Gene

KWMTBOMO05605  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006767

Annotation

ecdysone_receptor_isoform_B1_[Bombyx_mori]

Location

Bomo_Chr10(+):6136445-6167293      View in EpiBrowser

Full name

Ecdysone receptor      

Alternative Name

20-hydroxy-ecdysone receptor
EcRH
Ecdysteroid receptor
Nuclear receptor subfamily 1 group H member 1
HvEcR

Transcription factor

THR-like

Location in the cell

Nuclear   Reliability : 4.724

CDS

ATGAGAGTCGAGAACGTGGATAACGTATCGTTTGCTTTGAACGGACGCGCTGACGAGTGGTGTATGTCTGTAGAGACGCGTTTAGATAGTTTAGTGCGAGAAAAAAGTGAAGTGAAAGCCTACGTCGGAGGATGTCCCTCGGTAATCACGGATGCTGGAGCGTATGACGCGCTCTTCGACATGAGACGCCGCTGGTCTAATAACGGTGGCTTCCCGCTGCGAATGCTTGAAGAGAGCTCTTCAGAAGTGACATCGTCTTCGGCACTGGGTTTGCCACCGGCCATGGTTATGTCGCCGGAATCCTTGGCGTCGCCCGAGTATGGAGCCCTCGAGCTATGGAGCTACGATGACGGAATCACTTATAATACAGCCCAGTCTCTGCTGGGTGCATGCAATATGCAACAGCAACAGCTACAACCTCAGCAACCACATCCAGCACCACCGACGCTCCCCACGATGCCTTTACCAATGCCTCCCACAACACCGAAATCAGAAAATGAATCGATGTCATCAGGTCGAGAGGAACTTTCGCCGGCTTCAAGCATAAATGGCTGCAGTGCTGATGCTGACGCCAGACGGCAGAAGAAAGGTCCTGCACCTCGACAGCAAGAGGAGCTATGTCTTGTCTGCGGCGACAGAGCCTCCGGATACCACTACAACGCACTGACGTGTGAAGGATGCAAAGGATTCTTCAGGCGGAGTGTCACCAAAAACGCAGTATATATTTGTAAATTTGGACATGCCTGTGAAATGGATATGTACATGAGGAGGAAATGTCAAGAGTGTCGATTAAAGAAATGTCTAGCGGTAGGAATGAGGCCTGAATGTGTCATACAGGAGCCCAGTAAAAATAAAGACAGGCAAAGACAAAAGAAAGACAAAGGAATATTATTACCTGTTAGTACGACCACAGTCGAAGACCACATGCCCCCGATCATGCAATGTGATCCACCTCCGCCCGAGGCCGCCAGGATTCACGAAGTCGTCCCGAGGTATCTTTCGGAGAAGCTGATGGAGCAGAACAGGCAGAAGAACATACCACCATTGTCGGCGAATCAGAAGTCTCTGATCGCGAGGCTCGTGTGGTACCAGGAGGGATATGAGCAGCCCTCCGACGAGGATCTCAAAAGAGTAACGCAGACTTGGCAGTCGGATGAAGAGGACGAGGAATCCGATCTACCCTTCCGCCAGATCACGGAGATGACGATCTTAACGGTCCAGTTGATCGTCGAGTTCGCCAAGGGTCTACCGGGCTTTTCGAAGATATCACAGTCTGATCAAATCACCTTATTAAAAGCCTCGTCCAGCGAGGTGATGATGCTGCGGGTGGCGAGGCGATACGACGCCGCGTCCGACAGCGTGCTGTTCGCCAACAACAAGGCGTACACGCGCGACAACTACCGCAAGGCGGGCATGGCCTACGTCATCGAAGACCTCCTACACTTCTGCCGGTGCATGTTCGCGATGGGCATGGACAATGTGCACTTTGCACTGCTCACGGCCATCGTTATATTCTCAGATCGGCCCGGGCTCGAGCAGCCGTCGCTGGTAGAAGAGATCCAGAGATACTACCTGAACACGTTGCGAATTTACATCATCAACCAGAACAGCGCGTCGTCGCGCTGCGCCGTGATCTACGGCAGGATCCTGAGCGTGCTGACCGAGCTACGCACGCTCGGCACGCAAAACTCCAACATGTGCATCTCGCTGAAGCTGAAGAACAGGAAGCTGCCGCCGTTCCTCGAGGAGATCTGGGACGTGGCGGAGGTGGCCACGACGCATCCCACGGTGCTGCCGCCCACCAACCCGGTGGTGCTATAG

Protein

MRVENVDNVSFALNGRADEWCMSVETRLDSLVREKSEVKAYVGGCPSVITDAGAYDALFDMRRRWSNNGGFPLRMLEESSSEVTSSSALGLPPAMVMSPESLASPEYGALELWSYDDGITYNTAQSLLGACNMQQQQLQPQQPHPAPPTLPTMPLPMPPTTPKSENESMSSGREELSPASSINGCSADADARRQKKGPAPRQQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAVYICKFGHACEMDMYMRRKCQECRLKKCLAVGMRPECVIQEPSKNKDRQRQKKDKGILLPVSTTTVEDHMPPIMQCDPPPPEAARIHEVVPRYLSEKLMEQNRQKNIPPLSANQKSLIARLVWYQEGYEQPSDEDLKRVTQTWQSDEEDEESDLPFRQITEMTILTVQLIVEFAKGLPGFSKISQSDQITLLKASSSEVMMLRVARRYDAASDSVLFANNKAYTRDNYRKAGMAYVIEDLLHFCRCMFAMGMDNVHFALLTAIVIFSDRPGLEQPSLVEEIQRYYLNTLRIYIINQNSASSRCAVIYGRILSVLTELRTLGTQNSNMCISLKLKNRKLPPFLEEIWDVAEVATTHPTVLPPTNPVVL

Description

Receptor for ecdysone. Binds to ecdysone response elements (ECRES) (By similarity).
Receptor for ecdysone. Binds to ecdysone response elements (ECRES).

Subunit

Heterodimer of ECR and CF1.
Heterodimer of USP and ECR. Only the heterodimer is capable of high-affinity binding to ecdysone.

Similarity

Belongs to the nuclear hormone receptor family. NR1 subfamily.
Belongs to the nuclear hormone receptor family.

Keywords

Alternative splicing   Complete proteome   DNA-binding   Metal-binding   Nucleus   Receptor   Reference proteome   Transcription   Transcription regulation   Zinc   Zinc-finger   3D-structure  

Feature

chain  Ecdysone receptor
splice variant  In isoform 2.

Uniprot

P49881   P49881-2   A7UBN8   A0A1V0J8X2   A0A220QT58   B1PHV7   + More
M4IQS5   E3UJZ5   A0A2A4JZQ0   I3RQB7   A9UEF6   A6ZIC7   A0A0E3TVQ6   P49883   A0A3S2P057   A0A212EQ34   G9M5R0   Q8MYA6   B9UCQ4   O77255   Q6RVD3   I3RQB8   O18473   G5CV07   B0L963   A0A1C9EGN0   A0A0N9K857   A0A1Z2RRH6   A0A2H1VT35   Q8MYA7   A0A194PKH4   A0A0L7LP96   D1L3C3   P49880-2   Q9U3Y4   A0A1Q3G0B9   U5ENQ7   A0A2M4BCI6   A0A1L8DG58   A0A2M3Z5W6   A0A2M4AHB7   A0A182R1F1   A0A2M3ZGP1   A0A2M4AIH9   A0A2M4BH65   A0A2M4BE81   A0A2M4BDP7   A0A2M4CX79   A0A1L8DG95   A0A2M4CYU8   A0A2M4CY19   A0A2M4BFQ1   A0A182NZ10   A0A2M3Z4S0   A0A2M3Z689   A0A2M3Z5S8   A0A2M4AEX5   A0A2M4CY38   A0A182JN95   A0A182FZQ6   A0A182S4L2   A0A182PYX8   A0A182WQL4   A0A182VPJ8   A0A182II15   A0A084WHH9   A0A182XU88   A0A1S4HF14   A0A087ZGY1   A0A182Y203   W5J5J4   A0A1W5C8V2   B4KLY6   B3MJ68   B4LIK9   A0A1W4UUQ1   A0A0P8XRQ9   A0A1W4UHR3   O18531   A0A1I8NAY9   A0A1B0F935   A0A1W4UH67   A0A0P9AHJ6   K9LFW0  

Pubmed

7633470    22044719    18023454    7633469    22118469    12213236    + More
8641050    15233798    10528411    26325588    28605547    26354079    26227816    7711747    12385823    17510324    10644973    24438588    20920257    25244985    12364791    17994087    9304790    25315136   

EMBL

L35266    D43943    EU043114    ABS87644.1    KY411159    ARD05165.1    + More
KY328717    ASK12085.1    EU426551    ACA30302.1    JQ731607    AGA17965.1    HM445734    ADO64595.1    NWSH01000351    PCG77124.1    JQ730731    AFK27930.1    EU180021    ABX79143.1    EF667891    ABS00249.1    KP869130    AKC43542.1    U19812    RSAL01000073    RVE49011.1    AGBW02013342    OWR43574.1    AB568469    BAL41654.1    AB067812    BAC11714.1    EU526831    ACD74807.1    U29531    AAC36491.2    AY489269    AAR84611.1    JQ730732    AFK27931.1    Y09009    JN410826    AEP25402.1    EF417852    ABQ81864.1    KX778610    AON96649.1    KT363834    ALG36653.1    KY938813    ASA46454.1    ODYU01004298    SOQ44015.1    AB067811    BAC11713.1    KQ459606    KPI91595.1    JTDY01000435    KOB77179.1    GQ427083    ACY80739.2    U02021    AY345989    CH477596    CH477685    AF210733    AAF19032.1    GFDL01001794    JAV33251.1    GANO01003976    JAB55895.1    GGFJ01001592    MBW50733.1    GFDF01008642    JAV05442.1    GGFM01003087    MBW23838.1    GGFK01006791    MBW40112.1    AXCN02001080    GGFM01006941    MBW27692.1    GGFK01007263    MBW40584.1    GGFJ01003150    MBW52291.1    GGFJ01002219    MBW51360.1    GGFJ01002039    MBW51180.1    GGFL01005633    MBW69811.1    GFDF01008633    JAV05451.1    GGFL01006267    MBW70445.1    GGFL01005923    MBW70101.1    GGFJ01002650    MBW51791.1    GGFM01002697    MBW23448.1    GGFM01003296    MBW24047.1    GGFM01003122    MBW23873.1    GGFK01005951    MBW39272.1    GGFL01006001    MBW70179.1    APCN01003279    APCN01003280    ATLV01023827    KE525347    KFB49673.1    ADMH02002064    ETN59727.1    AAAB01008986    EAA00117.5    CH933808    EDW10775.2    CH902619    EDV38162.1    CH940648    EDW60379.2    KPU77295.1    U75355    KPU77296.1    JQ034623    AFI99107.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000007151    UP000053268    UP000037510    + More
UP000008820    UP000075886    UP000075884    UP000075880    UP000069272    UP000075900    UP000075885    UP000075920    UP000075903    UP000075840    UP000030765    UP000076407    UP000076408    UP000000673    UP000007062    UP000009192    UP000007801    UP000008792    UP000192221    UP000095301    UP000092443   

PRIDE

P49881    A7UBN8    P49883    O18473   

Pfam

PF00105   zf-C4        + More
PF00104   Hormone_recep

Interpro

IPR000536   Nucl_hrmn_rcpt_lig-bd        + More
IPR001628   Znf_hrmn_rcpt       
IPR003069   Ecdystd_rcpt       
IPR013088   Znf_NHR/GATA       
IPR001723   Nuclear_hrmn_rcpt       
IPR035500   NHR-like_dom_sf       
IPR041889   NR_LBD_EcR       

SUPFAM

SSF48508   SSF48508       

Gene 3D

1.10.565.10     3.30.50.10    

CDD

cd06938  NR_LBD_EcR

ProteinModelPortal

P49881   P49881-2   A7UBN8   A0A1V0J8X2   A0A220QT58   B1PHV7   + More
M4IQS5   E3UJZ5   A0A2A4JZQ0   I3RQB7   A9UEF6   A6ZIC7   A0A0E3TVQ6   P49883   A0A3S2P057   A0A212EQ34   G9M5R0   Q8MYA6   B9UCQ4   O77255   Q6RVD3   I3RQB8   O18473   G5CV07   B0L963   A0A1C9EGN0   A0A0N9K857   A0A1Z2RRH6   A0A2H1VT35   Q8MYA7   A0A194PKH4   A0A0L7LP96   D1L3C3   P49880-2   Q9U3Y4   A0A1Q3G0B9   U5ENQ7   A0A2M4BCI6   A0A1L8DG58   A0A2M3Z5W6   A0A2M4AHB7   A0A182R1F1   A0A2M3ZGP1   A0A2M4AIH9   A0A2M4BH65   A0A2M4BE81   A0A2M4BDP7   A0A2M4CX79   A0A1L8DG95   A0A2M4CYU8   A0A2M4CY19   A0A2M4BFQ1   A0A182NZ10   A0A2M3Z4S0   A0A2M3Z689   A0A2M3Z5S8   A0A2M4AEX5   A0A2M4CY38   A0A182JN95   A0A182FZQ6   A0A182S4L2   A0A182PYX8   A0A182WQL4   A0A182VPJ8   A0A182II15   A0A084WHH9   A0A182XU88   A0A1S4HF14   A0A087ZGY1   A0A182Y203   W5J5J4   A0A1W5C8V2   B4KLY6   B3MJ68   B4LIK9   A0A1W4UUQ1   A0A0P8XRQ9   A0A1W4UHR3   O18531   A0A1I8NAY9   A0A1B0F935   A0A1W4UH67   A0A0P9AHJ6   K9LFW0  

PDB

4UMM     E-value=1.05832e-127,     Score=1171

KEGG

692756    K14034 ecdysone receptor | (RefSeq) EcR; ecdysone receptor

PATHWAY

04214    Apoptosis - fly - Bombyx mori (domestic silkworm)

GO

GO:0043565   GO:0003707   GO:0005634   GO:0004879   GO:0035100   GO:0035076   GO:0008270   GO:0046872   GO:0003677   GO:0016021   GO:0005700   GO:0046982   GO:0007390   GO:0042803   GO:0007468   GO:0016322   GO:0008340   GO:0010002   GO:1904801   GO:0008544   GO:0007616   GO:0035071   GO:0043065   GO:0045938   GO:0008231   GO:0007406   GO:0007476   GO:0008258   GO:0005102   GO:0035180   GO:0030425   GO:0018990   GO:0044130   GO:0008362   GO:0000977   GO:0035193   GO:0002164   GO:0006914   GO:0048738   GO:0035073   GO:0042632   GO:0035206   GO:0001047   GO:0035188   GO:0043457   GO:0001228   GO:0007488   GO:0007422   GO:0042220   GO:0035297   GO:0007298   GO:0006911   GO:0007291   GO:0007155   GO:0070491   GO:0016319   GO:0001225   GO:0035053   GO:0010506   GO:0005737   GO:0008232   GO:0004884   GO:0005496   GO:0006355   GO:0043401   GO:0003700  

Subcellular location

Nucleus  

Length:

606

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.11607

Exp number, first 60 AAs:

0.03087

Total prob of N-in:

0.00353

outside

1  -  606

 

 

Pi

215.320778

Theta

192.645746

Tajima's D

0.644134

CLR

0.182671

CSRT

0.55887205639718

Interpretation

Uncertain