Gene

KWMTBOMO05592

Pre Gene Modal

BGIBMGA006760

Annotation

PREDICTED:_protein-lysine_N-methyltransferase_EEF2KMT_[Papilio_xuthus]

Location

Bomo_Chr10(+):5468890-5473824      View in EpiBrowser

Full name

Protein-lysine N-methyltransferase EEF2KMT      

Alternative Name

eEF2-lysine methyltransferase

Location in the cell

Cytoplasmic   Reliability : 2.013 Nuclear   Reliability : 1.391

CDS

ATGAATAACAGTGCTATAGAAGACTATTGTTACCGGCACTATGTTATCAGCAATGATCTTAATAATATTATAACTATGAAAGAAACGAAGAATATGGTTGTTAATGGTACCACAGGAATGCGCACCTGGGAGGCTGCATTGATGCTTTCTGATTGGATTCTATGTAACAAAGAGCTGTTTTCATCAAAAGACGTCCTAGAATTAGGATCAGGTATAGGATTCACTGGTATCACATTAGCAAAATTTTGTGAACCTAAATCAGTAACAATGACTGATTGTCATGAAGATGTTCTACAAGTACTGTGTGAAAATGTGGATATAAATTTTCCATCACAATGTAAAAACAGAAGCTCTGATGGCACAACATATGAATTAGACAATGTTAGTAGAGTTGATGTTAAGATGTTAGATTGGAATGAAATTACCGATCTACCAAATAAAAGGCCCGATGTAATACTTGGTGCAGATATTGTATATGATCCTTCAATACTGAAGCCACTCTGTAATGTACTGAAAATATTCTGTGACAGAAAAAATGACGTGAACATTTATATCGCCAGTATTATAAGAAATGAGTTAACCTTTGAAAGTTTTTTACAAGTTTTGGAAACCTATAATTTTCATTGTGAAAAATTAATGCAACCAACAAATGCGCACATTGAGTGGGATCATACTCATATTAACCGATGCTTACTAAAGATCATGAGGAAATAA

Protein

MNNSAIEDYCYRHYVISNDLNNIITMKETKNMVVNGTTGMRTWEAALMLSDWILCNKELFSSKDVLELGSGIGFTGITLAKFCEPKSVTMTDCHEDVLQVLCENVDINFPSQCKNRSSDGTTYELDNVSRVDVKMLDWNEITDLPNKRPDVILGADIVYDPSILKPLCNVLKIFCDRKNDVNIYIASIIRNELTFESFLQVLETYNFHCEKLMQPTNAHIEWDHTHINRCLLKIMRK

Description

Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'.

Subunit

Interacts with FAM86B2 and FAM86C1.

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.

Keywords

Acetylation   Alternative splicing   Complete proteome   Cytoplasm   Methyltransferase   Reference proteome   S-adenosyl-L-methionine   Transferase  

Feature

chain  Protein-lysine N-methyltransferase EEF2KMT
splice variant  In isoform 2.

Uniprot

A0A2A4JBK2   A0A2H1WV61   A0A212EVC8   A0A3S2NHV3   A0A1C9EGL3   A0A195FN98   + More
A0A195C637   A0A195AVP7   A0A195E927   A0A0A0AYD6   A0A093RWW6   A0A158NF26   A0A1Q3FFV0   A0A151WHY0   A0A2I4D7V5   A0A1Q3FFM2   A0A1Q3FFQ0   A0A091FL81   A0A1I8QEQ3   R7T7X9   A0A1B6DGU6   B0W680   A0A2D4NBK6   F4WEL4   Q173U5   A0A2I0LWV5   A0A1W4XIQ1   A0A091R895   A0A1V4KT99   A0A182G6Q2   A0A023ERF2   A0A182SX91   A0A226NT43   A0A293N160   A0A0L0C872   A0A087QI92   A0A1W3JTU9   J9JSN5   A0A2D4HVN2   U3I6R4   A0A3B1IIY7   A0A3P8QH70   R0JVP8   H0VPL8   A0A093NZA9   W5L2E3   F6TKJ5   H3D146   I3MQU1   A0A182KC85   A0A091J897   A0A2D4KP71   E9J353   A0A3Q4GQ25   A0A3P9AZX5   A0A093K0A1   A0A091WLE4   A0A182M3V0   A0A182RX58   A0A3Q3CWM6   H3AZ04   A0A182U4P4   A0A182ID75   Q7QB05   Q4SAS7   A0A2M4ARR4   A0A182US78   A0A1V4KT72   H3BW61   A0A182PS79   A0A1A9W1W2   A0A1X7VTR5   A0A1S3ES16   A0A1B6I953   A0A1A6HQA3   T1E9S9   K7GDG6   A0A3B4FQR7   A0A182Y5C1   H3CRR6   A0A2S2PIB1   A0A3Q2PRF2   Q4SN38   A0A093GIC5   F6TPM4   A0A088AJK3   Q3UZW7-2   A0A182FPS2   H0YZ08   A0A182NCY5   A0A1B6IS42   W5J5K2   A0A084WP34   K7GDG1   A0A182W189   A0A2M3Z7V0   A0A2M3Z7R2  

EC Number

2.1.1.-

Pubmed

22118469    21347285    23254933    21719571    17510324    23371554    + More
26483478    24945155    24621616    26108605    25329095    21993624    17495919    15496914    21282665    25186727    9215903    12364791    14747013    17210077    17381049    25244985    12481130    15114417    16141072    19468303    15489334    21183079    20360741    20920257    23761445    24438588   

EMBL

NWSH01002007    PCG69455.1    ODYU01011300    SOQ56948.1    AGBW02012210    OWR45446.1    + More
RSAL01000092    RVE47965.1    KX778610    AON96638.1    KQ981490    KYN41364.1    KQ978287    KYM95636.1    KQ976736    KYM76044.1    KQ979479    KYN21334.1    KL873367    KGL98508.1    KL669029    KFW75239.1    ADTU01013712    GFDL01008644    JAV26401.1    KQ983106    KYQ47405.1    GFDL01008710    JAV26335.1    GFDL01008713    JAV26332.1    KL447254    KFO71260.1    AMQN01014733    KB311212    ELT89739.1    GEDC01012463    JAS24835.1    DS231847    EDS36427.1    IACM01154212    LAB42529.1    GL888103    EGI67377.1    CH477416    EAT41351.1    EAT41352.1    AKCR02000070    PKK21915.1    KK810912    KFQ35472.1    LSYS01001700    OPJ87620.1    JXUM01045410    JXUM01063366    KQ562245    KQ561437    KXJ76315.1    KXJ78594.1    GAPW01002349    JAC11249.1    AWGT02000778    OXB70975.1    GFWV01020407    MAA45135.1    JRES01000755    KNC28638.1    KL225618    KFM00946.1    ABLF02027754    IACK01052083    LAA76034.1    KB743068    EOB01626.1    AAKN02007436    AAKN02007437    KL225088    KFW67300.1    AGTP01046858    KL218765    KFP07946.1    IACL01075894    LAB10448.1    GL768057    EFZ12746.1    KL206595    KFV84064.1    KK735903    KFR16452.1    AXCM01000508    AFYH01108017    AFYH01108018    APCN01005045    AAAB01008880    EAA08636.3    CAAE01014679    CAG02255.1    GGFK01010166    MBW43487.1    OPJ87621.1    GECU01024230    JAS83476.1    LZPO01017330    OBS80638.1    GAMD01001052    JAB00539.1    AGCU01096445    GGMR01016007    MBY28626.1    CAAE01014544    CAF97944.1    KL215786    KFV66539.1    AK017533    AK133590    AK163493    AC124576    BC051078    ABQF01051220    GECU01017955    JAS89751.1    ADMH02002178    ETN58044.1    ATLV01024864    KE525362    KFB51978.1    GGFM01003846    MBW24597.1    GGFM01003812    MBW24563.1   

Proteomes

UP000218220    UP000007151    UP000283053    UP000078541    UP000078542    UP000078540    + More
UP000078492    UP000053858    UP000053258    UP000005205    UP000075809    UP000192220    UP000053760    UP000095300    UP000014760    UP000002320    UP000007755    UP000008820    UP000053872    UP000192223    UP000190648    UP000069940    UP000249989    UP000075901    UP000198419    UP000037069    UP000053286    UP000007819    UP000018467    UP000265100    UP000005447    UP000054081    UP000002280    UP000007303    UP000005215    UP000075881    UP000054308    UP000261580    UP000265160    UP000053584    UP000053605    UP000075883    UP000075900    UP000264840    UP000008672    UP000075902    UP000075840    UP000007062    UP000075903    UP000075885    UP000091820    UP000007879    UP000081671    UP000092124    UP000007267    UP000261460    UP000076408    UP000265000    UP000053875    UP000008144    UP000005203    UP000000589    UP000069272    UP000007754    UP000075884    UP000000673    UP000030765    UP000075920   

PRIDE

Q3UZW7   

Pfam

PF14904   FAM86        + More
PF10294   Methyltransf_16
PF09768   Peptidase_M76

Interpro

IPR019410   Methyltransf_16        + More
IPR029426   FAM86       
IPR029063   SAM-dependent_MTases       
IPR019165   Peptidase_M76_ATP23       

SUPFAM

SSF53335   SSF53335       

ProteinModelPortal

A0A2A4JBK2   A0A2H1WV61   A0A212EVC8   A0A3S2NHV3   A0A1C9EGL3   A0A195FN98   + More
A0A195C637   A0A195AVP7   A0A195E927   A0A0A0AYD6   A0A093RWW6   A0A158NF26   A0A1Q3FFV0   A0A151WHY0   A0A2I4D7V5   A0A1Q3FFM2   A0A1Q3FFQ0   A0A091FL81   A0A1I8QEQ3   R7T7X9   A0A1B6DGU6   B0W680   A0A2D4NBK6   F4WEL4   Q173U5   A0A2I0LWV5   A0A1W4XIQ1   A0A091R895   A0A1V4KT99   A0A182G6Q2   A0A023ERF2   A0A182SX91   A0A226NT43   A0A293N160   A0A0L0C872   A0A087QI92   A0A1W3JTU9   J9JSN5   A0A2D4HVN2   U3I6R4   A0A3B1IIY7   A0A3P8QH70   R0JVP8   H0VPL8   A0A093NZA9   W5L2E3   F6TKJ5   H3D146   I3MQU1   A0A182KC85   A0A091J897   A0A2D4KP71   E9J353   A0A3Q4GQ25   A0A3P9AZX5   A0A093K0A1   A0A091WLE4   A0A182M3V0   A0A182RX58   A0A3Q3CWM6   H3AZ04   A0A182U4P4   A0A182ID75   Q7QB05   Q4SAS7   A0A2M4ARR4   A0A182US78   A0A1V4KT72   H3BW61   A0A182PS79   A0A1A9W1W2   A0A1X7VTR5   A0A1S3ES16   A0A1B6I953   A0A1A6HQA3   T1E9S9   K7GDG6   A0A3B4FQR7   A0A182Y5C1   H3CRR6   A0A2S2PIB1   A0A3Q2PRF2   Q4SN38   A0A093GIC5   F6TPM4   A0A088AJK3   Q3UZW7-2   A0A182FPS2   H0YZ08   A0A182NCY5   A0A1B6IS42   W5J5K2   A0A084WP34   K7GDG1   A0A182W189   A0A2M3Z7V0   A0A2M3Z7R2  

PDB

4QPN     E-value=1.35968e-09,     Score=148

KEGG

101739366    K22696 protein-lysine N-methyltransferase EEF2KMT [EC:2.1.1.-] | (RefSeq) protein-lysine N-methyltra

GO

GO:0004222   GO:0008168   GO:0003746   GO:0016279   GO:0032991   GO:0018023   GO:0005737  

PANTHER

PTHR21711  

Subcellular location

Cytoplasm  

Length:

237

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0658099999999999

Exp number, first 60 AAs:

0.03436

Total prob of N-in:

0.27524

outside

1  -  237

 

 

Pi

320.477064

Theta

188.850486

Tajima's D

2.191875

CLR

0.497323

CSRT

0.910204489775511

Interpretation

Uncertain