Silkworm Genome Informatics Database

Gene

KWMTBOMO05664

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_mitochondrial_Rho_GTPase-like_[Bombyx_mori]

Location

Bomo_Chr10(-):7524508-7536812 View in EpiBrowser

Full name

Mitochondrial Rho GTPase

Location in the cell

Cytoplasmic Reliability : 1.459 PlasmaMembrane Reliability : 1.875

CDS

ATGAGCGAGCCAGGAGTTGGTAAAACATCACTTATTTTATCGTTAGTGACTGAAGAATTTACAGAACATGTGCCTCCAAAAGCTGAAGAAATAACTATACCTGCTGATGTAACGCCAGAACAAGTTCCAACCAATATTATTGATATTTGTATTCCTGAACAATCTTTGGAACAAGTTGCTGAAGAGATAGAAAGGGCACATGTAATATGCATAGTATTTTCAGTGGATAGACAAGAGACTTTAAATAAAATAGCCACCTACTGGTTACCATTTGTAAGAGATAATTGCCCAGAAGATTATAGAAAGCCTGTTATTCTCGTCGGAAATAAGATTGATTTGATTGATTACTCAGTGATTGATAATATATGGGATATAGCAGAAGAATATCCAGAGGTGGACAGATGTATAGAATGTTCTGCGAAATCTCTAATAAATGTATCCGAAATGTTTTACAATGCACAAAAGGCAGTTCTGCATCCCATCAATCCTATTTATTCCATAGAAGAACAAGAATTAACGGAAAAGTGCAAAAAAGCATTATCTAGGATATTTAAAATATGTGATTTGGATGGTGATGGCTTACTTGATGATTATGAAGTGACAATATTTCAAAAAAAGTGTTTCGATTCGCCTTTGCAATTACAGGTTTTAGATGAAGTAAAGTCAGTGATTGCTCAAAATGTCGCTGGTGGAATTGAAAATGATTGTATAACAATAAAGGGCTTTATTTTTTTACATTGTTTATTTATACAAAGGGGCAGAAATGAGACAACTTGGACAGTTTTAAGAAAATTTGGTTATGATGAAAGTCTAGAATTGACACCCAGCTATTTGTATGCAAGTATAAAAGTACCTGTCGGATGTACCACCGAATTATCGTACAAAGGACAACAGTTTTTGACGCAATTATTTGAAAAATACGACAAAGATAAAGACGGCATGCTAAATCCGACAGAATTAAAAAATGTATTTTCCTGTTGTCCGAGAATACCCTGGCACAATTTGAGGTACACTGTACCGACGAATGAAAAGGGCTACTTAACACTTCAAGGTTGGATGTGCCGATGGACACTCATGACGTTACTGGACTTACAGAACACTAGTGCATATTTAGCGTATCTTGGATTTAATTTTCTTGAGAACGAGTCACAAAAATTAGCAATACATATAACACGCGAGAAGAAAATCGACATAGCGAAGAAACAGTCTAGTCGTAATGTCTATCAGTGTCACGTTATAGGTCCCCGGTCATGTGGGAAGACGTCGATTTGTAGAAGCTTTCTCGGAATAGGACATAAGAAAATAAAAGCACACGCAAATGAACGGGGAGATGGCAATAACACAGATAATTGTTGCATTAACACAGTATTAGTTTACGGACAAGAGAAATATCTGGTATTGAAGGAAATACCCATAACTCGAGTGTCGGATCCTTTACAGCCGCATGAAGTCAACTGCGACGTGGCGTGCCTCGTGTACGACGTTGGAGCCAGTCGTTCGTTCGAATACATTGCTAGGATTTATATTAAATATTTCGCGGAAAGTCATATTCCTGTCCTTATTGTTGGTACAAGAGGAGACGCACTAATCGCCAGACAGGAATATATACTACAACCTGAAATGTTTTGCAATAAGTACCAGCTGCTATCGCCTCATTTTTTTTTCATCAAAGAAAATAAAAACGATGTCTTCGTTAAATTAGCGACAATGGCCGCATTTCCACATTTGAAGCATTTCGCAAGTCTTTCTGGAGAGAACTCATCTTGGTGGAAAGCTGGTATTGGAGTTGCAGCTGCAACTGTTGTGGGCTTCGTTCTTATCAAGATATTTAGCTTCCAGAAACGATAG

Protein

MSEPGVGKTSLILSLVTEEFTEHVPPKAEEITIPADVTPEQVPTNIIDICIPEQSLEQVAEEIERAHVICIVFSVDRQETLNKIATYWLPFVRDNCPEDYRKPVILVGNKIDLIDYSVIDNIWDIAEEYPEVDRCIECSAKSLINVSEMFYNAQKAVLHPINPIYSIEEQELTEKCKKALSRIFKICDLDGDGLLDDYEVTIFQKKCFDSPLQLQVLDEVKSVIAQNVAGGIENDCITIKGFIFLHCLFIQRGRNETTWTVLRKFGYDESLELTPSYLYASIKVPVGCTTELSYKGQQFLTQLFEKYDKDKDGMLNPTELKNVFSCCPRIPWHNLRYTVPTNEKGYLTLQGWMCRWTLMTLLDLQNTSAYLAYLGFNFLENESQKLAIHITREKKIDIAKKQSSRNVYQCHVIGPRSCGKTSICRSFLGIGHKKIKAHANERGDGNNTDNCCINTVLVYGQEKYLVLKEIPITRVSDPLQPHEVNCDVACLVYDVGASRSFEYIARIYIKYFAESHIPVLIVGTRGDALIARQEYILQPEMFCNKYQLLSPHFFFIKENKNDVFVKLATMAAFPHLKHFASLSGENSSWWKAGIGVAAATVVGFVLIKIFSFQKR

Description

Mitochondrial GTPase involved in mitochondrial trafficking.
Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).

Subunit

Interacts with kinesin-associated protein milt.

Similarity

Belongs to the mitochondrial Rho GTPase family.

Keywords

3D-structure Alternative splicing Calcium Complete proteome GTP-binding Hydrolase Membrane Metal-binding Mitochondrion Mitochondrion outer membrane Nucleotide-binding Reference proteome Repeat Transmembrane Transmembrane helix

Feature

chain Mitochondrial Rho GTPase
splice variant In isoform B.

Uniprot

A0A2A4JM44 A0A2H1VAL5 A0A212ERP1 A0A194PET0 A0A194QKS1 A0A0L7L805 + More
A0A1Q3FES0 A0A1Q3FBQ1 B0W0F0 A0A182IRR3 A0A182MN96 A0A182WT12 A0A182RFI6 A0A182UFY5 A0A182HV09 A0A182L1V3 A0A182W7E5 Q17JY4 A0A0K8U817 A0A182XZX5 Q7Q3R6 A0A182P4R9 A0A034VHG5 A0A182G4S0 A0A0A1XTC9 A0A1J1IM58 A0A1J1IP23 A0A182Q383 A0A1Q3G2Z9 A0A1L8E3N2 A0A0K8V754 U5EXQ2 A0A182USL7 A0A034VJ35 A0A0P6K0U7 W8BZQ5 A0A182F1L2 W5JS34 A0A0A1XMS8 A0A0L0CDE7 A0A1I8MIZ9 A0A1I8PUU8 A0A0K8V6H1 A0A2M4AET8 A0A2M4BGQ6 A0A034VIF1 A0A182JU65 A0A1L8E3G0 A0A0A1WNL4 A0A2M3Z6R8 A0A0K8UDU8 A0A0K8TZD8 A0A034VGD2 A0A0Q9X3H1 W8BN06 A0A1I8MIZ4 A0A182NTM6 A0A1I8PUS2 T1PLI1 A0A0Q9X6E0 W8B0Z9 A0A1I8MJ01 A0A1I8PUT9 A0A0Q9WUG2 Q8IMX7 A0A3B0JK69 B4JII1 B4NH46 A0A1W4UJA0 A0A0R1E9A9 A0A0M5J7G7 A0A0Q9WYZ6 B4K798 N6TY59 A0A0Q9WSM3 I5ANY4 Q298L5 A0A0P8YLF5 B4M0H7 V5GTM6 A0A0B4J3Z9 B3P8A4 A0A1W4U7I3 A0A3B0KAN7 A0A084WD81 A0A0K8TK97 Q8IMX7-2 A0A0B4KGW0 A0A0R1EBC3 A0A3B0KGG3 A0A1W4UL30 B4HGG5 A0A1Y1KMN1 B4PL33 B4G438 A0A0R3NL19 A0A3B0K9J3 A0A0P9C867 A0A1W4WF63 D6X1S3

EC Number

3.6.5.-

Pubmed

22118469 26354079 26227816 20966253 17510324 25244985 + More
12364791 14747013 17210077 25348373 26483478 25830018 26999592 24495485 20920257 23761445 26108605 25315136 17994087 10731132 12537572 12537569 16055062 14605208 16717129 17550304 23537049 15632085 12537568 12537573 12537574 16110336 17569856 17569867 24438588 26369729 28004739 18362917 19820115

EMBL

NWSH01001013 PCG73127.1 ODYU01001529 SOQ37867.1 AGBW02012957 OWR44163.1 + More
KQ459606 KPI91528.1 KQ461198 KPJ06122.1 JTDY01002341 KOB71628.1 GFDL01009010 JAV26035.1 GFDL01010068 JAV24977.1 DS231817 EDS39689.1 AXCM01003104 AXCM01003105 APCN01002488 CH477229 EAT47016.1 GDHF01029517 JAI22797.1 AAAB01008964 EAA12403.3 GAKP01017385 JAC41567.1 JXUM01042526 JXUM01042527 JXUM01042528 KQ561328 KXJ78964.1 GBXI01004473 GBXI01000005 JAD09819.1 JAD14287.1 CVRI01000055 CRL01307.1 CRL01308.1 AXCN02000795 GFDL01000909 JAV34136.1 GFDF01000979 JAV13105.1 GDHF01017726 JAI34588.1 GANO01002434 JAB57437.1 GAKP01017389 JAC41563.1 GDUN01000727 JAN95192.1 GAMC01011806 JAB94749.1 ADMH02000259 ETN67217.1 GBXI01002434 JAD11858.1 JRES01000655 KNC29494.1 GDHF01017787 JAI34527.1 GGFK01005969 MBW39290.1 GGFJ01003094 MBW52235.1 GAKP01017387 JAC41565.1 GFDF01000972 JAV13112.1 GBXI01014284 JAD00008.1 GGFM01003450 MBW24201.1 GDHF01027591 JAI24723.1 GDHF01032869 GDHF01015347 GDHF01006856 JAI19445.1 JAI36967.1 JAI45458.1 GAKP01017388 JAC41564.1 CH964272 KRG00068.1 GAMC01011804 GAMC01011803 JAB94751.1 KA649621 AFP64250.1 CH933806 KRG00932.1 GAMC01011805 JAB94750.1 CH940650 KRF83797.1 AE014297 BT016011 AY058555 OUUW01000007 SPP82737.1 CH916369 EDV93062.1 EDW84543.2 CM000160 KRK04611.1 CP012526 ALC47444.1 KRG00933.1 EDW14222.1 APGK01050296 KB741169 ENN73316.1 KRF83796.1 CM000070 EIM52669.1 CH902617 KPU79695.1 EDW68356.1 GALX01003489 JAB64977.1 AAF56222.2 CH954182 EDV53928.1 SPP82736.1 ATLV01022955 KE525338 KFB48175.1 GDAI01002871 JAI14732.1 AGB96275.1 KRK04610.1 SPP82738.1 CH480815 EDW43418.1 GEZM01081163 JAV61838.1 EDW99018.1 CH479179 EDW24449.1 KRT00351.1 SPP82739.1 KPU79696.1 KQ971371 EFA10155.2

Proteomes

UP000218220 UP000007151 UP000053268 UP000053240 UP000037510 UP000002320 + More
UP000075880 UP000075883 UP000076407 UP000075900 UP000075902 UP000075840 UP000075882 UP000075920 UP000008820 UP000076408 UP000007062 UP000075885 UP000069940 UP000249989 UP000183832 UP000075886 UP000075903 UP000069272 UP000000673 UP000037069 UP000095301 UP000095300 UP000075881 UP000007798 UP000075884 UP000009192 UP000008792 UP000000803 UP000268350 UP000001070 UP000192221 UP000002282 UP000092553 UP000019118 UP000001819 UP000007801 UP000008711 UP000030765 UP000001292 UP000008744 UP000192223 UP000007266

PRIDE

Q8IMX7

Pfam

PF00071   Ras        + More
PF08355   EF_assoc_1
PF08356   EF_assoc_2
PF13202   EF-hand_5
PF00628   PHD
PF07524   Bromo_TP

Interpro

IPR013566   EF_hand_assoc_1        + More
IPR018247   EF_Hand_1_Ca_BS
IPR020860   MIRO_dom
IPR013567   EF_hand_assoc_2
IPR021181   Miro
IPR001806   Small_GTPase
IPR011992   EF-hand-dom_pair
IPR002048   EF_hand_dom
IPR027417   P-loop_NTPase
IPR005225   Small_GTP-bd_dom
IPR011011   Znf_FYVE_PHD
IPR006565   BTP
IPR019787   Znf_PHD-finger
IPR013083   Znf_RING/FYVE/PHD
IPR001965   Znf_PHD
IPR019786   Zinc_finger_PHD-type_CS
IPR009072   Histone-fold

SUPFAM

SSF52540   SSF52540        + More
SSF47473   SSF47473
SSF57903   SSF57903

Gene 3D

1.10.20.10 3.30.40.10

ProteinModelPortal

A0A2A4JM44 A0A2H1VAL5 A0A212ERP1 A0A194PET0 A0A194QKS1 A0A0L7L805 + More
A0A1Q3FES0 A0A1Q3FBQ1 B0W0F0 A0A182IRR3 A0A182MN96 A0A182WT12 A0A182RFI6 A0A182UFY5 A0A182HV09 A0A182L1V3 A0A182W7E5 Q17JY4 A0A0K8U817 A0A182XZX5 Q7Q3R6 A0A182P4R9 A0A034VHG5 A0A182G4S0 A0A0A1XTC9 A0A1J1IM58 A0A1J1IP23 A0A182Q383 A0A1Q3G2Z9 A0A1L8E3N2 A0A0K8V754 U5EXQ2 A0A182USL7 A0A034VJ35 A0A0P6K0U7 W8BZQ5 A0A182F1L2 W5JS34 A0A0A1XMS8 A0A0L0CDE7 A0A1I8MIZ9 A0A1I8PUU8 A0A0K8V6H1 A0A2M4AET8 A0A2M4BGQ6 A0A034VIF1 A0A182JU65 A0A1L8E3G0 A0A0A1WNL4 A0A2M3Z6R8 A0A0K8UDU8 A0A0K8TZD8 A0A034VGD2 A0A0Q9X3H1 W8BN06 A0A1I8MIZ4 A0A182NTM6 A0A1I8PUS2 T1PLI1 A0A0Q9X6E0 W8B0Z9 A0A1I8MJ01 A0A1I8PUT9 A0A0Q9WUG2 Q8IMX7 A0A3B0JK69 B4JII1 B4NH46 A0A1W4UJA0 A0A0R1E9A9 A0A0M5J7G7 A0A0Q9WYZ6 B4K798 N6TY59 A0A0Q9WSM3 I5ANY4 Q298L5 A0A0P8YLF5 B4M0H7 V5GTM6 A0A0B4J3Z9 B3P8A4 A0A1W4U7I3 A0A3B0KAN7 A0A084WD81 A0A0K8TK97 Q8IMX7-2 A0A0B4KGW0 A0A0R1EBC3 A0A3B0KGG3 A0A1W4UL30 B4HGG5 A0A1Y1KMN1 B4PL33 B4G438 A0A0R3NL19 A0A3B0K9J3 A0A0P9C867 A0A1W4WF63 D6X1S3

PDB

4C0L E-value=5.36212e-147, Score=1338

KEGG

101746359 K07870 mitochondrial Rho GTPase 1 [EC:3.6.5.-] | (RefSeq) mitochondrial Rho GTPase-like

PATHWAY

04137 Mitophagy - animal - Bombyx mori (domestic silkworm)
04214 Apoptosis - fly - Bombyx mori (domestic silkworm)

GO

GO:0005525 GO:0031307 GO:0005509 GO:0007005 GO:0003924 GO:0047497 GO:0007266 GO:0010821 GO:0046982 GO:0016021 GO:1904115 GO:0048489 GO:0045202 GO:0097345 GO:0034643 GO:0051646 GO:0000226 GO:0000287 GO:0019725 GO:0019896 GO:0008168 GO:0007264 GO:0005739 GO:0008270 GO:0003700 GO:0043565

Subcellular location

Mitochondrion outer membrane

Length:

615

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

20.85477

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00070

outside

1 - 588

TMhelix

589 - 611

inside

612 - 615

Pi

214.564747

Theta

19.253682

Tajima's D

-1.627369

CLR

168.868798

CSRT

0.0446477676116194

Interpretation

Possibly Positive selection

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics