Gene

KWMTBOMO05697

Pre Gene Modal

BGIBMGA006857

Annotation

AF032873_1_inebriated_protein_[Manduca_sexta]

Location

Bomo_Chr10(+):8473022-8493859      View in EpiBrowser

Full name

Transporter       + More
Sodium- and chloride-dependent GABA transporter ine      

Alternative Name

Protein inebriated
Protein receptor oscillation A

Location in the cell

PlasmaMembrane   Reliability : 4.969

CDS

ATGAACAAAGCCGAATCTTCGACGGAAACCGCCGCGCCCAGCGTGGCGATCCACGTGGAACAGTATGACGACTGTCAGGACGTCGAAAGCTCAAAGCTTCTCAACCTGCAAGAACCGGCAGCTACAATTAATACCTCTGCACCAATGAGAAAAGTTAAGAGCTTTAGTGACACCCAAAAAATTCGTGATGTTGCCGCTGCTTCCGGAGCTGCTTCTGCAAGAAGTTTACGACCATATGAACAAGTGATTCCTTACCCTGAAGGATCCGAAAACGGAACTAACCAATATGGAGCGCCATCGGTTCGATCCCTCGCTTCAATCGGCATGGGCTGCACCGATGGTCGCAAAATGGTTATTAGACGAGTACCTACTTCGCCCACAGAATTGTTCCATCTAGTGCGTCCTCCTACACCCCCCGATGAAGATTCGGCATCCCACGAGAGTGACTGTGAAGAAGAAGAAGAAGATGCCGCAGTACATTTGAAACCCCGAAGGCCCTTTTGGGCTAACAAGATTCAGTTCGTGTTGGCATGCGTCGGATACTCCGTTGGCCTCGGCAATGTTTGGCGCTTTCCTTATCTCTGTTACAAAAGTGGAGGAGGTGCATTTTTGATACCTTACTTCATAATATTGTTAGTTTGCGGCGTCCCGATGCTCTTTATGGAACTGGCTATAGGGCAATACACAGCTCACGGACCTATAGGAGCTTTGTCGCAGATATGTCCACTTTTTAAAGGTGCAGGTTTAGCGAGTGTGGTGATCTCATTTTTAATGTCCACATACTATGCTGTGATAATCGCGTGGGCAATTTATTATTTCTTCACGTCTTTCAAAACGGAAGTACCATGGGCCAGTTGTTCAAATCGATGGAACACGGATATGTGCTGGGTGCCAAACCATAACTACACAAAACCGAATGGATCTCAAACACCCACCGAACAATTCTTCGAGAAGAAGGTATTGAGTATGAGTGCCGGTATAGAATTTCCTGGTGGCATGCGGTGGGAATTGGCAGCTTGCTTGGTCTGTGCTTGGGTGTTAGTTTATTTCGCCCTGTGGAAAAGTATCAAGTCATCCGCCAAAGTTCGTTATATCACCACGACACTGCCTTTTCTGCTAATTTTAGTATTCTTAGGTAGATCTCTAACACTCGATGGGGCGGACAGAGGCTTGAGATTTTTCTTCAAACCAGAATGGGAACTTCTAAAACAATCCAGACCATGGGTTAACGCCGCTTCACAAATTTTCAATTCCATCGGCATAGCGTTCGGATCTATGATCATGTTCGCTTCATATAACAGATTCGACAACAATTTTCTACACGATACTGTGGCTGTAACATTGGTCAATGCAATAACCAGTCTCATAGTCGGAATATTCACCTTCGCTACTATTGGAAATATCGCATTTGAACAAAACACACCGGTCAAAGATGTTATCGCAGATAGTCCCGGACTTTTATTCGTGGTTTATCCACAAGCAATTGCAAAGATGCCAGCTTCGCAACTTTGGGCAGTTTTATTTTTCTTTATGTTCCTGTGCCTTGGCCTGAACAGTCAGTTTGCCATTGTGGAAGTTGTCGTTACTTCGATACAAGATGGTTTCCCAGATATGATCCGTAGGAAACTTGTCTATCATGAGCTCTTAGTATTATTGGTGTGCGCGGTGTCACTCGTATTCGGCCTACCACATATAATACATAGCGGCATATACATATTCCAATTAATGGACTACTATGCCGCTTCGCTCAGTATCACGTATCTTGCATTTTTCGAAGTTGTTGCCATAGCTTGGTTCTATGGAGTGGGGAGACTTTCTCGAAACATTAAACAGATGACAGGTCGACGTCCGTCAATTTATTTCCGATTTTGTTGGCTGATTGCTACACCTGCTCTATTAATAGCACTATGGGTGGCAAGTCTCGTCGATTATACTCCCCCCAGCTACCGGCAGTACCAATATCCAGCATGGGCACAAGCAATTGGTTGGATTATCGCCTCCCTTTCCTTATTATGCATTCCTGTGTACGCTGTAATAGTCGTATTTAGAGCACCCGGGGAAAATTTACTTGAGAAATTACGTTATTCCATTCGCCCGAGTTCTATTTGCGACTGTGGCGTGAATGGTTGTGATATATGCTGCTCGGAATCCGAAACTCCTGAAGATAAAACTGTTATAACTTAG

Protein

MNKAESSTETAAPSVAIHVEQYDDCQDVESSKLLNLQEPAATINTSAPMRKVKSFSDTQKIRDVAAASGAASARSLRPYEQVIPYPEGSENGTNQYGAPSVRSLASIGMGCTDGRKMVIRRVPTSPTELFHLVRPPTPPDEDSASHESDCEEEEEDAAVHLKPRRPFWANKIQFVLACVGYSVGLGNVWRFPYLCYKSGGGAFLIPYFIILLVCGVPMLFMELAIGQYTAHGPIGALSQICPLFKGAGLASVVISFLMSTYYAVIIAWAIYYFFTSFKTEVPWASCSNRWNTDMCWVPNHNYTKPNGSQTPTEQFFEKKVLSMSAGIEFPGGMRWELAACLVCAWVLVYFALWKSIKSSAKVRYITTTLPFLLILVFLGRSLTLDGADRGLRFFFKPEWELLKQSRPWVNAASQIFNSIGIAFGSMIMFASYNRFDNNFLHDTVAVTLVNAITSLIVGIFTFATIGNIAFEQNTPVKDVIADSPGLLFVVYPQAIAKMPASQLWAVLFFFMFLCLGLNSQFAIVEVVVTSIQDGFPDMIRRKLVYHELLVLLVCAVSLVFGLPHIIHSGIYIFQLMDYYAASLSITYLAFFEVVAIAWFYGVGRLSRNIKQMTGRRPSIYFRFCWLIATPALLIALWVASLVDYTPPSYRQYQYPAWAQAIGWIIASLSLLCIPVYAVIVVFRAPGENLLEKLRYSIRPSSICDCGVNGCDICCSESETPEDKTVIT

Description

Plays a role in neuronal membrane excitation, important for normal response properties of the photoreceptor. Able to control excitability from either neurons or glia cells. Ine negatively regulates neuronal sodium channels. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve, ine and eag control perineurial glial growth through partially redundant pathways. Isoform A and isoform B are both functional, although isoform A functions with greater efficiency. Has a role in osmolyte transport within the Malpighian tubule and hindgut.

Similarity

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.

Keywords

Alternative splicing   Complete proteome   Developmental protein   Differentiation   Glycoprotein   Membrane   Neurogenesis   Neurotransmitter transport   Reference proteome   Symport   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Sodium- and chloride-dependent GABA transporter ine
splice variant  In isoform B.

Uniprot

H9JBG2   Q9U5A5   A0A2H1VK69   A0A194RBW5   A0A194PK53   A0A0L7LTT3   + More
A0A2A4JWJ5   A0A212F710   A0A1L8DJZ1   A0A182WG85   A0A1S4GZP7   A0A182Y0E7   A0A2M4CIM3   A0A2M4CIC0   U5EUA5   A0A1Q3FUS3   A0A1Q3FQM0   A0A1Q3FQP0   B4LUW5   D6X2M1   A0A0A1X708   B4MTX2   T1PET9   A0A0L0C6X9   A0A1I8NQS7   A0A1I8MTT9   B4NYY7   B3MU16   A0A1W4WA05   K7J4G0   A0A0J9QVL8   A0A1I8NQS8   B4I3A5   B3N3T6   B4KLF2   A0A0K8UTA4   E1JHT2   Q9VR07   E2BGZ3   A0A1Y1L6M7   A0A3B0K6Z8   B4GQE8   Q29LA0   A0A182P1M5   B4JQR8   A0A026WPJ4   A0A182I7E3   E2A8H3   A0A182NUS7   A0A310SJ50   A0A084W1U8   A0A2A3EH09   A0A1A9VW31   A0A195BBM1   A0A1S4GZP4   A0A182LUR7   A0A195D5A3   A0A1A9XJP4   A0A088A4T6   A0A1B0C304   X2D4U8   A0A195DXM1   A0A182F1I2   A0A182QL93   A0A158NJT5   A0A182J770   W5JAR1   Q7YZC7   A0A182LMQ1   F4X6F1   A0A1Q3FQS7   A0A182UTC3   A0A1Q3FR06   Q7PWJ5   B0WB25   A0A195FMG1   A0A182G8W1   A0A1A9ZCS2   A0A1J1IWZ2   A0A0Q9WA98   E9IFV1   A0A232FDE8   A0A154P7S6   A0A336MFN3   A0A0R1DJ70   A0A0M4E6D1   A0A1B6CQI5   A0A0P9A7T6   A0A1W4VY60   A0A1I8M2G9   A0A151X6F1   A0A0J9TFF7   A0A0Q9X5I5   A0A0Q5W9A0   A0A0A1XCF1   A0A1B6LKH7   Q9VR07-2   C8VV47   A0A3B0JGD1   A0A0K8WJF4  

Pubmed

19121390    11060215    26354079    26227816    22118469    12364791    + More
25244985    17994087    18362917    19820115    25830018    26108605    25315136    17550304    18057021    20075255    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    1334137    10876650    8917579    12537569    11517334    11861562    11880499    17893096    20798317    28004739    15632085    23185243    24508170    30249741    24438588    21347285    20920257    23761445    17510324    20966253    21719571    26483478    21282665    28648823   

EMBL

BABH01030871    BABH01030872    AF032873    AAF21642.1    ODYU01002761    SOQ40654.1    + More
KQ460398    KPJ15092.1    KQ459606    KPI91475.1    JTDY01000103    KOB78852.1    NWSH01000473    PCG76156.1    AGBW02009960    OWR49499.1    GFDF01007312    JAV06772.1    AAAB01008984    GGFL01000921    MBW65099.1    GGFL01000922    MBW65100.1    GANO01003971    JAB55900.1    GFDL01003843    JAV31202.1    GFDL01005124    JAV29921.1    GFDL01005104    JAV29941.1    CH940649    EDW64292.2    KQ971372    EFA09465.2    GBXI01007616    JAD06676.1    CH963852    EDW75561.2    KA647302    AFP61931.1    JRES01000827    KNC28025.1    CM000157    EDW87651.1    CH902624    EDV33345.1    KPU74417.1    CM002910    KMY88097.1    CH480820    EDW54250.1    CH954177    EDV57745.2    CH933807    EDW12833.2    KRG03437.1    GDHF01022596    JAI29718.1    AE014134    ACZ94162.1    Y08362    U66460    AY128432    BT009955    AAC47292.1    AAF51001.1    AAM75025.1    AAQ22424.1    CAA69649.1    GL448255    EFN85026.1    GEZM01063070    JAV69333.1    OUUW01000006    SPP81406.1    CH479187    EDW39820.1    CH379060    EAL34145.2    KRT04538.1    CH916372    EDV99248.1    KK107144    QOIP01000003    EZA57571.1    RLU24820.1    APCN01003386    GL437616    EFN70243.1    KQ762842    OAD55412.1    ATLV01019462    KE525272    KFB44192.1    KZ288251    PBC31055.1    KQ976526    KYM81956.1    AXCM01004211    KQ976818    KYN08080.1    JXJN01024742    KC713793    AHH29251.1    KQ980155    KYN17462.1    AXCN02000741    ADTU01018181    ADTU01018182    ADMH02002027    ETN59874.1    AY314994    CH477389    AAP88701.1    EAT42015.1    GL888812    EGI57991.1    GFDL01005126    JAV29919.1    GFDL01005119    JAV29926.1    EAA14797.4    DS231876    EDS41983.1    KQ981424    KYN41855.1    JXUM01008641    JXUM01008642    JXUM01008643    KQ560265    KXJ83471.1    CVRI01000063    CRL04725.1    KRF81546.1    GL762903    EFZ20541.1    NNAY01000425    OXU28498.1    KQ434835    KZC07903.1    UFQT01001069    SSX28740.1    KRJ97284.1    CP012523    ALC38115.1    GEDC01021509    JAS15789.1    KPU74416.1    KQ982482    KYQ55914.1    KMY88095.1    KRG03439.1    KQS70099.1    GBXI01005671    JAD08621.1    GEBQ01015821    JAT24156.1    BT099793    ACV91630.1    SPP81407.1    GDHF01001038    JAI51276.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000037510    UP000218220    UP000007151    + More
UP000075920    UP000076408    UP000008792    UP000007266    UP000007798    UP000037069    UP000095300    UP000095301    UP000002282    UP000007801    UP000192221    UP000002358    UP000001292    UP000008711    UP000009192    UP000000803    UP000008237    UP000268350    UP000008744    UP000001819    UP000075885    UP000001070    UP000053097    UP000279307    UP000075840    UP000000311    UP000075884    UP000030765    UP000242457    UP000078200    UP000078540    UP000075883    UP000078542    UP000092443    UP000005203    UP000092460    UP000078492    UP000069272    UP000075886    UP000005205    UP000075880    UP000000673    UP000008820    UP000075882    UP000007755    UP000075903    UP000007062    UP000002320    UP000078541    UP000069940    UP000249989    UP000092445    UP000183832    UP000215335    UP000076502    UP000092553    UP000075809   

PRIDE

H9JBG2    E1JHT2    Q9VR07    C8VV47   

Pfam

PF00209   SNF        + More
PF00179   UQ_con
PF12937   F-box-like

Interpro

IPR002944   Na/ntran_symport_inebriated        + More
IPR000175   Na/ntran_symport       
IPR037272   SNS_sf       
IPR036047   F-box-like_dom_sf       
IPR016135   UBQ-conjugating_enzyme/RWD       
IPR000608   UBQ-conjugat_E2       
IPR001810   F-box_dom       

SUPFAM

SSF161070   SSF161070        + More
SSF81383   SSF81383       
SSF54495   SSF54495       

Gene 3D

3.10.110.10    

CDD

cd00195  UBCc

ProteinModelPortal

H9JBG2   Q9U5A5   A0A2H1VK69   A0A194RBW5   A0A194PK53   A0A0L7LTT3   + More
A0A2A4JWJ5   A0A212F710   A0A1L8DJZ1   A0A182WG85   A0A1S4GZP7   A0A182Y0E7   A0A2M4CIM3   A0A2M4CIC0   U5EUA5   A0A1Q3FUS3   A0A1Q3FQM0   A0A1Q3FQP0   B4LUW5   D6X2M1   A0A0A1X708   B4MTX2   T1PET9   A0A0L0C6X9   A0A1I8NQS7   A0A1I8MTT9   B4NYY7   B3MU16   A0A1W4WA05   K7J4G0   A0A0J9QVL8   A0A1I8NQS8   B4I3A5   B3N3T6   B4KLF2   A0A0K8UTA4   E1JHT2   Q9VR07   E2BGZ3   A0A1Y1L6M7   A0A3B0K6Z8   B4GQE8   Q29LA0   A0A182P1M5   B4JQR8   A0A026WPJ4   A0A182I7E3   E2A8H3   A0A182NUS7   A0A310SJ50   A0A084W1U8   A0A2A3EH09   A0A1A9VW31   A0A195BBM1   A0A1S4GZP4   A0A182LUR7   A0A195D5A3   A0A1A9XJP4   A0A088A4T6   A0A1B0C304   X2D4U8   A0A195DXM1   A0A182F1I2   A0A182QL93   A0A158NJT5   A0A182J770   W5JAR1   Q7YZC7   A0A182LMQ1   F4X6F1   A0A1Q3FQS7   A0A182UTC3   A0A1Q3FR06   Q7PWJ5   B0WB25   A0A195FMG1   A0A182G8W1   A0A1A9ZCS2   A0A1J1IWZ2   A0A0Q9WA98   E9IFV1   A0A232FDE8   A0A154P7S6   A0A336MFN3   A0A0R1DJ70   A0A0M4E6D1   A0A1B6CQI5   A0A0P9A7T6   A0A1W4VY60   A0A1I8M2G9   A0A151X6F1   A0A0J9TFF7   A0A0Q9X5I5   A0A0Q5W9A0   A0A0A1XCF1   A0A1B6LKH7   Q9VR07-2   C8VV47   A0A3B0JGD1   A0A0K8WJF4  

PDB

4XPF     E-value=8.21111e-117,     Score=1078

KEGG

101739258    K05039 solute carrier family 6 (neurotransmitter transporter, taurine) member 6 | (RefSeq) sodium- a

GO

GO:0019226   GO:0016021   GO:0005328   GO:0005034   GO:0042065   GO:0009414   GO:0042066   GO:0047484   GO:0016323   GO:0050891   GO:0005886   GO:0006836   GO:0009881   GO:0003707   GO:0043565  

PANTHER

PTHR11616  

Subcellular location

Membrane  

Length:

727

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

267.8359

Exp number, first 60 AAs:

0

Total prob of N-in:

0.98126

inside

1  -  171

TMhelix

172  -  194

outside

195  -  203

TMhelix

204  -  226

inside

227  -  246

TMhelix

247  -  269

outside

270  -  330

TMhelix

331  -  353

inside

354  -  361

TMhelix

362  -  384

outside

385  -  410

TMhelix

411  -  433

inside

434  -  445

TMhelix

446  -  468

outside

469  -  505

TMhelix

506  -  528

inside

529  -  547

TMhelix

548  -  570

outside

571  -  579

TMhelix

580  -  602

inside

603  -  622

TMhelix

623  -  645

outside

646  -  659

TMhelix

660  -  682

inside

683  -  727

 

 

Pi

240.272545

Theta

172.800898

Tajima's D

1.115228

CLR

0.01149

CSRT

0.686865656717164

Interpretation

Uncertain