Gene

KWMTBOMO05684  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006850

Annotation

calcineurin_A_[Bombyx_mori]

Location

Bomo_Chr10(+):8180632-8182302      View in EpiBrowser

Full name

Serine/threonine-protein phosphatase       + More
Serine/threonine-protein phosphatase 2B catalytic subunit 3      
Serine/threonine-protein phosphatase 2B catalytic subunit 2      

Alternative Name

Calmodulin-dependent calcineurin A3 subunit
Calmodulin-dependent calcineurin A2 subunit

Location in the cell

Cytoplasmic   Reliability : 2.574

CDS

ATGTCCGGGAGCAATGATAAAGTGTCGACTACGCAGCGTATGATTCAAAGTGTCGCTTTCCCTCCCAGCCACAAGCTCACAGTATCGGAAGTGTTCGATGAAAAAACTGGAAAGCCACTACCAGATGTATTGAAGCAACATTTTATCCTAGAAGGTCGGATCGAAGAAAATGCGGCCTTACGGATTATTCAAGATGGTGCCACCTTATTACGATCAGAAAAAACTATGATCGAGATCGATTCACCGGTGACTGTGTGTGGAGACGTCCATGGGCAATTTTATGATTTGATGAAATTGTTCGAGGTTGGAGGTTCTCCCTCTTGTACTAAGTATTTATTCTTAGGTGATTATGTCGACCGAGGTTATTTCAGTATAGAATGTGTTCTCTATCTTTGGGCTTTAAAATTATGCTATCCGAAGACATTATTCCTATTACGCGGCAACCACGAATGCAGACACTTGACAGAATATTTCACTTTCAAACAAGAATGTAAAATCAAATATTCAGAGAAGGTGTATGATGCGTGCATGGACGCATTCGATTGCTTGCCCCTGGCTGCTCTTATGAACCAACAGTTCCTCTGCGTTCATGGAGGTCTTTCTCCTGAAATCAACAGCTTAGATGATATCCGTAAACTAGATAGATTCAAAGAGCCACCTGCATTTGGAGCCATGTGTGACCTGCTGTGGTCTGATCCTCTTGAAGATTTTGGCAATGAAAAAAATGCAGAACATTTCTCGCATAACTCCGTTAGGGGTTGCTCATATTTCTATAGCTATGCAGCCTGCTGTGATTTTCTCCAAAGAAACAATTTACTTTCTATCATCCGTGCTCATGAAGCTCAAGATGCTGGCTACCGAATGTATCGTAAAAGCCAAACAACTGGCTTTCCCAGTCTGATAACTATCTTCTCAGCACCAAACTATTTGGATGTCTATAACAATAAGGCTGCTGTATTAAAATATGAAAACAATGTGATGAACATACGCCAATTCAACTGTTCTCCACATCCATATTGGCTACCCAACTTCATGGATGTTTTTACTTGGTCTCTTCCATTTGTAGGTGAAAAAGTTACAGAGATGCTGGTCAATGTTCTGAACATTTGTTCTGATGATGAATTGATGTCAGAAGGAGATGATGCATTGGAGGAAGCTAATCTCAGAAAAGAAGTCATTCGCAATAAAATCCGTGCAATTGGAAAGATGGCTCATGTATTCTCTGTTCTTCGTGAGGAAAGTGAATCTGTTTTGCAATTGAAGGGCTTAACTCCTACTGGTGCTTTACCCCTGGGAGCACTTTCTGGTGGCAAGACATCTTTAAAAAATGCTTTGCAAGGTTTCTCACCTAACCATAAGATAACCTCTTTTGCTGAAGCCAAGGGGTTAGATGCCATCAATGAGCGCATGCCACCAAGGCGGGATGGTCAACGCACTCCTGATACCCAAGAAAAGAAACCGCATGTGAACAGCAATGCTCATTCGTGA

Protein

MSGSNDKVSTTQRMIQSVAFPPSHKLTVSEVFDEKTGKPLPDVLKQHFILEGRIEENAALRIIQDGATLLRSEKTMIEIDSPVTVCGDVHGQFYDLMKLFEVGGSPSCTKYLFLGDYVDRGYFSIECVLYLWALKLCYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSEKVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINSLDDIRKLDRFKEPPAFGAMCDLLWSDPLEDFGNEKNAEHFSHNSVRGCSYFYSYAACCDFLQRNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMSEGDDALEEANLRKEVIRNKIRAIGKMAHVFSVLREESESVLQLKGLTPTGALPLGALSGGKTSLKNALQGFSPNHKITSFAEAKGLDAINERMPPRRDGQRTPDTQEKKPHVNSNAHS

Description

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Catalytic Activity

H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate
H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate

Cofactor

Fe(3+)
Zn(2+)

Subunit

Interacts with sra in a complex that contains Pp2B-14D.
Interacts with sra in a complex that contains CanA-14F.

Similarity

Belongs to the PPP phosphatase family.
Belongs to the PPP phosphatase family. PP-2B subfamily.

Keywords

Calcium   Calmodulin-binding   Complete proteome   Hydrolase   Iron   Metal-binding   Phosphoprotein   Protein phosphatase   Reference proteome   Zinc  

Feature

chain  Serine/threonine-protein phosphatase 2B catalytic subunit 3

Uniprot

Q95P82   A0A212EU70   S4NU97   A0A0U2JFS6   A0A2A4JTL7   A0A2H1VH62   + More
A0A194QL31   A0A0L7KKD8   V5U5Q7   A0A139WLI0   D6WD80   A0A0C9RXI4   A0A158NYL6   A0A1B6CZM2   K7IVY4   V9IEF1   A0A1B6CV22   A0A088ADM2   A0A0A9Z3H2   A0A224XMA6   E0W2P1   A0A023F4X1   A0A0A9X0Y3   A0A2S2QZM4   X1WIM7   A0A195DE59   A0A0K8TNN8   A0A067RKD4   A0A0P6H765   E9FYP9   A0A1L8DKI1   A0A194PE03   A0A0P5BMW1   A0A0P5TYS7   A0A2H8TF16   A0A195AZB2   A0A151WTT2   A0A182LYV5   A0A182RA34   A0A0P5BVT7   A0A3L8DVJ9   A0A151IEW5   A0A182NQM6   A0A182YBG5   A0A0N8CF89   A0A182VVV7   A0A182TA24   A0A0P5UNJ3   A0A182TEX0   A0A182X9I5   Q7PKK6   A0A182HKG8   A0A2M3Z259   A0A2M4AAF3   W5J6V7   A0A182FRN0   A0A182V0E8   A0A2R5LKI3   A0A0P6E2C8   A0A1Z5LII5   V5HZ35   A0A182PRQ5   A0A084W0M7   A0A182GKH3   A0A182IS85   Q16XB2   B0XGP7   A0A293N1W5   W8AXI9   A0A2Z5U7C1   A0A1Q3EZ84   A0A195FV96   A0A0N7ZQ70   W8B526   B4IF94   B3NVI9   A0A0A1WV17   M9NEL1   Q9VXF1   B4PXU5   A0A0B4UHQ1   B4M1N8   T1E763   B4L2U4   A0A087UU11   A0A0M4ESJ9   B4IF93   A0A023GFC6   A0A224Z4F3   A0A131YRD9   A0A023FLU3   L7LYW8   A0A131X9Z9   A0A0A1X629   M9NE01   Q27889   A0A0K8UYX9   A0A034VSK2   B4JNU5   A0A0P4WJW9  

EC Number

3.1.3.16

Pubmed

11886782    19121390    22118469    23622113    26354079    26227816    + More
24132154    18362917    19820115    21347285    20075255    25401762    26823975    20566863    25474469    26369729    24845553    21292972    30249741    25244985    12364791    14747013    17210077    20920257    23761445    28528879    25765539    24438588    26483478    17510324    24495485    17994087    25830018    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    8849894    16860743    18327897    22421435    17550304    25541080    28797301    26830274    25576852    28049606    8313960    25348373   

EMBL

BABH01030845    AF287250    AAK83038.1    AGBW02012455    OWR45036.1    GAIX01013397    + More
JAA79163.1    KR185962    ALS92679.1    NWSH01000646    PCG75038.1    ODYU01002544    SOQ40185.1    KQ461198    KPJ06094.1    JTDY01009385    KOB63580.1    KF425265    AHB72693.1    KQ971321    KYB28792.1    EEZ99522.2    GBYB01013857    GBYB01013858    GBYB01013860    JAG83624.1    JAG83625.1    JAG83627.1    ADTU01004024    ADTU01004025    ADTU01004026    ADTU01004027    ADTU01004028    ADTU01004029    ADTU01004030    ADTU01004031    ADTU01004032    ADTU01004033    GEDC01018412    JAS18886.1    JR039408    AEY58679.1    GEDC01020215    JAS17083.1    GBHO01007244    GBRD01010192    GDHC01008044    GDHC01004680    JAG36360.1    JAG55632.1    JAQ10585.1    JAQ13949.1    GFTR01006856    JAW09570.1    DS235879    EEB19897.1    GBBI01002176    JAC16536.1    GBHO01032844    GBRD01010194    JAG10760.1    JAG55630.1    GGMS01013972    MBY83175.1    ABLF02035604    ABLF02035609    ABLF02035610    KQ980953    KYN11171.1    GDAI01001850    JAI15753.1    KK852417    KDR24331.1    GDIQ01023704    JAN71033.1    GL732527    EFX87567.1    GFDF01007132    JAV06952.1    KQ459606    KPI91492.1    GDIP01187423    JAJ35979.1    GDIP01137536    JAL66178.1    GFXV01000507    MBW12312.1    KQ976701    KYM77377.1    KQ982748    KYQ51319.1    AXCM01006655    GDIP01183382    JAJ40020.1    QOIP01000003    RLU24332.1    KQ977854    KYM99346.1    GDIP01137535    JAL66179.1    GDIP01112500    JAL91214.1    AAAB01008987    EAA43224.5    APCN01000829    GGFM01001845    MBW22596.1    GGFK01004428    MBW37749.1    ADMH02002066    ETN59716.1    GGLE01005809    MBY09935.1    GDIQ01083651    JAN11086.1    GFJQ02000219    JAW06751.1    GANP01002651    JAB81817.1    ATLV01019123    KE525262    KFB43771.1    JXUM01013211    JXUM01033462    KQ560989    KQ560371    KXJ80107.1    KXJ82744.1    CH477543    EAT39262.1    DS233050    EDS27741.1    GFWV01021460    MAA46188.1    GAMC01012875    JAB93680.1    AP017513    BBB06846.1    GFDL01014434    JAV20611.1    KQ981276    KYN43789.1    GDIP01223377    JAJ00025.1    GAMC01012874    GAMC01012873    JAB93682.1    CH480832    EDW46148.1    CH954180    EDV46381.1    GBXI01011952    JAD02340.1    AE014298    AFH07430.1    U30493    BT004864    AAC47079.1    AAF48623.4    AAO45220.1    CM000162    EDX01931.1    KP126618    AJD07838.1    CH940651    EDW65592.1    GAMD01003322    JAA98268.1    CH933810    EDW06911.2    KK121610    KFM80850.1    CP012528    ALC48314.1    EDW46147.1    GBBM01003745    JAC31673.1    GFPF01011713    MAA22859.1    GEDV01007050    JAP81507.1    GBBK01002358    JAC22124.1    GACK01008981    JAA56053.1    GEFH01004738    JAP63843.1    GBXI01008092    JAD06200.1    AFH07428.1    X77768    S68806    BT010083    GDHF01020445    JAI31869.1    GAKP01014167    JAC44785.1    CH916371    EDV92388.1    GDRN01050461    GDRN01050460    JAI66468.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000053240    UP000037510    UP000007266    + More
UP000005205    UP000002358    UP000005203    UP000009046    UP000007819    UP000078492    UP000027135    UP000000305    UP000053268    UP000078540    UP000075809    UP000075883    UP000075900    UP000279307    UP000078542    UP000075884    UP000076408    UP000075920    UP000075901    UP000075902    UP000076407    UP000007062    UP000075840    UP000000673    UP000069272    UP000075903    UP000075885    UP000030765    UP000069940    UP000249989    UP000075880    UP000008820    UP000002320    UP000078541    UP000001292    UP000008711    UP000000803    UP000002282    UP000008792    UP000009192    UP000054359    UP000092553    UP000001070   

PRIDE

Q95P82    V5HZ35    M9NEL1    Q9VXF1    M9NE01    Q27889    + More

Pfam

PF00149   Metallophos

Interpro

IPR004843   Calcineurin-like_PHP_ApaH        + More
IPR041751   MPP_PP2B       
IPR006186   Ser/Thr-sp_prot-phosphatase       
IPR029052   Metallo-depent_PP-like       

Gene 3D

3.60.21.10    

CDD

cd07416  MPP_PP2B

ProteinModelPortal

Q95P82   A0A212EU70   S4NU97   A0A0U2JFS6   A0A2A4JTL7   A0A2H1VH62   + More
A0A194QL31   A0A0L7KKD8   V5U5Q7   A0A139WLI0   D6WD80   A0A0C9RXI4   A0A158NYL6   A0A1B6CZM2   K7IVY4   V9IEF1   A0A1B6CV22   A0A088ADM2   A0A0A9Z3H2   A0A224XMA6   E0W2P1   A0A023F4X1   A0A0A9X0Y3   A0A2S2QZM4   X1WIM7   A0A195DE59   A0A0K8TNN8   A0A067RKD4   A0A0P6H765   E9FYP9   A0A1L8DKI1   A0A194PE03   A0A0P5BMW1   A0A0P5TYS7   A0A2H8TF16   A0A195AZB2   A0A151WTT2   A0A182LYV5   A0A182RA34   A0A0P5BVT7   A0A3L8DVJ9   A0A151IEW5   A0A182NQM6   A0A182YBG5   A0A0N8CF89   A0A182VVV7   A0A182TA24   A0A0P5UNJ3   A0A182TEX0   A0A182X9I5   Q7PKK6   A0A182HKG8   A0A2M3Z259   A0A2M4AAF3   W5J6V7   A0A182FRN0   A0A182V0E8   A0A2R5LKI3   A0A0P6E2C8   A0A1Z5LII5   V5HZ35   A0A182PRQ5   A0A084W0M7   A0A182GKH3   A0A182IS85   Q16XB2   B0XGP7   A0A293N1W5   W8AXI9   A0A2Z5U7C1   A0A1Q3EZ84   A0A195FV96   A0A0N7ZQ70   W8B526   B4IF94   B3NVI9   A0A0A1WV17   M9NEL1   Q9VXF1   B4PXU5   A0A0B4UHQ1   B4M1N8   T1E763   B4L2U4   A0A087UU11   A0A0M4ESJ9   B4IF93   A0A023GFC6   A0A224Z4F3   A0A131YRD9   A0A023FLU3   L7LYW8   A0A131X9Z9   A0A0A1X629   M9NE01   Q27889   A0A0K8UYX9   A0A034VSK2   B4JNU5   A0A0P4WJW9  

PDB

4IL1     E-value=0,     Score=2199

KEGG

692577    K04348 serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16] | (RefSeq) Cna; calci

PATHWAY

04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0004721   GO:0005737   GO:0005516   GO:0005955   GO:0033192   GO:0097720   GO:0030431   GO:0046872   GO:0004722   GO:0006470   GO:0045995   GO:0007143   GO:0035220   GO:0004723   GO:0051321   GO:0016787   GO:0003676   GO:0008138   GO:0003677   GO:0004725   GO:0004887   GO:0043401   GO:0003707   GO:0043565  

Length:

495

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.11414

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00842

outside

1  -  495

 

 

Pi

159.4428

Theta

162.153794

Tajima's D

-0.280838

CLR

108.741996

CSRT

0.292385380730963

Interpretation

Uncertain