Gene
KWMTBOMO05676
Pre Gene Modal
BGIBMGA006834
Annotation
AAEL009360-PA_[Aedes_aegypti]
Full name
Serine/threonine-protein kinase PLK4
Alternative Name
Polo-like kinase 4
Serine/threonine-protein kinase SAK
Serine/threonine-protein kinase SAK
Location in the cell
Nuclear Reliability : 2.103
Sequence
CDS
ATGTTTGGTGAGAAAGTGGAAGATTATGAAATTTTGGAACATCTAGGCAAAGGTGGATTTGCACATGTTTATAGAGCAAAATGTCGAAACAGTGGATTGTTTGTTGCTATAAAAATGATAGACAAAGTGTTGATGGCAAGTTCTGGAATGATCAGTAGAGTGCGACAAGAAGTCACAATACATTCTCGACTAAAGCATCCTGCAATTTTAGAGCTTTACACCTTTTTTGAAGATTCACACTATGTTTATTTAGTTTTAGAGCTAGCACATAATGGTGAACTCGCAAAACACTTTAAACTTGGTACACGTGGGCTTGATGAAAAAGCAGCTGCAGATATATTCCGGCAAGTTCTTAGTGGTGTAATATACCTACACACTCATAATATAATTCATAGAGATTTGTCTTTAAATAATTTACTTTTAACTAAAGACTTAAAAGTCAAGATAGCTGATTTTGGCCTTGCCACACAACTAAACGGGCCAGATGAAAAACATGTAACAATGTGTGGAACACCTAATTATATTTCTCCAGAAGTTGCTTCCAGAGAGGTACATGGCCTTCCAGCTGATGTTTGGGGATTGGGCTGTATGTTATATACCTTATTAGTAGGAAGTCCTCCTTTCCACACTCAGCATATAAAAACTACCTTAAATAAAGTAATTAATGCTGATTATAAAATACCATCAGAGCTATCAAGGGAAGCACAAGATTTACTCCAAAAACTTCTATGCAAAGATCCGATAAAAAGAATAAGTTTAAAAGGTGCCAGTAATCAGCCACCAAGTAATATTGCGAGAAATCTGTACGGTGAGGTTTTGCAGCACAAGAAGCAACATACAGTCTTGCCACATGTAATTGAAAATAACAATGATAAGGATAATGAATTCATGCATTTCAAAAATTTACATGTCAAATGCAAGTCTACTCAATATATGAGTTCCAAAAGCAATAGTGATGAAAATAAAGAAAATATTCCCAAAGCTTGCATTAATACAAATTCATTAAATGTCCCACCCTTATGTGCTGACCGATTACCAACAATATCTCATAGAACTCGAAATGCCATATTGAAAATAGAACCATTAGGAGTAACTGTAGAGTTTATAAAGAAAAAAGGAAAAAATAGAGAAGAAAAGATTGTAGAAGTTTGCAAAATCTCTAAAGATGGAATGAAAATTGTTATTTTTAAACCTGACACTGAAAAAACCAAAGATTATCCTCATGTGGAGCATGACCCTAACCCTGATGAAGTATTTTCGTATCATAATTTGCCACAAAAGCACTGGAAGAAATATCTATATGCTGCACGTTTTGTTGATCTTGTCAAAGCCAAAACTCCTAAAATAACACTATATTCTAAATTAGCCAAGTGTCAACTGATGGAAAATGGAACAGATTTAGAAGCATTCTTTTATACTGGGGAAAAGGTCACAAATACAGCTTCAGAAGGGTTGAAGATTATTGATAAAAATTTGAAAACATATTGTAATGCTGTGGGGGTTCAAGAATTAAAATCTATATTTGAACATTTTGAAGAATGTTCAGGTCGTATGAAGCGTGTACAAGAAACACTATCATGCCTATCTGATGAATGTTACCCGTTAATTATTGGTAGAAGGCCCACATATTCAATGGAAAACATTTCATCCCCACATCAAGGAAGAATTAACAGCAATCTTATGACACCAGTGATAAACATAGATTCATTTCACAGAGGTGCAAGTAGTTCTAATCATGCTTACAGTGATTACAACAGATAA
Protein
MFGEKVEDYEILEHLGKGGFAHVYRAKCRNSGLFVAIKMIDKVLMASSGMISRVRQEVTIHSRLKHPAILELYTFFEDSHYVYLVLELAHNGELAKHFKLGTRGLDEKAAADIFRQVLSGVIYLHTHNIIHRDLSLNNLLLTKDLKVKIADFGLATQLNGPDEKHVTMCGTPNYISPEVASREVHGLPADVWGLGCMLYTLLVGSPPFHTQHIKTTLNKVINADYKIPSELSREAQDLLQKLLCKDPIKRISLKGASNQPPSNIARNLYGEVLQHKKQHTVLPHVIENNNDKDNEFMHFKNLHVKCKSTQYMSSKSNSDENKENIPKACINTNSLNVPPLCADRLPTISHRTRNAILKIEPLGVTVEFIKKKGKNREEKIVEVCKISKDGMKIVIFKPDTEKTKDYPHVEHDPNPDEVFSYHNLPQKHWKKYLYAARFVDLVKAKTPKITLYSKLAKCQLMENGTDLEAFFYTGEKVTNTASEGLKIIDKNLKTYCNAVGVQELKSIFEHFEECSGRMKRVQETLSCLSDECYPLIIGRRPTYSMENISSPHQGRINSNLMTPVINIDSFHRGASSSNHAYSDYNR
Summary
Description
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting the importance of centrosome regulation in cancers (By similarity).
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, leading to the recruitment of centriole biogenesis proteins. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase (By similarity).
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, leading to the recruitment of centriole biogenesis proteins. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase (By similarity).
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Subunit
Homodimer.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Keywords
ATP-binding
Complete proteome
Cytoplasm
Cytoskeleton
Kinase
Nucleotide-binding
Reference proteome
Transferase
Ubl conjugation
Feature
chain Serine/threonine-protein kinase PLK4
Uniprot
EC Number
2.7.11.21
EMBL
Proteomes
Interpro
SUPFAM
SSF56112
SSF56112
Gene 3D
ProteinModelPortal
PDB
4YUR
E-value=6.39869e-80,
Score=759
Ontologies
KEGG
GO
PANTHER
Topology
Subcellular location
Length:
586
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.11122
Exp number, first 60 AAs:
0.085
Total prob of N-in:
0.00561
outside
1 - 586
Population Genetic Test Statistics
Pi
293.147826
Theta
241.479111
Tajima's D
0.668661
CLR
0.010219
CSRT
0.565071746412679
Interpretation
Uncertain
