Gene

KWMTBOMO05635

Pre Gene Modal

BGIBMGA006783

Annotation

tRNA_(guanine-N(7)-)-methyltransferase_[Bombyx_mori]

Location

Bomo_Chr10(+):6995123-7002256      View in EpiBrowser

Full name

tRNA (guanine-N(7)-)-methyltransferase       + More
tRNA (guanine(46)-N(7))-methyltransferase      

Alternative Name

tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Methyltransferase-like protein 1

Location in the cell

Cytoplasmic   Reliability : 2.838

CDS

ATGGCTTTGCCGCAAAAGAAATATTATAGACAACGTGCGCATTCTAACCCTATCGCAGATCACTGTTTTGATTATCCATCTCACCCTGATGATTATGACTGGACTCCCTTATATCCAATTATATCAGAAAAACCAAATCAGGTGGAGTTTTTAGATGTTGGTTGTGGTTATGGAGGACTTTTGGTTGCATTGTCTCCAATGTTTCCCAGTAACTTGATGTTGGGTTTGGAAATAAGAGTTAAAGTATCTGACTATGTAAATGATAGGATAAAAGCACTCAGGGTACAGTATCCTGATCAATATCAAAATGTAGCTGTGTTAAGGACAAATGCCATGAAATATCTTCCTAACTTTTTTCATAAAGGCCAGCTAAAAAAAATGTTTTTCTTATATCCAGATCCACATTTCAAGAAAGCAAAACATAAATGGAGGATAATTAACAAATGGCTCCTTTCTGAATATGCTTACGTACTGTGTGAACAGGGTATTGTATACACAATTACTGATGTAAAGGATTTGAATGAATGGATGGTTGCACATTTTGAGGAACATCCATTATTTGAAAGTGTTCCTGAAGAAGAATTGAAAGAAGATCCGATAATAGAAAAACTTTATGAGAGTACTGAAGAAGGTCAAAAAGTAACTAGGAATAATGGAGAGAAATTTCTAGCAGTGTTTAGAAGGATTGCTGATAAAACGAAAACTAATTAA

Protein

MALPQKKYYRQRAHSNPIADHCFDYPSHPDDYDWTPLYPIISEKPNQVEFLDVGCGYGGLLVALSPMFPSNLMLGLEIRVKVSDYVNDRIKALRVQYPDQYQNVAVLRTNAMKYLPNFFHKGQLKKMFFLYPDPHFKKAKHKWRIINKWLLSEYAYVLCEQGIVYTITDVKDLNEWMVAHFEEHPLFESVPEEELKEDPIIEKLYESTEEGQKVTRNNGEKFLAVFRRIADKTKTN

Description

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

Catalytic Activity

guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine

Subunit

Forms a complex with WDR4.
Forms a complex with wdr4.

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

Keywords

Complete proteome   Methyltransferase   Nucleus   Reference proteome   RNA-binding   S-adenosyl-L-methionine   Transferase   tRNA processing   tRNA-binding  

Feature

chain  tRNA (guanine-N(7)-)-methyltransferase

Uniprot

Q1HPU2   A0A2H1VV07   A0A2A4J8W6   A0A212EUR2   A0A3S2P042   A0A194QKT7   + More
S4PBF3   A0A194PFS2   A0A026WGF8   J3JTL7   A0A232F597   A0A3L8E3Z7   A0A0J7KZC4   E2AU15   A0A1Y1K937   A0A2A3E4X7   F4WIR9   A0A154P1F2   A0A023GJK9   A0A1Y1K433   A0A023GH46   G3MQC9   A0A151JRN7   A0A195BNS6   A0A158P479   A0A151WLQ4   A0A310S9F9   E2B4E9   A0A1B6MQR3   A0A195CVC4   A0A131XD58   A0A1B6FR27   A0A0C9PIN7   A0A224Z2C4   A0A0C9QYQ8   L7M2C0   A0A293LHY9   A0A0M9ABR8   A0A2R5LBH8   A0A2S2NCG7   A0A2H8TS48   C3ZAN8   A0A195FNY8   E9FWC0   J9JNT7   A0A0V0G8T3   V4C725   A0A1S3HAD5   A0A0P5FS87   A0A0A9YJL3   A0A0P5CEL3   A0A224XWQ9   A0A146L0I9   A0A0P6HBG5   A0A0P5EHF5   A0A069DRA6   A0A034VG49   A0A2B4R9Z6   A0A1E1XBW4   Q0IEN3   A0A0P4XKE9   A0A2K7P6B8   A0A2P2HWG0   A0A0L8G1E2   C1BMF1   A0A1W4VEQ2   B3P8V8   A0A1I8MCP4   B4R338   R4G831   G1KN86   B4Q1B6   A0A182GV25   W8BEE3   A0A0P5RFW7   A0A1W4WLN1   B4I9N7   A0A084WQV1   A0A1I8NNL1   A0A182IRH4   A0A1A9VEK8   D3TR10   C1BTP4   A0A0M4EXW1   A0A1E1XR30   D3PHV0   A0A088AHP7   A0A3B4Z052   O77263   Q29I16   U5EUQ6   A0A2C9JZH1   B4N278   A0A1S4EL54   B4H4I3   A0A1L8HI54   Q6NU94   B4L529   A0A3Q1EN61  

EC Number

2.1.1.33

Pubmed

22118469    26354079    23622113    24508170    22516182    28648823    + More
30249741    20798317    28004739    21719571    22216098    21347285    28049606    28797301    25576852    18563158    21292972    23254933    25401762    26823975    26334808    25348373    28503490    17510324    17994087    25315136    26483478    24495485    24438588    20353571    29209593    10731132    12537572    10731137    12537569    15632085    15562597    27762356   

EMBL

DQ443310    ODYU01004435    SOQ44302.1    NWSH01002591    PCG67900.1    AGBW02012332    + More
OWR45201.1    RSAL01000073    RVE48977.1    KQ461198    KPJ06142.1    GAIX01005937    JAA86623.1    KQ459606    KPI91549.1    KK107260    EZA54144.1    BT126574    AEE61538.1    NNAY01000908    OXU25974.1    QOIP01000001    RLU26708.1    LBMM01001804    KMQ95716.1    GL442767    EFN63058.1    GEZM01093600    JAV56225.1    KZ288371    PBC26745.1    GL888177    EGI65865.1    KQ434796    KZC05652.1    GBBM01002195    JAC33223.1    GEZM01093601    JAV56224.1    GBBM01002224    JAC33194.1    JO844080    AEO35697.1    KQ978615    KYN29860.1    KQ976435    KYM87024.1    ADTU01008699    KQ982959    KYQ48721.1    KQ768478    OAD53131.1    GL445552    EFN89443.1    GEBQ01001707    JAT38270.1    KQ977279    KYN04119.1    GEFH01004239    JAP64342.1    GECZ01017103    JAS52666.1    GBYB01000803    JAG70570.1    GFPF01012860    MAA24006.1    GBYB01008944    JAG78711.1    GACK01007756    JAA57278.1    GFWV01003394    MAA28124.1    KQ435689    KOX81230.1    GGLE01002700    MBY06826.1    GGMR01002285    MBY14904.1    GFXV01005212    MBW17017.1    GG666602    EEN50441.1    KQ981382    KYN42275.1    GL732526    EFX88456.1    ABLF02023335    GECL01001628    JAP04496.1    KB201305    ESO97474.1    GDIP01144407    JAJ78995.1    GBHO01010347    GBRD01007047    JAG33257.1    JAG58774.1    GDIP01187552    JAJ35850.1    GFTR01004015    JAW12411.1    GDHC01016525    JAQ02104.1    GDIQ01022072    JAN72665.1    GDIP01159959    JAJ63443.1    GBGD01002707    JAC86182.1    GAKP01018409    JAC40543.1    LSMT01000777    PFX14461.1    GFAC01002443    JAT96745.1    CH477558    GDIP01241350    JAI82051.1    IACF01000323    LAB66111.1    KQ424537    KOF70846.1    BT075780    ACO10204.1    CH954183    CM000366    ACPB03018200    GAHY01001682    JAA75828.1    CM000162    JXUM01090180    KQ563823    KXJ73224.1    GAMC01009528    JAB97027.1    GDIQ01107589    GDIP01019965    JAL44137.1    JAM83750.1    CH480825    ATLV01025759    KE525399    KFB52595.1    EZ423862    ADD20138.1    BT077973    ACO12397.1    CP012528    ALC48692.1    GFAA01001644    JAU01791.1    BT121206    HACA01027719    ADD38136.1    CDW45080.1    AE014298    AL031765    AY094742    CH379064    GANO01001362    JAB58509.1    CH963925    CH479209    CM004468    OCT95780.1    BC068703    CH933811   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000053240    UP000053268    + More
UP000053097    UP000215335    UP000279307    UP000036403    UP000000311    UP000242457    UP000007755    UP000076502    UP000078492    UP000078540    UP000005205    UP000075809    UP000008237    UP000078542    UP000053105    UP000001554    UP000078541    UP000000305    UP000007819    UP000030746    UP000085678    UP000225706    UP000008820    UP000053454    UP000192221    UP000008711    UP000095301    UP000000304    UP000015103    UP000001646    UP000002282    UP000069940    UP000249989    UP000192223    UP000001292    UP000030765    UP000095300    UP000075880    UP000078200    UP000092553    UP000005203    UP000261400    UP000000803    UP000001819    UP000076420    UP000007798    UP000079169    UP000008744    UP000186698    UP000009192    UP000257200   

PRIDE

Q1HPU2    B3P8V8    B4R338    B4Q1B6    O77263    B4N278    + More
Q6NU94   

Pfam

PF02390   Methyltransf_4

Interpro

IPR025763   Trm8_euk        + More
IPR003358   tRNA_(Gua-N-7)_MeTrfase_Trmb       
IPR029063   SAM-dependent_MTases       

SUPFAM

SSF53335   SSF53335       

ProteinModelPortal

Q1HPU2   A0A2H1VV07   A0A2A4J8W6   A0A212EUR2   A0A3S2P042   A0A194QKT7   + More
S4PBF3   A0A194PFS2   A0A026WGF8   J3JTL7   A0A232F597   A0A3L8E3Z7   A0A0J7KZC4   E2AU15   A0A1Y1K937   A0A2A3E4X7   F4WIR9   A0A154P1F2   A0A023GJK9   A0A1Y1K433   A0A023GH46   G3MQC9   A0A151JRN7   A0A195BNS6   A0A158P479   A0A151WLQ4   A0A310S9F9   E2B4E9   A0A1B6MQR3   A0A195CVC4   A0A131XD58   A0A1B6FR27   A0A0C9PIN7   A0A224Z2C4   A0A0C9QYQ8   L7M2C0   A0A293LHY9   A0A0M9ABR8   A0A2R5LBH8   A0A2S2NCG7   A0A2H8TS48   C3ZAN8   A0A195FNY8   E9FWC0   J9JNT7   A0A0V0G8T3   V4C725   A0A1S3HAD5   A0A0P5FS87   A0A0A9YJL3   A0A0P5CEL3   A0A224XWQ9   A0A146L0I9   A0A0P6HBG5   A0A0P5EHF5   A0A069DRA6   A0A034VG49   A0A2B4R9Z6   A0A1E1XBW4   Q0IEN3   A0A0P4XKE9   A0A2K7P6B8   A0A2P2HWG0   A0A0L8G1E2   C1BMF1   A0A1W4VEQ2   B3P8V8   A0A1I8MCP4   B4R338   R4G831   G1KN86   B4Q1B6   A0A182GV25   W8BEE3   A0A0P5RFW7   A0A1W4WLN1   B4I9N7   A0A084WQV1   A0A1I8NNL1   A0A182IRH4   A0A1A9VEK8   D3TR10   C1BTP4   A0A0M4EXW1   A0A1E1XR30   D3PHV0   A0A088AHP7   A0A3B4Z052   O77263   Q29I16   U5EUQ6   A0A2C9JZH1   B4N278   A0A1S4EL54   B4H4I3   A0A1L8HI54   Q6NU94   B4L529   A0A3Q1EN61  

PDB

3CKK     E-value=7.13962e-76,     Score=719

KEGG

732983    K03439 tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33] | (RefSeq) tRNA (guanine-N7-)-methyltransf

GO

GO:0005634   GO:0000049   GO:0008176   GO:0036265   GO:0016021   GO:0030488   GO:0005829   GO:0005654   GO:0005730   GO:0006400   GO:0006468   GO:0005886   GO:0006171   GO:0035076   GO:0043401   GO:0008270   GO:0003700   GO:0043565  

PANTHER

PTHR23417   PTHR23417:SF16  

Subcellular location

Nucleus  

Length:

236

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.57644

Exp number, first 60 AAs:

0.89252

Total prob of N-in:

0.32016

outside

1  -  236

 

 

Pi

260.235528

Theta

186.323813

Tajima's D

1.136754

CLR

0.716855

CSRT

0.700664966751662

Interpretation

Uncertain