Gene

KWMTBOMO05666

Pre Gene Modal

BGIBMGA014044

Annotation

PREDICTED:_sphingomyelin_phosphodiesterase_4_[Amyelois_transitella]

Location

Bomo_Chr10(-):7549214-7557142      View in EpiBrowser

Full name

Sphingomyelin phosphodiesterase 4      

Alternative Name

Neutral sphingomyelinase 3
Neutral sphingomyelinase III

Location in the cell

PlasmaMembrane   Reliability : 3.16

CDS

ATGTTTCGACTGTGCTATAGGTTATTATCTGACACTCAGTTGAAGTACGAATTGCCATTAAATGTATTACCTCTTGATCTACAGGTGACATTAGAAAGAGGGAGATGCCCACAATTTTATGCTGACATGTTAACTGCAGATGCACAAACAATGAATATGATTTCTTTGGCACTCAATCCTTTCGATTATTACATTTTCAATTTTGCCTTATACTTGATTAATAATAATCAAAATAAGAACACATGGGAGAATTGGAATAGTGTGTACTTTGCATTAGCGTGTGATTATTTGATGCATTTTCTGCCTTTGGATCCCAACATGCCTGTGCTTCCACACATATCAAATTACACTGGAAAAGTACCTATAGCAGCTCCATTGAAAACTGCTAACAGGCCTCTGTACTCACCATCACTGTTATTAATATCAGACTTAACTGGTTCTGTTATAAACAATCAGCATACATCACAAACACAATCTAGAAACGAAGTATGGAGATCTGAAACAGTACTGCAAGTTTTTATTGATATCTGGATGAGTGTTGAACAATTAAATGCAAGGTCTATTGAGATGTATCAAAGGTCGTATCAAATCAATACAGCAAGTCCAGAAAGAGTACGAATTGTTAGAGTGCTTATAAAGCATTTGCATTCGTTTTCAGCAAAATACGTTTCTGATCCAGCTGTGCGTTCGTCTGCATTACGAAAGTACGCACGCCAGATATTGTGTGTACGTGCATATCATTATGTCAAACATTTGGTTACAACATGGCCTCTAGATGCTTCATTCCGGCTTGTTATGGAATTATGGTTAAGCCTTATTCAACCTTGGCGATACGTTAACAACAACATTAATCAAGATAGATTTCCATCAAACAACCATCAAGATGAAAATCCAACACACACCCTCGATGCCAGCTTTACTCAGTTTATTGCCGAGAATTTTCCATCATACACTTGCATTTTTCAGTTGATTCTGCCAAGATTTATGAGATTGGATCTCACGACGTACAAAAATGCTGTGATGCTTTTTAGATTGGGAAAGGTGTTTTCCCAACCGCATTTAGTACCAATTCTGTGGAACTTAGAACATGCAATTCTGGATAGTGGATCTGGAGTGACACACAGTTCAGACTTAAATTTTAGCAATTCAATGACTGATCAAAGTTATACATACAACGGAGTGTCGTTGCAAAAATGGGTAGCGATAGCGAAACAAGCAATATCAGAATTCAATATGCCTGAAAATTTCGAATATAAACCTATATGGAATGATAACATGCGATCTTTTGCTTTAGAATTTGTAAAGAAAATTATTTCTGCTAAAACTATAGCGGAAAAGAACGTTGAAGAATTTAGTAAAAAAATCGACATGAGCAATCAAGGATTTTGGTCATCTTTAATGCACTGGCTAATGATAGCCACTCAGGATGAAAGTGATGGACATCTAGAAGAAGTAAAAAAAGTGCCAACTTATTTAAATACATCTATACACAATTTTGCAGTTATATTTGGTTTAAGTGAAGCACTACTACTCCCTTCAGAACCAATTGCGGATGACAGTTTAGAAAACTCATCATTTGTAAATTCAACTGCTTTTCCATTTTCTATAACAAACAAGCTGAGAAGTAAATCAACAAATGTACATTATATGGGTAATCCAGACCTCATGCCTATAGCATCCTATGAAAGTACAATTTTAGTCAGAATACTGCATCAAATTTCAACTAAAATAAATGAATTGGTGAGTTATGTCAATAGATTAACATTCTAG

Protein

MFRLCYRLLSDTQLKYELPLNVLPLDLQVTLERGRCPQFYADMLTADAQTMNMISLALNPFDYYIFNFALYLINNNQNKNTWENWNSVYFALACDYLMHFLPLDPNMPVLPHISNYTGKVPIAAPLKTANRPLYSPSLLLISDLTGSVINNQHTSQTQSRNEVWRSETVLQVFIDIWMSVEQLNARSIEMYQRSYQINTASPERVRIVRVLIKHLHSFSAKYVSDPAVRSSALRKYARQILCVRAYHYVKHLVTTWPLDASFRLVMELWLSLIQPWRYVNNNINQDRFPSNNHQDENPTHTLDASFTQFIAENFPSYTCIFQLILPRFMRLDLTTYKNAVMLFRLGKVFSQPHLVPILWNLEHAILDSGSGVTHSSDLNFSNSMTDQSYTYNGVSLQKWVAIAKQAISEFNMPENFEYKPIWNDNMRSFALEFVKKIISAKTIAEKNVEEFSKKIDMSNQGFWSSLMHWLMIATQDESDGHLEEVKKVPTYLNTSIHNFAVIFGLSEALLLPSEPIADDSLENSSFVNSTAFPFSITNKLRSKSTNVHYMGNPDLMPIASYESTILVRILHQISTKINELVSYVNRLTF

Description

Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide.

Catalytic Activity

H2O + sphingomyelin = an N-acylsphing-4-enine + H(+) + phosphocholine

Cofactor

Mg(2+)

Keywords

Complete proteome   Endoplasmic reticulum   Golgi apparatus   Hydrolase   Magnesium   Membrane   Metal-binding   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Sphingomyelin phosphodiesterase 4

Uniprot

A0A2A4JMT4   A0A2H1VAJ9   A0A194QMD9   A0A194PDW1   S4PY96   A0A212ERR0   + More
A0A2J7RJ29   N6UB69   A0A1Y1LXI8   A0A067RMT8   U4U4I3   A0A0C9RGV9   A0A0P6IV43   A0A232EH66   A0A1B0CYY0   A0A154PD11   D6X2Y7   Q17GU0   A0A336LQY2   A0A336MSM4   A0A3L8DQ70   B0WGE8   A0A310SA06   A0A0N1IT29   A0A2A3EL81   A0A0L0CBK2   A0A1Q3F087   A0A1Q3F0D4   K7IQC1   A0A195ER78   A0A195DNT6   A0A195AVQ5   A0A0C9R7R2   A0A3B4DNA2   A0A1B6GZN4   A0A151WP29   A0A3Q3LZF2   A0A1I8MJ86   A0A1B6FXC2   A0A0L7RIY7   A0A1A8ER15   I3J9S6   A0A3Q1HW65   A0A1J1I9D6   E2B014   A0A151I7Z3   A0A3P8PNQ7   A0A3P9BS01   A0A3B5ATS0   A0A1A8J2L0   A0A1B6G0A0   A0A3Q2WX16   A0A0P6F667   A0A3Q3G471   A0A1A9X2R9   A0A3B4BSH4   A0A0P4YYL8   A0A146VR63   A0A158P2J8   A0A026WC08   A0A1I8NS43   A0A3Q1GLX0   A0A0P6ACM7   A0A146R3P5   A0A1A8C5J9   A0A146VQT9   A0A1I8MJ82   A0A0P6I758   A0A1I8MJ89   A0A1A7XYK2   A0A146VQT6   A0A088AJ03   A0A3B1J7M5   A0A146VRV9   A0A146VQI3   A0A146MVN2   A0A1A9V723   A0A3Q3K6Q8   A0A1A8UZ20   A0A3P8Y268   A0A1A8DYS9   A0A1A8K296   A0A1A8L5H6   A0A2D0T1I2   A0A3P9BR89   Q6PFJ7   A0A182GI02   I3J9S5   A0A1B0CLM3   A0A3P8PP09   F1R680   A0A1S3KYX9   A0A1S3KZ02   A0A3B3Q1P4   E2B8N3   F4W644   A0A3B5B169   A0A3B4BVK1  

EC Number

3.1.4.12

Pubmed

26354079    23622113    22118469    23537049    28004739    24845553    + More
26999592    28648823    18362917    19820115    17510324    30249741    26108605    20075255    25315136    25186727    20798317    21347285    24508170    25329095    25069045    26483478    23594743    29240929    21719571   

EMBL

NWSH01001013    PCG73129.1    ODYU01001529    SOQ37869.1    KQ461198    KPJ06120.1    + More
KQ459606    KPI91526.1    GAIX01003673    JAA88887.1    AGBW02012957    OWR44165.1    NEVH01003008    PNF40841.1    APGK01041795    APGK01041796    KB740997    ENN75882.1    GEZM01044445    JAV78219.1    KK852530    KDR21935.1    KB632100    ERL88814.1    GBYB01012407    JAG82174.1    GDUN01000900    JAN95019.1    NNAY01004566    OXU17710.1    AJVK01020478    AJVK01020479    KQ434874    KZC09713.1    KQ971372    EFA10294.2    CH477256    EAT45847.1    UFQT01000123    SSX20454.1    UFQS01002437    UFQT01002437    SSX14033.1    SSX33452.1    QOIP01000005    RLU22392.1    DS231926    EDS26945.1    KQ766110    OAD53738.1    KQ435922    KOX68502.1    KZ288226    PBC31909.1    JRES01000630    KNC29788.1    GFDL01014070    JAV20975.1    GFDL01014020    JAV21025.1    KQ982021    KYN30412.1    KQ980724    KYN14149.1    KQ976731    KYM76323.1    GBYB01012409    JAG82176.1    GECZ01006507    GECZ01001876    JAS63262.1    JAS67893.1    KQ982892    KYQ49626.1    GECZ01014921    JAS54848.1    KQ414582    KOC70912.1    HAEB01002785    SBQ49312.1    AERX01048901    CVRI01000044    CRK96885.1    GL444334    EFN60972.1    KQ978397    KYM94210.1    HAED01017407    SBR03852.1    GECZ01028602    GECZ01013901    GECZ01006369    JAS41167.1    JAS55868.1    JAS63400.1    GDIQ01052846    JAN41891.1    GDIP01221730    JAJ01672.1    GCES01066625    JAR19698.1    ADTU01006902    KK107293    EZA53176.1    GDIP01031493    JAM72222.1    GCES01123401    JAQ62921.1    HADZ01010397    SBP74338.1    GCES01066617    JAR19706.1    GDIQ01008513    JAN86224.1    HADW01017203    HADX01000876    SBP23108.1    GCES01066622    JAR19701.1    GCES01066624    JAR19699.1    GCES01066623    JAR19700.1    GCES01163576    JAQ22746.1    HADY01009017    HAEJ01012873    SBS53330.1    HAEA01009469    SBQ37949.1    HAEE01006428    SBR26448.1    HAEF01001762    HAEG01003315    SBR39144.1    BC057525    JXUM01011921    KQ560341    KXJ82956.1    AJWK01017455    CU467622    GL446361    EFN87939.1    GL887707    EGI70179.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000007151    UP000235965    UP000019118    + More
UP000027135    UP000030742    UP000215335    UP000092462    UP000076502    UP000007266    UP000008820    UP000279307    UP000002320    UP000053105    UP000242457    UP000037069    UP000002358    UP000078541    UP000078492    UP000078540    UP000261440    UP000075809    UP000261640    UP000095301    UP000053825    UP000005207    UP000265040    UP000183832    UP000000311    UP000078542    UP000265100    UP000265160    UP000261400    UP000264840    UP000261660    UP000091820    UP000005205    UP000053097    UP000095300    UP000257200    UP000005203    UP000018467    UP000078200    UP000261600    UP000265140    UP000221080    UP000000437    UP000069940    UP000249989    UP000092461    UP000087266    UP000261540    UP000008237    UP000007755   

PRIDE

Q6PFJ7   

Pfam

PF14724   mit_SMPDase

Interpro

IPR024129   Sphingomy_SMPD4       

ProteinModelPortal

A0A2A4JMT4   A0A2H1VAJ9   A0A194QMD9   A0A194PDW1   S4PY96   A0A212ERR0   + More
A0A2J7RJ29   N6UB69   A0A1Y1LXI8   A0A067RMT8   U4U4I3   A0A0C9RGV9   A0A0P6IV43   A0A232EH66   A0A1B0CYY0   A0A154PD11   D6X2Y7   Q17GU0   A0A336LQY2   A0A336MSM4   A0A3L8DQ70   B0WGE8   A0A310SA06   A0A0N1IT29   A0A2A3EL81   A0A0L0CBK2   A0A1Q3F087   A0A1Q3F0D4   K7IQC1   A0A195ER78   A0A195DNT6   A0A195AVQ5   A0A0C9R7R2   A0A3B4DNA2   A0A1B6GZN4   A0A151WP29   A0A3Q3LZF2   A0A1I8MJ86   A0A1B6FXC2   A0A0L7RIY7   A0A1A8ER15   I3J9S6   A0A3Q1HW65   A0A1J1I9D6   E2B014   A0A151I7Z3   A0A3P8PNQ7   A0A3P9BS01   A0A3B5ATS0   A0A1A8J2L0   A0A1B6G0A0   A0A3Q2WX16   A0A0P6F667   A0A3Q3G471   A0A1A9X2R9   A0A3B4BSH4   A0A0P4YYL8   A0A146VR63   A0A158P2J8   A0A026WC08   A0A1I8NS43   A0A3Q1GLX0   A0A0P6ACM7   A0A146R3P5   A0A1A8C5J9   A0A146VQT9   A0A1I8MJ82   A0A0P6I758   A0A1I8MJ89   A0A1A7XYK2   A0A146VQT6   A0A088AJ03   A0A3B1J7M5   A0A146VRV9   A0A146VQI3   A0A146MVN2   A0A1A9V723   A0A3Q3K6Q8   A0A1A8UZ20   A0A3P8Y268   A0A1A8DYS9   A0A1A8K296   A0A1A8L5H6   A0A2D0T1I2   A0A3P9BR89   Q6PFJ7   A0A182GI02   I3J9S5   A0A1B0CLM3   A0A3P8PP09   F1R680   A0A1S3KYX9   A0A1S3KZ02   A0A3B3Q1P4   E2B8N3   F4W644   A0A3B5B169   A0A3B4BVK1  

KEGG

101740952    K12353 sphingomyelin phosphodiesterase 4 [EC:3.1.4.12] | (RefSeq) sphingomyelin phosphodiesterase 4-

PATHWAY

00600    Sphingolipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0050290   GO:0016021   GO:0046513   GO:0006685   GO:0046475   GO:0004767   GO:0000139   GO:0005789   GO:0046872   GO:0003899   GO:0006351   GO:0032549   GO:0005739   GO:0007005   GO:0031307   GO:0008270   GO:0003700   GO:0043565  

PANTHER

PTHR12988  

Subcellular location

Endoplasmic reticulum membrane  
Golgi apparatus membrane  

Length:

589

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.92772

Exp number, first 60 AAs:

0.92315

Total prob of N-in:

0.02230

outside

1  -  589

 

 

Pi

323.174344

Theta

204.987604

Tajima's D

1.692234

CLR

0

CSRT

0.828508574571271

Interpretation

Uncertain