGNGGPIILVQVENEYGSYDSDLAYKEKMRDLISAHVGDKALLYTTDGPSLVGAGMIPGVHATIDFGVTSQPTEQFDSLFHLRPAPGPLMNSEFYPGWLTHWGERMARVGTNDIVLTLRNMIVNKIHVNFYVFFGGSNFEFTSGANFDGTYQPDITSYDYDAPLSEAGDPTPKYYAIRETLKQLNFVDEKIEPPQPSPKGRYGAVPVAAKLSIMSPKGRCDLGKRYEDVSGGTLPTFEELRQRSGLVLYETTLNETEGVLVLNKPRDLVFVFVDGKPQGVLSRMHKKYHLRISSTAGSKLSLLVENQGRINYGTLLHDRKGILSEVIYNNKVIGGKWSITGYPLETVQFNSSVSEVTQGPTFYEGTFVLPEGQKPLDTFLDTTGWDKGYVWVNGHNLGRYWPGVGPQVTLYVPGVWLLEAPQPNVLQILELNKPSDSSTMEFIDNPILNRTGNLHAWKFP

Description

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.

Catalytic Activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subunit

Homodimer. May form higher multimers.

Similarity

Belongs to the glycosyl hydrolase 35 family.

Keywords

Complete proteome   Disulfide bond   Glycoprotein   Glycosidase   Hydrolase   Lysosome   Reference proteome   Signal   Zymogen  

Feature

chain  Beta-galactosidase

Uniprot

C6G4I3   H9JBC0   A0A2A4K6F0   A0A212FGU2   A0A2H1WN59   A0A194PFG8   + More
A0A0L7LCZ3   A0A026WTW5   E1ZZY3   F4W7H0   A0A151JT53   A0A151INT7   A0A195EL31   A0A158NPS6   A0A0L0BWU5   A0A067RST2   A0A310STN5   A0A0L7RA13   A0A1I8ME14   A0A1I8QBI3   A0A1W4UB11   A0A088A3V9   T1P9I9   A0A0A1XFR4   B4PN17   B3P1H8   B4QTI2   A0A0K8WK00   A0A034WG74   A0A1A9WJE9   E0VB38   Q9VGE7   B3M035   J9K9V7   W8C273   A0A1A9VBD8   A0A1A9ZNU6   K7JAK6   A0A1S3DJB5   B4JT75   B4NA51   A0A1B6C0R4   A0A2P8XG02   A0A2H8TRJ9   A0A1B6G640   B4K5L9   A0A1L8DQZ9   A0A2S2P399   A0A1B0BT61   A0A2H8TM91   A0A0C9R9S9   A0A1B6HET1   A0A154NVQ8   A0A1L8DR03   A0A1A9YG57   A0A2S2R7V6   A0A1B6JR85   K7JAK4   X1WYK3   A0A0M3QXH0   A0A1B0G5H2   W5J746   B4LWG7   Q295T2   A0A0R3NIQ0   B4GFQ3   A0A336KH92   A0A3B0JQP0   A0A3B0JTU6   A0A1L8FWQ8   Q08B07   A0A1Y9HF65   E2BZ52   A0A3S3SG59   Q7PYQ3   A0A3S4RBZ1   A0A182UA42   A0A3S3PDE4   A0A023EUJ4   A0A1B6MBZ2   A0A1W7R8I8   A0A1Y9H284   B4HHI5   A0A340TBP5   A0A2C9GRJ5   B0W8M8   A0A1B6JXA2   A0A182T141   A0A195ATA4   A0A1J1HUZ7   A0A151X8K0   J9K4B3   A0A1Q3FSN2   A0A1S4F815   O19015   A0A182MKK0   M3WZ71   A0A182VZ59   F7BZN6  

EC Number

3.2.1.23

Pubmed

19121390    22118469    26354079    26227816    24508170    30249741    + More
20798317    21719571    21347285    26108605    24845553    25315136    25830018    17994087    17550304    25348373    20566863    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    24495485    20075255    29403074    18057021    20920257    23761445    15632085    27762356    12364791    14747013    17210077    24945155    17510324    17975172    17495919   

EMBL

FJ571146    ACS36117.1    BABH01030912    NWSH01000130    PCG79240.1    AGBW02008596    + More
OWR52955.1    ODYU01009765    SOQ54416.1    KQ459606    KPI91444.1    JTDY01001608    KOB73378.1    KK107105    QOIP01000011    EZA59457.1    RLU16850.1    GL435531    EFN73255.1    GL887844    EGI69843.1    KQ982014    KYN30661.1    KQ976914    KYN07126.1    KQ978730    KYN28933.1    ADTU01022726    JRES01001227    KNC24481.1    KK852482    KDR22879.1    KQ760085    OAD61978.1    KQ414621    KOC67596.1    KA645369    KA649251    AFP59998.1    GBXI01010699    GBXI01006987    GBXI01004522    JAD03593.1    JAD07305.1    JAD09770.1    CM000160    EDW97029.1    CH954181    EDV49437.1    CM000364    EDX13287.1    GDHF01000843    JAI51471.1    GAKP01006199    JAC52753.1    DS235021    EEB10594.1    AE014297    AY119565    AAF54736.1    AAM50219.1    CH902617    EDV41992.1    ABLF02040120    GAMC01006659    JAB99896.1    AAZX01002446    CH916373    EDV94965.1    CH964232    EDW80694.1    GEDC01030473    JAS06825.1    PYGN01002274    PSN30941.1    GFXV01005000    MBW16805.1    GECZ01011864    JAS57905.1    CH933806    EDW14056.1    KRG00828.1    GFDF01005287    JAV08797.1    GGMR01011342    MBY23961.1    JXJN01020023    JXJN01024948    GFXV01003468    MBW15273.1    GBYB01004980    JAG74747.1    GECU01034530    JAS73176.1    KQ434769    KZC03775.1    GFDF01005253    JAV08831.1    GGMS01016855    MBY86058.1    GECU01005976    JAT01731.1    ABLF02038094    CP012526    ALC45913.1    CCAG010000321    CCAG010000322    ADMH02002125    ETN58685.1    CH940650    EDW66604.1    CM000070    EAL28626.3    KRT00897.1    CH479182    EDW34438.1    UFQS01000478    UFQT01000478    SSX04286.1    SSX24651.1    OUUW01000008    SPP84484.1    SPP84483.1    CM004476    OCT76011.1    BC124927    AAI24928.1    GL451563    EFN79021.1    NCKU01000925    RWS13656.1    AAAB01008987    EAA01064.5    NCKU01000768    RWS14246.1    NCKU01001143    NCKU01001142    RWS12980.1    RWS12988.1    GAPW01000513    JAC13085.1    GEBQ01006526    JAT33451.1    GEHC01000205    JAV47440.1    CH480815    EDW42524.1    APCN01002030    DS231859    EDS39078.1    GECU01004183    JAT03524.1    KQ976745    KYM75453.1    CVRI01000021    CRK91904.1    KQ982409    KYQ56701.1    ABLF02029063    GFDL01004436    JAV30609.1    AF006749    AF029974    AXCM01002611    AANG04001816   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000037510    UP000053097    + More
UP000279307    UP000000311    UP000007755    UP000078541    UP000078542    UP000078492    UP000005205    UP000037069    UP000027135    UP000053825    UP000095301    UP000095300    UP000192221    UP000005203    UP000002282    UP000008711    UP000000304    UP000091820    UP000009046    UP000000803    UP000007801    UP000007819    UP000078200    UP000092445    UP000002358    UP000079169    UP000001070    UP000007798    UP000245037    UP000009192    UP000092460    UP000076502    UP000092443    UP000092553    UP000092444    UP000000673    UP000008792    UP000001819    UP000008744    UP000268350    UP000186698    UP000075900    UP000008237    UP000285301    UP000007062    UP000075902    UP000075884    UP000001292    UP000076407    UP000075840    UP000002320    UP000075901    UP000078540    UP000183832    UP000075809    UP000011712    UP000075883    UP000075920    UP000002280   

PRIDE

C6G4I3    H9JBC0    A0A088A3V9    Q9VGE7    O19015   

Pfam

PF01301   Glyco_hydro_35        + More
PF13364   BetaGal_dom4_5
PF01979   Amidohydro_1
PF00988   CPSase_sm_chain
PF02142   MGS
PF02729   OTCace_N
PF00185   OTCace
PF02787   CPSase_L_D3
PF02786   CPSase_L_D2
PF00117   GATase
PF16012   DUF4780

Interpro

IPR031330   Gly_Hdrlase_35_cat        + More
IPR008979   Galactose-bd-like_sf       
IPR026283   B-gal_1-like       
IPR019801   Glyco_hydro_35_CS       
IPR025300   BetaGal_jelly_roll_dom       
IPR001944   Glycoside_Hdrlase_35       
IPR017853   Glycoside_hydrolase_SF       
IPR011761   ATP-grasp       
IPR032466   Metal_Hydrolase       
IPR002195   Dihydroorotase_CS       
IPR029062   Class_I_gatase-like       
IPR002082   Asp_carbamoyltransf       
IPR036897   CarbamoylP_synth_lsu_oligo_sf       
IPR006274   CarbamoylP_synth_ssu       
IPR016185   PreATP-grasp_dom_sf       
IPR006131   Asp_carbamoyltransf_Asp/Orn-bd       
IPR006130   Asp/Orn_carbamoylTrfase       
IPR005479   CbamoylP_synth_lsu-like_ATP-bd       
IPR035686   CPSase_GATase1       
IPR011607   MGS-like_dom       
IPR036914   MGS-like_dom_sf       
IPR006680   Amidohydro-rel       
IPR036901   Asp/Orn_carbamoylTrfase_sf       
IPR006132   Asp/Orn_carbamoyltranf_P-bd       
IPR013815   ATP_grasp_subdomain_1       
IPR005483   CbamoylP_synth_lsu_CPSase_dom       
IPR011059   Metal-dep_hydrolase_composite       
IPR036480   CarbP_synth_ssu_N_sf       
IPR017926   GATASE       
IPR005480   CarbamoylP_synth_lsu_oligo       
IPR002474   CarbamoylP_synth_ssu_N       
IPR006275   CarbamoylP_synth_lsu       
IPR031961   DUF4780       

SUPFAM

SSF51445   SSF51445        + More
SSF49785   SSF49785       
SSF48108   SSF48108       
SSF51556   SSF51556       
SSF52440   SSF52440       
SSF51338   SSF51338       
SSF52335   SSF52335       
SSF53671   SSF53671       
SSF52317   SSF52317       
SSF52021   SSF52021       

Gene 3D

2.60.120.260     1.10.1030.10     3.30.1490.20     3.40.50.1370     3.40.50.1380     3.40.50.880     3.50.30.20    

CDD

cd01744  GATase1_CPSase

ProteinModelPortal

C6G4I3   H9JBC0   A0A2A4K6F0   A0A212FGU2   A0A2H1WN59   A0A194PFG8   + More
A0A0L7LCZ3   A0A026WTW5   E1ZZY3   F4W7H0   A0A151JT53   A0A151INT7   A0A195EL31   A0A158NPS6   A0A0L0BWU5   A0A067RST2   A0A310STN5   A0A0L7RA13   A0A1I8ME14   A0A1I8QBI3   A0A1W4UB11   A0A088A3V9   T1P9I9   A0A0A1XFR4   B4PN17   B3P1H8   B4QTI2   A0A0K8WK00   A0A034WG74   A0A1A9WJE9   E0VB38   Q9VGE7   B3M035   J9K9V7   W8C273   A0A1A9VBD8   A0A1A9ZNU6   K7JAK6   A0A1S3DJB5   B4JT75   B4NA51   A0A1B6C0R4   A0A2P8XG02   A0A2H8TRJ9   A0A1B6G640   B4K5L9   A0A1L8DQZ9   A0A2S2P399   A0A1B0BT61   A0A2H8TM91   A0A0C9R9S9   A0A1B6HET1   A0A154NVQ8   A0A1L8DR03   A0A1A9YG57   A0A2S2R7V6   A0A1B6JR85   K7JAK4   X1WYK3   A0A0M3QXH0   A0A1B0G5H2   W5J746   B4LWG7   Q295T2   A0A0R3NIQ0   B4GFQ3   A0A336KH92   A0A3B0JQP0   A0A3B0JTU6   A0A1L8FWQ8   Q08B07   A0A1Y9HF65   E2BZ52   A0A3S3SG59   Q7PYQ3   A0A3S4RBZ1   A0A182UA42   A0A3S3PDE4   A0A023EUJ4   A0A1B6MBZ2   A0A1W7R8I8   A0A1Y9H284   B4HHI5   A0A340TBP5   A0A2C9GRJ5   B0W8M8   A0A1B6JXA2   A0A182T141   A0A195ATA4   A0A1J1HUZ7   A0A151X8K0   J9K4B3   A0A1Q3FSN2   A0A1S4F815   O19015   A0A182MKK0   M3WZ71   A0A182VZ59   F7BZN6  

PDB

3THD     E-value=1.11548e-123,     Score=1137

KEGG

100302607    K12309 beta-galactosidase [EC:3.2.1.23] | (RefSeq) Gal; beta-galactosidase

PATHWAY

00052    Galactose metabolism - Bombyx mori (domestic silkworm)
00511    Other glycan degradation - Bombyx mori (domestic silkworm)
00531    Glycosaminoglycan degradation - Bombyx mori (domestic silkworm)
00600    Sphingolipid metabolism - Bombyx mori (domestic silkworm)
00604    Glycosphingolipid biosynthesis - ganglio series - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0005975   GO:0004565   GO:0046872   GO:0006541   GO:0004088   GO:0004070   GO:0006207   GO:0005524   GO:0016597   GO:0016812   GO:0016021   GO:0008152   GO:0005773   GO:0005764   GO:0044262   GO:0005794   GO:0005615   GO:0042803   GO:0004553  

PANTHER

PTHR23421  

Subcellular location

Lysosome  

SignalP

Position:   1 - 19,         Likelihood:  0.994909

 

 

Length:

650

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.25893

Exp number, first 60 AAs:

0.24684

Total prob of N-in:

0.01359

outside

1  -  650

 

 

Pi

198.124932

Theta

159.622283

Tajima's D

0.73709

CLR

0.05328

CSRT

0.582120893955302

Interpretation

Uncertain