Gene

KWMTBOMO05696  Validated by peptides from experiments

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_notch-like_protein_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr10(+):8365672-8470735      View in EpiBrowser

Full name

Fibrillin-1       + More
Fibrillin-2      
Neurogenic locus notch homolog protein 1      
Neurogenic locus Notch protein      
Neurogenic locus notch homolog protein 2      
Neurogenic locus notch homolog protein 3      
Latent-transforming growth factor beta-binding protein 2      
Fibrillin-3      
Protein eyes shut homolog      
Latent-transforming growth factor beta-binding protein 4      
Latent-transforming growth factor beta-binding protein 1      
Neurogenic locus notch homolog protein 4      
Fibropellin-1      
Latent-transforming growth factor beta-binding protein 3      
Fibulin-2      
Transmembrane cell adhesion receptor mua-3      
Adhesion G protein-coupled receptor E1      
Adhesion G protein-coupled receptor E2      
Fibulin-1      
Protein jagged-1a      
Protein jagged-1b      
Protein jagged-1      
Sushi, nidogen and EGF-like domain-containing protein 1      
Mucin-like protein      
Multiple epidermal growth factor-like domains protein 6      
Protein kinase C-binding protein NELL1      
Protein jagged-2      
Signal peptide, CUB and EGF-like domain-containing protein 3      
Protein serrate      
Hemicentin-1      
Protein crumbs homolog 1      
Signal peptide, CUB and EGF-like domain-containing protein 1      
Protein crumbs      
Signal peptide, CUB and EGF-like domain-containing protein 2      
Protein lin-12      
Protein crumbs homolog 2      

Alternative Name

MP340
Motch B
Motch A
mT14
p300
Translocation-associated notch protein TAN-1
Transforming growth factor beta-1-binding protein 1
Epidermal growth factor-related protein 1
Fibropellin-I
SpEGF I
UEGF-1
Transforming growth factor beta-1-masking protein large subunit
Muscle attachment abnormal protein 3
Cell surface glycoprotein F4/80
EGF-like module receptor 1
EGF-like module-containing mucin-like hormone receptor-like 1
EMR1 hormone receptor
Jagged3
Epidermal growth factor-like protein 10
Epidermal growth factor-like protein 11
Protein spacemaker homolog
Insulin-responsive sequence DNA-binding protein 1
Epidermal growth factor-like protein 3
NEL-like protein 1
Nel-related protein 1
Protein beaded
Fibulin-6
Secreted protein SST-3
Stromal nidogen extracellular matrix protein
Basement-membrane protein 90
95F
Protein CEGP1
Scube/You
Abnormal cell lineage protein 12
Protein You
Crumbs-like protein 2

Location in the cell

Extracellular   Reliability : 2.967

CDS

ATGTATATAGACAGTCTACCGCTCGTGGTTTGGACGCTCTTAGTCACAACGACACATGTAGCGACACAAAGCCAGTATGGAATAGGCTTAGGAATAAAACGAGAAGTATTTTTCTTAAATTTAGAAGACGGCTACTTTGGTTGTCAAGTTAACGAATCAACACAAATTTTGCAATTATATGAACTATCGAAACTATGCGACGGTGTTACGGATTGTTACAAAGGCTCTGATGAGTTGAAGTCGGAGTTAAAATGTTCAGACGATTGTACCAAAGAAGATGGCGCCCAGTGTGTGAACGGTGCCTGTCTAAACGGTGTGTGCCATTGTAATGACGGTTTCGGCGGCTGCAACTGCCAAGACCCCGATATAAATGAATGCAAAGACAGGCCCTGTGATGTTTTTGCACACTGTACAAACACCGTCGGCAGTTTTCAATGTTCTTGCTTTCCCGGTTATGAGGGCGACGGTTTTACTTGCAGAGATATAAACGAATGTGAAGACCCGGCTATAGCATCTCGTTGTGTTGAAAACGCGGAATGCTGTAATCTGCCAGCTCACTTTATCTGCAAATGCAACCGTGGCTTTGAAGGCGACGGCGAAGAAGAATGCAGAGATATCGATGAATGTCGTCGACCTGGTGCTTGTGGAACGCATGCAATTTGTCGTAATTATCCTGGAAACTACACGTGCTCATGTCAAGCCGGCTACACTGGGAATCCATTCGATGGTTGCGTTGATGTTGATGAATGCATCAATGAATCAACGTGTGGCGAAGTGGCCATTTGTCGCAACATAGACGGCGGCTACGAGTGCAGCTGTCCACCTGGCTACGAAGGCGATCCACGAGTCGCATGTCATGATCATGACGAGTGCGCTCGCGCTGCCTGCGGTCGCGGTGCTTTGTGTGAAAATCTTCCGGGAGCATACCGCTGCGTCTGCCCGCCAGGTTTTGATGGAAACCCCGATGTTCTCTGTTCCGACGTGGATGAATGTAAGAGTAGCGAGACTGTGTGCGGTGCACATGCTGTCTGCACGAACACGGCAGGCAGCTATGTGTGCACTTGCGCGCCTGAATACACCGGAGACGCATACGCGCAAGATGGTTGCCTGGACTTGGACGAATGTCAGACGCTAGAGAAGCCGTGTGGAACAAATGCTATTTGTGAAAACTCTGCGCCAGGCTACAATTGCGTCTGTCCTCAAGGATTCGCAGCACAACCAGACCCTCAAATTGCATGTGAACAGGTTGACGTCAATATTCTGTGCAAATCAAACTTTGATTGCACTAATAATGCCGAGTGTATTGATCATCAATGTTTCTGCAAGGAAGGCTTCAATGCCAAGGGCTCCATCTGCGAAGACGTTGATGAGTGTTCAAATAATAAATCAGTATGCGGTGAAAATGCTTTATGTATTAATATTCCCGGGGGCTACAATTGCCAATGTGCTGCGGGATTTGTTGGATCTCCGCCAAAGATTGGATGTCGTGCCCCTTGTGAAGATGTTAAATGTGGAAAACATGCTTATTGTAAGCCTGATGGAATGGAGGCGTATTGTGTTTGTGAAGATGGATGGACATTTAATCCCCATGATATAGCAGCTGGTTGTATTGATTTAGACGAATGCGACATATCACTGGGTCCAGTAGGCCGCTGTGGAAAAAATGCCATTTGCTCAAACACTCCTGGAAGTTTTTCATGTAATTGTCCCGAAGGATATACTGGTGATGCATACAAACAGTGTTCAGATATTGATGAATGTCAATTAGAAGGAGCATGTGGCTTAGGAGCCGATTGTTTGAATCGAGATGGATCTTATAGTTGCGAATGTCCCGACGGTACTATACCAGATCCAGACCCACACATACGATGCGCTGAAATTCTTGCTTGCAAAGGAGACAAGGACTGTCCTGGAAATGCAGTATGTGATTCTAATGCTAGGTGTTTGTGCCCCGAGCCCAATATCGGAAATGATTGCCGACATCCTTGTGAATCTCTGCAATGTGGCACTAATTCAGAGTGCTTATTAAGTGATCAAGAAGCCCAATGTACTTGCAAGAGTGGATTCACAGGTGATCCATCTTCACTACTAGGGTGTCAGGATATGAATGAGTGTGATGAAAAACCATGCGGCGTAGGTGCTGTCTGTAAAAATCTACCAGGACGTTTTCAATGTGAATGTCCTGCGACGTTCACTGGAAATCCATACGTTGAAGGATGTAATCCTGGTAAAATACTAAGCGAGTGTAGCAACTTAAATCCTTGTCCAGAAGGTGAACAATGTATTTTACATGATGGTGGAAATGTTTGTATTTGCCCTCAAGGATTCACACGTAATTCTGAAACTGGATTATGTGAAGATATTAACGAATGTGTTCAACACGGACGTTCTCCATGTGGTTTAAATGCTATTTGTAAAAATCTACCTGGAAGCTATGAATGTAAATGTCCTCAGGATTATAGTGGTAACCCATATAAAATTTGCGAGCTTTGTGATGACATTTCATGCCAGTGTCAACCACCATATAAAATGATAGACGGAAGCTGTGTTCTTTCTGGTTGCGGTAAAGATAATAAATGTGGTACAGGCGCAGAATGCATTGTAATTTCTGATGAAGTTAGTTATTGTGCATGTCCAGCCGGTTACACGCAGACCAGTGACAGTACTTGTGAAGACATTAATGAATGCACCTCAGGCACACCTGTATGTGGATTTGGGGCAGAATGTATAAATACCGTGGGCTCTTTTGAATGTAAATGTCCTCCCGGATATAGTAAAGACAAGATCGAAGGACACTGTTCATTAAACCAAAAACGATGCATTAGTGATTCCGATTGTTTCCCTAACGAAAAATGCGTTCAACCAGGTAAATGTATGTGCCCTCCGCCGTTTTATTTAGATGTCACAGATGGGCAAAAGTGCAAAAGTCCTTGCGAACGTTTTACTTGTGGTATTAACGCTAAATGCACTCCAAGTGATCCACCGCGTTGCATGTGTATGGCTGGTTATGAAGGCGATCCTTACACCGGTTGCACGAAAAGAAACGAATGTCACAGTTCTCCTTGCGCATACGGAGCTATTTGTCATGATCAAAAAGGGGGTTATAAATGCGATTGTCCACCGAATATGATCGGAGATCCATACAGGAGTGGATGCGTATTTGAAGAGGAACCAACACAAAAACATTTATGTAGCTCTGATGATCAATGCCCTAATACATTAGCATGCTTAAATCATACATGCATCTCACCATGTGCCACCATTTCTTGTGGACCAAATGCATTTTGTGAAGTTGAAAATCATGCAGCATGGTGTCGATGCGATCCAGGTTACACCAAACCTGAAGGTGGAAAATGTATTTCAGCATGTGACACATATAATTGTGCCCCAGGAGCTCAGTGTATTATTTCGAAAACGGGACCGACATGTGTTTGCGTTGAGGGCTTTGTAGGAAATCCGTTTCCTGGTGGTTCGTGCAGTAGAGACCAGTGTGGACCAGGGATTCCATGTGAAGATCCTTTGACCTGTGTGGCTGGACGTTGCAGACAACGATGTGAGGGAGTTCTTTGTGGTGTTGGCGCGACTTGTGACTCTCAAACCGGTAGATGTGTTTGTAATCCATTCTTCATTGGAAATCCGGATTTGTTGTGCATGCCACCTGTCTCTCCACCAGCTTGTGAACCCAATTGTGGAACCAATGCACATTGCGTATATGGAAAAGACAACATTTGCAAATGCAATAAAGGTTTCACAGGAAATCCGTATAAAAAGTGTTTATCACGTAAACAAATAACATGCGCCACAGCCTCCTGCGGTCGAAATGCTGTGTGTCAACAAACGAAATCTTCCATAGAATGTTTATGTCCACCAGGTTATGTAGGGAATCCTAATATTCAATGTAAAGATATAGATGAATGTGGTACAAATCCATGTGGTGAGAACGCACTTTGTATTAATACGCCAGGAAGTTTTAGTTGTATATGTAGGAGCAGATACGTCGGTAACCCATATGAATTGTGCTCACAAGTTTCAGTTGCAAAATGCACTGATGGCGCTGTGTGTACTTGTTCACATAATACTACATGCCCTCATGGATTTGTTTGTGACAAATCTAAGTGTGTTGATCTTTGCGAGAAACTTGCGTGCGGACCTAAATCTGTTTGCGAAGAAGGCGTATGTCACTGTTTACCAAGTCATACTGGAGATCCTAATGACCTACGAAAAGGCTGCGTACCCGATGATAGCTGCCTAGTTGACGGAGATTGCAAAGATTCGGAAATCTGTTTTCAAGTAGCAAAAAACACTCGCAAGTGTGTTGACTCATGTAGTAAATTACAATGTGGACCAAATTCACTTTGTATTGGTGCCAACCATCAAGCCCATTGCATTTGTGCAGATGGATACATTGGAAAACCCACAGACGTTAAGGTTGGCTGTCATTTAGAACAAAGAGAGCCAAATGAATTCGAATGTAATGACAATAGCGATTGCAATGAGCCTTTTGTTTGTATGTCACTAGAAGGATCTACGAAAAGATGCATAGACTTATGTACCACCATAGCTTGTAGTGCAAATGAAGTTTGCAGAGTAGTTGCGGAAAGCGCTCGTTGTGAGTGTGATAATGGTTTTCTATGGAATCCTGTTACCTCGAATTGCGAACAACCTTCAACGCCAAATTGTCAAGAAGATGATGATTGCGATGATAATAAATCGTGTAATAAAGATGTTCTAGGTGTCAAAAAATGTGAGGATAGCTGCTCTGTTTTCAATTGTCCTGAAAATTCTAAATGTGTAACAAAAAATCATAAAAGTAAATGTGAATGTATTAATGGATTTATCGGAAATCCTAATGATCGTGATGGCTGTTTAGCGATAGATAAAAACGAGTGCTCAGATGACGCACAGTGCAGAGAAAGCGAAGTGTGTAGGACCTTTGGTGGTAATAAAAAGTGTGTATCGGCATGTCAAAACGTCGTGTGTGGTCCTAATGCTTTTTGTATTACTAAAAATCATATTGCCAGATGCCAATGTCCGTCTGGACCATTTACTGGAAGTCCTGATGATTTAGAAAAAGGATGCCAATCTGTACCATGTGTACATAATGATGATTGCTTGTCGCACCAATTGTGTAACCGTATGACATACACATGCATCAATGCTTGTACTGTAAATTCTTGTGGTGATAATGCAGTGTGTATAGCAGAAAATCATAAAATTATTTGCCAATGTCCTAATGGTTACAGTCCCGATCCGAAGCCTGAAGTAAGCTGCCAAAAAGACGATGCTTGTAATTCAAATCCTTGTCACCCGTCAGCGATTTGCGAGTCCAGCTTCTCTTCCTTTAGTTGTCAGTGTCCTAATGGATATGTAGGTGATCCAATCAAAGACGGCTGTCGAAAACAAGATATTTGTCTCAGAGATGGTGACTGTCCCAGAGAAGCTGTCTGTGTTGAAAATCGCTGCGTCAATACTTGTGATGGAGCATGCGGGCTCAATTCATTATGTCAAATTATCAATAGAAAGGCCGTTTGTATGTGTCCAGAGGGATATGAAAAAATACAAGACAATGCATGTAAAAAGAAGTTGTTGGCATGCTCGAGTGAAAAAGATTGCGGCGGAGACATTTGTAACAATGGCCAATGTTTTACGGCTTGTAAAAACTCAAGCCAGTGTGAATTTGGAGATATATGCAAAAATAACCTTTGTGTTGCTCAATGTAATAAGCATACACAATGTGGACATGGCCAGGCATGCATTGGCGGACAGTGTTTAATTGGTTGCAGAAATAATGAAGATTGTTTTTCCGAAGAAGCATGTGTAAACAACAAGTGTGTGAATCCCTGTCTGACAACAAAACCATGTGGTCCAAACGCTATTTGTTCCAGAATAAACCACAGTACAAATTGTGAATGCCCTCTAGGTTTTCAAGGTGCACCGACACCTCAACAAGGCTGCGTCCGAAAACCAAGTGTCTGTGATAGAACATCTGATTGCCCACCGGATCATATGTGCATAGGGTTTTTGTGTCAAGTACCATGCAAAGACAGTACTGGTTGTGCTATTGGAGAAAAATGTAGTGACAATAAATGTTTAAGAATTTGTCATTCGAGTACTAATTGCTTACACGGGGAACATTGCGATGCGGGCGTATGTGTACCGGGATGTAAATCAGATTTAGATTGCCTGAACAATCTAGTGTGCAATAACATGAAATGTCAATGTACTGCTGGATTCGAACTACGGAACGAAGAATGTACTAATTTAAACGAATGTTTGGAATATCCATGTCATCCATCAGCTCAATGTGTTGATACTCCAGGATCTTATAAATGTGTCTGCTCAGTAGGAGCTGCTGGTGATCCTTACAGAAGCGGTTGTTTACTGCCTAATCAATGCAGAAATGATGAACAGTGTGACAATTCATTAGCTTGTATACAAGGAAAATGTTCAAATCCCTGTCAAAACAACACTTGCGGCACAAATGCAGAATGTTCTGTTATGAATCATAATGTAATGTGTGCTTGCAAAAAAGGATATCTCGGAAATCCATTTGACAAAAACATAGGATGCTTTAAGGTGGAATGCGTGGATGATTCAGACTGCAATACTGAAAAATATTGTGATTTAAAATTCAATAAATGTTCAGACGTATGCGAACCGTCAATCTGCGATGGTGGCAACTGCAAAATAGAGAATCATAAAATGCTGTGTACCTGTCCAACAGGATATTTGTTCAAAGATAAAAAATGCGTAGACTTAAATGAATGTCTTAGCAGCCCATGTCCGCTTAATTCGAAGTGTTTTAATACACTCGGATCTTACAAATGCGAATGTGTAAATGGAACAGTACAAGATACAATCACGGGCAGCTGTAAGCTTCCAGGAGATTGTGTTACCGATGACGATTGTACTCAAGTAACAAAATGCTTCAACAACCATTGTGTCAATCCTTGCGAAAAATTGTCACCTTGTGGCGAAAATGCTAATTGTTTTGTAACAAAACATAAAGCTGAGTGTGAGTGTCCGTCTGATAGTCAAGGTGATCCCTACAAGAAATGCATTAAGTTTGAATGCACAAAAGACAACCACTGCCCACAAGAGGAGGCGTGTGTTAATAACAAATGCAAAAATGCATGCAGTTTGCCAAGGGCATGTGGCCGGAATGCGGATTGTTTCTCCAAAAGTCACGTTGGGAACTGTATCTGCTCGCCTGGTTATACCGGGGATCCTGTTCTTGGCTGTGTTCCAATTCAATACTGTACCACTGATGACAGATGCTCTTCAGGAACAAAATGCGTGGATAATTTATGCGTTGGCCTGTGTAAAAACTCCAGAGACTGTTTGAACAACCAAGTTTGTATAAAAAATACATGTCGAGTAAGTTGCAGTCTCAACGATACTTGTCCAGAATTTCAATATTGTTTAAATAGTATATGTACCAAAGAAGTTCAGTGCATATCTAACGATGATTGTCTGGATGACGAAAAGTGTTCGACGGGGAAAAATGGAATACCTCAATGTATTAAAGTTTGCGATAAACATCCATGCGGCCGACAGGCTGAATGTCTTGGAAAAAATCATCAACCAACTTGTTCTTGCGCTTTAGGATTCTTCGGTGATCCGTTGGAAGGATGCCAACGAAAAGAATGCGACACGGACACAGAATGCTCTGAAGATAAAGTATGTGATCGTAACATGTGTAAAATAGCCTGTCTAGTTAAAAACGAATGCCGCGAAAATTCTATTTGTTCATCAGAGAAGCATAAAAATGTATGCTATTGTCAACCTGGCTATACCGGTGATCCAATAAAAGGATGTACTGAAATAAATTGGTGTAAATTAAGCCCTTGTGCAAATGGAGCGGAATGTAAAAGTGCGCGAGACCGGGCAGAATGTACATGTCCAGCAAATACTGTGGGAAATCCGTACGAAGAAGGATGTCGGAAGGCTGAAGAGTGTAGGTTTAACCGAGATTGTCCAACTGCTGCACGTTGTACCGTTATCGATGGTACAAGGAAGTGTACAGATGCCTGTGAAAATGTAAAATGTGGATTAAATGCAGAATGTTTCGCTTCGAGACATAGCGCTCAGTGCAGATGTAAAACTGGATTCATAGGAAACGCTAATAGTGAGAAAGGATGTCACCTACGTGAAATATCGTGTACTTCTAAATCGAACTGTCCCGATGATCAGTATTGCCACAAGGGAATTTGCAAAGCTTTATGCCTCCTGGACGAAGAATGTGCATCCAACGAGAAATGCTTCGGCGGACAGTGCCTTAATCCATGTCAGTTAGAAAAAACTTGTGGCTTAAATGCTATATGTCGGACTGATAACCACATTGTTCAATGCAGCTGTCCTCAAAGTTTTACAGGAAATCAAGACATGGAATGCATTCGAATTCCGAGATTGTGCGGTTCAGCTGGTGATTGTGAAAATGGCCACATGTGCAAAGATTCCATGTGCATTCCTCGATGTAATATCGATGAAGAATGTGCTTTGAACGAAAGGTGCACGAAAGGTGGATGTTTATTGACTTGTCGGGTTGATAATGATTGTTTCCCAGGACACATTTGTCTAGAACAAAGTTGTCAATATGGCTGTAGATACGACGATGATTGTGGGCCTGAAGAATTTTGCAAGAATGATGTTTGCAAAAATCCTTGTGATAGTGATGTGAATCCTTGTGGACCAAATGCTGTATGTTCAGTCTTGGAGAGAATAGCACATTGTTCGTGTATTGAGGGCTTGATACCGAATCCAACGCCAAATATTGGTTGTATCCGTGCTCCGTCATCAGAATGTCGTCAAAACACTGATTGTACAGATGGATGGACATGTGAGGACAGCCGATGCAGACCTGCATGCACAGCCGATGGCTCACAATGCTTGCAAGGAGAAAGGTGCGACGAAGGTGTCTGTCGTTATGCGTGTACCTCAGATGAACATTGTTCCGATGATGAAATATGTGACGGACGCTCATGCACCATAGGGTGCAGGTCGAATTCACATTGTTCAAGTAAATTAGCTTGTATATCAGGACAGTGTCGGGACCCATGCACCGAACCGGCAAGTTGTGGAATTAATGCGATCTGTGCCACGAAAGATCATCAACCTGTTTGTACATGTCCACGAAAGTTAGCAGGTGACCCTAAGTTAGTGTGCTCGCGAGTCACCACTTCTTGTGGTTCTAACCAAAACTGTCCAGATGGTTTTAGTTGTTATGGAGATACATGCCATCCGTCCTGCAGGAGCGATAATGTCTGTTTGTCTAACGAAAAATGTATACGAGGTATCTGCAGAACAATTTGTAATAGTGACACTGCCTGTAGTGAGGGTTACATTTGCGAGAATCGGATTTGTAAGCAGGGCTGTCGCGATGATAATGCTTGCGAAGAAACACATGCATGTGTCAAAGGACAATGCAAAGATCCATGTAGTCAAGGTGCATGTGGAATTTGTTCGGAATGTAAAGTTCAGAATCATCGTCCTCAGTGCAGCTGTGCCAGCAACTATACAGGCAACCCCCTTGTAGAGTGCCGAAGGAAAAAGACTTTGTGTGATGGTTTTTGTCCGTGCGATCAGAGTGGTTATTGTATTTCGTTATGCGATGAGAACTCGGACTGCCCTTGCGGTGATAAATGTATCGAAGGAGGATGCCTGACTCGATGCTCTCCTAGAAATAAATGTCCAGAGAGACAAATTTGTCAGCAAGGCGTTTGTACTCCTGGTTGTAACAACGACAAAGATTGCAGCGATGATATGTTTTGTTCTTCAAATTTATGCGTGAATGCATGCCAAGAGGAGTCTTGCGGCATAAATGCTCTTTGCCTTACTACAAGACATCGTGCTGTCTGCAGCTGTCCAAGTGGATATTCCGGTGATCCTTTAAAAGAATGTAATCAATTCGAATGCCAGAATAACGAAGACTGTGGCACCGATGAGGAGTGTTATACCGACGGCAAATGTAAAAATGTGTGTTCGGGGGCTTGTGGGCTCAATGCTTTATGTCGTTCAGTCGACCGATCACCTCAGTGTTCATGTCCACCTAATTATCAAGGTAACCCACAAATTGAGTGTACTAAACCAACAACAGGCAGTTGTCTACGTAATCCGTGCGGCGTAAATGCAAGATGTCGCGACCTGGACGACGGTAGTTATGAATGTACATGTCCACCGAATTGTGCTGGAAATCCACAGAGACAGTGTTTTTGTGGCAAAATGGAGCCGTGTGCATACAAACCGTGCGGTACTAATGCGCAATGTCGAGTGAATCGTATCGGCGAAGCACAATGCTATTGTCCCCGTAACTATCCAAATGGAGATCCCAATATTGAATGTGCCCAAGAACGCAGTGTGATTGATTGTCGAACTACGGGCTGTGGTATTAATGGTGAATGTTTAAGGGAAGGTGCGGAATTTGTGTGTCGCTGCGTACCTGGAACCGAAGGTCAAGCCGATATCGAATGTCATACTAGTATCGAATGCACGAGTGACGTGGAATGCCCTGTCGATAAAGTGTGTCTGAGCTTACACTGTGTGGACCCGTGCACGCTGCGAGGCGCCTGTGGGGAAGATGCTCTTTGTGCACCACTGATGCACATGGCTCAATGCTCGTGTCCGCAATGTTATGTCGGCCAGCCAAGGATCTCTTGTAGACTCGATCCCAACTGCAAACCGACAACAGACTACAACTCAACATTCAGTTGTTCCGAAGATAAACCTTGTCCACCAAAACTAGCCTGTGATCTCAACAGTAATCAATGCCGAAATCCTTGTCTCGGTTATCAAAATTGTAAGCTAAATCAAAAATGTGAAGTAAGAGATCATAAGCCCGTATGTGTATGTCGTAATGGATTCGCCCTAAATGAAAAAGGTGAGCTAACATGTGCCCCAGAGCACGCAGAATGTACAAGAGATGACCAATGTCCATCAAATGCGGCCTGCCGTGATTACAAATGTGTGAATCCTTGTTTGACATCAAAAGAACCAATTTGTCCAAAAGGGAAACAGTGCGAAGTACTTGATCATCGTGCCATGTGTTTATGTGTACAAGACTGTAATCCATCCGTATCGATATGTCGGACAGACAAAGGGTGTCCAAACAATTTAGCTTGCAGAGATTATCAATGCAAGGATCCATGTAATGGTGCTTGCGGAGGTGCTCCGTGCACTGTAGAAGACCACCACCCTGTATGCAAGTTCTGTCCACATGGGTTCACACATGACGAAAAACATGGCTGTATCAAAGCTGTAGAATGCAGCGATCACGAGCAGTGTCCCAGCAATATGGCGTGCATGGCTGATCGTTGCGCCGACCCTTGTTCTCAAGGTGGACCTTGCACTCCCGGGCAGTCTTGCACTGTTTTAAATCATCAGCCAGTATGTTCTAAAGTTTGTCAGTGTCAAACCTCATCGGATTGTGTCAGCTATTCAAATTCTGTCTGCGACGGCTGTAATTGTGTTCTGGGCGATAAACCAAAGACGAACTGCGCTCATTGCAGACCAGGTGTTCCTTGCGATCCCTTCTCTGGAGCTTGTATGGAAAATGATCAACCTAAAAATGTCCCACTAACTGATGTCACAAGTACTACAACGAGCGAAGACACCGAAACCTCTACAAAAGATGATTCTTTAAATTATCTTACGTACTCGACTAATATTGACGACGAACAAATTGATACGACATCATCCGACTTAAAACTGTCTACGGACTATCACAATATTATTACTGAAAAACCATCTACATTACATATTGACGATATAGCAACCAAAAGTACACTCGCCGATGATTTATCTACAACGGATTCGTTTGATGAAACTTATCTCACAAAAAGTATAACACGGTCAGGATTAAACGCTACGGCTGATACTAACATTTCCTTATTCAATTACACATCCACAAAGTTCCATACTACTGATAGTTTGTTAACTGACATCTACGATTTTCAAAATGTTACCGAAGCTGATCAAAAGAGCTACGCAACAATACCAATAAATACCGAAAAAATATACGACAGTGAAAAACCTGCGTTTACTACACAAAAATATATAGACACTACAATTAATGAGAAAACAACAATATTCTCCTCTTTAGTTAAAGAGCCAATTAGTAAACCACTTTATTTAGATAAAAGTGATGAACCTGTACAGAGTAGCAGTACAATTCATGAAGAAAGTACCCTTAAACCCAACGTTAAACAGACAACACAAGTTGCTGAAAAACCAATATCAATTGAAAATAAGAACACTAAAACTCCTGAAAATCAAAGAAAACTGAATGGTAATTACACAAACATTGCCGATGGATACGGTCCTGTATCACACTCGGTTAATGAGAAATCAGCAACGAAAATGACAACTCCACTACCAAAAACTAAGCCAACAAATCCATCGGAAATACCATTAACGGCTTCTGAAATTACGATCAATTATTATACAACAGAAGGTAGCAGCGTTGAGAGTACTCTTAGTGAAGAAATTACGTTGACAAATCAAGACACTGCAGCTACAAGTATGAAAACATTAACTTCAGGTATAGAAATGGATACAGGTGTCAATGCGGAAGAGAATAATAAAAGTACTAATTTTTATACTAGCACAATACAATATAGTACTCAAAATGACATGTCTGATAGCCATGAAACTGTTTCAACTGACTTTAAAGTTGCTACCACAACATCACCTACAGTTCACATCATTGACAATCAATCAGATCAGATCAATTATTCAGAAAAAAATGCCTATCAGACAACAAAAAACGCACCTAGCTTAAACCCAACTACAACAAACTATTATCATACTGTCATTACAATGGAAGAAAAATGGGATAGTTCGGAAAATGATTTAATTGAAACTACTACAGAAGCTCAGCTTAAACAAACAAATTATGAATTTAAATTAACAGACACAAATGACTTAAACAAACAAAACGATACTACAACAATACCTACCGGAGGTATAGTAGAATTTTTAACACATAAAGCAACAAAATCAGATGATACTATTGTTACTATTTCAACTGAACCCTATACAATATTCAATTCTAATGAAGAAACAACACATAAACCTGTTCAACCACTAAACAAACAGAAACCCACTCAATTTATAAAATATGAGACGACTACTGAATTTACGCAATCATCAAATGATGATATCAAACAGCTTTCTGAATATCCTAAAGAACAGTTTAATATTTTAAATGAAAGAATAACTACTGGTAGTTCACTGGCTTCTCAAACAGACGCCGAAGGTGTTGAGATTACTTCTTCACTAACGACAATGTCGAAATCAACAATATCAACTCTTGATATACATGAAACAATACCCAATTTAGGTCTATCTACACAATCTGGAAGCTATGAATTCACTTCATCAATACCACAAGTTTTCTCGACAACGAACTCTGACGTCATTTTAGATCAGGATAATTTATTTTTACACCCCAATATAGCCACAATCAACTATAAGGCGACTGATAAAAATGATAATCAAGAGACGACCTCACAATACAATGACAACGAAAACGAATTTCCTCTAACCTCTACGGTTACATATGACAATACTGGAAAATCAGAACCGGCAGAATCACAACATATGCACAGTTCGGATATTAATAAAGTCACGAATGGCAATGAAAATAATTTACTTTCAACCACCTATAGAGATGTCACTACGTCACAGTATGACAGCGAAACTGAGGATTCCAATTCAGAGTCACAAAGTATGCAGAGTGCAACCACTGACCAACCCATTAACATACAAACAAATGAAAATGAAAATAAATTACCATCAACCACATCTATCACTACGTCACATTATGACAGTGAAACTGAGGATTCCAATTCAAAATCACAAAGTACGCAGAGTGCAACCACTGACCAACTCACTAGCGTACAAATGAATGACAACGACAATAAATTACCATCAACCGTCTCTGTCACTACGTCACGTTATGACGGCGAAACTGAGAATTCCGTTTCAGAGTCACAAAGTGGGCAAAGTACAAACGTTAACCGAGCCACCAGCATGTATGCCAATGACAATGAAAATAATTTACCATCAACCACCTCTATCACTAGGTCACATTATGACAGCGAAACTGAGGATTCCAACTCAGAGTTACAAATAACACAAAGTACAACTACTACCCAAGCCACTAGCATACAACCTAATGACAATGAAAATAAATTACCATCAACCACTTTTATCACTACATCACATGATGACAGTGAAACTGAGGATTCTGATTCAGAATCACAAACAACACACAGCAGAACCACTAACCAAGCCACTAGCATGTATGCCAATGACAATGAAAACAAGTTACCATCAACCGCCTCTGTCACTACGGTACATTATGGCACTGAAACGGAGGATTATAATTCAGAATCACAAACTACGCAGAGTACAATCACTAACCAAGCCACTGGCATACAAACTAATGATAATGTAAACAAATTACCATCAACCGCTTATGGTACTACGTCACATTATGACAGTGAAACTGAGGATTCTATTTCAGAATCACAAAGTACTCAAAGTACAATCACTAACCAAGCCTCTAGCATTTATGCTAATGACAATAAAAATAAATTACCATCAACCGCCTCTGTCACTAAATCACATTATGATAGTGAAACCGAGGATTCTGATTCAGAATCACAAACAACGCACAGGAGAACCACTAACCAAGCCACTAGAATGTATGCCAATGACAATGAAAACAAATTACCATCAACCGCCTCTCCTACTACGTCATATTATGACACTGAAACGCAGGATTATAATTCGGAATCACAAAGTACACACAACGTAACCACTGATCAAGCCACTAGCATATATGCTAATGAAAACGAAAACAAGTTACCATCAACTGCCTCTATCGCTACGTCACACTATGACAGTGAAACTGAGGATTTCAATTTAGAATCACAAACTCCGCAAAGTACAATCACTAAACAAGCCACTAACACATATGCTAATGACAATGAAAATAAATTACCATCAACCGCCTCTGTCACTACATCACATTATGACAGTGAAACCGAGGAGTCTGATTCAGAATCACAAACAACGCACAGCAGAACCACTAACCAAGCCACTAGCATGTATGCCAATGACAATGAAAACAAATTACCATCAACCGCCTCTCCTACTACGTCACATTATGACACTGAAACGCAGGATTATAATTCGGAATCACAAAGTACACACAGCGTAACCACTGATCAAGCCACTAGCATATATGCTAATGAAAACGAAAACAAATTACCATCAACTGCCTCTATCGCTACGTCCCATTATGAAAGTGAAACTGAGGATTCCAATTTAGAATCACAAACTCCGCAAAGTACAATCACTAACCAAGCCACTAACACATATGCTAATGACAATGAAAATAATTTAACATCAACCGCCTCTGTCAATACGTCACATTATGACAGTGAAACTGACGATTCCAATTCAGAATCAAAAAGTACGCAACGTACAATCACTAATCAAGTGACTAGTATATATGCCAATGACAATGAAAACAAATTACCATCAACCGCCTCTGTCACTACGGTACATTATGACACTGAAACGCAAGACTATAATTCAGAATCACAAACTACGCAGAGTACAATCACTAACCAAGCCACTAGCATACAAACTAATGACAATGAAAACAAATTACCATCAACCGCCTCTGTCACTACGGTACATTATGACACTGAAACGCAGGATTATAATTCGAAATCACAAACTACGCAGAGTACAATCACTAACCAAGCCACTAGCATATATGCTAATGACAATGAAAATAATTTACCATCAACCGCCTTTGTCACTGCGTCACATTATGATAGTGAAACTGAGGATTCCAATTCAGAATCACAAACTACGCAACGTACAATCTCTAACCAAGTCACTAACATACATGCTAATGACAATGAAAACATATTAGCATCAACCGCTTCTGGTACTACGTCACATTATAACAGTGAAACTGAGGATTCTATTTCAGAATCACAAACTACGCAGAGTACAATCGCTAACCAAGCCACAAGCATACAAACTAATGACAATGAAAACAAATTACCATCAACCGCCTCTGTCACTACGGTACATTATGACACTGAAACGCAGGATTATAATTCGAAATCACAAACTACGCAGAGTACAATCACTAACCAAGCCACTAGCATATATGCTAATGACAATGAAAATAATTTACCATCAACCGCCTTTGTCACTGCGTCACATTATGATAGTGAAACTGAGGATTCCAATTCAGAATCACAAACTACGCAACGTACAATCTCTAACCAAGTCACTAACATACATGCTAATGACAATGAAAACATATTAGCATCAACCGCTTCTGGTACTACGTCACATTATAACAGTGAAACTGAGGATTCTATTTCAGAATCAAAAAGTACTCAAAGTACAATCACTAACCAAGCCACTAGCACTTATGCTAATGACAATGAAAATAAATTACTATCAACTGCCTCTGTCACTGCGTCACATTATGACAGTGAAACTGACGATTCTAATTCAGAATCACAAAGTACTCAAAGTAGAAACATTAACCGAGCCACTACCATATATGCTAATGAAAATGAAAATAATTTACCATCAACCGCCTTTGTCACTGCGTCACATTATGACAGTGAAACTGAGGATTCCATTTCAGAATCACAAACTCCGCAAAGTACAATCACTAACCAAGCCACTAGTGTACAAACTAATGACAATGAAAACATATTACCATCAACCGCCTCTGTCACTACGGTACATTATGACACTGAAACGCAAGACTATAATTCAGAATCAAAAAGTACTCAAAGTACAATCACTAACCAAGCCACTAGCATACAAACTAATGACAATGAAAACAAATTACCATCAACCGCCTCTGTCACTACGGTACATTATGACACTGAAACGCAAGACTATAATTCAGAATCACAAAGTACTCAAAGTACAATCACTAACCAAGCCACTAGCATATATGCTAATGACAATGAAAATAATTTACCATCAACCGCCTTTGTCACTGCGTCACATTATGACAGTGAAACTGAGGATTCCAATTCAGAATCACAAACTCCGCAAAGTACAATCACTAACCAAGCCACTAGCGTACAAACTAATGACAATGAAAACATATTACCATCAACCGCCTCTGTCACTACGGTACATTATGACACTGAAACGCAAGACTATAATTCAGAATCACAAAGTACTCAAAGTACAATCACTAACCAAGCCACTAGCATACAAACTAATGACAATGAAAACAAATTACCATCAACCGCCTCTGTCACCACGGTACATTATGACAGTGAAACTGACGATTCTAATTCAGAATCACAAACTCCGCAAAGTACAATCACTAACCAAGCCACTAGCATATATGCTAATGACAATGAAAATAATTTACCATCAACCGCCTTTGTCACTGCGTCACATTATGATAGTGAAACTGAGGATTCCAATTCAGAATCACAAACTACGCAACGTACAATCTCTAACCAAGTCACTAACATACATGCTAATGACAATGAAAACATATTACCATCAGCCGCCTCTGTCACTACGGTACATTATGACACTGAATCGCAAAATTCTAATTCAGAATCACAAACTACGCAAGTTACAATCACTAAACAAGCCACTAGCATACAAACTAATGACAATGAAAACAAATTACCATCAACCGCCTCTATCACTGCGTCATATTATGACAATGAAACTGAGAATTCCAATTTAGAATCACAAACTCCGCAAAATACAATCACTAACCAAGCCACTAGCACATATGCTAATGACAATGAAAACAAATTACCATCAACCGCATCTGTCACTACGGTACCTTATAACAATGAATCTGATGAGTTTAAAACAGGATCACAAAGTATCCATAGTACAGCTGCGAATCAACATTCAAGCATACAAACTAATGAAACTAGAATACCATTGACCACCCCGATCGTTGAGTCGTACCACAACACCGAAATTAAAGGTTCCCAAAGAGAATCACATAATACACAAAGTACTGATACAACGTATACAGAATCATATGACAGTAAATATGAATTGCCATTGACTACTGCTTTCACCACGTTATATTATAACAGCGAATCTGACCTTTCCCGGACAGAGTCTTTAGCTACGCAAAGAATAGCTACTGGAAAAGACACAAATATAGAATCTAATCAGGATCATTATCAGACAACAGTTGATGCTACAGAATCATTATCAACAGAAAACGTTGTTGATTCATTCACATCTACTGCAGTAACAAATTTAGCCACTTTGATCGACGAAAACGTTAACAAGTTTTCGGAGAGTCAACATTCTACAACTATATTAACAGCACAAGATGAAACCACCTTTAAACCGTATTCTGAAGTCGATTTCACTACAGTGTTTCATAATATTAAGACAGTTGAAAATGACTTTAATGCAGATAAAGATGATGATTATTTAACACAGGAAATATCTACTACAACAGAACCGTCAACGATTGATTACCTGAACAACCCATGTGATTTGCCTGAGATGAAGTGTGCCCAGAATACTTCCTGTAAAGTTGTCAACCACGCTGCTGTTTGTGTTTGTGACTCAGCTGGAAACAACTGTGTAAGAGAATCATCTGGAACGCCAAAAGTACCAGAGCCGTGTCATTCCGATCGAGATTGTATAGAAATTGAAGCCTGTTTTATGGGACTATGTCAAGATCCATGTGAGTTTGATAATGTTTGTGGAATACAAGCAAACTGCCAGCGCGTAAAACACAGGCCTATGTGTTCCTGCCCTGCGGGCTACGATGGAGACCCTGCAATTAAATGTTCACCTAAAATATTTGGATGCACGCGAAACGACGACTGTCAATCTACAGAGGCTTGTATAAATAATGCATGTCAACACCCTTGTGCCATACACAACCCATGCGCACCTAATGCTGTATGTATAAACACAAACCATGGATCTGACTGTAGCTGTGTGGAAGGTTTTCAAGGCAACGGATACGTTGGTTGTGTACCAGTTGTGGAATCTACATCAGTATGTCAATATAACGAGGATTGTCCACCTGAATTACTATGCGATAGATTAAATAGAAAATGCATTAATCCTTGTGCAATTAACAAATGTGGAGATAATGCTGAATGTTTACCTTCAAATCATGGTATACAATGTAAATGTGCCCCTGGTTTTACTGGTAATGCCTTCCTGGAATGCTATCAAGTTCAAGGCTGTCGTTCAGATAACGAGTGTGCCAATTCTGAAGCGTGTATAAATGGTAAATGTGGTTCTCCATGCCGTTGTGGTATAAACGCTGTCTGTGATGTAATTAACCATCGAGCATCTTGTAAATGTCTACAAGGATATACCGGTAATCCACAAATTGGTTGTGAACCACCAACAAATCCATGTAGTCCGAACCCTTGTGGAATAAATGCATTATGTGAAATCGACAACGGAAATCCAATTTGTTACTGTCCGAAAGGCTTAACCGGAAATCCTTTCAAGAATTGCATCCCAGAAGGAAACGAATGTGAACCAAATCCATGTGGACCAAACTCAGGATGTCGACTAATAGATGATAAACCAGCCTGTTTCTGTCTACCAAATTACGAAGGGAGTCCGCCAAGAATGCCATGCAAATTACCAAACAATCCCTGTAATCCATCACCTTGCGGTCCTAACACTCAATGTACAGTACTGTCTAATGGATTTTCAAAGTGTTCTTGTTTACCTGGTTATGTCGAAAGCCCGAATACTGTTCGTGGATGTATTGAAGCACGAAACCCTTGCGAACCGAGTCCCTGCGGAGTCGGCGCTCGATGTGATCCAAACAAAACTCCATCTTGTTTCTGTCCAGAAAATACTGTTGGAAATCCATACAAATCATGCGACAGTAACCGTGGATATCTTCCACCAGTTGCGAATGTTCTCTGTCAGCCAGGACCATGTGGACCAAATGCGGATTGTTTTGTTAGTAGCAATAGAGAAGTGTGCTATTGCAAAACTGGTTTTAGTGGTGACCCATATCTGGGTTGCCAAAATCAAATAAGTCCTTGTGCTCCCAACGCTTGTGGACCACGAGCAATCTGTCAAGTAAAGTTTGATGGACAAGCCTTCTGTGTGTGTCCTGAAGGAAGTGTGGGTGATGCTTACAGCATTGAAGGCTGTATTTTACGGGAATGTGAGGTCGATGATGGCTGTCCCACAAATAAAGCATGTATTGGATATAGTTGCCAAGATCCCTGTCCTGGAGTATGTGGGTTGAATACCAAATGTCACGTAGAGGCTCATCGACCAGTATGTTTCTGTGAAGAAGGTTTCATCGGAAATCCATTAATATGTTGTCTTCCACCCGAAGATCAGAAATCAATATCACCATGTAACAAAATACAATGTGGTATTAACGCAATCTGTCAAGAAGTCGGAGATAGAGCCGTTTGCTCTTGTCCACTTGATTTCATTGGTGATCCAACAATAGAATGTAAGCCTGAATGTATGATGAACTCCGATTGTTCCTCGAACGAAGCTTGCATTAACAAAAAATGTATTGATCCTTGTGCATCTGCCAACATCTGTGGAATAAATGCTGTTTGCCTATGTTCAGATCATACTGTTTCTTGTCTGTGTCCCGATGGTTATATAGGAGATCCGTTAACTCAATGTATATACAAACCTATAATAATTGTACCAGATAATTCTACAGCGCAGCCTTGTTCACCAAATCCATGCGATCAAAATGCGCCTTGTGATACTTATGGTAACCAGTTTGCAATTTGCGACGCATGTGTTGGACTGAATTCTTTAAATAACCCATCGTGTAGACCGGAGTGCGTTTTGAATTCGGATTGTAGTTTTGATAAATCTTGCTTAAGAAACAAGTGCTTGAATCCTTGCCCTGGTTCTTGTGGTATAAATGCAGAGTGCACAGTTTATAATCACGATCCAGTTTGCCAGTGCGTTAATGGTTTCGAAGGGAATCCATACGAACATTGTAAACCAAGTGTCCGGCCTATCACACATGAAACTTGCAACAATGTGCAATGCGGTGCAAATGCAATTTGTAGAGACTTCAATGGTGCTTTAGCTTGCCATTGTCTGCCCGACTTTTATGGAAATCCTTATATTTCGTGCCGACCGCAATGTGTTGTTAACAGCGACTGTTCACCGGAATTGGCTTGTTTCCACAATAAATGCGAAGACCCTTGTACAAATGTGTGTGGCATAGGAGCTTTGTGTAAAACAGTCAATCATCATGCCGTGTGCTATTGTGAATCTGGACAAATTGGAGATCCTTATGTTAGATGCCAAAACGCACCAGCGTTGCCTCCTTCTTTATCTGTATGTGATCCATCTCCTTGTGGGCCTTACAGTCGTTGTCTTGTTTCATCTAACGGTTTTGCAATGTGTTCCTGTTTACCAGGACATAAAGGGATAGCCCCTATGTGTCAACCAGAATGTGTCAGTAATGCAGATTGTCAACAGATGGAAACATGTGTTAATCAACGATGCATAAACCCTTGCCTCGGTAGTTGTGGTGTTAACGCTGACTGTGTTGTTGTTAATCACAACCCAATATGTACCTGTAGTCGAGGAAAATCTGGTGACCCCTTTGTAGCCTGTACTGATATAACAGAAGTGGTGCCTTCCGAAAGAAATCCATGTGTACCTTCTCCATGTGGGCCGAACTCCGTTTGTGAAATTAAGTCGAATCACCCAGTATGTTCATGTCGACCTAACTACTCTGGTACTCCACCGTACTGTAGACCTGAGTGTGTCATAAGTCAAGAATGTCCTTCTAACAAAGCTTGCATCAATGAAAAATGTTTAGACCCATGTACAGGGGCTTGTGGTAATAATGCCAAATGTGTTGTAATTAATCACACGCCGTTATGTAGCTGTTTAGATGGATATAAAGGCGATGCATTCGTAGGATGCAATGCAATTTCAAACGACGATACCGAGACTCTTTGTAATCCTTCACCATGCGGAGAGAACACAATCTGCAATGTAATAAACAATATTGCGCGCTGCTCATGTATTCCGCCCAACATAGGAAACCCGTATGCGGGGGGATGTCGACCAGAGTGTTCATTAAACTCAGATTGTCCGAATCATTTGGCTTGTCTGTCAAACCACTGCAGGGATCCATGTAAGGATCTATGTGGTGTTAATGCGGAATGTATAGTGACTAATCATGTACCTGTATGTACATGCTTTAGAGGTCACGAAGGAGACCCTTTTATTGCATGCAATCGTCAAGAACAAAAACCACGAAATCCAGAGAGTCCTTGTGAGCCTTCTCCGTGCGGAGCGAACAGTGACTGCCATATAGTGAGCGGTCGAGCGGCATGTTCTTGTCGTCCGGGCTACTTGGGCGCGCCACCAGCGTGTCGTCCTGAGTGTGCGGTCAACTCAGATTGTCCTGCTACTAGAGCGTGTATTAATCACAAATGCAAAGATCCATGCATAAATAGTTGCGGTATTGACGCTCGTTGCCATGTTGTTGGACACAATCCTATTTGTACGTGTCCCGAAAATCTCTCGGAAGGTGATCCATTCATTAAGTGCACCAGAAAAACCATTATGCCGACACATACTGATCCGTGCTTAATGTCACCGTGTGGACCTTACGCAACATGTAGAAATGAAGATGGACGTGCCATATGCGCATGTGAACCTGGAACTCTTGGAGCACCACCATCTTGCCGGCCACAATGTGTTATTAACCAAGATTGTCCTTTAGCGCTGGCTTGCCTCGGCGGTAATTGTGTAAATCCGTGCATTGGTTCATGCGGATTTAATGCCCGATGTTCTGTGCAAAATCATCGTCCAGTGTGTTCATGCGACGACGGATTCTCTGGTGACCCATTCGCTGGATGCAACCCAATTGAAATTTCTAAAGAAGCACCTCGTCAACCTTGTCATCCTTCACCTTGCGGTGCTAATGCGATATGTCGAGAAAAGGATGGTGCTGGTTCTTGTACATGCTTAGATGATTTTTACGGTGACCCATATAGTGGTTGTCGCCCTGAGTGCCTTATGAATACAGACTGTGCTAGGGAAAAATCTTGTTTTAATAACAGATGTATAGACCCTTGTTCTGGGACTTGTGGACAAAACACTCAATGTAGAGTTGTAAATCATGCTCCTTCATGTTACTGCTTATCTGGATTTACGGGAAATCCTCTTCACGCATGTGTTCCTGTTAAACCTTTTCCGGATAATCTGGATCCTTGTCACCCTTCGCCCTGTGGACCATATAGTAAATGCCGAATATCAAACGGTCATGCTGTATGCACATGTCTTGACATGTGTATCGGTTCTCCGCCTAATTGTCATCCGGAATGTATTGTTAGTTCTGATTGCCGCTCAGATAAAGCTTGTATAAATCAGAAATGTCAGGACCCTTGTTCTGGCATTTGTGGCATTAACGCGAAATGCCAAGTGGTGAATCACAATCCAATTTGCAGTTGCTTAAGTGATTATACTGGCGATCCGTTTGTCCGGTGTTATATTGATGACCGCCAAATGACGCCGATAAATAATTGTGTTCCAAGCCCTTGTGGTCCAAATTCACAATGTAAGGAAGTAGACGGAGTAGCAGTTTGCTCATGCATTGAAAATTATGTGGGTCGTCCCCCTAATTGTAGACCAGAATGCGTCATGAATGTTGAGTGCTCGGGGAATTTAGCATGTATAGCGGAAAGATGCAGCGATCCTTGTCCTGGTTCTTGTGGGTTCCATGCGATTTGTACTGTTGTGAATCATGTGCCGACGTGTACTTGTGATCATGGGTACACAGGTGACCCCTTCTCTGGATGTTCATCTATTCCTTCAATAGAACCTCAACCACAAAGTCTTTGTTCTCGTTCGCCGTGTGGAGCTAACGCAATATGTAAGGAAAGGAACGGAGTTGGATCATGTTCATGTTTACCTGATTATTACGGAGACCCATATATTGAATGTCGCCCTGAGTGTGTTTTGAACTCAGACTGTACTAAAGACAAGGCTTGTATTAACAACAAGTGTAAAGATCCATGCCCTGGTGTTTGTGGTATGAACGCCGAATGTCGCGTAAATAATCACGCGCCTTCATGTGCATGTCTACCTGGGTACGAAGGAAACCCATTTTCTTCATGTTACATAAGTACCTTCGAAGATCCAGTAAATCCTTGTGTACCGTCACCTTGTGGTCCTTACAGTTTATGTCGTGAAAATAACGGACACGCAATATGCTCTTGTCAGGAACATTACTTTGGTTCACCGCCTTTTTGCCGCCCCGAATGTATGGTCAGCAGCGATTGTATGCCAAATAAAGCTTGCATTAATAAAAAATGCGTGGATCCATGCTCAGGTGCATGTGGCAACAACGCTAAATGTACAGTCGTAAATCATAATCCGTTATGTAGCTGCCCAAAAGATTATACAGGCGATCCGTTTGTACACTGTTCTTATGAAACAAGACCAGAACCAAAACCGTCAGGAAATCCGTGTATTCCTTCCCCTTGCGGACCTCACTCGCAATGTCGTGTAATAGGAGAGACGGCCGCTTGTTCTTGCCAACTCGGATTTATTGGTCGTGCTCCTAACTGTCGGCCTGAATGTATATTCGATGAAGAATGTCCTAGTAATCTAGCGTGTATCCGAGAAAAGTGTGCTAACCCTTGCGAAGGTTCATGTGGGTCAAACACTAATTGTGTTGTCATCAACCATAAAGCAGTCTGTCATTGTCGTGAGAGCTATACTGGCGATCCTTTCAGTGGATGTTACTTTATAGTAACCGTACCGAGTGAAGAAGAAACAAATCCATGTAATCCGTCACCATGTGGTCCAAACGCTCTATGTAAAGAACGAAATTCTGCTGGATCATGTACTTGTATACCTGATTACTTTGGAGATCCGTACTTAGGATGTAGACCCGAATGTGTCACAAATAACGACTGCACCTTCGACAAAGCCTGTTCGAATAACAAGTGCGTAGACCCGTGTCAAGGAGCTTGTGGCATAAACTCGCAATGTACAGTAGCACACCATAATCCAGTTTGTCTTTGCGTAGATGGTTATGAAGGCAATCCTGCGGTATCTTGTCATCCACAGCGTAAACCTCCACTTGCGGATACAAATCCTTGCATACCTTCGCCTTGTGGACCTTATAGTCATTGTAAAGTGGTCGATGACCACGGAGTGTGTTCATGCCAAGAGGGATATATTGGATCGCCTCCTGCATGTAGACCGGAGTGTGTAACAAGTACAGATTGTCCGCAAAATCAGGCATGCATTCGACAAAAGTGTAAGGATCCATGTCCTGGAACTTGCGGCACAAATGCACGATGCTTAGTGATAAACCATAATCCAATTTGTACGTGCAAACCTGGTTTTACTGGAGATCCGTTCAATTTCTGTCAATTAGAACAAAAACCTATCATAGAGGGGCCTAAAGGAAACCCATGCATTCCTTCGCCATGCGGTCCATATTCTCAATGTAAAATAATCGCAGATGCGCCTGCATGTTCATGCTTGCCCAATTATCTTGGTGTTGCACCAAACTGTAGACCTGAATGCTCGATAAATGCTGAATGTCCGGGTAGTCTTGCATGTCAAAATGAAAAATGTGTGGACCCATGTCCTGGGTCTTGTGGTTTTAACGCTGAATGCTCCGTAGCAAATCACGTAGCATTATGTAACTGTATACCCGGATACTCTGGTGATCCATTCAGTGGATGTTCATTATTTCAACATATACCAGAACCCCCACCCAATCCATGCAGTCCTTCTCCATGTGGAGCTAATGCTATTTGCAAGGAAAGGAATGGAGTAGGCTCTTGTACTTGTTTACCAGAATATTTCGGAGATCCATACACTGGTTGTCGTCCAGAATGTGTTTCTAATTCTGACTGCGACCGTAATAAGGCTTGTTCAAATAACAGATGTAAAGATCCTTGCCCTGGTACTTGTGGTATTAACGCTGAATGTAGAACAGTAAACCATTCTCCAACCTGCTCTTGCTTAACGGGATACACCGGAGATCCTTTAGTGAAGTGTGACTTTGAAACTATAACGGAAAAGAATGAACCAGTTCAGAATCCATGCAAACCATCGCCTTGCGGCCCCAACAGTCTTTGCAAAGTTGTGAACGGTCATAGCGTTTGCACTTGTGATACTGGTTATATTGGCACACCACCCTCTTGTCGTCCAGAATGTCTTGTGAGTGTGGAATGTTCCCAAGATAAAGCATGTATAGGGAAAAAATGTCTGGATCCGTGTCCCAATACCTGTGGCCTCAATGCTCGTTGTCAAGTAATCAATCACAATCCTGTATGCAGCTGTACGCCTGGATTTACGGGAGATCCGTTCACTAAGTGTAATCCTGAAGAACGAATGGTACAATCAAATCCATGTCAACCATCACCATGCGGACCGAACGCAGAATGTCGAGTAATCGGTGATCAAGCAGCTTGTTCTTGTTTACCGAATTATATTGGAAGAGTACCAAACTGTAGACCTGAATGTACGATAGATGCTGAATGTCCTAGCAACGCGGCTTGTATCAATGAGCGTTGTAAAGATCCTTGCGAGCGTGCATGTGGTGTAAATGCCATGTGCTTAACTGTAAATCACAAACCGATTTGTTCTTGCCAGCAAGGTTTTACAGGTGACGCATCTATAAGTTGTGATCAACTTATCATATCATCAACCGAAATGACGCCGACATCAAGTCCATGTACTCCATCACCCTGCGGGCCTAATGCTGAATGCAGAGAACATAACGGAGCCGGAGCATGTGTTTGCTCCGAGGGCTATGAAGGAGATCCGTATAGTCCACAAGGATGTCGAAGGGAATGCGAGAGTAATGATGAATGTGCACCTAATCTAGCTTGCACCCGATATAAGTGCATTGACCCATGTCCAAGAACATGTGGACAGTTGGCGCAATGTATAGTAGAAAATCATGCACCAGTTTGCAGTTGTCCTCGTGGTTATACTGGAGATCCATTCTTCCAGTGCAAACAAATATTAATGGACCCATCCCCTCCGAAGAACCCTTGTGAACCAACACCTTGCGGCCCCAACAGTCAATGTAGACAAGTAAACATGCAAGCTGTATGTTCTTGTCTTCCAAATTATATTGGATCTCCACCATCATGCAGACCACAATGTGTTGTAAACAGCGAATGTGACACATCGAAAGCTTGCATTAATCAAAAGTGTGACGATCCCTGTCCAAACACGTGCGGACTTAGAGCTCATTGTTTGGTTAAAAACCACAATCCGATATGTACTTGTCCAGTGGGAATGACAGGGGATCCATTTACACAATGTTATCAGATTCCGCCTACAACTGAACGACCTCCAACATGTACTCCATCTCCATGCGGACCACATTCTCGATGTCAGTTGCTAGCCAGTGGACCAGCCTGCTCTTGTTTACCAGGATATGTGGGTTCACCACCTTCGTGTCGTCCCGAATGTACAATTAATTCTGAATGTCCTGCTTCATTAGCTTGTGTGCGTCAGAAATGTGAAGATCCATGCCCTGGCTCATGTGGAGTAGATGCAAATTGCCATGTTCTAAATCACGTTGCCATATGTGTTTGCAATGAAGGTTTCACCGGTGATCCATTTTCAAGATGTCTACCAATAAGTGGAACACCTACAACGCCAGAACCATCAGATCCATGTAATCCCTCACCATGCGGGCCAAATGCTCGTTGTGATAACGGATTCTGTACATGTTTACCAGACTATAGTGGAAACCCTTATGAATCATGCCGACCTGAATGTACCGGCAGTCAAGAATGTCCTAGGGATAAGGCCTGCTTTAGAAACAAATGTCGGGACCCCTGCCCTGGAGTGTGCGGGCTTAATGCTAAATGTGATGTTATAAACCACATTCCGACTTGTTCATGTATATCAGACTTTACTGGAAATCCATTTACACACTGTAACAGAATAGAAGGAAAACAAACTGATAAACCAAGAGACCCCTGCCATCCTTCGCCTTGTGGACCGAACAGTGTCTGTAAAACTGTTGATAACGCTGCAGTGTGCGCCTGTTTAGAATCTTTCCAAGGAACACCGCCAGCTTGTAGACCTGAATGTATTGTTAGTTCAGAATGTCCATCAACCAAAGCTTGTGTTAATCAAAAATGTATAAATCCCTGTATAAACGCTTGCGGCGTGTCAGCACGCTGTGAAGTTATAAATCATAGCCCTATATGCAGTTGCAGTCCTGAACAAACAGGAGATCCTTTCAAGAGCTGTTACGATGTTGTAAATACACCACCTGAACCAATCGATGCATGTAATCCTTCTCCTTGCGGACCAAATGCTCAGTGCATCCAACGTAACGAAAAAGCCAATTGTAGATGTTTGGAGAATTACATTGGCCAGCCTCCTAATTGTAGACCCGAATGTGTTATCAATCCTGACTGTCCATCTAATCAAGCATGCGTAAGAAATAAATGCATTGACCCGTGTCCAGGTTCTTGTGGTATTAATGCTGATTGTGTGATAGTAAGTCACACAGTTTCATGTATCTGTAGAGAAAAATATACTGGAAATCCCTTTATGCAATGTGTTCCACAAGAAGAAATTGTCACGAAGCCTTGCGATCCCTCACCTTGTGGTGCTAATGCTCTGTGTACCCAAAGAGAAGGAGCTGGTTCCTGTTCATGTTTGGAAGGCTATCAAGGAAATCCTTACGAAGGCTGCCGTCCCGAGTGTGTGCTCAGCTCAGATTGTCCAGCTGATAAATCATGTATTAGAAATAAGTGTGCAGACCCATGCCCAGGAATTTGTGGTACTAATGCAGAATGTAACGTCATCAATCATGTACCAAGCTGCGCATGTCTTAAAGGATACTCTGGAAATCCATTTACCCAATGCTCTAAAGATGAACCTATAGAATTTAGTCGACCATGTCAACCATCACCATGTGGGCCTAATAGTGTCTGCAGAGAAAATGGAGGATTAGCATCTTGTGAATGTCTACCAGAATATATTGGTGCACCTCCAGACTGTCGACCAGAATGTACCGTTAGTAATGAATGTCCATCAGATCGCGCATGTCATAAACTGAAATGTGCGGATCCTTGCAGAGGTACATGCGGTATAGGTGCACATTGTCAAGTTGTTAATCATAGTCCATTATGCAGCTGCCCAGCTGGTACTTCTGGTGATCCCTTCAAGAGATGCTTTGAAACTGTACTTTATGAACCAGGACAGCCGGTGCAACCATGTCAACCAAATCCTTGTGGCCCATACAGTGAATGTCGTGCTCTTAATGAAAATCCATCATGCTCTTGTATGCAAGGATACGCAGGTGTACCTCCAAACTGTCACCCGGAATGTCTTGTGAATACGGACTGTCCTTCTCATCAAGCGTGCATCGCTGAAAAGTGCACAAATCCTTGTGAAGGATCATGTGGATTTAAAGCAGAATGCCGAGTGCAAGACCATATTCCGATTTGTAGTTGCCCAGTTGGATATTCCGGTGATCCATTCATCCAATGTTCTGAAGTTATAATTACACCAACACCTTCCCCAGAGCCTTGCAACCCATCACCTTGCGGAAGTAATGCTTTATGTAATGCTGGTCTCTGTACATGTGCACATGGTTATTTCGGAGATCCATACGTCGGTTGTAGGCTTGAATGCTCGACCAATGGTGAATGTTCACCTACGCGTACTTGTCAAGGAGGAAAATGTGTTGATCCATGCCCGGGAGCTTGCGGTACTAATGCTATCTGCTCAATCAACAATCATATCCCGTCTTGTACTTGCCCACCGAATACTTTCGGAGACCCGTTCACTTTCTGTACTGAAGTCGTTCACCAAGATACACCTACTTCGGCGTGTTCTCCTTCGCCATGTGGTCCATACAGTGAATGTTCCGTAAGCGCAAACGGTGCCGCTGCCTGCTCCTGTAAATCAGGTCATGTTGGGTCGCCTCCATCTTGTAGACCTGAATGCCTCGTTAGTGCGGAATGCAAACTTCAACAAGCTTGTATAGATCGCCGTTGCCGTGACCCTTGTGAAGGTGCTTGTGGCCGTGGTGCGCGCTGCCAAGTAATCGCACATTCCCCGATATGTACCTGTAATGATGGTTTTACCGGAGACCCATTCTCATATTGTTACCCGGCACCAGCCACCCCACCCACACCTATTGACCCTTGCCAACCATCACCATGTGGACCAAATTCGATGTGCGTTAATTCTGGTGAAACACCTGCGTGCAGTTGTCATCCAGGATTTATAGGAACGCCTCCAAACTGTCGACCTGAGTGTACAATTAGTGCAGAATGCCCTGCCACTCTGGCGTGTGTTGGACAAAAATGTAAAAACCCGTGTGAACAAGCTTGCGGTCCACGTGCTCTCTGTTCGGTGGTTGATCATCGTGCAACCTGCGCTTGTGAACCCGGATTAGAAGGTGACCCATTCCAGGGTTGTTCTCCAGCACGAGCTCCGCCAAAGATTGAATATTTAAATCCTTGTGAACCTTCGCCTTGTGGCGCGAATGCAGTGTGTAAAATCCAAGGAAATGCCGGTTCGTGCACTTGTTTGCCTGAATATTTTGGTGATCCATATCAAGGATGTAGACCAGAATGCTTAACAGATTCTGATTGTCCACTGGTATCATCTTGCAGCAGAAACAAATGCATAAATCCTTGTCTCGGTGCATGTGGTGTTAATACTGAATGTTTCGTTAACAACCACAAGCCGATGTGCAACTGTAAGAGTGGTTTCACAGGAAATCCAATGACTATATGTTCCGCACTAAGAGAAAATGATGTTTACATTGAAAATGTTTGTAATCCTTCACCGTGCGGTAACAATGCAATTTGTAAAAATATAAACGAACAGCCTGTGTGTTCCTGTTTGGCGAATTTCATTGGATCTCCGCCAAATTGTCGACCAGAATGTATTGTTAATTCGGAATGCAAACCTAGTAAAGCTTGTATAAATCAGAGGTGCATCAATCCGTGTCCAAAACCGTGCGGAAAGAACAGTGAATGTAAGGTAATCAACCACAGTCCCATATGCAGCTGCCGCCAAGGCTACAGTGGGAACCCATTCACAATGTGCAACCTAGTTCTTCAGACCTTACCAAGTGTAGTTGAAACGTCCAATCCATGCTCACCGTCGCCATGCGGCCCATACTCTGAATGCCGTAACAACAATGGATTAGCAAGCTGTTCTTGCTTATCAACCTACATTGGGTCTCCACCGTTTTGCAAACCAGAATGTGTTGTTAACTCGGATTGTCCGAGTAACTTGGGATGCATTTCAGAAAAATGTAGAGATCCTTGTGAGGGCTCATGCGGCTTATTTGCGAAATGCTTCGTAAATAACCACGTACCGGTTTGTTTATGCCCGGAAGGTTTTACGGGAGATCCATTCAGTCAATGTGTGGAAAAGCCTGTGAAAGAAATAACTCCAACTCTTCAATTAGACCCATGTCAACCAAGCCCTTGTGGACCTAATACTGAGTGTAGGAATGGCGTTTGTTCGTGTATAAATGGGTATCACGGAGATCCTAATTTAGGTTGCCGACCTGAATGCGTCTATAATGCCGACTGCCCCTCCGATAAAGGTTGCCAGAAAAATAAATGTATCAATCCATGTATTGGCACCTGCGGAGTGAATGCTATTTGTGATGTGATGAACCATATTCCAATGTGCTCTTGCCCCAAAGGAATGGTCGGAAATGCATTTGTGGAGTGTAGAGCTGTTGCAGTGACAGCTACAAGCCCGTGTAGTCCATCTCCTTGTGGACCTAATAGTCAATGTCAGCAAAGTAATGGACAAGCAGTATGTTCATGTGTACCTGGATATAAAGGCAGTCCGCCTACTTGTAGACCTGAATGCGTAGTCAGCCTGGAATGTCCTCTTAATCAAGCTTGCAACAACCAAAAATGTCTTAATCCTTGCATTGGAGCTTGTGGCGCTGGAGCTGTTTGTGATGTAATTAATCACAACCCAATATGCACCTGTCCTCCTTCGTTTACTGGAGACCCATTTGTTAGATGTTCAGTCATAGTTGCGGTAGAACCAACGGTAAACCCGTGTGAGCCGTCACCTTGTGGTCCTAACTCTATTTGTAAAATAAGTGGAGAGAATCCAATTTGTGCTTGTTTACAAGATTACAAAGGGACTCCTCCAAATTGTCGTCCAGAGTGTATCAGTAACAGTGAATGCGAGTATCATCTAGCCTGTCAAAATAAAAAATGCATTGATCCGTGTCTTGGTACCTGCGGGTCTAACGCAGAATGTAGAGTAGTTAGTCATGCCCCAAATTGTATCTGTCAAGTAGGATATACTGGAGACCCTTTTGCTTACTGTAGTATGTTAGCAGTAATGGATTACACAGAAATTCTGACACCGTGCAGTCCTAGTCCCTGTGGCGCTAACGCTATTTGTAGAGAACAAAAAGGAGTTGGATCATGTCAATGTTTGGACGGTTATTCGGGCAATCCCTATGAAGGTTGTCGACCAGAATGTGTCGTCAATTCCGATTGTCCTCTTAATAAAGCTTGTTCGAGGATGAAGTGCGTCGATCCTTGTCCAGGAGTATGTGGTTCAAATGCTTTATGCCTAGTTAACAATCATATGCCAACATGCATTTGTCAGCCGGGATATACCGGAAATCCGTTCGGATATTGTACTATTATGCAAGAACCTCAAGTATTGGAAACAAATCCTTGTAACCCTACGCCCTGTGGTGCCAACAGTCAGTGAAAGAAATAAATGGACAAGCTGTATGTTCCTGTTTACCTTCATTTAGTGGTTCCCCACCGAACTGCCGACCAGAATGTGTTGTAAGCTCGGAATGCCCACCGGATTTGTCTTGCAGTTCACAAAAATGCATTAATCCCTGCGAAGGCGCATGTGGAGAAAACGCTCGCTGTAATGTTATTAATCACAGTCCTATTTGTGTATGCAAGCAAGGATTAACTGGAAATCCTTTCACAAGATGCTATCCAATAACAGGTTCTAAACCGCCTCAAAATATACCAATACAAGATCCGTGCATCTCTTCGCCATGTGGACCATACGCAGAATGTAGAAATATAGAACATGCTCCATCTTGCGCTTGTAAATTGAATTATGTTGGAACTCCACCTAACTGTAGACCGGAGTGCACTATAAACTCTGAATGCTCTAGTAACCAAGCGTGTATTAATGAAAAGTGCCGCGACCCGTGTCTTGGTGCCTGTGGAATTAATGCTCAATGCTCTGTATTTAATCATGTCGCACAGTGTAGTTGCATTGAACAACACACTGGAGATCCTTTTACTCGTTGCTCACCTGCAATAGAACAAGACGAATTCTCGGAACCTGACCCATGCAACCCGTCGCCCTGTGGAGGAAACGCAGAATGCAATAATGGAATTTGTACATGTTTGCCTGATTACCAAGGTGACCCGTATTTTGGATGCAGGCCTGAATGTTTGCTCAACAACGACTGTCCTCAAGAAAAGGCTTGTGTGAAGAAAAAATGTGTGGACCCATGCTTTAATACGTGTGGCACAGACGCAATTTGCAACGTGTATAATCACTTGCCAATGTGCTCGTGTCCAAATGGATTTACAGGAAATGCTTTTCTACAATGTCGACCTATAAAGAATATTGAAGAAATAAACCCATGTAGTCCTTCGCCTTGTGGTCCAAATAGTCAGTGCCGAGAAGTTAACGGACAAGCGATTTGCTCCTGTTTCCCCGGATTTTTCGGAGCTCCTCCAACTTGCAGACCAGAATGCATATCGAGTGCTGAATGTGCATTGAACAAAGCTTGTTCTAATCAACGTTGTATTGATCCTTGCAAAGGAAATTGTGGTACAGCGGCCATATGTCAAGTTATTAACCACAATCCTATATGCTCTTGTCCACAACGATTCACCGGCGATCCATTTTCGAGATGTTCTGTTCAAGAAGAAGAAATACCTCAATATGTAAATCCTTGTGAGCCATCACCTTGTGGACCGAACTCAATTTGCAAAGAAGTTGGTAACTCGCCATCTTGCGCATGCTTGGAAACATACTTAGGCCATCCACCAAATTGTCGACCAGAATGTATCGCAAATTCAGAATGTCCCAATAGTATGGCATGTATGAATCAAAAATGCAAGGATCCATGCCCCGGTTCTTGCGGATCTAATGCAGAATGTAAGGTTGTGAGTCACGCGCCGCAGTGTATTTGTTCCCCTGGTTATACAGGAGACCCATTCATAGCTTGTTTAGTGCAAGACATACCTTTGACGCCATGTCAACCTTCACCTTGTGGTCCGAATGCAATATGTAAGCAGCAAGGAAATGCCGGCGCTTGTGTATGTTTACCAGAATATTTAGGAAATCCATACGAGGGCTGTCGTCCAGAATGTATAGTTAATTCTGACTGTGCAACCAATCTAGCATGTATTCAAAACAAATGTAAAAATCCATGTAACAGCGCTTGTGGCCTCAACGCGATATGTAATGTCATAAATCATTCACCAAAATGTGAGTGTTTGCCGGGATTAACTGGAAATCCATACCAAAACTGCTATGAGCAAAGCGCAGATACTCCTTCGGTTACGAAAAATCCTTGTACGCCTTCGCGGTGTGGTCCCAACAGTATATGCAAGATTAATAATGAACAGGCTGTGTGCACTTGTCAACAAGATTTCATTGGAACACCACCATCATGCAAACCCGAATGCGTGGTCAGCTCTGAATGCTCGCAACAACAAGCTTGTATTAAAAAAAAATGCAGAAATCCTTGTGAAGGTGTTTGCGGACAGAACTCTGAGTGCAAAGTTATCAATCATAGTCCCATTTGCACATGTCGTGTACATTACACCGGCGATCCATTTAATGGTTGTTCTAAAATTGTTGCTGCTGAGATTATTCCTCTGCCAACAAATCCATGTCTACCATCTCCGTGTGGTCCATTTGCACAATGTCGTGATATAGGTGGATCGCCTTCATGTTCTTGTTTACCTCTTTATATTGGCCAACCTCCAAATTGTAGACCAGAATGTACTATCAACACCGATTGTCCTAGCGATAAATCGTGCATCAATGAAAGATGCATAGATCCGTGCCCTGGGTCGTGTGGAATCTACGCAGAATGCAGAGTTCAAAATCACGTTTCAATCTGCACATGTCTTGAGGGTTACACAGGAGATCCCTTTAATGCATGTATACTGAAACCACAAAAAGACCCTGTTCCTTCTGATCTTTGTAATCCATCACCTTGTGGACCAAATGCCATTTGCAATGACGGGATATGTTCTTGTCTACCTGAATTCCAAGGTGACCCGTACTTTGAATGTCGTCCAGAGTGCACGATAAGTTCAGAATGTCCGATGAATAAAGCTTGTGTTAAAAATCATTGCGTGGATCCATGTCCGAATACATGTGGTACTAATGCCATTTGTCAAGCAATAAATCACATGGCAGTGTGTACATGTCCGGCAGGGATGTCTGGCAACGCATTTATACAATGCAACCCTATAAAAGAATTTTCCATTGTAAACCCATGTCAACCAAGCCCGTGTGGAGCAAATAGTCAATGCCGAGAATTAAATGGTCAAGCAATATGTACATGTTTACCGGGATATCGCGGAACTGCGCCTTATTGTCGCCCAGAATGTGTGGCAAGCTCTGAATGCCCATCGGACAAAGCCTGTAGCAATCAGAAATGTATTAACCCATGCCAGGGAACTTGTGGTGTTGCAGCCCAATGTCAAGTAATACATCATAACCCCATTTGTACGTGTTCTACAGGTTTTACGGGAGATCCATTTACACGATGTACTGCTACGCCTCTCGAGTTACCTACGGCCCCTATAAATCCTTGTCAACCATCACCGTGTGGTCCTAATTCAATTTGTCAAGAAAACGGCAGCCAAATACCTTCTTGTCAGTGTATGCCCGAATACATTGGTGCACCGCCGAATTGTCGTCCTGAATGTCTCGCAAACAGTGAATGTGCTCCTCATTTAGCCTGTATCAATAAAAAATGCCAAAATCCATGTGAAAAAGCATGTGGTACAAACGCTGAGTGTCGAGTTGTGAGTCATACAGCGGTCTGCATTTGTCCAGAAGGATATAGCGGTGATGCAGCAATTCAGTGTTCACAAAATGCTGTTGTTCCATTCGAAACACTTTCAGCTTGTGAACCTTCGCCCTGTGGAGCAAACGCAGAGTGTATAGAACGGGCTAGTGCAGGTGCTTGCATTTGCCGAAAAGGATATATCGGAAATCCATATGATGGCTGTCATCCAGAATGTGTTGTAAGTTCGGACTGTCCGAGTAACAAGGCTTGCACAAGAAATAAGTGTATAGATCCATGTCCTGGTACATGTGCATCGAACGCTAATTGCCAAGTTGTTAACCATTCGCCTCTTTGTACATGTAAAACGGGATACATTGGAGATCCATTCACCGCATGCAAACTCGAACCTCAACTCGATTTACCAGTTAATCCGTGTCAGCCATCTCCTTGTGGACCAAACAGTCAATGCAAGGTTTCGAATGGCCTGAGCATTTGCTCATGTTTACCAGAGTACAGCGGATCGCCTCCAAATTGTAGACCAGAATGTGTTGTGAGCGCAGAATGTCCTTCAGAAAAAACATGCAGAAACAAAAAATGTGTGTCACCATGTCCCGACCCTTGCGGTCAAAACACGAACTGCAAAGTTATTAATCACAGTCCAATATGCTCTTGCCAAAGCGGATACACTGGAGACCCATTCTCACGTTGTTACCGTGTAACTATCACGGAACTTCCACCTCAACAACAAAGAGACCCTTGTGTGCCTTCCCCTTGTGGGCCGAACTCCTATTGTCAAGACCTAAGAGGTATTCCCTCGTGTTCTTGTTTACCCAACTTCGAAGGGAATCCGCCTAACTGCAGACCTGAGTGTACTATCAATGAAGACTGTGCCAGTAATTTAGCGTGCATAAATCAAAAATGTAAAGATCCATGCCCTGGTTCATGTGGTATTAATGCTAACTGTCAGACTCAAAATCATATAGCGATCTGTTCATGTATCGAAAGCTTTACCGGAGATGCTTTCACGCAATGCAAACCAATACCATTTATAGAAGAAAGTGATCCCTGTAATCCATCTCCATGTGGTATAAATGCTGAGTGCTCAAACGGAAAATGTACCTGCTTTGAGGAGTACCAAGGTGACCCATACACTGGTTGCCGACCGGAGTGCTTGGAAAGTTCAGAATGTGAACGGGATAAAGCTTGCATTAAAAATAAATGTAAAGATCCGTGTCCAGGAACCTGCGCGTCGAATGCTGAATGTAATGTCATCAATCACATACCTATGTGTAGCTGTCCTGAACGAATGACTGGCAATGCATTTGTAGAGTGCCGTCCAATAATAGAAGCAGTTATAACGAATCCTTGTGAACCATCACCTTGCGGGCCTAATAGTCGCTGCAGAGATGTGAATAATCAAGCTGTTTGTTCATGTGCACCAAATAACATAGGTTCTCCGCCGTCATGTCGTCCTGAATGTACAATTAGTTCTGAATGTCCTCTCAATCAGGCCTGCAGTAATCAACGTTGTGTGGATCCTTGCATCGGTTCATGTGGTGTTAATGCAGAATGCAAAGTTGTAAATCATAATCCAATTTGTTCGTGTCCAACATTTTACACAGGAGACCCATTCTCAAGATGTATGAGGCAACCTGAACGTCTTCCTGAGCCAACGAATCCGTGCGCACCATCACCATGTGGTCCAAACTCGGTTTGTCGAGAAGTAAACGGGGCGCCATCGTGTATTTGTTTAGAAGGATTCAAGGGTCAACCTCCCTATTGCAAGCCCGAATGTAGTAGTAATGAAGAATGTTCTCCACACTTGTCTTGTATTCGCAATAAATGTAAAAATCCCTGTGAAAACGTATGCGCTGTAAACGCTGAATGTAAAGTTGTGAGCCATTCGCCGGTTTGCGTGTGCCAATATGGTTTTACTGGGGACCCATTCTTCGAATGTATTCAAGAACCCTTATATACAGAACCTATCACATCTCCCTGTTCGCCATCACCTTGTGGAGCTAATGCTATCTGTAAAGAACGTGACAACGCAGGGTCCTGTTCATGTATCGATGGTTACATGGGTAATCCATATGAAGGATGTAGACCTGAATGTGTAGTTAATACTGATTGCCCGTCAAACAGAGCCTGTGTTAATTATAAATGCAATGATCCGTGTCCAGGAAGTTGTGGTACCAATGCGGAATGTCAGACTGTTAATCATGTGCCCTTATGTACTTGTATTAATGGCTATACTGGTGATCCATTTAGATACTGTGTTTATCAAGATTCTCCAGTACTAGCTCCGGTTGACGTATGTAACCCTTCGCCGTGTGGACCTAACAGCCAATGTAGAACTATTAACGGCCAAGCTGTGTGTTCCTGTTTGATAGAATATGTTGGATCTCCACCTAATTGTCGGCCAGAATGCATAGTCAGCTCTGAGTGTTCGCACGACAAAGCATGCGTCAACAATAAGTGTGTAAATCCTTGTCCTAAACCATGCGGAGTCAATGCTGACTGTAAAATGATTAATCACAGTCCAATTTGTTCATGTAAAAATGCTTACACTGGAGATCCATTTACTGTTTGCACCGCAATAAAACATGAACCTGTACCAGATACGAGCGATCCTTGCGTACCCTCCCCATGTGGACCATATTCGCAGTGTCGAAACATTGGAAACAATCCGTCATGTTCTTGTCTTCCAACGTATACAGGCAGTCCACCTAACTGTAGACCAGAATGTATTATACATTCTGATTGCCCTGGTGATCGAGCATGTATTGGTTCCAAATGTCTAGATCCTTGTCCAGGATCATGTGGTATTTCAGCTACCTGTAACGTTCAAAATCACATACCAATTTGTACGTGCATTGAGGGATACATAGGTGATCCATTCACCGATTGTAAACCTAAACCCTTAGAAGTTGAACCAAGTGTGACAGATGCTTGTACAAACATAAGATGCGGTTCCAATGCTGAATGCATTAACGGTCAATGTCAATGCTTCCCGGAATACCACGGTGATCCTTACTTTAGTTGTCGACCAGAATGTGTGTTTAGTAGCGACTGTGATGAAACCAAAGCCTGTATACTAAAGAAATGTGTGGATCCTTGCATTGGAGCTTGCGGACAGAATGCTATTTGTCAAGTTTTCAATCACATTCCGATGTGTAGTTGTAATAATGGCTTCACTGGTAATGCGTTTGTCAGGTGCAATGCAGTCAGAGAACCGACTATCAAACATCCTTGCAGTACAGCGGTATGTGGTCCAAATAGCCAATGCCGAGAGGTACACGATCAAGCAGTTTGTTCTTGTTTACCATCGTATTTGGGCACACCGCCCGCTTGCAGACCCGAATGTGTAGTTAACGCTGAATGCCCACAAAATCAAGCTTGTATGAAACAAAAATGTATTAACCCATGCGCTGGTACATGCGGTTCGAGAGCATCGTGCGATGTCATCAATCATAACCCCATTTGTACTTGTCCTGCTGGTTATTCTGGGGATCCATTTGTAGAATGCAAAGTTTTATACAATACACCGCCTGTTGTTATTGACCCATGTCAACCATCACCCTGCGGACCTAATTCTATTTGTGAAGTCAAAAATAACAATCCATCCTGTACATGCAAAGAAGAATACAATGGACAACCTCCATACTGTAAACCAGAATGTATAAGTAACAGCGAATGTGCACCACATCTTGCATGCATCAAACAAAAATGTAGAGATCCTTGTATAAAAGCGTGCGGAACAAACGCAGAGTGTCGTGTTGTCAGCCATTCGGCTATGTGTATTTGCCCACAAGGATATTTAGGTGACCCCTTCATTCAGTGTTCTGTTAAAATTGAAGATGAAATTCTTCCTCCATGTTCTCCATCACCTTGTGGACCTAATGCGATTTGCCGTGAACATCACAACATTGGTGCGTGCATTTGCAATGACGGCTACTTCGGTAATCCTTATGAAGGATGTCGTCCTGAATGTATTTCTAACTCCGACTGCCCAGGCGACAGAGCTTGTATCGGTAACAAATGTCAAGATCCATGTCCAGGAACGTGTGGTATTAACTCTGAATGCACAACAGTATATCATTCACCAACTTGCACATGTATTCAGGGTTACACTGGAGATGCTCTCCGTCGCTGCAATCCTATTTTGCCTCAAGAAAATATTCAAGAAAACCTTTGTATTCCAAATCCATGTGGAGCACATAGTCAGTGTCGAGAAATTAACGATTGTAACTCAAACAAGGCCTGCGTTAATCATAAATGTATTAATCCTTGTCCGGGACCATGTGGCGAAAAAGCTGAATGCAAAGTGTTTAATCATAATCCTATCTGCAGCTGTCATTCAGGTTTCACAGGAGATCCTTTCACGCGATGCTATCCAAAACCAGTAATACAAACCATATACGAGGAAAGAAACGACCCATGCGTACCTTCGCCTTGTGGTCCACTCTCAATATGTAGAAATGTCGGTGATCAACCTTCCTGTTCCTGTGCTCCCGGCTACATCGGTAGTCCTCCAAATTGTCGCCCTGAATGTGTTACAAATCAAGAATGTCAAAGTTCACTGGCTTGCATCAACGAAAAGTGCAAAGATCCTTGTCCAGGTTCTTGTGGTCAAAATGCGAAATGTTCAGTTATAGAACACGTATCTATTTGCACCTGTCTGGAAGGCTATAAGGGTGATCCGTTTACTTCGTGTGCACCGCAACCAATACAAGACCTGGTTCCAGCTGATCTTTGTAATCCATCTCCTTGCGGATCAAATGCCGAATGCAATAACGGGGAATGCTCATGTTTACCCGATTACAGAGGTGATCCCTATCTGGGATGTCGACCTGAATGCACGATCAGTTCAGATTGTCAAAAGAATCAAATATGTGCTAAAAAGAAGTGTTTCAATCCGTGTCCTGACACGTGTGGTCAGAATGCTATTTGTGAAGTCATTAATCACGTGCCTATGTGCAGTTGCCCTGCAGGATTTACTGGAAACTCTTTTGTTACTTGCAATGCTATTCAAGTACCCATAGCGATTAACCCTTGCAATCCAAGTCCTTGTGGACCGAACAGCCAGTGCAAAGAAATTAAGAATGTCGCTGTATGCTCTTGTATACCAGGCTTTTCAGGAAACCCACCTACTTGCAGGCCTGAGTGTACCACAAGTGCAGAGTGCTCTTTAGATAAAGCTTGCAATAACTATAAATGCATCAACCCATGTAATGGTGCTTGTGGCATTGGAGCATTTTGTCAAGTGGTAAATCACAATCCAATATGTTCGTGTCCAAACGAATATACGGGAGATCCATTTACTAGATGTGTACTGAAACCTGCAGAAATACAACCGCAAGTTAATCCGTGCTCACCTTCGCCTTGTGGACCAAACTCAATATGCCAAAATAATAATGATTCTCCCTCATGTTCCTGCCTACCGGAATATACTGGAGTACCCCCGAATTGCCGTCCGGAATGTACAAGTAATAGTGAATGTGGAAACCATTTGGCGTGTATCAACAATAAATGTGGAGACCCTTGTGTCGGCGCTTGTGGACAAAATGCTGAATGCCGAGTAGTCAGCCACACGCCGAACTGTGTCTGCCCGTCAGGCTTTATTGGAGATCCATTTATACAATGTTCAATACAACAAATTTTACATGAAAATATCACTCCGTGTGTCCCGTCGCCTTGTGGAAGCAATGCTTTATGTAAAGAACGTAACAATGCTGGTTCGTGTGTTTGCTTACCTGGATATTTCGGGAATCCATATGAAGGATGCAGACCCGAATGCATAGTAAATACTGACTGTCCTTCGAATAGAATTTGTCAACAAAATAAATGTCAAGATCCATGTCCAGGAACATGCGCTGCAAATGCTCAGTGCAACACAGTGAACCACGCTCCGATATGCACTTGTTTACCTGGCTTCACTGGAAATCCTTTCCAAAGCTGTCTTATCATTCAAAACATTGAAATTGAAACGAACCCTTGCTCACCAAATCCGTGCGGACCAAATAGTATATGTAAAGAAGTAAACGAACAAGCAGTTTGCACATGTTTGGCAGATTATCGCGGCGCTCCTCCAAATTGTAGGCCAGAATGTGTAGTCAGTGCTGAATGTCCAACAAATAAAGCTTGTGTCTCCTTGAAATGTCAAGATCCATGCATAGGACAGTGTGGTCTTAACACGAAATGTCAAGTTATAAATCATAGTCCTATATGTTCATGTATAGAAAGGTTTACAGGTGATCCTTTTAGCCGATGTTTTGCTTTAGTATCTAGCCCACCTACGCACGAGGAACAACCAAAGAATCCATGCTTACCATCGCCTTGTGGACCATTTAGTGAATGCAGAGATATCGGAGGTATATCCTCATGTATTTGTTTGCCTAATTACATTGGGGCCCCTCCAAATTGTCGCCCAGAGTGTACAATTAATGCTGATTGTCCTAGTAATTTGGCTTGTATGAACCAGAGATGCAAAGATCCTTGTCCAGGCTCTTGTGGTTTAAACGCTCAATGTTTTGTCAAGAAGCACATGCCGATTTGCACTTGTCTTGACAATTATGAAGGAGATGCATTTACTGAATGTAAACTTCAAGAACAAATTAATGATGAAATAGATTTGTGTAATCCATCACCCTGTGGTCCTAATGCCATTTGTAATAACGGAGAGTGTACATGCCTTCCTGAATACCAAGGAGATCCGTTCTTTGAATGCAGGCCTGAATGTGTTCTGAATTCCGATTGTCCCCAAGACAAAGCTTGCCAAAAGAATAAATGTACAAACCCATGTTTAAGCAACGCTTGTGCCGCTAATGCGATATGCGAAGTTTTCAATCATGTTGCCATGTGTAGATGCCCAGAACGTATGACAGGAAACGCATTTGTTCTATGCTCACACCTGGAAGTTGTCAAACCACAGCCATGTCAACCAAGTCCTTGTGGTCCTAACAGTCAATGCCGTGAAATTAATGGGCAAGCTATATGTGCTTGTTTCATTGGATTTGTTGGAAGTCCTCCATCTTGTAGGCCTGAATGTACAGTGAGCACTGATTGTTCTCCCAACGAAGCCTGCAGCAATCAAAAATGTATCAACCCATGCCAAGGAACTTGTGGAGTGAACGCACAATGCCAAGTTATTAATCATAATCCTATTTGCTCATGTCCATCTTCTCTGACTGGAAATCCATTTGTAAGATGCTTTGTGCAAGAGTTTAAGCCTGAGTATAGTGATCCGTGCACACCATCACCTTGTGGACCAAACTCTATGTGCCAAGAAATTTCTGGAGCACCGTCATGTTCCTGTCTTGATGAATATATTGGAAAACCACCTTACTGTAAACCTGAATGTATCAGTAATACTGAATGCCCACTACACTTGGCTTGCATTAACCAGAAGTGTAAAGACCCTTGCCCAGGTTCTTGCGGATTAAACACGCAATGTCATGTAGTAAGTCACTCTCCAACCTGTTCTTGTGATTTAGAATATACAGGAAATCCATTCATAGAATGTCACCGCATACAAATAATATCTGAAGCAACAACTCCATGTCAACCTTCACCCTGTGGTGCAAATACTATTTGTAAAGAATTCAATGGTGCTGGTTCATGTGTGTGTTTGGAAGAATATTTTGGAAATCCTTATGAAGGTTGTAAACCAGAATGCATAATTAATACGGATTGTCCTTCAAACAAAGCTTGTCTGCAAAACAAATGTCAAGACCCTTGTCCAAGTGCATGCGCACCGAATGCAGTATGCCAAGTAGTGAACCATAACCCATCTTGCTCGTGCGAACGAGGATATACTGGAGATCCCTTCCGATACTGTACACCAGAACAAATTTTGGAAACGCCAATTAACGTATGTCAGCCCTCACCGTGCGGGCCGAATAGTAGATGTCAAGAAGTCAACAAACAAGCTGTATGTTCTTGTCTACCAAATTACGTTGGGTCTCCTCCTGGTTGTCACCCCGAATGTGTAACTAATGGAGAATGTCCTAGAGACATGGCTTGCATTAATCAGAAATGCGGTAACCCCTGCCTGGATGCCTGTGGAATCAATGCAGAATGCAGGGTTATAAATCATAATCCAATCTGCCAATGCACAATGCATTATACTGGAGATCCATTCACAAGATGTAATCCTATACCCCCTCCAGTTGCTAATGCTGATTTAGAACCATACAGAAATCCCTGCGTTCCGTCACCCTGTGGGCCAAATTCCATATGTCACGAAATAGGAAACATTCCCTCCTGCGCTTGTATGGATAATTATATAGGAAATCCACCGAACTGTAGGCCAGAGTGTATAGTAAATTCGGAATGTCCAACATCATTAGCTTGTATACAACAAAAATGTAAAGACCCCTGTAAAGGATCATGCGGATTAGGTGCCATATGTACAGTTTCTCGTCATACACCGATTTGTGTGTGTCCTGATGGCTATATTGGAGATGCCTTTACCATATGCCAGCCAAAACCACCAGAAGCAGATATTGTTGATAAATGCAATCCTTCACCATGCGGTTCAAATGCCATTTGTTCTGATGGTGTTTGTAGTTGCATAGAAGAACACCAAGGAGATCCATATATTGGATGCAGACCTGAATGTGTTCTTAGTACTGATTGTCCTAGAGATAAAGCTTGTGTTAAAAATAAATGCATAAATCCATGCGTAGACACATGTGCTTCTAATGCCATATGTGACGTGATAAACCACACGCCAATGTGCAGTTGTCCTCAAGGCATGACTGGAAATGCTTTCTACTCTTGTGATTTCATAAAAGTGCCTGTTGTGACAAATCCTTGCCTTCCATCACCTTGTGGTCCGAACAGTCAATGTCGTGAAATAAATGGGCAGGCTGTATGTACCTGCATCCAAGGTTATATTGGCAGTCCTCCTTTATGTCGGCCAGAATGTGTTGTGAGTTCAGACTGTCCTTCTGACAAAGCGTGCAGCAACCAAAAATGTATTAACCCATGCGATGGATCTTGTGGAATAGAAGCAAAATGCATGGTAGTTAAACACAACCCAATTTGTACCTGTCCAAATAAATACACTGGAGATCCGTTTACAAGATGCGTGCCATTTAGAGTACCTACAGCGGACGTGACGCCTTGTACGCCATCTCCATGTGGTCAAAATTCAATTTGCAAAGAAGTATCTGGAACTCCATCTTGCATGTGCATGCCAGATTTCTTTGGTACACCGCCATATTGCAAACCTGAATGCACTAGTAACAATGAATGTCCCGTTAACAAAGCTTGCATAAATCAAAAATGTGCTGATCCTTGTACCAGCGCATGTGGACTTAATGCTCTGTGTAGGACAATAAGTCATACGCCGACCTGTTTTTGTGATAACGGTTATACTGGTGATCCATTTACGAGATGCTTTATTGAAGAAATTTTATACGAACATTCGTCACCATGCGAACCCTCGCCGTGCGGACCTAATGCTTTATGCAAAGAACATAATTCAGCCGGATCGTGTGTTTGTTTACCCGATTATATTGGCAATCCGTATGAAGGTTGCAGACCAGAATGTACCATCAATACTGACTGTGAACCTAGTAAGAGTTGTATTCGCAACAAATGCCAAGACCCATGTCCAGGAACATGTGGAGCATTAGCAACGTGTGCCGTTGTAAATCATTTACCAACTTGCTCGTGTCTGGAAGGTTACACCGGAGATCCGTATAGAAGATGTGATATTATGCAAGTTCCAACAGCTATATCGATCACACCGTGCGTGCCTAATCCATGTGGCCCGAACAGTATCTGCCACACAGTTAATAATCAGAGCGCATGTTCATGTATGCCTGAATACGTGGGATCACCGCCTGGTTGCAGACCAGAATGTACAGTTAGCTCGGAATGTCCACAGAATAGAGCATGTATCAATTTAAAATGCGCAGACCCTTGTCCAAGTCATTGTGGAATAAATTCCCAATGTAAAGTCATAAACCATAGTCCTATTTGTACTTGTAAACTAGGATTTCTCGGAGACCCATTCACAAGATGTTATCCTCAACCTGAAGATATACCAGTTACTAAGAATCCGTGTTTGCCAAATCCTTGCGGTGATAACGCTATTTGTAGAGAAATAAACGGTTCGCCGTCTTGTGCATGCATACCGAATTTCCTAGGAATTCCACCAAATTGTCGACCAGAATGTGCTATAAATGAAGACTGTCCTTCTGACAAAGCCTGTTTCAATATGAAATGTGGAGATCCCTGTCCCGGAAGCTGTGGCCAAAACGCTGAGTGCTCAGTGTTCAATCATGTTCCATCCTGTGCTTGTATCCAAGGATATACCGGAAATCCATTTTCGGCTTGTTTCCTGATGAAACCTATTCAAGATGAAATACCAAAAGATCCTTGCTATCCGTCTCCGTGCGGATTCAATGCCCAATGCAATGATGGAATTTGTACATGTTTAGAAGAGTACTTCGGTGATCCTTACTTAGGTTGCAAGCCCGAATGCGTGATAAATTCAGATTGTCCCCTGAACAAAGTATGTTCAAAGAACAAATGTATGAATCCTTGTCCCGGAACATGTGCACCTACTGCCCAGTGCAGTGTTTATAACCACATACCAATTTGTACTTGTCCCGACGGTACAACGGGCAATGCTTTTGTGGAATGCCATACTATACAAGTTGTCCACGAGGAACCATGCAATCCGAGTCCGTGCGGACCAAGCAGTCAGTGTCGGTCTGTGAATAACCAAGCAGTATGCTCGTGCTTGCCATCATTCATTGGAACTCCTCCATCTTGTCGACCAGAATGCATAATTAGCGCTGAATGTCCTAGAAATGAAGCGTGTAACAACCATAAATGCATTAATCCCTGTCAAGGTAGCTGCGGATATGGAGCTAAATGTGAAGTTGTAAACCACAATCCCATATGTTCTTGTCCACCACAGTATACGGGTGATCCGTTTACAAACTGCCAGCCGATAGTGACAGCGCAATTACCTCCTGTTGATCCTTGCACGCCATCACCCTGCGGTCCATATTCTATATGTAAAGTAATCGCAGAATCACCTTCTTGCACCTGTCAGCCGGATTTCTCGGGAACGCCACCAAATTGCCGTCCAGAGTGTGTCAGTAACTCAGAGTGCCCAAGTAGTCAGGCTTGTATCAATCAGAAATGTAAAGATCCGTGTCCAGGTAGCTGTGGTTATAATGCTGACTGCAAAGTTATAAGTCATGCATTAGTTTGTTCTTGTCCAAATGGTCAAACAGGAGATCCACTTATTTCATGCAGTCCAATACGCGAAACCTTCATTGAATACAGCACGCCGTGTGAGCCTTCGCCTTGCGGTCTAAACGCAGAATGCACGCAGAAAGATAACGCTGGCTCCTGTAAATGCATTGATGGCTATATGGGAAATCCATACGAAGGATGTAGGCCAGAGTGTGTTATTAATAGTGACTGCGCTCCTATGTTGGCTTGTATTCAAAACAAATGTAAAAATCCTTGTCCCGGAGTGTGTGCGCCAAACGCAATTTGTCAAGTGGTTAATCATCTGCCATCATGTCACTGTCCACCTGGCTTAGCGGGTAATGCGTATCAATACTGTGTTACTAAAGTTGAAGACGTTAAACCAACACCGTGTAGCCCATCGCCATGCGGTCCCAACAGTGAGTGTCGCGAAGTAAACTCACAAGCCGTATGTAGTTGTCAAGCTGATTTTATGGGAACTCCTCCAAACTGTCGCCCCGAGTGCACCATCAACAGTGAATGCTCTGTTGTGAAATCATGTATTAACCGAAAATGTGTTGATCCATGCATAGGACAATGTGGTAGAAATGCAAATTGTAGAGTTATTTCTCACAATCCGATTTGTTCTTGTCAAGATCGATTTACAGGAGATCCGTTCACTAATTGCGTCCCAATTGCCATATCGAGTCTCGAAACGTATCCTGAAGTTAACCCGTGTATTCCATCACCCTGTGGACCTAATTCCATTTGTCAAGAAGTAAATGGAAATGCCCGTTGTACTTGTGTACCTAATTACAAAGGTTCTCCTCCCCGGTGCAGACCCGAGTGCACAATAAACTCCGAATGCAATGCAGCAACGGCTTGCATTAACAACATGTGCTTGGACCCCTGTCCTGGGGCATGTGGAAATAATGCTCAGTGTATTGTAAACAACCATTTGCCAATATGTTCGTGTTTGCCAGGATATACAGGAAATCCATTCAGTAGCTGTTTCCTGAAACAAGAAGAACATGTTGACCTATGTTCTCCCTCACCGTGCGGTTCAAATGCTATTTGCGAAGATGGACTGTGCACTTGTATACCAGAATATCATGGTGATCCGTATTTCGGATGTAAGCCAGAATGTGTCCTAAATTCGGACTGTGCTAGGGACAAGGCATGTATTAATAGTAAATGCAAAGATCCATGTATTGGAACTTGTGGAACAGACGCAATTTGTGAAACTATTAATCACATTCCCATGTGCTCATGTCCATCTGGTTTTACTGGTTCGCCTTTCAGTTATTGCACACAAATTTTAGAGCTACCCACGCCTGTCAATCTTTGTGTACCGTCACCTTGCGGACCAAACAGTCAATGCAGAGAGTTGAATGGACATGCCGTGTGTGTTTGTGTGAGTGGCTATCTCGGAAGTCCTCCAAATTGTCGCCCGGAGTGCATATTGAGCTCTGATTGTAAATTAAATGAAGCCTGTTCCAACCAAAAATGCATAGACCCGTGTCCTGGAGCATGTGGTCGCAATACAAAATGCATTGTTGTCAATCATAACCCCATATGCACGTGTTCGCCTGGATTTTCTGGAGATCCATTCTCATCATGCCAAATTATCCCTGCCACACCGCCTGCGAAGGTCACTCCGTGCCTACCTTCACCGTGTGGTCCAAATTCAGAATGTACAGAGAATGGTGAAAATGCAGAATGCAAATGTTTATTAGAATATATTGGCTCACCTCCTAATTGTCGACCGGAGTGTACAAGTAACACTGAATGTTCTCAAAATATGGCTTGTATTAACAGAAAATGTCAAAACCCCTGCGCAGGGGCATGTGGTATAAACGCTGAATGCAGGGTAGTAAGCCATACTCCCATATGCTTGTGTGAAAATGGATACTCAGGAGATCCATTCCTTAGCTGTAATATAATAGTATCATCCGCAGTGGTGGAACGTCCGACACCTTGTATACCATCACCATGTGGTGTTAATGCTGAATGCAGAGAACGGAATGGTGTTGGATCTTGTATTTGTTTACCTGACTATTTCGGAAACCCATACGAAGCGTGTAAGCCAGAATGCATTCAAAATTCTGACTGCCCTTCGAACCTTGCATGCTACAATAACAAATGCAAAGATCCATGCCCGGGCACTTGTGGAATTAACGCTCAGTGTAACGTCGTTAATCACAATCCTTCGTGTTCGTGTATTGAGAAATATCATGGAGATCCATACAAGATGTGCGCATTTAAAGCTGAATCGGAAATTTTAGACCCTTGCGAACCTTCGCCGTGTGGACCTAACAGCCAATGTAAATCTCAAAACGGCTTGGCGATATGTACTTGCATGCTTGGCTATCAAGGAACACCACCTTCTTGTCGCCCAGAATGTATCACTAGTTCAGAGTGCTCTCTAGATAAAGTCTACGCTTTGTGCAATGTTGTGAAGCACGTTCCTGTTTGCTCTTGTCCTAGTGGTTACGAAGGAGATCCATTTTCCATCTGTCACATCAAGCTTCCAGAATTACCACAATCAGTAGATCCATGTCAGCCAACTCCATGTGGACCCAATGCTGTATGCCACAATGGCGTATGTTCCTGCTTACCAGAGTATCAAGGGGACCCCTATTTTGGCTGTCGGCCTGAATGTGTATTGAGCACCGATTGTCCTCTGGATAAGGCTTGTTTCCGTTCAAAGTGTGTTGATCCTTGTCGTGACATGTGCGGAGTCAATGCAGAATGTAATGTCTACAACCATGTCGCTATATGTAGCTGCCCAATGGGACATACCGGAGATGCATTTACCCATTGTAAAATAATTGAAAAACCAGCCAATAAACCTTGTGAGCCTTCGCCTTGTGGACCTAACAGTGTTTGCAGAGAAGTAAATGGACAGGCAATCTGCGCTTGCATCGAATCTTTTATTGGTAATCCGCCAAACTGCCGACCTGAGTGTATTCAAAGTACAGATTGCTCTCCCTCAAAAGCTTGTATAAATAGAAAGTGCCAAGATCCATGTCCAGGATCGTGTGGTCGAAACGCTATATGCATTGTTAACAAGCATAATCCTATATGCAGCTGTCCTGCAAAGTACACAGGATCTCCATTCACTTATTGTTACGTTCAATTAGAAGAAGAGCCACAGTCTAATCCATGCGTACCATCGCCTTGTGGACCAAATAGTCTATGTAAACCAACAGCTGACGGGAAATCTTATGTGTGCACATGCCAACCATCTTTTGAAGGAACTCCACCTCTATGTCGTCGCGAATGTACAACAAGTGATGATTGTTCGTCTGACAAAGCTTGCATTAATTACAAATGTTCGGATCCTTGCCCTGGCTCCTGCGGTTTGAACACGCTTTGCGTCGTTCGACTGCACACACCTATGTGCTCATGTGAAAACGGGTACACTGGAGATCCATTTTTATCATGCTATCTGATGCAGCCAGCACATGAACCAGTTGATCCTTGCAATCCTTCACCTTGTGGCGCCAATGCTCAATGCAAAGAAACACGTAGCGGCGCAGTTGCTTGTATTTGTGAAACTGGATATTTCGGAAATCCTTACGAATCTTGCCGACCAGAGTGTGTGGTTAATACTGATTGCCCATTTAACAAAGCGTGCCTAAGAAACAAGTGTGATGACCCGTGTCCCGGTGTTTGCGGCTCTACAGCAAATTGTGAAGTTATTAATCATGTACCATCTTGCACGTGCGCGCCAGGTTACACCGGAAATCCGTACACGTACTGTCATATCATCATTAATGAACCAGTACCGAAACCGAAAAATCCTTGTTTACCGAACCTCTGTGGCAGTAATACTATATGTAACTACTCCAATGGCCAAGTATCGTGCTCATGTATGCCTGAGTTCTACGGCTCACCACCGAATTGTCGTCCAGAATGTACTGTCAATGCTGAATGTGATAAATCGAAAAGTTGCATAAGACAAAAATGTATTGATCCTTGCATTGGAGTGTGCGGACAAAATGCAGAATGTAGAGTTATTAACCACGCACCTATATGCTCGTGTAGTCTTGGATTTGAAGGTGATCCGTTTATTAGGTGCATGGAAAAGGAAAAAACACCTACGCCAATTACCAATCCTTGTATACCATCTCCTTGTGGATCCAATTCTATTTGTCAAGCTGTAAATGAAATACCGATGTGTTCGTGTGTAGAAAAATATATTGGTTCGCCGCCGAACTGCAGAGCGGAATGTGTCATTAATTCTGATTGTCCAAGCACTGAAGCTTGCATTAACCAGAAATGTAGAGATCCATGCCCTGGCTCTTGTGGTCTTTACACAGAATGTCACGTTTATCAACATTCAGCCATATGTAGTTGCAATGAAGGGTACACCGGAAATCCTTTCCAGAGCTGTCAAATCAAGCAAAATATTGAACCTGTTCCAAGTACATATGATAATTGTAATCCAAATCCATGTGGCGCAAATGCTGATTGCAATGATGGAGTTTGTAAATGTAGAAATAATTACTTCGGTAATCCCTATCTTAGCTGCCGACCAGAATGTACTCACAGTTCGGAATGCGCAAAATCTTTAACATGTATTAACAACAAATGTACAAATCCATGTATTAATATATGTGGTGAAAATGCCTTGTGTGAAGTATACAATCATATGCCTATGTGTAGCTGCCCTCCAAATACAACTGGGAATGCATTTTTCTCGTGTACACCGATTAAAGTAATCCAGGATACGAACCCTTGCCAACCATCTCCTTGTGGTCCAAACAGCGTATGCCGTGCACTTTCAGGACAAGTAATGTGCTCTTGTATAACTGGTTACATCGGTACGCCACCATCTTGTAGACCAGAATGTTTAGTGGATTCTGATTGCACGATTCTTTTGTCTTGTTCGAATCAAAAATGTGTAGATCCATGTCAAGGTTCATGTGGAATGAACGCTGAGTGTAGAGTTCACAACCACAAACCAATATGCTACTGTAGGAATGGACTTACTGGTGATCCTTTCTCTTACTGTAGAGTTATTCAAAAAGAACCACCAAAAACCGCACCATGTGAACCATCGCCATGTGGACCAAACTCTGTTTGTAAATCAAACGGCGAAGAGCCACAGTGCCTATGTCAAACTGGATTTATTGGGTCTCCTCCATACTGTCGTCCAGAGTGTATTTCTAATAGCGAATGCAGCTTCAATAAGGCGTGCATCAACAATAAGTGCGACGATCCCTGTCTTGGAGCATGCGGTCCTAACGCTGAATGTCGAGTTATCAGTCATTCACCACAATGCACTTGCCAATCTGGCTATGAAGGAGATGCATTCAATTTGTGCCACCCTAAACGAGACCACGAACCAGTCACACCTTCCGAACCTTGTGTTCCAAATCCCTGCGGTCCGAATGCTATCTGTCAAGAACGTTATAATATCGGCAGTTGTACTTGTGCGAATGGTTTCTTCGGTGATCCTTACGAAGGTTGCAGACCTGAATGTATTGTTAATTCTGATTGTGCCGAAAGCAGAGCTTGTATAAACAAAAAATGCCAAGATCCTTGCCCAGGGCTTTGTGGAGTAAACGCTCAATGCCAAACAACTAACCACGTTCCATCATGTACTTGTATACATGGATATGTGGGAAATGCTTACGAAAGCTGTATACTCAGAGAAGAAAAACCGACAAACCCATGCTCACCGTCGCCTTGTGGTGCCTACAGTACTTGTAAAACTATAAGCAACCAGGCAGTTTGTACGTGCTTGCCAGATTACGTTGGAAATCCGCCAAGTTGTCGACCAGAATGTATCATTAGTTCGGAGTGTCCCTTGAATAAAGCATGCGTTCGTAAGAAATGTGTAGATCCATGCATAGGAACATGCGGGGAAAATTCAGAATGTCGCGTACATCAACACAGTCCCTATTGTACTTGTCTGCCAGGCTATGAAGGCGATCCCTTTATAAGATGCTCTAAAGAAATTTTATCCACTCCACCTGTTGCCTCACCTTGTGAACCGAGTCCGTGTGGGCCATTCGCAACATGCAGAGACATAAATGATTCCCCAATATGCAGCTGCAAGCCAGGATATATCGGTGCTCCACCTCGCTGTGCACCAGAGTGTACTATAAATGAAGATTGCCCTAACAACAAAGCGTGTGTTCGTGAAAAATGTGTAGATCCATGTCTTGGATCTTGCGGTACTCATACCGACTGTCGAGCAATGAACCACGTAGCTATTTGTACTTGTCTTTCCGGATATCGAGGCGATCCGTTTATTGGTTGTTCATACCAAGACATTCAGCCACCGGTGTCATTCGACGCATGTATTCAATCACCGTGTGGTATTAACGCGGCGTGTGACAATGGAACGTGCACTTGCATTAGTGACTATCATGGCAATCCGTATATAGAATGTAGGCCGGAGTGCACTAGTGACAATGATTGCCAAAAACAACTAGCATGTGTCAACTATAAATGTATTAATCCTTGTAAAAATGCTTGCGGGATTAATGCGGTCTGTAATGTTTACAATCATATTGCAATTTGTGAATGTCCTACGCCACTTCAAGGAGACGCTTTTATATCCTGTCATCACGCGATTGAGCCATCAATATCAGATCCATGTACGCCTAACCCTTGCGGACCAAATAGTATTTGTCGTGCTGAAGGAATCGTAGCGCACTGTTCATGTCGGCCTCCAATGTTCGAAGATCCTCCAAGCTGTCGACCAGAATGTCGCGTAGATTCAGAGTGTCCACCTAACCGTGCTTGTAGAAACAACAGATGTCGCGACCCGTGTCCAGGATCATGTGGTGCTTCTGCAATTTGCCACATTCGATCACACTCACCTATATGTGTATGCCCAGCAAACTACGTTGGAGATCCGTTTATTCATTGTCTCCCAGCTATTGAAGCAGAGCCTTCGACTCAAGCACCTCAATCTTGCACAAACTGTGGACCAAATTCGGACTGTATAAATGGGCTCTGTAGCTGTAAATCGGGCTACGTTGGAGCGCCACCCTATTGCCGCCACGAGTGTCTCAGTTCCAGCGACTGCGAATGGCACCTTATGTGTTTGAATCTGCGTTGTGTAGACCCATGCCGCGGAGCCTGTGGACAAGGCGCTCTTTGCGAATCTCTTGCTCATGAGCCTCATTGTACTTGTCCTTCCTCCACTACTGGAAATCCGTTCTTCGAATGTCGGCCCATCGTTACAACCCAGAAAACTCCGAATGACCCTTGCAACCCATCACCATGTGGGCCTGGTGCTTTATGTAGCGCTAGGGGAGCGAGTGCGTCATGTGAATGTGAGCCTGGACTCTTCGGTGACCCATACAGTGGATGCCGCCCAGAATGTGTATCAGACTCGGACTGTTCACCTTCTCGTGCGTGCATGCGTTCTCATTGCCGGGATCCCTGTCAAGGAACTTGTGGTATAGGAGCTGACTGCGAAACTGTCAACCACATTCCTTTATGTTCTTGTCCAACAGGAACTAGAGGAAATGCTTTTGAAAAGTGTGAAAAGATTATTACAGCACCACCTTGCAACCCCTCACCGTGTGGACCAGGTGCTGTGTGCACTACATCAGGAAGCAGTGCCATATGTTCATGTCCAAGTGGAACTTATGGAGATGCTAAATCGACAGGATGCAGACCGGAATGTGTTGTTAGCTCTGAATGTCCACGTGATAGAGCATGTGTGCGCAACAAATGCATTGACCCATGTATTGGAACATGTGGAAATGGCGCGATGTGTCGAGTATTTGATCACGCACCAATTTGCTCTTGTCCACCGACTACTACCGGGAATCCATTTACAGAATGCACTTTAAAAGATGTCACTCCACCTACTTTTGACCCTTGCGACCCTAACCCTTGTGGAATTCATGGAACTTGCCGCGACGGACAATGCATATATCCAGAGTGTATCGTGAATGATGATTGTCCCGGTGACCGTGCGTGTATCAACAGGAAATGTGCCGATCCGTGTGTAAATGCTTGCGGTATAAACGCCATTTGTACGGGCATCAGACATACAGCGCCAACTCCACCGACACCTGAATGTGTAAATGATAATCAATGTGCTGATGATGCCGCTTGCGTTGATTCACGATGCTCACCAGTCTGCGGATCCAATAATTGTGGCATTAATGCCCGTTGCTTGGCTAAACAACACAGAGCACGTTGTACATGTTTACCGGGCTATGAAGGTGATGCTTACACTGGATGTTACTCGGTGCAATGTCACAGCAACAACGATTGTCCAGAAGACGAAAGTTGTGAAGGCGCTTCATGTGTGAAGGTTTGTTCACGCGTTCGTTGCGGAATCGAAGCGCGATGCGTCGCAAGAGGTCACACCGCATCATGTGAATGTAACCCTAGCGCAAGAGGAGACCCTTGGACCGAATGTCACATAGCCGAATGTAATGCAAATGAAGATTGCCCATTATGGTTAGCCTGTAAAGCGAATAAGTGTAAGGATCCTTGTCCTGGAGCTTGTGCACCTGGAGCCGTTTGCACAGTACTACGACATCAACCAACATGCGAATGTCCTCGAGGAACAAATGGCAATCCTAAAATAGAATGTCGACAAGTGGCAAACGAAGAGGAATGCCAATACGATGCTGAATGTGGACCAGGTCTGGCATGTCTACAAGGAAACTGCAAAAATCCGTGCGAACCAACTTCGTGTGGAACACGAGCCGTCTGTCGCGTTGCTAATACTCTACCTTTCCGCACCCTGGTTTGCGAATGTCCGAAACCACTCACTGGGGACGCATCTCTACAATGCAATCCAAGAGGAGAATGTACGTCAAACGACGATTGTAGTTCAGAAGAGAGCTGCATAAACAAGCGTTGCGTGAACGTTTGTAGCAACGGCGCCTGCGGTGTAGGTGCTGAATGCCGCGCTCAGTCTCATAGAGCTAACTGTGTCTGCGTACCACCATTACAGGGTGACCCACGTGTAGCTTGTATGCCTAGTACCCCGACTGCAGAATGCGTCGTAGATTCAGATTGTGGTAGCGCCGAGGCATGTGTATCACGACGATGTGTTTCGGCATGTATTGGAGCTTGCGGGACGGGTGCATTGTGTGACGCTGCGCAGCATAGAGCACGCTGTCACTGTCCACCGGGGACTGCTGGAGATCCTGCAAGAATATGCTATACACCTGAGTGTACATCTGATGACAACTGCCCATTCGATAAAACGTGTTTCAATGGATACTGCAAGGATCCTTGTGGTGTGGGCTCTCCGTGCGGACGCGACGCAAGCTGTGAGGTTGTAGCTCACGTCGCCACTTGTCGCTGTCCACCCGGTACGCAGGGCGACCCTCGTCGCGCCTGTATCTCAGCGGCCTGTCATTATAATGAAGACTGCGATGATTCACAACTCTGTAATCGTCTCAACCGCGTCTGCCAATCAGCGTGTACAGACAACTCTTGCGCTCCTGGTGCTTCATGTACAGGAGAGAATCACCGCCCCACCTGCAAGTGTATTCCTGGATATATTGGTGATCCATATCAACGTGGATGTACATTTGCCCAAGATACCACTGAATGTACAACGGATGCTGATTGCTCAGCGCCTTTAGCCTGTGTGGACGCACGCTGTATCGATCTCTGCCTGAATAATCCGTGCGATAGTGGTCTCATATGTAGAACAGTTGATGTGCTTCCTTTACGAGCAGTTGCTTGTGTATGCCCTGATGGAGGTCGAGCTGCACCGGATAGTGGCTGTCGCACACCACCAGAAGTAGAATGTTCCGTGGACTCGGATTGCGCTAGTAGTCAAATGTGCTTCCGTGGTAGTTGCGTCGAAGCCTGTAAAGCTGATCCATGTGGACAGAACGCCCTATGCGATTCGATTGATCATGCATCACGTTGCGTTTGTCCACCTGGATACAACGGAAACCCAAGATTTGAATGTAACACAGTGCCACAAGAACCAATAGTTTGGGAATGCTACGAAGACAACGAGTGTGGACCTGAACGCGCCTGTATCAAACGATCATGTGTCAATCCGTGTATTGATGGTTGTGGTATTGGAGCTCTATGTCGGGTGATTGATCATAAGCCACAGTGCTCTTGTCCAAACGGTTTTTCGGGCGATGCATACATTCGATGCTTACCACCATCCGAGAAGTCTTTTATTCCACTTGGTTGCAAAGCTAATTCAGAATGCCCATTATCTCAAGCCTGTATTAATGGTGCTTGTGCCGACCCATGTGCTTGTGGCGCACAAGCTGATTGCTCAATTGTGAGACATCATCCAGTTTGTTACTGTAAACAAGGCTATTCTGGAAATCCCTATATTGGATGCACTAAAGTTGGGTGCGACTCAGATTCTGAATGCTCGGACAGCGATTTATGTTACAACGGAGCTTGCCTTAATCCTTGCCTAATAGATACCCCGTGTGCTATTAGTGCTGAATGTTATGGCGTTAACCACCGTGCAAGTTGTCGTTGCCCATCTGGCACTGTTGGAAATCCATTCACGAGATGTATAGCAGCTGAATGCGAAACAGATAATGATTGCAATGATGATAGTGTTTGTGCGAAGGGAACGTGTTACAATGCTTGTTCTGTCAACGGCATTAGCTCTTGTGCAGATAATGCCGAATGTTTCTCGCGTAACCATGCGGCATCGTGTAGATGTCCACCAGCTTTCCCGATCGGAGATCCTTCTGTTCATTGCCAAAAAGCGACGGTATTAAACGAACCTGAGTGTATAATGGACGGTGATTGCCCCAGCGGTCACGCTTGTCTCAAGGATGAATGCCGTGAAGCTTGTTCCGAACTTAAGCCGTGCAAAGGAAATTCCCGTTGTTCAGTTTCAGACAGTATACCGTTCCGAACTCTGATTTGTCGTTGCCCAGAAGGCTTTGTACCTTCTGAAGATGGTAGCTGCAAGCCGGCCAATTTACCACCCCTTGGTTGCTCTTCGGATAATGACTGCACAGACCAAGAGTCTTGTGTTAACAGAAATTGCAGAAATCCATGTAACTGTGGTGATAACGCGGATTGTTTTGTTAAAGATCATAGACCTATTTGTTCATGCCGTAATGGATACGAAGGAGATCCTTACCGCACTTGTCGCGTTGTGGGTTGCCGTACAAATTCAGAGTGTGACACCCGAGAAGCTTGTATAAATGGAAATTGTATAAATCCTTGTTTAACAAACAGCACATGTGGACCAAATGCCGAATGCTTCGTTCAAAAGAACCAACCGCTGTGTCGTTGTCGTGTTGGATTTGAAGGAGACGCCTATTTAGGTTGTAATGCGATAGAATGTAGATCAAACGGAGATTGTCCACGTGATAAGCAATGTAAAGCTCACAGATGTATTAATCCTTGCTTCATTGACAATATATGCGGTACGCACTCTAATTGTCTGGTTCGTAATCATTTAGCAGTATGTAAATGCGACCAAGGATATGGCGGAAATCCATACATTGAATGTAAGCCGCAATTTGCTCAAGAATGCTACGTCGATGCTGATTGTCCGTCAAGAGCAGCCTGTTTGTCTTCCAGATGCGTTAACCCTTGCACGACATTAAAACCGTGCGCTAATCCTGCTACGTGTGAGGTCTCACCGACATTGCCAGTGCGTACAATGCTATGTACTTGCCCACCAGGTTTTGTGAGCAACGGTGGAGGCATATGTCGCCCAGTCATTGAATTCTTTGAATCGACTTGTGAAATTGATAGCAACTGTACATCGAACCATGCTTGTATATCATCTGTATGTAAAAATCCTTGTGATTGTGGACCAAACACTGACTGTATTATGAAAGATCACAAGCCTGTTTGTGCTTGTCGACAAGGCTTTATAGGGGATGCTTCGTCAGGTTGCTATGAAATACAATGCCAATCTGATTCTCATTGTGCTGACGACGAAACGTGTATAAATAGGCGTTGTGTCCCTGCTTGTTCGGTAAATGCTAATACGTGCGGGCAATCGGCTGAATGTTATGGATTAGAACATCGTGCATCCTGTCGCTGTAAGATCGGTACAGTTGGAAACCCATCTATAGCTTGCACTCCCATTGGCTGCAGAACTGACACAGATTGTCCATCTGATAAATCATGTATCAATTCCAAATGTGATACGCCCTGCAATGCAGATATTTGCCAGGAACCAGCTCAGTGCAAGGTACATTTACATCAAGCTCATTGCGCATGTCCTCCGGGATTCACCAATACAGGGAAAGAATGTAGAAAAACTGAAGGACCACAATGTATAAGTGATATAGACTGCCCTTCGGGAACAGGATGTCTTAATTATAGATGTGTCAACCCATGCCTGGTATCAAACCCATGTAGTGAAAATGCGCAGTGCAAGATTGTAGACACCATGCCTGTAAAAACCATGGTTTGTGAATGTTTGCCTGGATACAAAGGAAATGCATTACAAGAATGCAAGCCATATCAAACTGTTGCTAAATGCATCGAAGGTCAAGGATTAGACTTGTATGGTGAATGTATTCCTTGTCGACCAGCAGAAGGACGTATTATAGATTCTAGGGGTCGATGCGTTTGTGACTCGGAACGTGGTTTTATAATTCAAGGAGATAAATGCGTTGCTGGCGGCTGCCGCACTGACGACAATTGCGCAGATAATTCGCGATGCATTCGCGGTCAATGTGTAGATGCCTGCAAAGCTGAGCCTTGTGGTATTAACGCAACCTGTGATGCGGTGGGGCATCGCTCTCATTGCACTTGCATTGCCGGCTACACTGGAAATCCTAGAATTCAGTGTAATGCAACAACAACAATGTACCGAACCGATTTCCCAACACCAGATATTCAGGTCGAATGTTTGGCTGACGGAGTTAGAGTCCGACTTAAGATTAAAGATTTCAACGGCCTTTTGTACGTAAAAAGTTACAGTAAGGATGAGAGATGCAGGAAAGTTGTAGAGATGCCTAAAGACGAAGAAAGTTTTGTTTTCTTCACTGTACATTTCGGAGATTGCGGCCTTGTTCATGTCAATGGCTTAGCAAGCTTCGTTCTAGTAATGCAAACTCATCTGAAACTGGTAACATCAACCACAAAAGCATTCCACATCAAATGCATATACAAAACTGGTGAACAAAACGTAACTCTTGCATTCAATGTGTCCATGTTAACAACAGCAGGCACAATCGCCAATACCGGCCCTCCGCCTACTTGCTCCATGAGAATAATTTCACGTTCTGGAGACCAAGTCAGTTCCGCAGAAATAGGAGAGAACCTCGTTTTACAAGTTGATGTCCAACCATCTAGTATCTACGGAGGTTTTGCACGCAGCTGCGTTGCAAAAACAAGTGAAGTATCAACTAACGTAGAAAATGAGTATCTTGTAACAGACGAGGACGGTTGTGCTAAGGACCCCGCTATTTTCGGTGAATGGGAACGAAGCGAGGACGGCAGCGCGTTGCGTGCCGCTTTCAATGCTTTCAAGTTCCCCAGTAGTGACAATATACGATTCCAATGCAACATTCGCGTCTGCTTTGGAAAATGCGTACCGGTTAACTGTCGCGGTTCGGACGCATACGGTAAACGAAGAAAACGAGAAGTGACCGACGAAAGCACCGCTTTGACGATGCCGGTAGGTCAACTTCGAGAGGAGGTGACCGTCGAATCGAACCAAATACTAACGACGCAGCGACGCGAACCGTCACAAGTGGCTCGGCAGCGTGATGGTACTGGTGCAGAAGGTGCCAGTCAGAGCAGTGGAGAAGTGTGCGTGTCAGCAGCCGGACTCGCGGTCGCATTGGCGCTGACCGCATTACTGGCGTTAGTAGCCGTGGCGGCTGCGGTCGCTTGTTGGCTCGTAGCCTGGAGACGTGCACGTCCTCCTCCAGCACCGCTTCCACATCCGCCGGACTTCCCCAATCCGCTGTTCCAGCGTTGA

Protein

MYIDSLPLVVWTLLVTTTHVATQSQYGIGLGIKREVFFLNLEDGYFGCQVNESTQILQLYELSKLCDGVTDCYKGSDELKSELKCSDDCTKEDGAQCVNGACLNGVCHCNDGFGGCNCQDPDINECKDRPCDVFAHCTNTVGSFQCSCFPGYEGDGFTCRDINECEDPAIASRCVENAECCNLPAHFICKCNRGFEGDGEEECRDIDECRRPGACGTHAICRNYPGNYTCSCQAGYTGNPFDGCVDVDECINESTCGEVAICRNIDGGYECSCPPGYEGDPRVACHDHDECARAACGRGALCENLPGAYRCVCPPGFDGNPDVLCSDVDECKSSETVCGAHAVCTNTAGSYVCTCAPEYTGDAYAQDGCLDLDECQTLEKPCGTNAICENSAPGYNCVCPQGFAAQPDPQIACEQVDVNILCKSNFDCTNNAECIDHQCFCKEGFNAKGSICEDVDECSNNKSVCGENALCINIPGGYNCQCAAGFVGSPPKIGCRAPCEDVKCGKHAYCKPDGMEAYCVCEDGWTFNPHDIAAGCIDLDECDISLGPVGRCGKNAICSNTPGSFSCNCPEGYTGDAYKQCSDIDECQLEGACGLGADCLNRDGSYSCECPDGTIPDPDPHIRCAEILACKGDKDCPGNAVCDSNARCLCPEPNIGNDCRHPCESLQCGTNSECLLSDQEAQCTCKSGFTGDPSSLLGCQDMNECDEKPCGVGAVCKNLPGRFQCECPATFTGNPYVEGCNPGKILSECSNLNPCPEGEQCILHDGGNVCICPQGFTRNSETGLCEDINECVQHGRSPCGLNAICKNLPGSYECKCPQDYSGNPYKICELCDDISCQCQPPYKMIDGSCVLSGCGKDNKCGTGAECIVISDEVSYCACPAGYTQTSDSTCEDINECTSGTPVCGFGAECINTVGSFECKCPPGYSKDKIEGHCSLNQKRCISDSDCFPNEKCVQPGKCMCPPPFYLDVTDGQKCKSPCERFTCGINAKCTPSDPPRCMCMAGYEGDPYTGCTKRNECHSSPCAYGAICHDQKGGYKCDCPPNMIGDPYRSGCVFEEEPTQKHLCSSDDQCPNTLACLNHTCISPCATISCGPNAFCEVENHAAWCRCDPGYTKPEGGKCISACDTYNCAPGAQCIISKTGPTCVCVEGFVGNPFPGGSCSRDQCGPGIPCEDPLTCVAGRCRQRCEGVLCGVGATCDSQTGRCVCNPFFIGNPDLLCMPPVSPPACEPNCGTNAHCVYGKDNICKCNKGFTGNPYKKCLSRKQITCATASCGRNAVCQQTKSSIECLCPPGYVGNPNIQCKDIDECGTNPCGENALCINTPGSFSCICRSRYVGNPYELCSQVSVAKCTDGAVCTCSHNTTCPHGFVCDKSKCVDLCEKLACGPKSVCEEGVCHCLPSHTGDPNDLRKGCVPDDSCLVDGDCKDSEICFQVAKNTRKCVDSCSKLQCGPNSLCIGANHQAHCICADGYIGKPTDVKVGCHLEQREPNEFECNDNSDCNEPFVCMSLEGSTKRCIDLCTTIACSANEVCRVVAESARCECDNGFLWNPVTSNCEQPSTPNCQEDDDCDDNKSCNKDVLGVKKCEDSCSVFNCPENSKCVTKNHKSKCECINGFIGNPNDRDGCLAIDKNECSDDAQCRESEVCRTFGGNKKCVSACQNVVCGPNAFCITKNHIARCQCPSGPFTGSPDDLEKGCQSVPCVHNDDCLSHQLCNRMTYTCINACTVNSCGDNAVCIAENHKIICQCPNGYSPDPKPEVSCQKDDACNSNPCHPSAICESSFSSFSCQCPNGYVGDPIKDGCRKQDICLRDGDCPREAVCVENRCVNTCDGACGLNSLCQIINRKAVCMCPEGYEKIQDNACKKKLLACSSEKDCGGDICNNGQCFTACKNSSQCEFGDICKNNLCVAQCNKHTQCGHGQACIGGQCLIGCRNNEDCFSEEACVNNKCVNPCLTTKPCGPNAICSRINHSTNCECPLGFQGAPTPQQGCVRKPSVCDRTSDCPPDHMCIGFLCQVPCKDSTGCAIGEKCSDNKCLRICHSSTNCLHGEHCDAGVCVPGCKSDLDCLNNLVCNNMKCQCTAGFELRNEECTNLNECLEYPCHPSAQCVDTPGSYKCVCSVGAAGDPYRSGCLLPNQCRNDEQCDNSLACIQGKCSNPCQNNTCGTNAECSVMNHNVMCACKKGYLGNPFDKNIGCFKVECVDDSDCNTEKYCDLKFNKCSDVCEPSICDGGNCKIENHKMLCTCPTGYLFKDKKCVDLNECLSSPCPLNSKCFNTLGSYKCECVNGTVQDTITGSCKLPGDCVTDDDCTQVTKCFNNHCVNPCEKLSPCGENANCFVTKHKAECECPSDSQGDPYKKCIKFECTKDNHCPQEEACVNNKCKNACSLPRACGRNADCFSKSHVGNCICSPGYTGDPVLGCVPIQYCTTDDRCSSGTKCVDNLCVGLCKNSRDCLNNQVCIKNTCRVSCSLNDTCPEFQYCLNSICTKEVQCISNDDCLDDEKCSTGKNGIPQCIKVCDKHPCGRQAECLGKNHQPTCSCALGFFGDPLEGCQRKECDTDTECSEDKVCDRNMCKIACLVKNECRENSICSSEKHKNVCYCQPGYTGDPIKGCTEINWCKLSPCANGAECKSARDRAECTCPANTVGNPYEEGCRKAEECRFNRDCPTAARCTVIDGTRKCTDACENVKCGLNAECFASRHSAQCRCKTGFIGNANSEKGCHLREISCTSKSNCPDDQYCHKGICKALCLLDEECASNEKCFGGQCLNPCQLEKTCGLNAICRTDNHIVQCSCPQSFTGNQDMECIRIPRLCGSAGDCENGHMCKDSMCIPRCNIDEECALNERCTKGGCLLTCRVDNDCFPGHICLEQSCQYGCRYDDDCGPEEFCKNDVCKNPCDSDVNPCGPNAVCSVLERIAHCSCIEGLIPNPTPNIGCIRAPSSECRQNTDCTDGWTCEDSRCRPACTADGSQCLQGERCDEGVCRYACTSDEHCSDDEICDGRSCTIGCRSNSHCSSKLACISGQCRDPCTEPASCGINAICATKDHQPVCTCPRKLAGDPKLVCSRVTTSCGSNQNCPDGFSCYGDTCHPSCRSDNVCLSNEKCIRGICRTICNSDTACSEGYICENRICKQGCRDDNACEETHACVKGQCKDPCSQGACGICSECKVQNHRPQCSCASNYTGNPLVECRRKKTLCDGFCPCDQSGYCISLCDENSDCPCGDKCIEGGCLTRCSPRNKCPERQICQQGVCTPGCNNDKDCSDDMFCSSNLCVNACQEESCGINALCLTTRHRAVCSCPSGYSGDPLKECNQFECQNNEDCGTDEECYTDGKCKNVCSGACGLNALCRSVDRSPQCSCPPNYQGNPQIECTKPTTGSCLRNPCGVNARCRDLDDGSYECTCPPNCAGNPQRQCFCGKMEPCAYKPCGTNAQCRVNRIGEAQCYCPRNYPNGDPNIECAQERSVIDCRTTGCGINGECLREGAEFVCRCVPGTEGQADIECHTSIECTSDVECPVDKVCLSLHCVDPCTLRGACGEDALCAPLMHMAQCSCPQCYVGQPRISCRLDPNCKPTTDYNSTFSCSEDKPCPPKLACDLNSNQCRNPCLGYQNCKLNQKCEVRDHKPVCVCRNGFALNEKGELTCAPEHAECTRDDQCPSNAACRDYKCVNPCLTSKEPICPKGKQCEVLDHRAMCLCVQDCNPSVSICRTDKGCPNNLACRDYQCKDPCNGACGGAPCTVEDHHPVCKFCPHGFTHDEKHGCIKAVECSDHEQCPSNMACMADRCADPCSQGGPCTPGQSCTVLNHQPVCSKVCQCQTSSDCVSYSNSVCDGCNCVLGDKPKTNCAHCRPGVPCDPFSGACMENDQPKNVPLTDVTSTTTSEDTETSTKDDSLNYLTYSTNIDDEQIDTTSSDLKLSTDYHNIITEKPSTLHIDDIATKSTLADDLSTTDSFDETYLTKSITRSGLNATADTNISLFNYTSTKFHTTDSLLTDIYDFQNVTEADQKSYATIPINTEKIYDSEKPAFTTQKYIDTTINEKTTIFSSLVKEPISKPLYLDKSDEPVQSSSTIHEESTLKPNVKQTTQVAEKPISIENKNTKTPENQRKLNGNYTNIADGYGPVSHSVNEKSATKMTTPLPKTKPTNPSEIPLTASEITINYYTTEGSSVESTLSEEITLTNQDTAATSMKTLTSGIEMDTGVNAEENNKSTNFYTSTIQYSTQNDMSDSHETVSTDFKVATTTSPTVHIIDNQSDQINYSEKNAYQTTKNAPSLNPTTTNYYHTVITMEEKWDSSENDLIETTTEAQLKQTNYEFKLTDTNDLNKQNDTTTIPTGGIVEFLTHKATKSDDTIVTISTEPYTIFNSNEETTHKPVQPLNKQKPTQFIKYETTTEFTQSSNDDIKQLSEYPKEQFNILNERITTGSSLASQTDAEGVEITSSLTTMSKSTISTLDIHETIPNLGLSTQSGSYEFTSSIPQVFSTTNSDVILDQDNLFLHPNIATINYKATDKNDNQETTSQYNDNENEFPLTSTVTYDNTGKSEPAESQHMHSSDINKVTNGNENNLLSTTYRDVTTSQYDSETEDSNSESQSMQSATTDQPINIQTNENENKLPSTTSITTSHYDSETEDSNSKSQSTQSATTDQLTSVQMNDNDNKLPSTVSVTTSRYDGETENSVSESQSGQSTNVNRATSMYANDNENNLPSTTSITRSHYDSETEDSNSELQITQSTTTTQATSIQPNDNENKLPSTTFITTSHDDSETEDSDSESQTTHSRTTNQATSMYANDNENKLPSTASVTTVHYGTETEDYNSESQTTQSTITNQATGIQTNDNVNKLPSTAYGTTSHYDSETEDSISESQSTQSTITNQASSIYANDNKNKLPSTASVTKSHYDSETEDSDSESQTTHRRTTNQATRMYANDNENKLPSTASPTTSYYDTETQDYNSESQSTHNVTTDQATSIYANENENKLPSTASIATSHYDSETEDFNLESQTPQSTITKQATNTYANDNENKLPSTASVTTSHYDSETEESDSESQTTHSRTTNQATSMYANDNENKLPSTASPTTSHYDTETQDYNSESQSTHSVTTDQATSIYANENENKLPSTASIATSHYESETEDSNLESQTPQSTITNQATNTYANDNENNLTSTASVNTSHYDSETDDSNSESKSTQRTITNQVTSIYANDNENKLPSTASVTTVHYDTETQDYNSESQTTQSTITNQATSIQTNDNENKLPSTASVTTVHYDTETQDYNSKSQTTQSTITNQATSIYANDNENNLPSTAFVTASHYDSETEDSNSESQTTQRTISNQVTNIHANDNENILASTASGTTSHYNSETEDSISESQTTQSTIANQATSIQTNDNENKLPSTASVTTVHYDTETQDYNSKSQTTQSTITNQATSIYANDNENNLPSTAFVTASHYDSETEDSNSESQTTQRTISNQVTNIHANDNENILASTASGTTSHYNSETEDSISESKSTQSTITNQATSTYANDNENKLLSTASVTASHYDSETDDSNSESQSTQSRNINRATTIYANENENNLPSTAFVTASHYDSETEDSISESQTPQSTITNQATSVQTNDNENILPSTASVTTVHYDTETQDYNSESKSTQSTITNQATSIQTNDNENKLPSTASVTTVHYDTETQDYNSESQSTQSTITNQATSIYANDNENNLPSTAFVTASHYDSETEDSNSESQTPQSTITNQATSVQTNDNENILPSTASVTTVHYDTETQDYNSESQSTQSTITNQATSIQTNDNENKLPSTASVTTVHYDSETDDSNSESQTPQSTITNQATSIYANDNENNLPSTAFVTASHYDSETEDSNSESQTTQRTISNQVTNIHANDNENILPSAASVTTVHYDTESQNSNSESQTTQVTITKQATSIQTNDNENKLPSTASITASYYDNETENSNLESQTPQNTITNQATSTYANDNENKLPSTASVTTVPYNNESDEFKTGSQSIHSTAANQHSSIQTNETRIPLTTPIVESYHNTEIKGSQRESHNTQSTDTTYTESYDSKYELPLTTAFTTLYYNSESDLSRTESLATQRIATGKDTNIESNQDHYQTTVDATESLSTENVVDSFTSTAVTNLATLIDENVNKFSESQHSTTILTAQDETTFKPYSEVDFTTVFHNIKTVENDFNADKDDDYLTQEISTTTEPSTIDYLNNPCDLPEMKCAQNTSCKVVNHAAVCVCDSAGNNCVRESSGTPKVPEPCHSDRDCIEIEACFMGLCQDPCEFDNVCGIQANCQRVKHRPMCSCPAGYDGDPAIKCSPKIFGCTRNDDCQSTEACINNACQHPCAIHNPCAPNAVCINTNHGSDCSCVEGFQGNGYVGCVPVVESTSVCQYNEDCPPELLCDRLNRKCINPCAINKCGDNAECLPSNHGIQCKCAPGFTGNAFLECYQVQGCRSDNECANSEACINGKCGSPCRCGINAVCDVINHRASCKCLQGYTGNPQIGCEPPTNPCSPNPCGINALCEIDNGNPICYCPKGLTGNPFKNCIPEGNECEPNPCGPNSGCRLIDDKPACFCLPNYEGSPPRMPCKLPNNPCNPSPCGPNTQCTVLSNGFSKCSCLPGYVESPNTVRGCIEARNPCEPSPCGVGARCDPNKTPSCFCPENTVGNPYKSCDSNRGYLPPVANVLCQPGPCGPNADCFVSSNREVCYCKTGFSGDPYLGCQNQISPCAPNACGPRAICQVKFDGQAFCVCPEGSVGDAYSIEGCILRECEVDDGCPTNKACIGYSCQDPCPGVCGLNTKCHVEAHRPVCFCEEGFIGNPLICCLPPEDQKSISPCNKIQCGINAICQEVGDRAVCSCPLDFIGDPTIECKPECMMNSDCSSNEACINKKCIDPCASANICGINAVCLCSDHTVSCLCPDGYIGDPLTQCIYKPIIIVPDNSTAQPCSPNPCDQNAPCDTYGNQFAICDACVGLNSLNNPSCRPECVLNSDCSFDKSCLRNKCLNPCPGSCGINAECTVYNHDPVCQCVNGFEGNPYEHCKPSVRPITHETCNNVQCGANAICRDFNGALACHCLPDFYGNPYISCRPQCVVNSDCSPELACFHNKCEDPCTNVCGIGALCKTVNHHAVCYCESGQIGDPYVRCQNAPALPPSLSVCDPSPCGPYSRCLVSSNGFAMCSCLPGHKGIAPMCQPECVSNADCQQMETCVNQRCINPCLGSCGVNADCVVVNHNPICTCSRGKSGDPFVACTDITEVVPSERNPCVPSPCGPNSVCEIKSNHPVCSCRPNYSGTPPYCRPECVISQECPSNKACINEKCLDPCTGACGNNAKCVVINHTPLCSCLDGYKGDAFVGCNAISNDDTETLCNPSPCGENTICNVINNIARCSCIPPNIGNPYAGGCRPECSLNSDCPNHLACLSNHCRDPCKDLCGVNAECIVTNHVPVCTCFRGHEGDPFIACNRQEQKPRNPESPCEPSPCGANSDCHIVSGRAACSCRPGYLGAPPACRPECAVNSDCPATRACINHKCKDPCINSCGIDARCHVVGHNPICTCPENLSEGDPFIKCTRKTIMPTHTDPCLMSPCGPYATCRNEDGRAICACEPGTLGAPPSCRPQCVINQDCPLALACLGGNCVNPCIGSCGFNARCSVQNHRPVCSCDDGFSGDPFAGCNPIEISKEAPRQPCHPSPCGANAICREKDGAGSCTCLDDFYGDPYSGCRPECLMNTDCAREKSCFNNRCIDPCSGTCGQNTQCRVVNHAPSCYCLSGFTGNPLHACVPVKPFPDNLDPCHPSPCGPYSKCRISNGHAVCTCLDMCIGSPPNCHPECIVSSDCRSDKACINQKCQDPCSGICGINAKCQVVNHNPICSCLSDYTGDPFVRCYIDDRQMTPINNCVPSPCGPNSQCKEVDGVAVCSCIENYVGRPPNCRPECVMNVECSGNLACIAERCSDPCPGSCGFHAICTVVNHVPTCTCDHGYTGDPFSGCSSIPSIEPQPQSLCSRSPCGANAICKERNGVGSCSCLPDYYGDPYIECRPECVLNSDCTKDKACINNKCKDPCPGVCGMNAECRVNNHAPSCACLPGYEGNPFSSCYISTFEDPVNPCVPSPCGPYSLCRENNGHAICSCQEHYFGSPPFCRPECMVSSDCMPNKACINKKCVDPCSGACGNNAKCTVVNHNPLCSCPKDYTGDPFVHCSYETRPEPKPSGNPCIPSPCGPHSQCRVIGETAACSCQLGFIGRAPNCRPECIFDEECPSNLACIREKCANPCEGSCGSNTNCVVINHKAVCHCRESYTGDPFSGCYFIVTVPSEEETNPCNPSPCGPNALCKERNSAGSCTCIPDYFGDPYLGCRPECVTNNDCTFDKACSNNKCVDPCQGACGINSQCTVAHHNPVCLCVDGYEGNPAVSCHPQRKPPLADTNPCIPSPCGPYSHCKVVDDHGVCSCQEGYIGSPPACRPECVTSTDCPQNQACIRQKCKDPCPGTCGTNARCLVINHNPICTCKPGFTGDPFNFCQLEQKPIIEGPKGNPCIPSPCGPYSQCKIIADAPACSCLPNYLGVAPNCRPECSINAECPGSLACQNEKCVDPCPGSCGFNAECSVANHVALCNCIPGYSGDPFSGCSLFQHIPEPPPNPCSPSPCGANAICKERNGVGSCTCLPEYFGDPYTGCRPECVSNSDCDRNKACSNNRCKDPCPGTCGINAECRTVNHSPTCSCLTGYTGDPLVKCDFETITEKNEPVQNPCKPSPCGPNSLCKVVNGHSVCTCDTGYIGTPPSCRPECLVSVECSQDKACIGKKCLDPCPNTCGLNARCQVINHNPVCSCTPGFTGDPFTKCNPEERMVQSNPCQPSPCGPNAECRVIGDQAACSCLPNYIGRVPNCRPECTIDAECPSNAACINERCKDPCERACGVNAMCLTVNHKPICSCQQGFTGDASISCDQLIISSTEMTPTSSPCTPSPCGPNAECREHNGAGACVCSEGYEGDPYSPQGCRRECESNDECAPNLACTRYKCIDPCPRTCGQLAQCIVENHAPVCSCPRGYTGDPFFQCKQILMDPSPPKNPCEPTPCGPNSQCRQVNMQAVCSCLPNYIGSPPSCRPQCVVNSECDTSKACINQKCDDPCPNTCGLRAHCLVKNHNPICTCPVGMTGDPFTQCYQIPPTTERPPTCTPSPCGPHSRCQLLASGPACSCLPGYVGSPPSCRPECTINSECPASLACVRQKCEDPCPGSCGVDANCHVLNHVAICVCNEGFTGDPFSRCLPISGTPTTPEPSDPCNPSPCGPNARCDNGFCTCLPDYSGNPYESCRPECTGSQECPRDKACFRNKCRDPCPGVCGLNAKCDVINHIPTCSCISDFTGNPFTHCNRIEGKQTDKPRDPCHPSPCGPNSVCKTVDNAAVCACLESFQGTPPACRPECIVSSECPSTKACVNQKCINPCINACGVSARCEVINHSPICSCSPEQTGDPFKSCYDVVNTPPEPIDACNPSPCGPNAQCIQRNEKANCRCLENYIGQPPNCRPECVINPDCPSNQACVRNKCIDPCPGSCGINADCVIVSHTVSCICREKYTGNPFMQCVPQEEIVTKPCDPSPCGANALCTQREGAGSCSCLEGYQGNPYEGCRPECVLSSDCPADKSCIRNKCADPCPGICGTNAECNVINHVPSCACLKGYSGNPFTQCSKDEPIEFSRPCQPSPCGPNSVCRENGGLASCECLPEYIGAPPDCRPECTVSNECPSDRACHKLKCADPCRGTCGIGAHCQVVNHSPLCSCPAGTSGDPFKRCFETVLYEPGQPVQPCQPNPCGPYSECRALNENPSCSCMQGYAGVPPNCHPECLVNTDCPSHQACIAEKCTNPCEGSCGFKAECRVQDHIPICSCPVGYSGDPFIQCSEVIITPTPSPEPCNPSPCGSNALCNAGLCTCAHGYFGDPYVGCRLECSTNGECSPTRTCQGGKCVDPCPGACGTNAICSINNHIPSCTCPPNTFGDPFTFCTEVVHQDTPTSACSPSPCGPYSECSVSANGAAACSCKSGHVGSPPSCRPECLVSAECKLQQACIDRRCRDPCEGACGRGARCQVIAHSPICTCNDGFTGDPFSYCYPAPATPPTPIDPCQPSPCGPNSMCVNSGETPACSCHPGFIGTPPNCRPECTISAECPATLACVGQKCKNPCEQACGPRALCSVVDHRATCACEPGLEGDPFQGCSPARAPPKIEYLNPCEPSPCGANAVCKIQGNAGSCTCLPEYFGDPYQGCRPECLTDSDCPLVSSCSRNKCINPCLGACGVNTECFVNNHKPMCNCKSGFTGNPMTICSALRENDVYIENVCNPSPCGNNAICKNINEQPVCSCLANFIGSPPNCRPECIVNSECKPSKACINQRCINPCPKPCGKNSECKVINHSPICSCRQGYSGNPFTMCNLVLQTLPSVVETSNPCSPSPCGPYSECRNNNGLASCSCLSTYIGSPPFCKPECVVNSDCPSNLGCISEKCRDPCEGSCGLFAKCFVNNHVPVCLCPEGFTGDPFSQCVEKPVKEITPTLQLDPCQPSPCGPNTECRNGVCSCINGYHGDPNLGCRPECVYNADCPSDKGCQKNKCINPCIGTCGVNAICDVMNHIPMCSCPKGMVGNAFVECRAVAVTATSPCSPSPCGPNSQCQQSNGQAVCSCVPGYKGSPPTCRPECVVSLECPLNQACNNQKCLNPCIGACGAGAVCDVINHNPICTCPPSFTGDPFVRCSVIVAVEPTVNPCEPSPCGPNSICKISGENPICACLQDYKGTPPNCRPECISNSECEYHLACQNKKCIDPCLGTCGSNAECRVVSHAPNCICQVGYTGDPFAYCSMLAVMDYTEILTPCSPSPCGANAICREQKGVGSCQCLDGYSGNPYEGCRPECVVNSDCPLNKACSRMKCVDPCPGVCGSNALCLVNNHMPTCICQPGYTGNPFGYCTIMQEPQVLETNPCNPTPCGANSQCKEINGQAVCSCLPSFSGSPPNCRPECVVSSECPPDLSCSSQKCINPCEGACGENARCNVINHSPICVCKQGLTGNPFTRCYPITGSKPPQNIPIQDPCISSPCGPYAECRNIEHAPSCACKLNYVGTPPNCRPECTINSECSSNQACINEKCRDPCLGACGINAQCSVFNHVAQCSCIEQHTGDPFTRCSPAIEQDEFSEPDPCNPSPCGGNAECNNGICTCLPDYQGDPYFGCRPECLLNNDCPQEKACVKKKCVDPCFNTCGTDAICNVYNHLPMCSCPNGFTGNAFLQCRPIKNIEEINPCSPSPCGPNSQCREVNGQAICSCFPGFFGAPPTCRPECISSAECALNKACSNQRCIDPCKGNCGTAAICQVINHNPICSCPQRFTGDPFSRCSVQEEEIPQYVNPCEPSPCGPNSICKEVGNSPSCACLETYLGHPPNCRPECIANSECPNSMACMNQKCKDPCPGSCGSNAECKVVSHAPQCICSPGYTGDPFIACLVQDIPLTPCQPSPCGPNAICKQQGNAGACVCLPEYLGNPYEGCRPECIVNSDCATNLACIQNKCKNPCNSACGLNAICNVINHSPKCECLPGLTGNPYQNCYEQSADTPSVTKNPCTPSRCGPNSICKINNEQAVCTCQQDFIGTPPSCKPECVVSSECSQQQACIKKKCRNPCEGVCGQNSECKVINHSPICTCRVHYTGDPFNGCSKIVAAEIIPLPTNPCLPSPCGPFAQCRDIGGSPSCSCLPLYIGQPPNCRPECTINTDCPSDKSCINERCIDPCPGSCGIYAECRVQNHVSICTCLEGYTGDPFNACILKPQKDPVPSDLCNPSPCGPNAICNDGICSCLPEFQGDPYFECRPECTISSECPMNKACVKNHCVDPCPNTCGTNAICQAINHMAVCTCPAGMSGNAFIQCNPIKEFSIVNPCQPSPCGANSQCRELNGQAICTCLPGYRGTAPYCRPECVASSECPSDKACSNQKCINPCQGTCGVAAQCQVIHHNPICTCSTGFTGDPFTRCTATPLELPTAPINPCQPSPCGPNSICQENGSQIPSCQCMPEYIGAPPNCRPECLANSECAPHLACINKKCQNPCEKACGTNAECRVVSHTAVCICPEGYSGDAAIQCSQNAVVPFETLSACEPSPCGANAECIERASAGACICRKGYIGNPYDGCHPECVVSSDCPSNKACTRNKCIDPCPGTCASNANCQVVNHSPLCTCKTGYIGDPFTACKLEPQLDLPVNPCQPSPCGPNSQCKVSNGLSICSCLPEYSGSPPNCRPECVVSAECPSEKTCRNKKCVSPCPDPCGQNTNCKVINHSPICSCQSGYTGDPFSRCYRVTITELPPQQQRDPCVPSPCGPNSYCQDLRGIPSCSCLPNFEGNPPNCRPECTINEDCASNLACINQKCKDPCPGSCGINANCQTQNHIAICSCIESFTGDAFTQCKPIPFIEESDPCNPSPCGINAECSNGKCTCFEEYQGDPYTGCRPECLESSECERDKACIKNKCKDPCPGTCASNAECNVINHIPMCSCPERMTGNAFVECRPIIEAVITNPCEPSPCGPNSRCRDVNNQAVCSCAPNNIGSPPSCRPECTISSECPLNQACSNQRCVDPCIGSCGVNAECKVVNHNPICSCPTFYTGDPFSRCMRQPERLPEPTNPCAPSPCGPNSVCREVNGAPSCICLEGFKGQPPYCKPECSSNEECSPHLSCIRNKCKNPCENVCAVNAECKVVSHSPVCVCQYGFTGDPFFECIQEPLYTEPITSPCSPSPCGANAICKERDNAGSCSCIDGYMGNPYEGCRPECVVNTDCPSNRACVNYKCNDPCPGSCGTNAECQTVNHVPLCTCINGYTGDPFRYCVYQDSPVLAPVDVCNPSPCGPNSQCRTINGQAVCSCLIEYVGSPPNCRPECIVSSECSHDKACVNNKCVNPCPKPCGVNADCKMINHSPICSCKNAYTGDPFTVCTAIKHEPVPDTSDPCVPSPCGPYSQCRNIGNNPSCSCLPTYTGSPPNCRPECIIHSDCPGDRACIGSKCLDPCPGSCGISATCNVQNHIPICTCIEGYIGDPFTDCKPKPLEVEPSVTDACTNIRCGSNAECINGQCQCFPEYHGDPYFSCRPECVFSSDCDETKACILKKCVDPCIGACGQNAICQVFNHIPMCSCNNGFTGNAFVRCNAVREPTIKHPCSTAVCGPNSQCREVHDQAVCSCLPSYLGTPPACRPECVVNAECPQNQACMKQKCINPCAGTCGSRASCDVINHNPICTCPAGYSGDPFVECKVLYNTPPVVIDPCQPSPCGPNSICEVKNNNPSCTCKEEYNGQPPYCKPECISNSECAPHLACIKQKCRDPCIKACGTNAECRVVSHSAMCICPQGYLGDPFIQCSVKIEDEILPPCSPSPCGPNAICREHHNIGACICNDGYFGNPYEGCRPECISNSDCPGDRACIGNKCQDPCPGTCGINSECTTVYHSPTCTCIQGYTGDALRRCNPILPQENIQENLCIPNPCGAHSQCREINDCNSNKACVNHKCINPCPGPCGEKAECKVFNHNPICSCHSGFTGDPFTRCYPKPVIQTIYEERNDPCVPSPCGPLSICRNVGDQPSCSCAPGYIGSPPNCRPECVTNQECQSSLACINEKCKDPCPGSCGQNAKCSVIEHVSICTCLEGYKGDPFTSCAPQPIQDLVPADLCNPSPCGSNAECNNGECSCLPDYRGDPYLGCRPECTISSDCQKNQICAKKKCFNPCPDTCGQNAICEVINHVPMCSCPAGFTGNSFVTCNAIQVPIAINPCNPSPCGPNSQCKEIKNVAVCSCIPGFSGNPPTCRPECTTSAECSLDKACNNYKCINPCNGACGIGAFCQVVNHNPICSCPNEYTGDPFTRCVLKPAEIQPQVNPCSPSPCGPNSICQNNNDSPSCSCLPEYTGVPPNCRPECTSNSECGNHLACINNKCGDPCVGACGQNAECRVVSHTPNCVCPSGFIGDPFIQCSIQQILHENITPCVPSPCGSNALCKERNNAGSCVCLPGYFGNPYEGCRPECIVNTDCPSNRICQQNKCQDPCPGTCAANAQCNTVNHAPICTCLPGFTGNPFQSCLIIQNIEIETNPCSPNPCGPNSICKEVNEQAVCTCLADYRGAPPNCRPECVVSAECPTNKACVSLKCQDPCIGQCGLNTKCQVINHSPICSCIERFTGDPFSRCFALVSSPPTHEEQPKNPCLPSPCGPFSECRDIGGISSCICLPNYIGAPPNCRPECTINADCPSNLACMNQRCKDPCPGSCGLNAQCFVKKHMPICTCLDNYEGDAFTECKLQEQINDEIDLCNPSPCGPNAICNNGECTCLPEYQGDPFFECRPECVLNSDCPQDKACQKNKCTNPCLSNACAANAICEVFNHVAMCRCPERMTGNAFVLCSHLEVVKPQPCQPSPCGPNSQCREINGQAICACFIGFVGSPPSCRPECTVSTDCSPNEACSNQKCINPCQGTCGVNAQCQVINHNPICSCPSSLTGNPFVRCFVQEFKPEYSDPCTPSPCGPNSMCQEISGAPSCSCLDEYIGKPPYCKPECISNTECPLHLACINQKCKDPCPGSCGLNTQCHVVSHSPTCSCDLEYTGNPFIECHRIQIISEATTPCQPSPCGANTICKEFNGAGSCVCLEEYFGNPYEGCKPECIINTDCPSNKACLQNKCQDPCPSACAPNAVCQVVNHNPSCSCERGYTGDPFRYCTPEQILETPINVCQPSPCGPNSRCQEVNKQAVCSCLPNYVGSPPGCHPECVTNGECPRDMACINQKCGNPCLDACGINAECRVINHNPICQCTMHYTGDPFTRCNPIPPPVANADLEPYRNPCVPSPCGPNSICHEIGNIPSCACMDNYIGNPPNCRPECIVNSECPTSLACIQQKCKDPCKGSCGLGAICTVSRHTPICVCPDGYIGDAFTICQPKPPEADIVDKCNPSPCGSNAICSDGVCSCIEEHQGDPYIGCRPECVLSTDCPRDKACVKNKCINPCVDTCASNAICDVINHTPMCSCPQGMTGNAFYSCDFIKVPVVTNPCLPSPCGPNSQCREINGQAVCTCIQGYIGSPPLCRPECVVSSDCPSDKACSNQKCINPCDGSCGIEAKCMVVKHNPICTCPNKYTGDPFTRCVPFRVPTADVTPCTPSPCGQNSICKEVSGTPSCMCMPDFFGTPPYCKPECTSNNECPVNKACINQKCADPCTSACGLNALCRTISHTPTCFCDNGYTGDPFTRCFIEEILYEHSSPCEPSPCGPNALCKEHNSAGSCVCLPDYIGNPYEGCRPECTINTDCEPSKSCIRNKCQDPCPGTCGALATCAVVNHLPTCSCLEGYTGDPYRRCDIMQVPTAISITPCVPNPCGPNSICHTVNNQSACSCMPEYVGSPPGCRPECTVSSECPQNRACINLKCADPCPSHCGINSQCKVINHSPICTCKLGFLGDPFTRCYPQPEDIPVTKNPCLPNPCGDNAICREINGSPSCACIPNFLGIPPNCRPECAINEDCPSDKACFNMKCGDPCPGSCGQNAECSVFNHVPSCACIQGYTGNPFSACFLMKPIQDEIPKDPCYPSPCGFNAQCNDGICTCLEEYFGDPYLGCKPECVINSDCPLNKVCSKNKCMNPCPGTCAPTAQCSVYNHIPICTCPDGTTGNAFVECHTIQVVHEEPCNPSPCGPSSQCRSVNNQAVCSCLPSFIGTPPSCRPECIISAECPRNEACNNHKCINPCQGSCGYGAKCEVVNHNPICSCPPQYTGDPFTNCQPIVTAQLPPVDPCTPSPCGPYSICKVIAESPSCTCQPDFSGTPPNCRPECVSNSECPSSQACINQKCKDPCPGSCGYNADCKVISHALVCSCPNGQTGDPLISCSPIRETFIEYSTPCEPSPCGLNAECTQKDNAGSCKCIDGYMGNPYEGCRPECVINSDCAPMLACIQNKCKNPCPGVCAPNAICQVVNHLPSCHCPPGLAGNAYQYCVTKVEDVKPTPCSPSPCGPNSECREVNSQAVCSCQADFMGTPPNCRPECTINSECSVVKSCINRKCVDPCIGQCGRNANCRVISHNPICSCQDRFTGDPFTNCVPIAISSLETYPEVNPCIPSPCGPNSICQEVNGNARCTCVPNYKGSPPRCRPECTINSECNAATACINNMCLDPCPGACGNNAQCIVNNHLPICSCLPGYTGNPFSSCFLKQEEHVDLCSPSPCGSNAICEDGLCTCIPEYHGDPYFGCKPECVLNSDCARDKACINSKCKDPCIGTCGTDAICETINHIPMCSCPSGFTGSPFSYCTQILELPTPVNLCVPSPCGPNSQCRELNGHAVCVCVSGYLGSPPNCRPECILSSDCKLNEACSNQKCIDPCPGACGRNTKCIVVNHNPICTCSPGFSGDPFSSCQIIPATPPAKVTPCLPSPCGPNSECTENGENAECKCLLEYIGSPPNCRPECTSNTECSQNMACINRKCQNPCAGACGINAECRVVSHTPICLCENGYSGDPFLSCNIIVSSAVVERPTPCIPSPCGVNAECRERNGVGSCICLPDYFGNPYEACKPECIQNSDCPSNLACYNNKCKDPCPGTCGINAQCNVVNHNPSCSCIEKYHGDPYKMCAFKAESEILDPCEPSPCGPNSQCKSQNGLAICTCMLGYQGTPPSCRPECITSSECSLDKVYALCNVVKHVPVCSCPSGYEGDPFSICHIKLPELPQSVDPCQPTPCGPNAVCHNGVCSCLPEYQGDPYFGCRPECVLSTDCPLDKACFRSKCVDPCRDMCGVNAECNVYNHVAICSCPMGHTGDAFTHCKIIEKPANKPCEPSPCGPNSVCREVNGQAICACIESFIGNPPNCRPECIQSTDCSPSKACINRKCQDPCPGSCGRNAICIVNKHNPICSCPAKYTGSPFTYCYVQLEEEPQSNPCVPSPCGPNSLCKPTADGKSYVCTCQPSFEGTPPLCRRECTTSDDCSSDKACINYKCSDPCPGSCGLNTLCVVRLHTPMCSCENGYTGDPFLSCYLMQPAHEPVDPCNPSPCGANAQCKETRSGAVACICETGYFGNPYESCRPECVVNTDCPFNKACLRNKCDDPCPGVCGSTANCEVINHVPSCTCAPGYTGNPYTYCHIIINEPVPKPKNPCLPNLCGSNTICNYSNGQVSCSCMPEFYGSPPNCRPECTVNAECDKSKSCIRQKCIDPCIGVCGQNAECRVINHAPICSCSLGFEGDPFIRCMEKEKTPTPITNPCIPSPCGSNSICQAVNEIPMCSCVEKYIGSPPNCRAECVINSDCPSTEACINQKCRDPCPGSCGLYTECHVYQHSAICSCNEGYTGNPFQSCQIKQNIEPVPSTYDNCNPNPCGANADCNDGVCKCRNNYFGNPYLSCRPECTHSSECAKSLTCINNKCTNPCINICGENALCEVYNHMPMCSCPPNTTGNAFFSCTPIKVIQDTNPCQPSPCGPNSVCRALSGQVMCSCITGYIGTPPSCRPECLVDSDCTILLSCSNQKCVDPCQGSCGMNAECRVHNHKPICYCRNGLTGDPFSYCRVIQKEPPKTAPCEPSPCGPNSVCKSNGEEPQCLCQTGFIGSPPYCRPECISNSECSFNKACINNKCDDPCLGACGPNAECRVISHSPQCTCQSGYEGDAFNLCHPKRDHEPVTPSEPCVPNPCGPNAICQERYNIGSCTCANGFFGDPYEGCRPECIVNSDCAESRACINKKCQDPCPGLCGVNAQCQTTNHVPSCTCIHGYVGNAYESCILREEKPTNPCSPSPCGAYSTCKTISNQAVCTCLPDYVGNPPSCRPECIISSECPLNKACVRKKCVDPCIGTCGENSECRVHQHSPYCTCLPGYEGDPFIRCSKEILSTPPVASPCEPSPCGPFATCRDINDSPICSCKPGYIGAPPRCAPECTINEDCPNNKACVREKCVDPCLGSCGTHTDCRAMNHVAICTCLSGYRGDPFIGCSYQDIQPPVSFDACIQSPCGINAACDNGTCTCISDYHGNPYIECRPECTSDNDCQKQLACVNYKCINPCKNACGINAVCNVYNHIAICECPTPLQGDAFISCHHAIEPSISDPCTPNPCGPNSICRAEGIVAHCSCRPPMFEDPPSCRPECRVDSECPPNRACRNNRCRDPCPGSCGASAICHIRSHSPICVCPANYVGDPFIHCLPAIEAEPSTQAPQSCTNCGPNSDCINGLCSCKSGYVGAPPYCRHECLSSSDCEWHLMCLNLRCVDPCRGACGQGALCESLAHEPHCTCPSSTTGNPFFECRPIVTTQKTPNDPCNPSPCGPGALCSARGASASCECEPGLFGDPYSGCRPECVSDSDCSPSRACMRSHCRDPCQGTCGIGADCETVNHIPLCSCPTGTRGNAFEKCEKIITAPPCNPSPCGPGAVCTTSGSSAICSCPSGTYGDAKSTGCRPECVVSSECPRDRACVRNKCIDPCIGTCGNGAMCRVFDHAPICSCPPTTTGNPFTECTLKDVTPPTFDPCDPNPCGIHGTCRDGQCIYPECIVNDDCPGDRACINRKCADPCVNACGINAICTGIRHTAPTPPTPECVNDNQCADDAACVDSRCSPVCGSNNCGINARCLAKQHRARCTCLPGYEGDAYTGCYSVQCHSNNDCPEDESCEGASCVKVCSRVRCGIEARCVARGHTASCECNPSARGDPWTECHIAECNANEDCPLWLACKANKCKDPCPGACAPGAVCTVLRHQPTCECPRGTNGNPKIECRQVANEEECQYDAECGPGLACLQGNCKNPCEPTSCGTRAVCRVANTLPFRTLVCECPKPLTGDASLQCNPRGECTSNDDCSSEESCINKRCVNVCSNGACGVGAECRAQSHRANCVCVPPLQGDPRVACMPSTPTAECVVDSDCGSAEACVSRRCVSACIGACGTGALCDAAQHRARCHCPPGTAGDPARICYTPECTSDDNCPFDKTCFNGYCKDPCGVGSPCGRDASCEVVAHVATCRCPPGTQGDPRRACISAACHYNEDCDDSQLCNRLNRVCQSACTDNSCAPGASCTGENHRPTCKCIPGYIGDPYQRGCTFAQDTTECTTDADCSAPLACVDARCIDLCLNNPCDSGLICRTVDVLPLRAVACVCPDGGRAAPDSGCRTPPEVECSVDSDCASSQMCFRGSCVEACKADPCGQNALCDSIDHASRCVCPPGYNGNPRFECNTVPQEPIVWECYEDNECGPERACIKRSCVNPCIDGCGIGALCRVIDHKPQCSCPNGFSGDAYIRCLPPSEKSFIPLGCKANSECPLSQACINGACADPCACGAQADCSIVRHHPVCYCKQGYSGNPYIGCTKVGCDSDSECSDSDLCYNGACLNPCLIDTPCAISAECYGVNHRASCRCPSGTVGNPFTRCIAAECETDNDCNDDSVCAKGTCYNACSVNGISSCADNAECFSRNHAASCRCPPAFPIGDPSVHCQKATVLNEPECIMDGDCPSGHACLKDECREACSELKPCKGNSRCSVSDSIPFRTLICRCPEGFVPSEDGSCKPANLPPLGCSSDNDCTDQESCVNRNCRNPCNCGDNADCFVKDHRPICSCRNGYEGDPYRTCRVVGCRTNSECDTREACINGNCINPCLTNSTCGPNAECFVQKNQPLCRCRVGFEGDAYLGCNAIECRSNGDCPRDKQCKAHRCINPCFIDNICGTHSNCLVRNHLAVCKCDQGYGGNPYIECKPQFAQECYVDADCPSRAACLSSRCVNPCTTLKPCANPATCEVSPTLPVRTMLCTCPPGFVSNGGGICRPVIEFFESTCEIDSNCTSNHACISSVCKNPCDCGPNTDCIMKDHKPVCACRQGFIGDASSGCYEIQCQSDSHCADDETCINRRCVPACSVNANTCGQSAECYGLEHRASCRCKIGTVGNPSIACTPIGCRTDTDCPSDKSCINSKCDTPCNADICQEPAQCKVHLHQAHCACPPGFTNTGKECRKTEGPQCISDIDCPSGTGCLNYRCVNPCLVSNPCSENAQCKIVDTMPVKTMVCECLPGYKGNALQECKPYQTVAKCIEGQGLDLYGECIPCRPAEGRIIDSRGRCVCDSERGFIIQGDKCVAGGCRTDDNCADNSRCIRGQCVDACKAEPCGINATCDAVGHRSHCTCIAGYTGNPRIQCNATTTMYRTDFPTPDIQVECLADGVRVRLKIKDFNGLLYVKSYSKDERCRKVVEMPKDEESFVFFTVHFGDCGLVHVNGLASFVLVMQTHLKLVTSTTKAFHIKCIYKTGEQNVTLAFNVSMLTTAGTIANTGPPPTCSMRIISRSGDQVSSAEIGENLVLQVDVQPSSIYGGFARSCVAKTSEVSTNVENEYLVTDEDGCAKDPAIFGEWERSEDGSALRAAFNAFKFPSSDNIRFQCNIRVCFGKCVPVNCRGSDAYGKRRKREVTDESTALTMPVGQLREEVTVESNQILTTQRREPSQVARQRDGTGAEGASQSSGEVCVSAAGLAVALALTALLALVAVAAAVACWLVAWRRARPPPAPLPHPPDFPNPLFQR

Description

Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function. Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction plays an important role in the assembly of microfibrils.
Asprosin: Hormone that targets the liver to increase plasma glucose levels. Secreted by white adipose tissue and circulates in the plasma. Acts in response to fasting and promotes blood glucose elevation by binding to the surface of hepatocytes. Promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation.
Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.
Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (PubMed:20855508).
Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:1860873, PubMed:15062093). Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921).
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).
Essential signaling protein which has a major role in many developmental processes (PubMed:3935325). Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination (PubMed:10935637, PubMed:15620650, PubMed:12909620, PubMed:18243100). Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex (PubMed:7671825). Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction (PubMed:11719214, PubMed:12369105, PubMed:3935325). Regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt; might also regulate dpn expression through the activation of the transcriptional regulator Su(H) (PubMed:27151950, PubMed:28899667, PubMed:20152183, PubMed:18342578, PubMed:23056424, PubMed:21262215).
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737).
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development.
May play an integral structural role in elastic-fiber architectural organization and/or assembly.
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (PubMed:10393120). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:10393120, PubMed:18710934). Affects the implementation of differentiation, proliferation and apoptotic programs (PubMed:10393120, PubMed:18710934). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation (By similarity). In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:18710934). Positively regulates self-renewal of liver cancer cells (By similarity).
Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (By similarity). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (PubMed:20855508). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction plays an important role in the assembly of microfibrils (By similarity).
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
Fibrillin-3: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support.
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (By similarity).
Required to maintain the integrity of photoreceptor cells (PubMed:27737822, PubMed:28378834, PubMed:30052645). Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (PubMed:27737822).
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity). Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (By similarity). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (By similarity). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (By similarity). Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus (By similarity). Important for follicular differentiation and possibly cell fate selection within the follicle (By similarity). During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia (PubMed:11182080). Represses neuronal and myogenic differentiation (By similarity). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation (By similarity). May be involved in mesoderm development, somite formation and neurogenesis (By similarity). May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity). Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742).
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May regulate branching morphogenesis in the developing vascular system.
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:7593177). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity).
Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.
Involved in cell adhesion and required for organ positioning and attachment (PubMed:25917920, PubMed:11470827, PubMed:11470828). At the hypodermal surface, required for attachment of the hypdermermis to the basal cuticle in postembryonic development, possibly through intermediate filaments of the cytoskeleton (PubMed:11470828).
Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.
Orphan receptor involved in cell adhesion and probably in cell-cell interactions involved specifically cells of the immune system. May play a role in regulatory T-cells (Treg) development.
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions.
Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).
Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions.
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis.
Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
Isoform a: Involved in regulating the shape and adhesion of cells in the developing pharynx, intestine, body-wall muscle and gonadal tissue (PubMed:16120639). During gonadogenesis, regulates the width of gonads and the migration of distal tip cells (DTC) (PubMed:15556862, PubMed:17043142, PubMed:22298704). Together with type IV collagen let-2 and downstream of metalloprotease mig-17, recruits nidogen nid-1 to the gonad basement membrane thereby inducing basement membrane remodeling required for the directional migration of DTCs (PubMed:15556863, PubMed:19104038). Acts antagonistically with metalloprotease gon-1 to maintain optimal levels of type IV collagen emb-9 in the gonad basement membrane during gonadogenesis (PubMed:15556862, PubMed:17043142, PubMed:22298704). Required for larval development (PubMed:17043142).
Isoform c: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall-muscle basement membranes.
Required to maintain the integrity of photoreceptor cells (By similarity). Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (By similarity).
Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.
Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).
Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.
Binds to TGFBR2 and activates TGFB signaling.
Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos (PubMed:21215633). May play a role in the architecture of adhesive and flexible epithelial cell junctions (PubMed:17015624). May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration (PubMed:24951538).
Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration.
Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization (By similarity).
Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
Plays a central role in cell polarity establishment (PubMed:2344615, PubMed:12900452, PubMed:10102271, PubMed:11740560). Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex (PubMed:11740560, PubMed:12900452, PubMed:10102271, PubMed:11076972). Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells (PubMed:11740560). It may act as a signal (PubMed:2344615). Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina (PubMed:12900452). Component of the crb-galla-Xpd (CGX) complex which is essential for proper mitotic chromosome segregation in early embryos (PubMed:25065591). The CGX complex is also required for cell proliferation in developing wing disks (PubMed:25065591). In the CGX complex, acts with galla-1 or galla-2 to recruit Xpd and thus form the functional complex. Together with apn, plays a key role in trachea development at larval stages (PubMed:30645584).
Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to cause an increase in SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).
Involved in several cell fate decisions that require cell-cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10.
Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).
Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis.
Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB. Also required for maintenance of the apical polarity complex during development of the cortex.

Subunit

Interacts with COL16A1. Interacts with integrin alpha-V/beta-3. Interacts with ADAMTS10; this interaction promotes microfibril assembly. Interacts with THSD4; this interaction promotes fibril formation. Interacts (via N-terminal domain) with FBLN2, FBLN4 and FBLN5. Interacts with ELN. Forms a ternary complex with ELN and FBLN2 or FBLN5 and a significant interaction with ELN seen only in the presence of FBLN2 or FBLN5. Interacts (via N-terminal domain) with LTBP2 (via C-terminal domain) in a Ca(+2)-dependent manner. Interacts (via N-terminal domain) with LTBP1 (via C-terminal domain). Interacts with integrins ITGA5:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. Interacts (via N-terminal domain) with BMP2, BMP4, BMP7, BMP10 and GDF5. Interacts (via N-terminal domain) with MFAP2 and MFAP5. Interacts with ADAMTSL5. Interacts with MFAP4. Interacts (via N-terminal domain) with TNFSF11 in a Ca(+2)-dependent manner.
Interacts with BMP2, BMP4, BMP7, BMP10 and GDF5 (PubMed:18339631). Interacts with MFAP2 and MFAP5 (PubMed:15131124). Interacts with ADAMTSL5 (PubMed:23010571). Interacts with MFAP4 (PubMed:26601954).
Interacts with BMP2, BMP4, BMP7, BMP10 and GDF5. Interacts with MFAP2 and MFAP5. Interacts with ADAMTSL5. Interacts with MFAP4.
Interacts with COL16A1 (PubMed:15165854). Interacts with integrin alpha-V/beta-3 (PubMed:15062093). Interacts with ADAMTS10; this interaction promotes microfibril assembly (PubMed:21402694). Interacts with THSD4; this interaction promotes fibril formation (By similarity). Interacts (via N-terminal domain) with FBLN2, FBLN4 and FBLN5 (PubMed:15790312, PubMed:17255108). Interacts with ELN (PubMed:15790312). Forms a ternary complex with ELN and FBLN2 or FBLN5 and a significant interaction with ELN seen only in the presence of FBLN2 or FBLN5 (PubMed:17255108). Interacts (via N-terminal domain) with LTBP2 (via C-terminal domain) in a Ca(+2)-dependent manner (PubMed:17293099). Interacts (via N-terminal domain) with LTBP1 (via C-terminal domain) (PubMed:17293099). Interacts with integrins ITGA5:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6 (PubMed:17158881, PubMed:12807887). Interacts (via N-terminal domain) with BMP2, BMP4, BMP7, BMP10 and GDF5 (PubMed:18339631). Interacts (via N-terminal domain) with MFAP2 and MFAP5 (PubMed:15131124). Interacts with ADAMTSL5 (PubMed:23010571). Interacts with MFAP4 (PubMed:26601954). Interacts (via N-terminal domain) with TNFSF11 in a Ca(+2)-dependent manner (PubMed:24039232).
Forms a ternary complex with nrarp and rbpj/suh.
Homomer. Interacts with Su(H) when activated. Interacts with Dx via its ANK repeats. Interacts with Dl via the EGF repeats and the Dl EGF repeats. Interacts with Nedd4 and Su(dx). Interacts with O-fut1; the interaction glycosylates N and transports N to early endosomes. Interacts with Akap200; the interaction stabilizes N/Notch protein levels by preventing Cbl-mediated ubiquitination and subsequent lysosomal degradation of N/Notch (PubMed:29309414).
Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH2. Interacts with RELA/p65 (By similarity). Interacts with HIF1AN. Interacts (via ANK repeats) with TCIM, the interaction inhibits the nuclear translocation of NOTCH2 N2ICD (PubMed:25985737). Interacts with CUL1, RBX1, SKP1 and FBXW7 that are SCF(FBXW7) E3 ubiquitin-protein ligase complex components (PubMed:29149593). Interacts with MINAR1; this interaction increases MINAR1 stability and function (PubMed:29329397). Interacts with NOTCH2NL (NOTCH2NLA, NOTCH2NLB and/or NOTCH2NLC); leading to enhance Notch signaling pathway in a non-cell-autonomous manner (PubMed:29856954). Interacts with MDK; this interaction mediates a nuclear accumulation of NOTCH2 and therefore activation of NOTCH2 signaling leading to interaction between HES1 and STAT3 (PubMed:18469519).
Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with PSMA1. Interacts with HIF1AN.
Interacts with PSMA1 (By similarity). Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with HIF1AN.
Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex (PubMed:7798248). Interacts with SDC4 (PubMed:20382221). Interacts (via C-terminal domain) with FBN1 (via N-terminal domain) in a Ca(+2)-dependent manner (PubMed:17293099).
Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex. Interacts with SDC4. Interacts (via C-terminal domain) with FBN1 (via N-terminal domain) in a Ca(+2)-dependent manner.
Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH2. Interacts with RELA/p65. Interacts with HIF1AN. Interacts (via ANK repeats) with TCIM, the interaction inhibits the nuclear translocation of NOTCH2 N2ICD (By similarity). Interacts with CUL1, RBX1, SKP1 and FBXW7 that are SCF(FBXW7) E3 ubiquitin-protein ligase complex components. Interacts with MINAR1; this interaction increases MINAR1 stability and function (By similarity). Interacts with MDK; this interaction mediates a nuclear accumulation of NOTCH2 and therefore activation of NOTCH2 signaling leading to interaction between HES1 and STAT3 (By similarity).
Interacts with COL16A1. Interacts with integrin alpha-V/beta-3. Interacts with ADAMTS10; this interaction promotes microfibril assembly (By similarity). Interacts with THSD4; this interaction promotes fibril formation (PubMed:19940141). Interacts (via N-terminal domain) with FBLN2, FBLN4 and FBLN5. Interacts with ELN. Forms a ternary complex with ELN and FBLN2 or FBLN5 and a significant interaction with ELN seen only in the presence of FBLN2 or FBLN5. Interacts (via N-terminal domain) with LTBP2 (via C-terminal domain) in a Ca(+2)-dependent manner. Interacts (via N-terminal domain) with LTBP1 (via C-terminal domain). Interacts with integrins ITGA5:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. Interacts (via N-terminal domain) with BMP2, BMP4, BMP7, BMP10 and GDF5. Interacts (via N-terminal domain) with MFAP2 and MFAP5. Interacts with ADAMTSL5. Interacts with MFAP4. Interacts (via N-terminal domain) with TNFSF11 in a Ca(+2)-dependent manner (By similarity).
Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with PSMA1 (By similarity). Interacts with HIF1AN (By similarity).
Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH2. Interacts with RELA/p65 (By similarity). Interacts with HIF1AN. Interacts (via ANK repeats) with TCIM, the interaction inhibits the nuclear translocation of NOTCH2 N2ICD (By similarity). Interacts with CUL1, RBX1, SKP1 and FBXW7 that are SCF(FBXW7) E3 ubiquitin-protein ligase complex components.Interacts with MINAR1; this interaction increases MINAR1 stability and function (By similarity). Interacts with MDK; this interaction mediates a nuclear accumulation of NOTCH2 and therefore activation of NOTCH2 signaling leading to interaction between HES1 and STAT3 (By similarity).
Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. Notch 1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Forms a trimeric complex with FBXW7 and SGK1. Interacts with HIF1AN. HIF1AN negatively regulates the function of notch intracellular domain (NICD), accelerating myogenic differentiation. Interacts (via NICD) with SNAI1 (via zinc fingers); the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts (via NICD) with MDM2A. Interacts (via NICD) with BCL6; the interaction decreases MAML1 recruitment by NOTCH1 NICD on target genes DNA and inhibits NOTCH1 transcractivation activity (By similarity). Interacts with THBS4 (By similarity). Interacts (via the EGF-like repeat region) with CCN3 (via CTCK domain). Interacts (via EGF-like domains) with DLL4 (via N-terminal DSL and MNNL domains). Interacts with ZMIZ1. Interacts (via NICD domain) with MEGF10 (via the cytoplasmic domain). Interacts with DLL1 and JAG1 (By similarity). Interacts (via NICD domain) with PRAG1 (By similarity). Forms a complex with PRAG1, N1ICD and MAML1, in a MAML1-dependent manner (By similarity). Interacts (via transmembrane region) with PSEN1; the interaction is direct (By similarity).
Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. Notch 1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Forms a trimeric complex with FBXW7 and SGK1. Interacts with HIF1AN. HIF1AN negatively regulates the function of notch intracellular domain (NICD), accelerating myogenic differentiation. Interacts (via NICD) with SNAI1 (via zinc fingers); the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts (via NICD) with MDM2A. Interacts (via NICD) with BCL6; the interaction decreases MAML1 recruitment by NOTCH1 NICD on target genes DNA and inhibits NOTCH1 transcractivation activity. Interacts with THBS4. Interacts (via the EGF-like repeat region) with CCN3 (via CTCK domain) (PubMed:12050162). Interacts (via EGF-like domains) with DLL4 (via N-terminal DSL and MNNL domains) (By similarity). Interacts with ZMIZ1. Interacts (via NICD domain) with MEGF10 (via the cytoplasmic domain) (PubMed:28498977). Interacts with DLL1 and JAG1 (PubMed:28089369). Interacts (via NICD domain) with PRAG1 (PubMed:25038227). Forms a complex with PRAG1, N1ICD and MAML1, in a MAML1-dependent manner (PubMed:25038227). Interacts (via transmembrane region) with PSEN1; the interaction is direct (By similarity).
Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. Notch 1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Forms a trimeric complex with FBXW7 and SGK1. Interacts with HIF1AN. HIF1AN negatively regulates the function of notch intracellular domain (NICD), accelerating myogenic differentiation. Interacts (via NICD) with SNAI1 (via zinc fingers); the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts (via NICD) with MDM2A. Interacts (via NICD) with BCL6; the interaction decreases MAML1 recruitment by NOTCH1 NICD on target genes DNA and inhibits NOTCH1 transcractivation activity (By similarity). Interacts with THBS4 (By similarity). Interacts (via the EGF-like repeat region) with CCN3 (via CTCK domain) (By similarity). Interacts (via EGF-like domains) with DLL4 (via N-terminal DSL and MNNL domains) (PubMed:25700513). Interacts with ZMIZ1 (By similarity). Interacts (via NICD domain) with MEGF10 (via the cytoplasmic domain). Interacts with DLL1 and JAG1 (By similarity). Interacts (via NICD domain) with PRAG1 (By similarity). Forms a complex with PRAG1, N1ICD and MAML1, in a MAML1-dependent manner (By similarity). Interacts (via transmembrane region) with PSEN1; the interaction is direct (By similarity).
Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex. Interacts with LTBP1 and TGFB1.
Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1 (PubMed:11101851, PubMed:12370315). The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ (PubMed:10713164). The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Forms a trimeric complex with FBXW7 and SGK1. Interacts with HIF1AN. HIF1AN negatively regulates the function of notch intracellular domain (NICD), accelerating myogenic differentiation (PubMed:17573339). Interacts (via NICD) with SNAI1 (via zinc fingers); the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts (via NICD) with MDM2A. Interacts (via NICD) with BCL6; the interaction decreases MAML1 recruitment by NOTCH1 NICD on target genes DNA and inhibits NOTCH1 transcractivation activity. Interacts with THBS4 (By similarity). Interacts (via the EGF-like repeat region) with CCN3 (via CTCK domain) (PubMed:12050162). Interacts (via EGF-like domains) with DLL4 (via N-terminal DSL and MNNL domains) (By similarity). Interacts with ZMIZ1. Interacts (via NICD domain) with MEGF10 (via the cytoplasmic domain). Interacts with DLL1 and JAG1 (By similarity). Interacts (via NICD domain) with PRAG1 (By similarity). Forms a complex with PRAG1, N1ICD and MAML1, in a MAML1-dependent manner (By similarity). Interacts (via transmembrane region) with PSEN1; the interaction is direct (PubMed:30598546).
Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex (PubMed:9660815). Interacts with LTBP1 and TGFB1 (PubMed:9660815).
Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1 (PubMed:10930463, PubMed:2022183, PubMed:8617200, PubMed:15567420, PubMed:8939931, PubMed:22278742). LTBP1 does not bind directly to TGF-beta-1, the active chain of TGFB1 (PubMed:10930463). Interacts (via C-terminal domain) with FBN1 (via N-terminal domain) (PubMed:12429738, PubMed:17293099). Interacts with FBN2 (PubMed:12429738). Interacts with ADAMTSL2 (PubMed:18677313).
Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.
Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.
Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1. LTBP1 does not bind directly to TGF-beta-1, the active chain of TGFB1. Interacts (via C-terminal domain) with FBN1 (via N-terminal domain). Interacts with FBN2. Interacts with ADAMTSL2.
Homotetramer.
Forms part of the large latent transforming growth factor beta (TGFB1) precursor complex; removal is essential for activation of complex.
Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex.
Homotrimer; disulfide-linked. Interacts with LAMA2 (PubMed:10022829). Interacts with FBN1 (via N-terminal domain). Forms a ternary complex with ELN and FBN1 (By similarity).
Homomultimerizes and interacts with various extracellular matrix components. Interacts with FBLN7 (By similarity). Interacts with the mature/soluble form of DTR. Interacts with CCN3 (By similarity).
Homotrimer; disulfide-linked. Interacts with LAMA2 (By similarity). Interacts with FBN1 (via N-terminal domain). Forms a ternary complex with ELN and FBN1 (PubMed:17255108).
Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, NID, AGC1 and CSPG2.
Interacts with NOTCH2 and NOTCH3 (By similarity). Interacts with NOTCH1 (in the presence of calcium ions) (PubMed:18660822).
Interacts with NOTCH1 (PubMed:28089369). Interacts with NOTCH2 and NOTCH3 (By similarity).
Interacts with NOTCH1, NOTCH2 and NOTCH3.
Homomultimerizes and interacts with various extracellular matrix components.
Homotrimer. Binds to PKC beta-1 (By similarity). Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization.
Forms homooligomers and heterooligomers with SCUBE1. Interacts with TGFBR2 through the CUB domain; this interaction does not affect TGFB1-binding to TGFBR2.
Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LAMA2, NID, ACAN, CSPG2 and type IV collagen. Interacts also with APP and FGB. Interacts with FBLN7 (By similarity). Interacts with CCN3 (PubMed:9927660).
(Microbial infection) Interacts with human papillomavirus/HPV type 16, 18 and 31 proteins E6.
Forms a complex with MPDZ (By similarity). Forms a complex with MPP4 and MPP5.
Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization (By similarity). Homotrimer. Binds to PKC beta-1.
Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LMA2, NID, ACAN, CSPG2 and type IV collagen. Binding analysis demonstrated for isoform C a 100-fold stronger binding to the basement membrane protein NID than for isoform D. Interacts with FBLN7. Interacts with CCN3 (By similarity).
Forms homooligomers and heterooligomers with SCUBE2 and SCUBE3.
Component of the SAC complex, a complex composed of crb, Patj and sdt (PubMed:11740560, PubMed:10102271, PubMed:11076972). May interact with the par-6 complex, which is composed of par-6, baz and aPKC, via its interaction with Patj (PubMed:12900452, PubMed:10102271, PubMed:11076972). Interacts with other proteins with Patj and sdt via its short cytoplasmic tail (PubMed:11740560). Component of the CGX complex composed of crb, galla (galla-1 or galla-2) and Xpd (PubMed:25065591). Able to interact independently (via intracellular domain) with galla-1, galla-2 and Xpd (PubMed:25065591). Interacts with apn (PubMed:30645584).
Interacts with SHH via the cholesterol anchor of the dually lipid-modified SHH (ShhNp) (PubMed:22902404). Interacts with PTCH1 (PubMed:22902404). Forms homooligomers and heterooligomers with SCUBE1 and SCUBE3 (By similarity). Interacts with VEGFR2 (PubMed:27834687).
Interacts with sel-10.
Interacts with SHH via the cholesterol anchor of the dually lipid-modified SHH (ShhNp) (PubMed:19480626, PubMed:22902404). Interacts with PTCH1 (PubMed:19480626, PubMed:22902404). Forms homooligomers and heterooligomers with SCUBE1 and SCUBE3 (By similarity). Interacts with VEGFR2 (PubMed:27834687).
Interacts with SHH via the cholesterol anchor of the dually lipid-modified SHH (ShhNp) (By similarity). Interacts with PTCH1 (By similarity). Forms homooligomers and heterooligomers with SCUBE1 and SCUBE3 (By similarity). Interacts with VEGFR2 (By similarity).

Miscellaneous

Asprosin: Was named after the Greek word for white, because of the reduction in subcutaneous white adipose tissue that is displayed by asprosin-deficient patients.
Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.
Although involved in the same pathway as gon-1 and mig-17, it is probably not cleaved by these metalloproteases.
Separation of neuroblasts from the ectoderm into the inner part of embryo is one of the first steps of CNS development in insects, this process is under control of the neurogenic genes.
Notch and Serrate may interact at the protein level, it is conceivable that the Serrate and Delta proteins may compete for binding with the Notch protein.
When exogenously expressed, the C-terminal part is nuclear, phosphorylated, and acts as an insulin-responsive transcriptional activator.

Similarity

Belongs to the fibrillin family.
Belongs to the NOTCH family.
Belongs to the LTBP family.
Belongs to the EYS family.
Belongs to the fibulin family.
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Belongs to the Crumbs protein family.

Keywords

Calcium   Complete proteome   Direct protein sequencing   Disulfide bond   EGF-like domain   Extracellular matrix   Glycoprotein   Hormone   Phosphoprotein   Reference proteome   Repeat   Secreted   Signal   Alternative splicing   Disease mutation   Polymorphism   3D-structure   Aortic aneurysm   Dwarfism   Heparin-binding   Activator   Angiogenesis   ANK repeat   Cell membrane   Developmental protein   Differentiation   Membrane   Metal-binding   Notch signaling pathway   Nucleus   Receptor   Transcription   Transcription regulation   Transmembrane   Transmembrane helix   Endosome   Neurogenesis   Oogenesis   Ubl conjugation   Cytoplasm   Methylation   Glaucoma   Growth factor binding   Hydroxylation   Cell projection   Cytoskeleton   Sensory transduction   Vision   Isopeptide bond   Proto-oncogene   Triplet repeat expansion   Cytoplasmic vesicle   Cleavage on pair of basic residues   Amelogenesis imperfecta   Cell adhesion   Cell junction   Adaptive immunity   G-protein coupled receptor   Immunity   Transducer   Deafness   Basement membrane   Sushi   Chromosomal rearrangement   Host-virus interaction   Cell cycle   Cell division   Leber congenital amaurosis   Retinitis pigmentosa   Age-related macular degeneration   Immunoglobulin domain   Mitosis   Lipid-binding   Gastrulation  

Feature

chain  Fibrillin-1
splice variant  In isoform 2.
sequence variant  In DA9; dbSNP:rs137852826.
glycosylation site  N-linked (GlcNAc...) asparagine

Uniprot

P98133.2   P35556.3   Q61555.2   P35555.4   P21783.3   P07207.3   + More
Q9TV36.1   Q04721.3   Q9UM47.2   Q61982.1   Q14767.3   Q28019.2   O35516.2   Q61554.2   Q9R172.2   A2RUV0.2   Q75N90.3   P46530.1   O35806.1   Q9QW30.1   O08999.2   B8JI71.2   G3I6Z6.2   Q01705.3   Q07008.3   Q8K4G1.2   P46531.4   Q8N2S1.2   Q14766.4   P31695.3   Q99466.2   Q8CG19.2   P10079.2   Q00918.1   Q61810.4   Q9NS15.4   P37889.2   P34576.2   Q61549.1   Q5Y4N8.1   Q14246.3   Q8MJJ9.1   Q90Y57.1   P98095.2   Q90Y54.1   O42182.1   P78504.3   Q63722.2   Q9QXX0.1   O77469.3   Q5R6R1.3   Q8TER0.2   B3EWY9.1   O88281.1   O73775.2   Q92832.4   Q9QYE5.2   Q9Y219.3   Q8IX30.1   P18168.3   P23142.4   Q66PY1.1   P97607.1   D3YXG0.1   P82279.2   Q96RW7.2   Q62919.2   Q70E20.2   Q5ZQU0.2   Q08879.2   Q8IWY4.3   P10040.3   Q9JJS0.1   P14585.1   Q6NZL8.2   Q9NQ36.3   A0A2K5V015.1   Q5G872.1   Q5IJ48.2  

Pubmed

7835900    19393038    8557636    21989719    8120105    14702039    + More
15372022    1852206    15131124    18339631    19159218    23010571    24899048    26601954    7493032    9714438    9737771    10797416    11754102    19006240    20799338    21248752    25834781    27196565    7744963    19468303    8307578    11470817    16407178    20855508    24039232    8364578    15221638    16572171    15489334    7691719    1852207    8430317    10636927    9817919    2739055    1860873    11461921    12807887    15165854    15790312    17158881    17255108    17293099    20979188    21594992    21594993    21402694    24665001    24039054    24613577    24275569    24982166    26091039    27026396    27087445    26860060    9362480    8568869    8653794    12511552    15062093    19446531    24035709    8594563    10633129    12203987    1852208    1301946    1569206    8406497    8504310    8281141    7977366    8188302    8004112    7951214    7911051    8040326    8071963    7870075    8136837    7762551    7611299    7738200    8882780    8863159    9254848    9150726    9338581    9338588    9401003    8988160    9016526    9837823    9452085    10694921    10441597    10425041    11700157    12203992    12402346    11826022    12161601    12525539    14695540    15161917    16222657    16220557    17657824    18435798    19533785    19293843    20803651    21034599    19941982    20547088    20375004    21683322    21542060    22772377    2402639    11485984    3935325    3097517    10731132    12537572    10731137    3037327    2981631    2780284    8162848    7671825    10206646    10206647    10935637    11719214    11799064    12369105    12909620    15620649    15620650    17329366    18243100    18342578    18327897    20152183    21262215    23056424    27268051    27151950    28899667    29309414    14573873    10036187    16710414    1303260    9244302    10079256    11101851    12370315    17081983    17573339    18469519    18669648    18299578    19690332    20068231    21681853    21378989    21378985    23186163    25985737    29149593    29856954    29329397    17401372    16773578    21793104    21712856    23389697    8878478    15057824    17292860    24129315    25394726    9388399    10227618    10371548    10854111    11058919    11102981    10802807    11559313    11755616    11810186    12146805    12136071    12589106    12810003    15229130    15364702    15378071    15350543    15300988    16009764    15818833    18273901    23731542    24000151    7918097    11518718    11459941    15019995    7798248    8697098    12508121    10930463    10743502    11104663    19361779    20617341    20382221    22539340    8524260    8440332    8917536    10393120    7609614    18710934    19144319    21183079    21949356    7829516    19940141    11182080    11438922    20431018    24226769    14962672    11347906    8297791    10028916    22673903    26479776    1295745    11577080    9602168    16141072    23594743    27737822    28378834    30052645    21804562    10734111    8449489    7956822    12123574    12807718    1426644    1425352    9653148    10437788    8486742    9384671    10882062    10882063    11226752    12050162    15240571    15965470    18628966    21464124    21757702    23160044    23886940    23615612    25038227    28089369    28498977    30127001    15802643    1764995    15057822    25700513    12208849    19836010    15164053    1831692    9590294    10713164    16025100    20616313    22128911    21147854    21245387    25547411    26522984    12795601    15576031    16011479    16530044    28439555    30598546    25132448    9271198    9660815    16157329    23440719    25641372    2350783    15815621    8537398    2022183    8617200    8939931    10677208    12429738    15184403    15567420    18088087    18677313    22278742    14607119    1312643    9150355    8681805    14656967    10233982    11344305    9168133    9693032    14574404    12711388    12711389    2514273    3498216    2784773    2060714    15659374    2247454    7593177    7730318    12062452    12154076    9620332    17974005    19344874    27068007    8245130    10406956    8841408    8850569    10022829    11737251    25917920    9851916    11470827    11470828    12754521    17761667    8550607    9169125    15883173    15578266    7601460    17823986    24530099    25713288    11846885    7806230    16641997    8737292    18318008    22171320    9268641    9207788    9462510    10329626    11780052    8955070    9207787    10978356    21269460    18660822    19586525    9585603    10220506    10533065    11058898    11152664    11157803    11139247    11180599    12022040    12297837    12442286    12649809    12497640    15712272    16575836    23801938    20437614    7697721    10551863    10556292    9923656    15556863    16120639    15556862    17043142    19104038    22298704    15194686    22490231    23765379    9693030    8975702    16554811    21723284    16959974    9341252    9486542    9315665    10662552    15234972    21441952    2125287    1840519    15829515    15760269    2269669    9106159    10318851    15498874    10591208    11829738    2527614    1400330    7534784    7642629    8552629    9278415    9393974    9811350    9466671    9927660    11792823    11238726    12200142    11836357    11850827    12644824    19139490    24084572    8948600    17015624    21215633    24951538    10508521    11734541    15914641    12567265    11389483    11231775    11559858    12573663    12700176    12843338    15024725    15459956    15623792    15691574    16205573    17128490    16936081    17438615    17724218    18055821    18682808    19140180    19956407    20108431    20683928    20591486    21987686    20956273    22128245    21602930    22065545    22334370    28819299    14570714    10548494    12665856    15162516    8354280    2249686    7844816    9299350    10400671    11589703    17699513    12270931    16753137    18691976    2344615    12537569    3107986    10102271    11076972    11740560    12900452    17893096    25065591    30645584    11528127    11287194    22677548    22902404    24522195    26875496    27834687    3419531    7906398    3000611    9389650    11087664    19480626    15753045    15660164    16626681    15851977    25557779    25557780   

EMBL

L28748    DAAA02029120    DAAA02029121    DAAA02029122    U03272    AK300440    + More
AC025169    AC034235    AC113387    X62009    AB209735    L39790    AC102317    AC127358    S69359    L13923    AB177803    GU143398    AC022467    AC084757    AC084758    CH471082    BC146854    L19896    X63556    X62008    S54426    S54425    M33874    M16152    M16153    M16149    M16150    M16151    K03508    M13689    K03507    AE014298    AL035436    AL035395    M16025    M12175    AF073800    AF308601    AF315356    AL359752    AL512503    AL596222    U77493    U97669    AF058900    AF058881    AF058882    AF058883    AF058884    AF058885    AF058886    AF058887    AF058888    AF058889    AF058890    AF058891    AF058892    AF058893    AF058894    AF058895    AF058896    AF058897    AF058898    AF058899    AC004257    AC004663    X74760    Z37976    S82451    AC013451    U35363    D32210    AC154173    AC164091    CH466620    X68279    U31881    L29454    U22493    AL844547    AL928930    AF164486    AAMC01043423    AAMC01043424    AAMC01043425    AAMC01043426    BC133053    AY165863    AY165864    AY165865    AB177797    AB177798    AB177799    AB177800    AB053450    AC008946    AC022146    X69088    Y12760    M93661    AF004874    AK052980    BX005106    BX323836    CR456624    CU570696    JH001398    Z11886    AF508809    AB100603    AL732541    CH466542    BC138441    BC138442    L02613    X68278    AK154528    AK157475    AJ238029    X82562    X57405    AABR06021907    AABR06021908    CH474001    AF410798    AF410799    AC157561    BC059016    AF308602    AL592301    AL354671    M73980    AB209873    Y13622    AF051344    AF051345    AK074499    AC010412    M34057    AF489528    AB208801    AC019195    AC019127    AC020594    CH471053    BC130289    L48925    BP291349    M80456    U43691    AF030001    CT009767    AB016771    AB016772    AB016773    AB016774    D63395    D86566    U95299    U89335    AL662884    BX284686    BX284927    CR812478    CR933878    AB023961    AB024520    AB024578    AF346465    AF346434    AF346435    AF346436    AF346437    AF346438    AF346439    AF346440    AF346441    AF346442    AF346443    AF346444    AF346445    AF346446    AF346447    AF346448    AF346449    AF346450    AF346451    AF346452    AF346453    AF346454    AF346455    AF346456    AF346457    AF346458    AF346459    AF346460    AF346461    AF346462    AF346463    AF346464    AY143161    AF022889    AC118018    AC126550    AC154178    AC154491    CT033758    BC094612    AK050380    AK080024    AAN38831.1    L08692    X17530    M17421    X17533    M55431    L40459    AK080869    AC134563    AF135960    AK024477    AF011407    BC008761    AL117551    X75285    AF135253    AF135239    AF135240    AF135241    AF135242    AF135243    AF135244    AF135245    AF135246    AF135247    AF135248    AF135249    AF135250    AF135251    AF135252    AC121990    AC131764    CH466523    AF139060    Z30974    Z30423    X93328    U66888    BC075688    AY686632    X81479    AB065918    DQ217942    AK131562    AK297003    AK297011    AC020895    AC025278    BC059395    AF395659    AF229448    X82494    AY130458    AY130456    AY130457    AY130459    AK304827    AC090509    AF229451    AF013751    AF013752    AF003837    U73936    AF028593    U61276    AK302554    AL035456    BC126205    BC126207    U77720    L38483    AF171092    BC058675    AB212860    AY851363    AF051401    AF051402    AF051403    AF070477    Z68749    Z68219    NDHI03003297    CR860424    AC005237    AC093585    AC104809    AK074062    AK074075    AF439717    AF439718    BC027939    JR987773    AB011532    AF051399    AF051400    D83017    AK313445    EU518937    AC010811    AC067794    AC069575    AC087279    AC090707    AC090857    AC099730    AC105190    AC108460    CH471064    BC069674    BC096100    BC096101    BC096102    U57523    AF038572    AC160929    AF010137    Y14495    AF020201    AF003521    AF029778    AF029779    AF111170    Y14330    AY639608    AF452494    AK092062    AK291218    Z97832    CH471081    BC052263    CR936607    AAH52263.2    AAN76808.1    AAU08347.1    BAC03798.1    M35759    X56811    AE014297    X53741    X53742    X53743    U01244    AF126110    AF217999    AL021391    Z95331    Z98047    BC022497    AY040589    AY639609    CT009658    BC079849    AAH79849.1    AAU08348.1    U70050    AC111145    AC113326    AC115051    AC124120    AF154671    AY043323    AY043324    AY043325    AJ748821    BX640729    AK299368    AL136322    AL139136    AL513325    AL356315    CH471067    BC136271    AF156100    AK056336    AK056557    AL118512    AL121996    AL133515    AL133553    AL135796    AL135797    AL391824    BX928748    AJ306906    U48246    AY169783    AJ584850    BC145886    AK032805    AABR03068156    AABR03069106    AABR03069488    AABR03071665    AABR03072503    AF439715    AF439719    X70854    X70853    AK086451    AK035388    BC007140    AY040588    AF525689    Z99756    Z82214    M33753    AY118509    X05144    AJ400878    M12069    Z14092    AF276425    AK041590    BC066066    AJ400877    AK123039    AC079296    BC111690    AB193554    AY741664    DQ438942    AY720432    AK123000    AK126775    AL445489    AL365504    DQ426866   

Proteomes

UP000009136    UP000005640    UP000000589    UP000000803    UP000008227    UP000002494    + More
UP000008143    UP000000437    UP000001075    UP000007110    UP000001940    UP000001595    UP000000539   

PRIDE

P98133    P35556    Q61555    P35555    P21783    P07207    + More
Q9TV36    Q04721    Q9UM47    Q61982    Q14767    Q28019    O35516    Q61554    Q9R172    Q75N90    P46530    O35806    Q9QW30    O08999    G3I6Z6    Q01705    Q07008    Q8K4G1    P46531    Q8N2S1    Q14766    P31695    Q99466    Q8CG19    P10079    Q00918    Q61810    Q9NS15    P37889    P34576    Q61549    Q5Y4N8    Q14246    Q8MJJ9    Q90Y57    P98095    Q90Y54    O42182    P78504    Q63722    Q9QXX0    Q5R6R1    Q8TER0    O88281    O73775    Q92832    Q9QYE5    Q9Y219    Q8IX30    P18168    P23142    Q66PY1    P97607    D3YXG0    P82279    Q96RW7    Q62919    Q70E20    Q5ZQU0    Q08879    Q8IWY4    P10040    Q9JJS0    P14585    Q6NZL8    Q9NQ36    Q5G872    Q5IJ48   

Pfam

PF00683   TB        + More
PF12662   cEGF
PF18193   Fibrillin_U_N
PF07645   EGF_CA
PF12661   hEGF
PF00008   EGF
PF12796   Ank_2
PF07684   NODP
PF00066   Notch
PF11936   DUF3454
PF06816   NOD
PF00023   Ank
PF02210   Laminin_G_2
PF01382   Avidin
PF00431   CUB
PF01821   ANATO
PF00057   Ldl_recept_a
PF01390   SEA
PF00092   VWA
PF00002   7tm_2
PF01825   GPS
PF07657   MNNL
PF01414   DSL
PF06119   NIDO
PF00041   fn3
PF00094   VWD
PF00090   TSP_1
PF00053   Laminin_EGF
PF12947   EGF_3
PF00093   VWC
PF07699   Ephrin_rec_like
PF07679   I-set
PF07474   G2F
PF00054   Laminin_G_1

Interpro

IPR026823   cEGF        + More
IPR009030   Growth_fac_rcpt_cys_sf       
IPR036773   TB_dom_sf       
IPR040872   Fibrillin_U_N       
IPR001881   EGF-like_Ca-bd_dom       
IPR000152   EGF-type_Asp/Asn_hydroxyl_site       
IPR017878   TB_dom       
IPR000742   EGF-like_dom       
IPR018097   EGF_Ca-bd_CS       
IPR013032   EGF-like_CS       
IPR000800   Notch_dom       
IPR024600   DUF3454_notch       
IPR002110   Ankyrin_rpt       
IPR036770   Ankyrin_rpt-contain_sf       
IPR035993   Notch-like_dom_sf       
IPR010660   Notch_NOD_dom       
IPR022362   Notch_1       
IPR020683   Ankyrin_rpt-contain_dom       
IPR011656   Notch_NODP_dom       
IPR008297   Notch       
IPR022336   Notch_2       
IPR022331   Notch_3       
IPR001791   Laminin_G       
IPR013320   ConA-like_dom_sf       
IPR022355   Notch_4       
IPR036896   Avidin-like_sf       
IPR005468   Avidin/str       
IPR000859   CUB_dom       
IPR005469   Avidin       
IPR035914   Sperma_CUB_dom_sf       
IPR017889   Avidin-like_CS       
IPR000020   Anaphylatoxin/fibulin       
IPR037286   Fibulin-2       
IPR036465   vWFA_dom_sf       
IPR002172   LDrepeatLR_classA_rpt       
IPR036055   LDL_receptor-like_sf       
IPR000082   SEA_dom       
IPR002035   VWF_A       
IPR000832   GPCR_2_secretin-like       
IPR017981   GPCR_2-like       
IPR001740   GPCR_2_EMR1-like_rcpt       
IPR017983   GPCR_2_secretin-like_CS       
IPR000203   GPS       
IPR017048   Fibulin-1       
IPR026219   Jagged/Serrate       
IPR011651   Notch_ligand_N       
IPR001774   DSL       
IPR001007   VWF_dom       
IPR036116   FN3_sf       
IPR035976   Sushi/SCR/CCP_sf       
IPR013783   Ig-like_fold       
IPR003961   FN3_dom       
IPR000436   Sushi_SCR_CCP_dom       
IPR003886   NIDO_dom       
IPR000884   TSP1_rpt       
IPR036383   TSP1_rpt_sf       
IPR001846   VWF_type-D       
IPR005533   AMOP_dom       
IPR002049   Laminin_EGF       
IPR011489   EMI_domain       
IPR024731   EGF_dom       
IPR033108   Jag2       
IPR011641   Tyr-kin_ephrin_A/B_rcpt-like       
IPR013106   Ig_V-set       
IPR009017   GFP       
IPR006605   G2_nidogen/fibulin_G2F       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR013098   Ig_I-set       
IPR036179   Ig-like_dom_sf       
IPR003598   Ig_sub2       

SUPFAM

SSF57184   SSF57184        + More
SSF57581   SSF57581       
SSF90193   SSF90193       
SSF48403   SSF48403       
SSF49899   SSF49899       
SSF49854   SSF49854       
SSF50876   SSF50876       
SSF57424   SSF57424       
SSF53300   SSF53300       
SSF57535   SSF57535       
SSF49265   SSF49265       
SSF82895   SSF82895       
SSF54511   SSF54511       
SSF48726   SSF48726       

Gene 3D

3.90.290.10     1.25.40.20     2.40.128.30     2.60.120.290     3.40.50.410     4.10.400.10     2.60.40.10     2.20.100.10    

CDD

cd00204  ANK
cd00041  CUB
cd00017  ANATO
cd00112  LDLa
cd00033  CCP
cd00063  FN3
cd00255  nidG2

ProteinModelPortal

P98133.2   P35556.3   Q61555.2   P35555.4   P21783.3   P07207.3   + More
Q9TV36.1   Q04721.3   Q9UM47.2   Q61982.1   Q14767.3   Q28019.2   O35516.2   Q61554.2   Q9R172.2   A2RUV0.2   Q75N90.3   P46530.1   O35806.1   Q9QW30.1   O08999.2   B8JI71.2   G3I6Z6.2   Q01705.3   Q07008.3   Q8K4G1.2   P46531.4   Q8N2S1.2   Q14766.4   P31695.3   Q99466.2   Q8CG19.2   P10079.2   Q00918.1   Q61810.4   Q9NS15.4   P37889.2   P34576.2   Q61549.1   Q5Y4N8.1   Q14246.3   Q8MJJ9.1   Q90Y57.1   P98095.2   Q90Y54.1   O42182.1   P78504.3   Q63722.2   Q9QXX0.1   O77469.3   Q5R6R1.3   Q8TER0.2   B3EWY9.1   O88281.1   O73775.2   Q92832.4   Q9QYE5.2   Q9Y219.3   Q8IX30.1   P18168.3   P23142.4   Q66PY1.1   P97607.1   D3YXG0.1   P82279.2   Q96RW7.2   Q62919.2   Q70E20.2   Q5ZQU0.2   Q08879.2   Q8IWY4.3   P10040.3   Q9JJS0.1   P14585.1   Q6NZL8.2   Q9NQ36.3   A0A2K5V015.1   Q5G872.1   Q5IJ48.2  

KEGG

692894    no KO assigned | (RefSeq) notch-like protein

GO

GO:0005509   GO:0042593   GO:0005201   GO:0005576   GO:0010737   GO:0005615   GO:0062023   GO:0005179   GO:0031012   GO:0006006   GO:0001527   GO:0034199   GO:0008201   GO:0030326   GO:0060346   GO:0035583   GO:0048048   GO:0030198   GO:0030501   GO:0043010   GO:0030023   GO:0045669   GO:0035108   GO:0005604   GO:0001656   GO:0001501   GO:0043687   GO:0035582   GO:0007507   GO:0005178   GO:0071560   GO:0005788   GO:2001205   GO:0044877   GO:0042802   GO:0044267   GO:0045671   GO:1990314   GO:0048050   GO:0033627   GO:0050793   GO:0030154   GO:0005886   GO:0038023   GO:0000122   GO:0001525   GO:0060271   GO:0016021   GO:0005654   GO:0061314   GO:0005737   GO:0035204   GO:0048749   GO:0010001   GO:1900087   GO:0008356   GO:0008284   GO:0008347   GO:0043525   GO:0030720   GO:0060250   GO:0007519   GO:0005829   GO:0030713   GO:0035003   GO:0097150   GO:0005634   GO:0022416   GO:0036099   GO:0007398   GO:0045466   GO:0007314   GO:0016360   GO:0002052   GO:0050877   GO:0007473   GO:0045893   GO:0010628   GO:2000035   GO:0007298   GO:0005915   GO:2000048   GO:0005769   GO:0048665   GO:0005796   GO:0007451   GO:0035153   GO:0061382   GO:0009952   GO:0060571   GO:0007450   GO:0007015   GO:0035162   GO:0007346   GO:0005768   GO:0007422   GO:0048052   GO:0008045   GO:0004888   GO:0035172   GO:0032991   GO:0030139   GO:0007474   GO:0042691   GO:0048863   GO:0046666   GO:0035214   GO:0042689   GO:0008587   GO:0007405   GO:0046667   GO:0060289   GO:0046329   GO:0016348   GO:0042676   GO:0045316   GO:0035222   GO:0001708   GO:0001745   GO:0035165   GO:0060288   GO:0048664   GO:0007440   GO:0040008   GO:0035171   GO:0048190   GO:0007498   GO:0007464   GO:0036011   GO:0014019   GO:0008407   GO:0050768   GO:0042688   GO:0048803   GO:0009986   GO:1902692   GO:1990433   GO:0030708   GO:0007297   GO:0002213   GO:0007476   GO:0048542   GO:0046843   GO:0007446   GO:0007400   GO:0009608   GO:0050767   GO:0016333   GO:0016330   GO:0007419   GO:0043697   GO:0035167   GO:0007423   GO:0007411   GO:0030718   GO:0007616   GO:0007455   GO:0010629   GO:0006110   GO:0005887   GO:0046331   GO:0005912   GO:0008340   GO:0007403   GO:0009950   GO:0046716   GO:0042067   GO:0007219   GO:0036335   GO:0003682   GO:0051489   GO:0007391   GO:0007447   GO:0005770   GO:0030707   GO:0042686   GO:0048477   GO:0007478   GO:0061331   GO:0007521   GO:0045595   GO:0045944   GO:0007293   GO:0006367   GO:0010838   GO:0006915   GO:0019827   GO:0003184   GO:0001709   GO:0016020   GO:0060413   GO:0007399   GO:2001204   GO:0046579   GO:0002315   GO:0030097   GO:0043235   GO:0007275   GO:0009887   GO:0043066   GO:0045967   GO:2000249   GO:0046849   GO:0070374   GO:0000139   GO:0007050   GO:0006355   GO:0005789   GO:0072104   GO:0048844   GO:0007221   GO:0030900   GO:0045296   GO:0048663   GO:0015629   GO:0045665   GO:0045746   GO:0019899   GO:0048661   GO:0045596   GO:0006605   GO:0097435   GO:0070062   GO:0019838   GO:0007179   GO:0050436   GO:0009306   GO:0005623   GO:0071953   GO:0072015   GO:0001701   GO:0005929   GO:0072014   GO:0001947   GO:0035264   GO:0006959   GO:0072602   GO:0001890   GO:1990705   GO:0002437   GO:0043065   GO:0006357   GO:0045672   GO:0035622   GO:0043011   GO:0070986   GO:0001889   GO:0060674   GO:0051059   GO:0072576   GO:0042742   GO:0061073   GO:0030513   GO:0042060   GO:0002011   GO:0007368   GO:0072574   GO:0001822   GO:0042246   GO:0021986   GO:0001756   GO:0021531   GO:0001840   GO:0048699   GO:0048259   GO:0031016   GO:0048337   GO:0048936   GO:0031017   GO:0021514   GO:0042663   GO:0035907   GO:0021523   GO:0055016   GO:0002244   GO:0005856   GO:0033165   GO:0050896   GO:0007601   GO:0046549   GO:0035845   GO:0045494   GO:0016324   GO:0021915   GO:0005794   GO:0035924   GO:0005112   GO:0003203   GO:0061384   GO:0043565   GO:0003162   GO:0010832   GO:0045668   GO:0045687   GO:0048708   GO:0030334   GO:0050434   GO:0045747   GO:0060253   GO:1903849   GO:0008593   GO:2000737   GO:2001027   GO:0055008   GO:0030514   GO:0003182   GO:0072044   GO:0007492   GO:0048711   GO:0003181   GO:0000978   GO:0060317   GO:0045618   GO:0001228   GO:0003198   GO:0048845   GO:0003209   GO:0045607   GO:0009912   GO:0003344   GO:0060843   GO:0090051   GO:0031069   GO:0045892   GO:0048103   GO:0060982   GO:0061344   GO:0003252   GO:0001726   GO:0060548   GO:0071372   GO:0032496   GO:0030182   GO:0002040   GO:0014031   GO:0003160   GO:0032495   GO:0021515   GO:0042127   GO:0072017   GO:0045608   GO:0031410   GO:0035914   GO:0048873   GO:0003241   GO:0007386   GO:0003219   GO:0060528   GO:0060740   GO:0062043   GO:0008285   GO:0071944   GO:0060956   GO:0045165   GO:0030216   GO:1901201   GO:0061419   GO:0008544   GO:0003157   GO:0043086   GO:0014807   GO:0003332   GO:0035148   GO:0003222   GO:0050679   GO:0060768   GO:0005783   GO:0003180   GO:1902263   GO:0030027   GO:2000974   GO:0001837   GO:0060411   GO:0046982   GO:0003256   GO:0035116   GO:0060979   GO:0045955   GO:0046533   GO:0003151   GO:0060948   GO:0010718   GO:0003270   GO:0003208   GO:0031960   GO:0003192   GO:0010614   GO:0003207   GO:0031100   GO:0007409   GO:0003197   GO:2000811   GO:0070168   GO:0007283   GO:0030324   GO:0003700   GO:0090090   GO:0003169   GO:0030335   GO:0045662   GO:0004857   GO:0010468   GO:0003213   GO:1902339   GO:0002051   GO:0046427   GO:0048754   GO:0060038   GO:0001669   GO:0060412   GO:0030279   GO:0010812   GO:0060842   GO:0050678   GO:0060045   GO:0003264   GO:0072144   GO:0002193   GO:0120163   GO:0045603   GO:0003214   GO:0003273   GO:0045070   GO:0048709   GO:1901189   GO:0048715   GO:0031490   GO:0007420   GO:0030162   GO:0046879   GO:0050431   GO:0006955   GO:0006457   GO:0001558   GO:0030252   GO:0005024   GO:0017015   GO:0005539   GO:0035904   GO:0003281   GO:0060976   GO:1901388   GO:0070613   GO:0001886   GO:0001944   GO:0001569   GO:0045446   GO:0045766   GO:0045602   GO:0032880   GO:0001763   GO:0030879   GO:0035278   GO:0048471   GO:0030425   GO:0038045   GO:0005739   GO:0032967   GO:0043025   GO:0032579   GO:0071305   GO:0071374   GO:0036120   GO:0071260   GO:2000741   GO:0060430   GO:0032331   GO:0045780   GO:0060349   GO:1902462   GO:0036363   GO:0030502   GO:0050840   GO:0010811   GO:0005518   GO:0005882   GO:0030056   GO:0019215   GO:0007160   GO:0007166   GO:0002250   GO:0004930   GO:0009897   GO:0007189   GO:0007155   GO:0007186   GO:0016504   GO:0030878   GO:0060218   GO:1903561   GO:0042472   GO:0031101   GO:0048752   GO:1904888   GO:0060325   GO:0032474   GO:0060351   GO:0009953   GO:0060117   GO:0060872   GO:0043589   GO:0090497   GO:0035122   GO:0045599   GO:0001953   GO:0061156   GO:0035909   GO:0061444   GO:0030336   GO:0008083   GO:0045639   GO:0005543   GO:0072006   GO:0061309   GO:0022408   GO:0005198   GO:0001974   GO:0003215   GO:0045445   GO:0002456   GO:0042491   GO:0072070   GO:0048018   GO:0045177   GO:0048839   GO:0008104   GO:0040017   GO:0005815   GO:0001750   GO:0010469   GO:0030197   GO:0005176   GO:0010669   GO:1903363   GO:0033689   GO:0005635   GO:0005080   GO:0030155   GO:0030217   GO:0045061   GO:1990134   GO:0042475   GO:0007605   GO:0042492   GO:0016331   GO:0003016   GO:0051291   GO:0022617   GO:0045880   GO:0051260   GO:0043208   GO:0007435   GO:0045179   GO:0035017   GO:0007436   GO:0048100   GO:0030673   GO:0014009   GO:1900025   GO:0001933   GO:1904237   GO:0016032   GO:2000146   GO:2000647   GO:1904188   GO:0008022   GO:0007566   GO:0070051   GO:0001968   GO:0007162   GO:0070373   GO:2001202   GO:0072378   GO:0048146   GO:0001666   GO:0008584   GO:0009617   GO:0051301   GO:0007049   GO:0032154   GO:0007157   GO:0007156   GO:0030054   GO:0042803   GO:0005913   GO:0050839   GO:0005938   GO:0007163   GO:0005902   GO:0001917   GO:0007267   GO:0042462   GO:0007009   GO:0045197   GO:0045667   GO:0070207   GO:0045778   GO:0006954   GO:0019897   GO:0009791   GO:0007512   GO:0007596   GO:0035332   GO:0016332   GO:0003383   GO:0061024   GO:0046621   GO:0106036   GO:0035239   GO:0061336   GO:0007443   GO:0005819   GO:0046664   GO:0007424   GO:0032435   GO:0035090   GO:0045570   GO:0098813   GO:0016028   GO:0033157   GO:0061541   GO:0016334   GO:0051642   GO:0046665   GO:0034332   GO:0042051   GO:0045186   GO:0030507   GO:0035088   GO:0045176   GO:0050821   GO:0045218   GO:0060438   GO:0042052   GO:0016327   GO:0035002   GO:0097108   GO:1902732   GO:0008289   GO:0003413   GO:0042661   GO:0045168   GO:0018991   GO:0043054   GO:0040028   GO:0001085   GO:0090575   GO:0040025   GO:0002119   GO:0042659   GO:0048747   GO:0042694   GO:0051146   GO:0007517   GO:0030141   GO:0007224   GO:0008015   GO:0055111   GO:0001707   GO:0010470   GO:0072358   GO:0010951   GO:0014028   GO:0019828   GO:0045199   GO:0005515   GO:0030414   GO:0008270   GO:0003707  

PANTHER

PTHR24039:SF32   PTHR24049:SF18  

Subcellular location

Secreted   Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin.   With evidence from 1 publications.
  
Cell membrane  
Nucleus   Following proteolytical processing NICD is translocated to the nucleus.   With evidence from 4 publications.
Endosome  
Cytoplasm   Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by TCIM (PubMed:25985737).   With evidence from 26 publications.
Cell projection   Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium (PubMed:27737822, PubMed:30052645). May localize to the cilium axoneme (By similarity). May also be expressed in the interphotoreceptor extracellular matrix (By similarity). Unlike the primate ortholog, does not appear to be expressed in the photoreceptor outer segment (PubMed:27737822).   With evidence from 1 publications.
Cilium   Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium (PubMed:27737822, PubMed:30052645). May localize to the cilium axoneme (By similarity). May also be expressed in the interphotoreceptor extracellular matrix (By similarity). Unlike the primate ortholog, does not appear to be expressed in the photoreceptor outer segment (PubMed:27737822).   With evidence from 1 publications.
Cytoskeleton   Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium (PubMed:27737822, PubMed:30052645). May localize to the cilium axoneme (By similarity). May also be expressed in the interphotoreceptor extracellular matrix (By similarity). Unlike the primate ortholog, does not appear to be expressed in the photoreceptor outer segment (PubMed:27737822).   With evidence from 1 publications.
Cilium axoneme   Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium (PubMed:27737822, PubMed:30052645). May localize to the cilium axoneme (By similarity). May also be expressed in the interphotoreceptor extracellular matrix (By similarity). Unlike the primate ortholog, does not appear to be expressed in the photoreceptor outer segment (PubMed:27737822).   With evidence from 1 publications.
Extracellular space   Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium (PubMed:27737822, PubMed:30052645). May localize to the cilium axoneme (By similarity). May also be expressed in the interphotoreceptor extracellular matrix (By similarity). Unlike the primate ortholog, does not appear to be expressed in the photoreceptor outer segment (PubMed:27737822).   With evidence from 1 publications.
Extracellular matrix   Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium (PubMed:27737822, PubMed:30052645). May localize to the cilium axoneme (By similarity). May also be expressed in the interphotoreceptor extracellular matrix (By similarity). Unlike the primate ortholog, does not appear to be expressed in the photoreceptor outer segment (PubMed:27737822).   With evidence from 1 publications.
Interphotoreceptor matrix   Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium (PubMed:27737822, PubMed:30052645). May localize to the cilium axoneme (By similarity). May also be expressed in the interphotoreceptor extracellular matrix (By similarity). Unlike the primate ortholog, does not appear to be expressed in the photoreceptor outer segment (PubMed:27737822).   With evidence from 1 publications.
Cytoplasmic vesicle  
Hyaline layer  
Apical lamina  
Cell junction   Co-localizes with cytoplasmic intermediate filaments at hemidesmosomes.   With evidence from 8 publications.
Hemidesmosome   Co-localizes with cytoplasmic intermediate filaments at hemidesmosomes.   With evidence from 8 publications.
Membrane  
Photoreceptor outer segment   Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium. Highly expressed in cone photoreceptor outer segments (By similarity). Weakly expressed in rod photoreceptor outer segments (By similarity). May localize to the cilium axoneme (By similarity). May also be secreted into the interphotoreceptor extracellular matrix (By similarity).   With evidence from 1 publications.
Microtubule organizing center   Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium. Highly expressed in cone photoreceptor outer segments (By similarity). Weakly expressed in rod photoreceptor outer segments (By similarity). May localize to the cilium axoneme (By similarity). May also be secreted into the interphotoreceptor extracellular matrix (By similarity).   With evidence from 1 publications.
Centrosome   Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium. Highly expressed in cone photoreceptor outer segments (By similarity). Weakly expressed in rod photoreceptor outer segments (By similarity). May localize to the cilium axoneme (By similarity). May also be secreted into the interphotoreceptor extracellular matrix (By similarity).   With evidence from 1 publications.
Nucleus envelope  
Cell surface  
Basement membrane   The antibody used in PubMed:17015624 and PubMed:21215633 to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 7 publications.
Cleavage furrow   The antibody used in PubMed:17015624 and PubMed:21215633 to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 7 publications.
Apical cell membrane  
Spindle   Specifically localized to the apical membrane (PubMed:11076972, PubMed:2344615). Expressed in a mesh punctate pattern that overlaps with metaphase spindle microtubules (PubMed:25065591). In tracheal cells, colocalizes with apn in the subapical region, a small region of the apical membrane apical to the adherens junctions (PubMed:30645584).   With evidence from 7 publications.

SignalP

Position:   1 - 22,         Likelihood:  0.933495

 

 

Length:

20388

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

27.82905

Exp number, first 60 AAs:

4.17121

Total prob of N-in:

0.18786

outside

1  -  20342

TMhelix

20343  -  20365

inside

20366  -  20388

 

 

Pi

224.68637

Theta

20.776996

Tajima's D

0.323287

CLR

0.730586

CSRT

0.471926403679816

Interpretation

Uncertain